Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

01.10.2016 | Originalien | Ausgabe 7/2016

Zeitschrift für Gerontologie und Geriatrie 7/2016

Intravenous iron administration in restless legs syndrome

An observational study in geriatric patients

Zeitschrift:
Zeitschrift für Gerontologie und Geriatrie > Ausgabe 7/2016
Autoren:
Benjamin Lieske, Ingrid Becker, Ralf Joachim Schulz, Maria Cristina Polidori, Jan Kassubek, MD, MPH Gabriele Roehrig

Abstract

Background

This observational study was carried out to investigate the effect of intravenous (i.v.) iron administration on the clinical symptoms of restless legs syndrome (RLS) in geriatric outpatients over 65 years old.

Methods

In this study geriatric outpatients (mean 4.5 ± 3.4 comorbidities and 5.7 ± 4.4 drugs taken) were recruited according to the following inclusion criteria: ≥ 65 years, diagnosis of RLS due to iron deficiency, i.e. ferritin < 50 µg/l or transferrin saturation (TFS) < 16 %) as well as no other iron therapy within 2 weeks prior to the study. Of the patients 7 (41 %) received 500 mg ferric carboxymaltose (FCM) and 10 patients (59 %) received iron gluconate (62.5 mg) based on the degree of iron deficiency. As assessed by the international RLS severity scale (IRLS) symptoms were recorded 3 times: at the beginning of iron therapy (t0), after 2 weeks (t1) and after 12 weeks (t2).

Results

A total of 17 patients (13 female, 4 male, mean age 73.2 ± 5.9 years) were included. The IRLS score significantly improved in all patients as shown by an average decrease from 30.2 (± 4.3) to 20.2 (± 4.7) (p < 0.001) after 2 weeks of i.v. iron treatment and to 23.2 ± 6.6 (p < 0.001) after 12 weeks. There was a high correlation between ferritin values and the IRLS score (C 0.729, p < 0.001). The part of the IRLS referring to activities of daily living (ADL) improved from a median of 3 (scores 3–4) to 2 (scores 2–3, p = 0.001) after 2 weeks (effect size − 0.6).

Conclusion

In this study group of geriatric outpatients i.v. administration of iron was associated with a significant improvement of symptoms in RLS as assessed by the IRLS score 2 weeks after treatment. In geriatric patients with RLS associated with iron deficiency, i.v. iron administration should be considered regarding improvement of RLS symptoms and ADL.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Sie möchten Zugang zu diesem Inhalt erhalten? Dann informieren Sie sich jetzt über unsere Produkte:

Zeitschrift für Gerontologie und Geriatrie

Print-Titel

• Themenbezogene Hefte behandeln Fragen der Gerontologie, der Biologie und Grundlagenforschung des Alterns und der geriatrischen Forschung

• Erweitert mit Beiträgen zu Therapie, Psychologie und Soziologie sowie der praktischen Altenpflege.  

• Hot topics von Experten knapp, aussagekräftig und provokativ kommentiert

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 7/2016

Zeitschrift für Gerontologie und Geriatrie 7/2016 Zur Ausgabe

Mitteilungen der DGGG

Mitteilungen der DGGG

Mitteilungen der ÖGGG

Mitteilungen der ÖGGG

Mitteilungsseiten des BV Geriatrie

Mitteilungsseiten des BV Geriatrie