nach oben

Erschienen in:

2016 | OriginalPaper | Buchkapitel

19. Fetale Programmierung

verfasst von : Ekkehard Schleußner

Erschienen in: Die Geburtshilfe

Verlag: Springer Berlin Heidelberg

Einloggen, um Zugang zu erhalten

Zusammenfassung

Prä- und perinatale Einflüsse spielen neben der genetischen Disposition und verschiedenen Lebensstilfaktoren eine entscheidende Rolle für Gesundheit und Krankheit im späteren Leben. Ein als Fetale Programmierung bezeichneter Prozess während besonders „kritischer“ Entwicklungsphasen ist Ausdruck einer Adaptation an unphysiologische Umwelteinflüsse wie intrauterine Mangel- oder Überversorgung und fetale Stressaktivierung und führt zu einer „Fehlprogrammierung“ von Organfunktionen und Stoffwechselregulationen, auf deren Basis sich später chronische Krankheiten wie Adipositas, Diabetes mellitus, kardiovaskuläre und mentale Erkrankungen, aber auch Krebs entwickeln können. Zunehmend werden die Mechanismen epigenetischer, molekularer, zellulärer und funktionell-regulatorischer Ebene erkannt. Präventionsorientierte Konzepte können bereits während der Schwangerschaft einen ganz wesentlichen Beitrag zur Primärprävention zahlreicher Erkrankungen im späteren Leben des Kindes leisten.

Vorheriges Kapitel Fetale Wachstumsrestriktion (FGR)

Nächstes Kapitel Blutungen im 3. Trimenon

Alexander BT (2006) Fetal programming of hypertension. Am J Physiol Regul Integr Comp Physiol 290:R1–R10CrossRefPubMed

Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ (1989) Weight in infancy and death from ischemic heart disease. Lancet 2(8663):577–580CrossRefPubMed

Barnes RB, Rosenfield RL, Ehrmann DA, Cara JF, Cuttler L, Levitsky LL, Rosenthal IM (1994) Ovarian hyperandrogenism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women. J Clin Endocrinol Metab 79:1328–1333PubMed

Bateson P, Barker D, Clutton-Brock T et al (2004) Developmental plasticity and health. Nature 430:419–421CrossRefPubMed

Beinder E (2007) Fetale Wachstumsrestriktion und Herz-Kreislauf-Erkrankungen im Erwachsenenalter. Gynäkologe 40:241–247CrossRef

Brand SR, Engel SM, Canfield RL et al (2006) The effect of maternal PTSD following in utero trauma exposure on behavior and temperament in the 9-month-old infant. Ann N Y Acad Sci 1071:454–458CrossRefPubMed

Braun T, Challis JR, Newnham JP, Sloboda DM (2013) Early-life glucocorticoid exposure: the hypothalamic-pituitary-adrenal axis, placental function, and longterm disease risk. Endocrine Rev. 34(6):885–916

Byrne M, Agerbo E, Bennedsen B, Eaton WW, Mortensen PB (2007) Obstetric conditions and risk of first admission with schizophrenia: a Danish national register based study. Schizophr Res 97:51–59CrossRefPubMed

Cannon M, Jones PB, Murray RM (2002) Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiat 159:1080–1092CrossRefPubMed

Ceelen M, van Weissenbruch MM, Vermeiden JP, van Leeuwen FE, Delemarre-van de Waal HA (2008) Pubertal development in children and adolescents born after IVF and spontaneous conception. Hum Reprod 23:2791–2798CrossRefPubMed

Cicognani A, Alessandroni R, Pasini A, Pirazzoli P, Cassio A, Barbieri E, Cacciari E (2002) Low birth weight for gestational age and subsequent male gonadal function. J Pediatr 141:376–379CrossRefPubMed

Claesson R, Åberg A, Marsal K (2007) Abnormal fetal growth is associated with gestational diabetes mellitus later in life: population-based register study. Acta Obstet Gynecol Scand 86:652–656CrossRefPubMed

Dalziel SR, Lim VK, Lambert A, McCarthy D, Parag V, Rodgers A, Harding JE (2005) Antenatal exposure to betamethasone: psychological functioning and health related quality of life 31 years after inclusion in randomised controlled trial. BMJ 331:665–668CrossRefPubMedPubMedCentral

Davies MJ, March WA, Willson KJ, Giles LC, Moore VM (2012) Birthweight and thinness at birth independently predict symptoms of polycystic ovary syndrome in adulthood. Hum Reprod 27(5):1475–1780CrossRefPubMed

Dempsey JC, Williams MA, Luthy DA, Emanuel I, Shy K (2003) Weight at birth and subsequent risk of preeclampsia as an adult. Am J Obstet Gynecol 189:494–500CrossRefPubMed

Dörner G (1974) Problems and terminology of functional teratology. Acta Biol Med Germ 34:1093–1095

Dötsch J, Plank C, Amann K (2012) Fetal programming of renal function. Pediatr Nephrol 27:513–520CrossRefPubMed

Dyer JS, Rosenfeld CR (2011) Metabolic imprinting by prenatal, perinatal and postnatal overnutrition: a review. Semin Reprod Med 29:266–276CrossRefPubMed

Edwards LJ, McMillen IC (2002) Periconceptional nutrition programs development of the cardiovascular system in the fetal sheep. Am J Physiol Regul Integr Comp Physiol 283:R669–R679CrossRefPubMed

Egeland GM, Skjaerven R, Irgens LM (2000) Birth characteristics of women who develop gestational diabetes: population based study. BMJ 321:546–547CrossRefPubMedPubMedCentral

French NP, Hagan R, Evans SF, Mullan A, Newnham JP (2004) Repeated antenatal corticoisteroids: effects on cerebral palsy and childhood behaviour. Am J Obstet Gynecol 190:588–595CrossRefPubMed

Gamborg M, Byberg L, Rasmussen F, Andersen PK, Baker JL, NordNet Study Group (2007) Birth weight and systolic blood pressure in adolescence and adulthood: meta-regression analysis of sex- and age-specific results from 20 Nordic studies. Am J Epidemiol 166(6):634–645CrossRefPubMed

Gluckman P, Hanson M, Cooper C, Thornburg KL (2008) Effect of in utero and early-life conditions on adult health and disease. NJEM 359:61–73CrossRef

Godfrey KM, Inskip HM, Hanson MA (2011) The long-term effects of prenatal development on growth and metabolism. Semin Reprod Med 29:257–265CrossRefPubMedPubMedCentral

Hajj N, Haaf T (2013) Epigenetic disturbances in in vitro cultured gametes and embryos: implications for human assisted reproduction. Fertil Steril 99(3):632–641CrossRefPubMed

Hales CN, Barker DJ (2001) The thrifty phenotype hypothesis. Br Med Bull 60:5–20CrossRefPubMed

HAPO Study Cooperative Research Group (2009) Hyperglycemia and adverse pregnancy outcome (HAPO) study - associations with neonatal anthropometrics. Diabetes 58:453–459CrossRef

Harder T, Bergmann R, Kallischnigg G, Plagemann A (2005) Duration of breastfeeding and risk of overweight: a meta-analysis. Am J Epidemiol 162:397–403CrossRefPubMed

Harder T, Rodekamp E, Schellong K, Dudenhausen JW, Plagemann A (2007) Birth weight and subsequent risk of type 2 diabetes: a metaanalysis. Am J Epidemiol 165:849–857CrossRefPubMed

Harder T, Roepke K, Diller N, Stechling Y, Dudenhausen JW, Plagemann A (2009) Birth weight, early weight gain, and subsequent risk of type 1 diabetes: systematic review and meta-analysis. Am J Epidemiol 169:1428–1436CrossRefPubMed

Herbst AL, Ulfelder H, Poskanzer DC (1971) Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284:878–881CrossRefPubMed

Holemans K, Aerts L, Van Assche FA (2003) Lifetime consequences of abnormal fetal pancreatic development. J Physiol 547(1):11–20CrossRefPubMedPubMedCentral

Huh S, Andrew R, Rich-Edwards J, Kleinman K, Seckl JR, Gillman M (2008) Association between umbilical cord glucocorticoids and blood pressure at age 3 years. BMC Med 6:25. doi:10.1186/1741-7015-6-25CrossRefPubMedPubMedCentral

Hunger-Dathe W, Mosebach N, Sämann A, Schulz A, Müller UA, Wolf G (2005) Prävalenz einer Glukosetoleranzstörung und Adipositas von Kindern im Alter von 6 Jahren nach Gestationsdiabetes der Mutter in der Indexgravidität. Geburtsh Frauenheilkd 65:942–949CrossRef

Ibanez L, Lopez-Bermejo A, Diaz M, Marcos MV (2011) Endocrinology and gynecology of girls and woman with low birth weight. Fetal Diagn Ther 30:243–249CrossRefPubMed

Innes KE, Byers TE, Marshall JA, Barón A, Orleans M, Hamman RF (2003) Association of a woman’s own birth weight with her subsequent risk for pregnancy-induced hypertension. Am J Epidemiol 158:861–870CrossRefPubMed

Kark M, Tynelius P, Rasmussen F (2009) Associations between birthweight and weight change during infancy and later childhood with systolic blood pressure at age 15 years: the COMPASS study. Paed Perinat Epidemiol 23:245–253CrossRef

Latimer K, Wilson P, Kemp J, Thompson L, Sim F, Gillberg C, Puckering C, Minnis H (2012) Disruptive behaviour disorders: a systematic review of environmental antenatal and early years risk factors. Child Care Health Dev 38(5):611–628CrossRefPubMed

Lazar L, Pollak U, Kalter-Leibovici O, Pertzelan A, Phillip M (2003) Pubertal course of persistently short children born small for gestational age (SGA) compared with idiopathic short children born appropriate for gestational age (AGA). Eur J Endocrinol 149:425–432CrossRefPubMed

Leeson C, Kattenhorn M, Morley R et al (2001) Impact of low birth weight and cardiovascular risk factors on endothelial function in early adult life. Circulation 103:1264–1268CrossRefPubMed

Lehnen H, Zechner U, Haaf T (2013) Epigenetics of gestational diabetes mellitus and offspring health: the time for action is in early stages of life. Mol Hum Reprod 19(7):415–422CrossRefPubMedPubMedCentral

Leonard H, Nassar N, Bourke J, Blair E, Mulroy S, de Klerk N, Bower C (2008) Relation between intrauterine growth and subsequent intellectual disability in a ten-year population cohort of children in Western Australia. Am J Epidemiol 167:103–111CrossRefPubMed

Luyckx VA, Bertram JF, Brenner BM, Fall C, Hoy WE, Ozanne SE, Vikse BE (2013) Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease. Lancet 382(9888):273–283CrossRefPubMed

Melo AS, Vieira CS, Barbieri MA, Rosa-e-Silva ACJS, Silva AAM, Cardoso VC, Reis RM, Ferriani RA, Silva-de-Sá MF, Bettiol H (2010) High prevalence of polycystic ovary syndrome in women born small for gestational age. Hum Reprod 25:2124–2131CrossRefPubMed

Moilanen K, Jokelainen J, Jones PB, Hartikainen AL, Järvelin MR, Isohanni M (2010) Deviant intrauterine growth and risk of schizophrenia: a 34-year follow-up of the Northern Finland 1966 Birth Cohort. Schizophr Res 124(1–3):223–230CrossRefPubMed

Murphy KE, Hannah ME, Willan AR et al (2008) Multiple courses of antenatal corticosteroids for preterm birth (MACS): a randomised controlled trial. Lancet 372:2143–2151CrossRefPubMed

Nomura Y, Wickramaratne PJ, Pilowsky DJ, Newcorn JH, Bruder-Costello B, Davey C, Fifer WP, Brooks-Gunn J, Weissman MM (2007) Low birth weight and risk of affective disorders and selected medical illness in offspring at high and low risk for depression. Compreh Psychiat 48:470–478CrossRef

Padmanabhan V, Veiga-Lopez A (2011) Developmental origin of reproductive and metabolic dysfunctions: androgenic versus estrogenic reprogramming. Semin Reprod Med 29:173–186CrossRefPubMedPubMedCentral

Park SK, Kang D, McGlynn KA, Garcia-Closas M, Kim Y, Yoo KY, Brinton LA (2008) Intrauterine environments and breast cancer risk: meta-analysis and systematic review. Breast Cancer Res 10:R8. doi:10.1186/bcr1850CrossRefPubMedPubMedCentral

Phillips D, Jones A (2006) Fetal programming of autonomic and HPA function: do people who were small babies have enhanced stress responses? J Physiol 572:45–50CrossRefPubMedPubMedCentral

Plagemann A (2005) Fetale Programmierung und Funktionelle Teratologie. In: Ganten, Ruckpaul, Wauer (Hrsg.) Molekularmedizinische Grundlagen von fetalen und neonatalen Erkrankungen, Springer Verlag, Berlin/Heidelberg, S 325–344

Plagemann A (2008) A matter of insulin: developmental programming of body weight regulation. J Matern Fetal Neonatal Med 21:143–148CrossRefPubMed

Poston L (2011) Influence of maternal nutritional status on vascular function in the offspring. Microcirculation 18(4):256–262CrossRefPubMed

Rossing MA, Cushing-Haugen KL, Doherty JA, Wicklund KG (2008) Characteristics related to the maternal intrauterine environment and risk of epithelial ovarian cancer. Ann Epidemiol 18:411–415CrossRefPubMedPubMedCentral

Schellong K, Schulz S, Harder T, Plagemann A (2012) Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally. PLoS ONE 7(10):e47776. doi:10.1371/journal.pone.0047776CrossRefPubMedPubMedCentral

Schlembach D, Lang U (2008) Präeklampsie und schwangerschaftsinduzierte Hypertonie – intrauterin determinierte Erkrankungen? Gynäkol Geburtsh Rundsch 48:225–230CrossRef

Schleußner E (2007) Fetale Programmierung der gonadalen Reifung. Gynäkologe 40:272–278CrossRef

Schleußner E, Hunger-Battefeld W, Westphal J, Schneider S, Hübler A, Wolf G (2008) Quality of treatment in women with gestational diabetes in a center of excellence for diabetes and pregnancy. Ultraschall Med 29:S91CrossRef

Schlotz W, Phillips DIW (2009) Fetal origins of mental health: evidence and mechanisms. Brain Behav Immun 23(7):905–16CrossRefPubMed

Schneider U, Fiedler A, Liehr M, Kaehler C, Schleussner E (2006) Fetal heart rate variability in growth restricted fetuses. Biomed Tech 51:248–250CrossRef

Schwab M (2009) Intrauterine Programmierung von Störungen der Hirnfunktion im späteren Leben. Gynäkol Geburtshilfliche Rundsch 49:13–28CrossRefPubMed

Seckl JR, Meaney MJ (2004) Glucocorticoid programming. Ann NY Acad Sci 1032:63–84CrossRefPubMed

Silverman BL, Rizzo TA, Cho NH, Metzger BE (1998) Long-term effects of the intrauterine environment. The Northwestern University Diabetes in Pregnancy Center. Diabetes Care 21(Suppl 2):B142–149PubMed

Simmen F, Simmen R (2011) The maternal womb: a novel target for cancer prevention in the era of the obesity pandemic? Eur J Cancer Prev 20(6):539–548CrossRefPubMedPubMedCentral

Simonetti GD, Raio L, Surbek D, Nelle M, Frey FJ, Mohaupt MG (2008) Salt sensitivity of children with low birth weight. Hypertension 52:625–630CrossRefPubMed

Skilton MR, Evans N, Griffiths KA et al (2005) Aortic wall thickness in newborns with intrauterine growth restriction. Lancet 365:1484–1486CrossRefPubMed

Thorn SR, Rozance PJ, Brown LD, Hay WW (2011) The intrauterine growth restriction phenotype: fetal adaptations and potential implications for later life insulin resistance and diabetes. Semin Reprod Med 29:225–236CrossRefPubMedPubMedCentral

Van den Bergh BR, Mulder EJ, Mennes M et al (2005) Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review. Neurosci Biobehav Rev 29:237–258CrossRefPubMed

Wagenaar K, van Weissenbruch M, Knol DL, Cohen-Kettenis PT, deWaal Delemarre-van H, Huisman J (2009) Information processing, attention and visual-motor function of adolescents born after in vitro fertilization compared with spontaneous conception. Hum Reprod 24:913–921CrossRefPubMed

Whincup PH, Kaye SJ, Owen CG et al (2008) Birth weight and risk of type 2 diabetes: a systematic review. JAMA 300(24):2886–2897CrossRefPubMed

Wilkin TJ (2008) Diabetes: 1 and 2, or one and the same? Progress with the accelerator hypothesis. Pediatr Diabetes 9:23–32CrossRefPubMed

Wojcik W, Lee W, Colman I, Hardy R, Hotopf M (2013) Foetal origins of depression? A systematic review and meta analysis of low birth weight and later depression. Psychol Med 43(1):1–12CrossRefPubMed

Titel: Fetale Programmierung
verfasst von: Ekkehard Schleußner
Verlag: Springer Berlin Heidelberg
Buch: Die Geburtshilfe
Print ISBN: 978-3-662-45063-5

Electronic ISBN: 978-3-662-45064-2

Copyright-Jahr: 2016
DOI: https://doi.org/10.1007/978-3-662-45064-2_19

Springerpflege

Zusammenfassung

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten