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Erschienen in:
05.07.2024 | Originalien
Association between anemia and vitamin D deficiency in German seniors
A retrospective data analysis
verfasst von: Dorothee Magdalena Schuchart, Ingrid Becker, Birgit Harbeck, Prof. Dr. med. habil Gabriele Röhrig, MPH
Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 7/2024
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Background
Anemia and deficiency of vitamin D (VDD) are frequently seen in seniors and an association is suspected. Approximately one third of the German population is affected by VDD, with a rising prevalence among seniors.
Aim
To analyze the association between anemia and VDD among German seniors aged ≥ 60 years.
Methods
Retrospective cross-sectional data analysis (n = 4008) in a nationwide working laboratory medical center (January–December 2019). Study parameters included amongst others: hemoglobin (Hb), calcifediol (25D) and calcitriol (1.25D), glomerular filtration rate (GFR) to assess the kidney disease outcomes quality initiative (KDOQI) state. The inclusion criteria were age ≥ 60 years, normal C‑reactive protein (CRP) and leucocyte levels.
Results
The 25D was estimated in 4008 patients and 1.25D only in 411 patients. Mean age 75 years (± 8.61 years; 60–99 years) with 30.6% males; mean GFR 62 ml/min/1.73 m3 (± 22.74); 20% of patients were anemic, 35% were deficient for 25D (< 50 nmol/l), with men > women (p = 0.014). Linear regression analysis revealed a significant effect of 25D values < 30 nmol/l on hemoglobin in males of KDOQI I–III and females of KDOQI I–IV (R2 = 0.052; p = 0.005; and R2 = 0.124; p < 0.001, respectively). For 1.25D a weak but significant effect on hemoglobin independent of KDOQI was only seen in women (R2 = 0.200; p = 0.005).
Conclusion
In this cohort deficiency of 25D and 1.25D was significantly associated with hemoglobin independent of renal function only in women but not in men.
