Skip to main content
Erschienen in:

03.06.2024 | Original Contributions

Proximal femoral fractures in patients with COVID-19

Pneumonia and admission from a nursing home are the strongest predictors of mortality

verfasst von: Petr Kohut, Vojtech Mezera, Ronny Langenhan, Niklas Reimers, Anica Kilper

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 7/2024

Einloggen, um Zugang zu erhalten

Abstract

Background

Proximal femoral fractures are severe injuries in geriatric patients. Additionally, geriatric patients are at a high risk of death due to coronavirus disease 2019 (COVID-19).

Objective

To identify predictors of mortality in geriatric patients with COVID-19 and concurrent proximal femoral fractures.

Material and methods

Patients who underwent surgical treatment for proximal femoral fractures and also tested positive for COVID-19 were included. The age, gender, the American Society of Anesthesiology (ASA) score and the admission from a nursing home were considered as variables. The rate of reoperations, the mortality at 3 months and discharge home were evaluated as outcomes.

Results

In this study 46 patients with COVID-19 (female/male 31/15, median age 87.0 years with an interquartile range [IQR] of 9.8 years) met the inclusion criteria. Of these, 32 patients (69.6%) had to be cared for in the intensive care unit and 26 patients (56.5%) had a severe course of COVID-19 with pneumonia. The median length of hospital stay for survivors was 19 (IQR 17.5) days and 4 of the patients (8.7%) required surgical revision. The in-hospital and 3‑month mortality were 40.0% (n = 17) and 43.5% (n = 20), respectively. The factors which influenced the in-hospital and 3‑month mortality rates were admission from a nursing home, the presence of pneumonia (increased the risk of death) and female gender (protective).

Conclusion

The occurrence of COVID-19 in patients with proximal femoral fractures has a high mortality. Admission from a nursing home and the presence of pneumonia increased the risk of death, whereas women were at lower risk.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Pass B, Vajna E, Knauf T, Rascher K, Aigner R, Eschbach D, Lendemans S, Knobe M, Schoeneberg C (2022) COVID-19 and Proximal Femur Fracture in Older Adults—A Lethal Combination? An Analysis of the Registry for Geriatric Trauma (ATR-DGU). J Am Med Dir Assoc 23:576–580CrossRefPubMed Pass B, Vajna E, Knauf T, Rascher K, Aigner R, Eschbach D, Lendemans S, Knobe M, Schoeneberg C (2022) COVID-19 and Proximal Femur Fracture in Older Adults—A Lethal Combination? An Analysis of the Registry for Geriatric Trauma (ATR-DGU). J Am Med Dir Assoc 23:576–580CrossRefPubMed
2.
Zurück zum Zitat Pincus D, Ravi B, Wasserstein D, Huang A, Paterson JM, Nathens AB, Kreder HJ, Jenkinson RJ, Wodchis WP (2017) Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA—J Am Med Assoc 318:1994–2003 Pincus D, Ravi B, Wasserstein D, Huang A, Paterson JM, Nathens AB, Kreder HJ, Jenkinson RJ, Wodchis WP (2017) Association between wait time and 30-day mortality in adults undergoing hip fracture surgery. JAMA—J Am Med Assoc 318:1994–2003
3.
Zurück zum Zitat Grigoryan KV, Javedan H, Rudolph JL (2014) Orthogeriatric care models and outcomes in hip fracture patients: a systematic review and meta-analysis. J Orthop Trauma 28:e49–55CrossRefPubMedPubMedCentral Grigoryan KV, Javedan H, Rudolph JL (2014) Orthogeriatric care models and outcomes in hip fracture patients: a systematic review and meta-analysis. J Orthop Trauma 28:e49–55CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Van Heghe A, Mordant G, Dupont J, Dejaeger M, Laurent MR, Gielen E (2022) Effects of Orthogeriatric Care Models on Outcomes of Hip Fracture Patients: A Systematic Review and Meta-Analysis. Calcif Tissue Int 110:162–184CrossRefPubMed Van Heghe A, Mordant G, Dupont J, Dejaeger M, Laurent MR, Gielen E (2022) Effects of Orthogeriatric Care Models on Outcomes of Hip Fracture Patients: A Systematic Review and Meta-Analysis. Calcif Tissue Int 110:162–184CrossRefPubMed
5.
Zurück zum Zitat Karagiannidis C, Mostert C, Hentschker C et al (2020) Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study. Lancet Respir Med 8:853–862CrossRefPubMedPubMedCentral Karagiannidis C, Mostert C, Hentschker C et al (2020) Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study. Lancet Respir Med 8:853–862CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Zhong H, Poeran J, Liu J, Wilson LA, Memtsoudis SG (2021) Hip fracture characteristics and outcomes during COVID-19: a large retrospective national database review. Br J Anaesth 127:15–22CrossRefPubMed Zhong H, Poeran J, Liu J, Wilson LA, Memtsoudis SG (2021) Hip fracture characteristics and outcomes during COVID-19: a large retrospective national database review. Br J Anaesth 127:15–22CrossRefPubMed
7.
Zurück zum Zitat Janssens WH, Van Den Noortgate NJ, Piers RD (2022) Terminal care in oldest old dying from COVID-19 in the acute hospital. Z Gerontol Geriatr: 129–134 Janssens WH, Van Den Noortgate NJ, Piers RD (2022) Terminal care in oldest old dying from COVID-19 in the acute hospital. Z Gerontol Geriatr: 129–134
8.
Zurück zum Zitat Köller M (2022) “ Coronavirus disease 2019 ” und Frailty. Z Gerontol Geriatr: 564–568 Köller M (2022) “ Coronavirus disease 2019 ” und Frailty. Z Gerontol Geriatr: 564–568
9.
Zurück zum Zitat Luengo-Alonso G, Pérez-Tabernero FG‑S, Tovar-Bazaga M, Arguello-Cuenca JM, Calvo E (2020) Critical adjustments in a department of orthopaedics through the COVID-19 pandemic. Int Orthop 44:1557–1564CrossRefPubMed Luengo-Alonso G, Pérez-Tabernero FG‑S, Tovar-Bazaga M, Arguello-Cuenca JM, Calvo E (2020) Critical adjustments in a department of orthopaedics through the COVID-19 pandemic. Int Orthop 44:1557–1564CrossRefPubMed
10.
Zurück zum Zitat Schoeneberg C, Eschbach; D‑A, Friess T, Lendemans S, Hoefer C, Ruchholtz S (2021) Effect of the COVID-19 Pandemic in German Trauma Centres and Geriatric Trauma Centres DGU. Z Orthop Unfall 159:209–215 Schoeneberg C, Eschbach; D‑A, Friess T, Lendemans S, Hoefer C, Ruchholtz S (2021) Effect of the COVID-19 Pandemic in German Trauma Centres and Geriatric Trauma Centres DGU. Z Orthop Unfall 159:209–215
11.
Zurück zum Zitat Jain A, Goyal V, Varma C (2021) Reflection of Epidemiological Impact on Burden of Injury in Tertiary Care Centre, Pre-COVID and COVID Era: “Lockdown, a Good Fortune for Saving Life and Limb”. Indian J Surg 83:139–143CrossRefPubMed Jain A, Goyal V, Varma C (2021) Reflection of Epidemiological Impact on Burden of Injury in Tertiary Care Centre, Pre-COVID and COVID Era: “Lockdown, a Good Fortune for Saving Life and Limb”. Indian J Surg 83:139–143CrossRefPubMed
12.
Zurück zum Zitat Jain KV, Lal H, Patralekh KM, Vaishya R (2020) Fracture management during COVID-19 pandemic: A systematic review. J Clin Orthop Trauma 11:S431–S441CrossRef Jain KV, Lal H, Patralekh KM, Vaishya R (2020) Fracture management during COVID-19 pandemic: A systematic review. J Clin Orthop Trauma 11:S431–S441CrossRef
13.
Zurück zum Zitat Dallari D, Zagra L, Cimatti P et al (2021) Early mortality in hip fracture patients admitted during first wave of the COVID-19 pandemic in Northern Italy: a multicentre study. J Orthop Traumatol 22:15CrossRefPubMedPubMedCentral Dallari D, Zagra L, Cimatti P et al (2021) Early mortality in hip fracture patients admitted during first wave of the COVID-19 pandemic in Northern Italy: a multicentre study. J Orthop Traumatol 22:15CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Haffner MR, Le HV, Saiz AMJ, Han G, Fine J, Wolinsky P, Klineberg EO (2021) Postoperative In-Hospital Morbidity and Mortality of Patients With COVID-19 Infection Compared With Patients Without COVID-19 Infection. Jama Netw Open 4:e215697CrossRefPubMedPubMedCentral Haffner MR, Le HV, Saiz AMJ, Han G, Fine J, Wolinsky P, Klineberg EO (2021) Postoperative In-Hospital Morbidity and Mortality of Patients With COVID-19 Infection Compared With Patients Without COVID-19 Infection. Jama Netw Open 4:e215697CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Patralekh MK, Jain VK, Iyengar KP, Upadhyaya GK, Vaishya R (2021) Mortality escalates in patients of proximal femoral fractures with COVID-19: A systematic review and meta-analysis of 35 studies on 4255 patients. J Clin Orthop Trauma 18:80–93CrossRefPubMedPubMedCentral Patralekh MK, Jain VK, Iyengar KP, Upadhyaya GK, Vaishya R (2021) Mortality escalates in patients of proximal femoral fractures with COVID-19: A systematic review and meta-analysis of 35 studies on 4255 patients. J Clin Orthop Trauma 18:80–93CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Lim MA, Pranata R (2021) Coronavirus disease 2019 (COVID-19) markedly increased mortality in patients with hip fracture—A systematic review and meta-analysis. J Clin Orthop Trauma 12:187–193CrossRefPubMed Lim MA, Pranata R (2021) Coronavirus disease 2019 (COVID-19) markedly increased mortality in patients with hip fracture—A systematic review and meta-analysis. J Clin Orthop Trauma 12:187–193CrossRefPubMed
17.
Zurück zum Zitat Holmes N, Virani S, Relwani J (2021) Hospital transmission rates of the SARS-CoV 2 disease amongst orthopaedic in-patients in a secondary care centre: A quantitative review. J Clin Orthop Trauma 16:43–48CrossRefPubMedPubMedCentral Holmes N, Virani S, Relwani J (2021) Hospital transmission rates of the SARS-CoV 2 disease amongst orthopaedic in-patients in a secondary care centre: A quantitative review. J Clin Orthop Trauma 16:43–48CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Baek YJ, Lee T, Cho Y et al (2020) A mathematical model of COVID-19 transmission in a tertiary hospital and assessment of the effects of different intervention strategies. PLoS ONE 15:e241169CrossRefPubMedPubMedCentral Baek YJ, Lee T, Cho Y et al (2020) A mathematical model of COVID-19 transmission in a tertiary hospital and assessment of the effects of different intervention strategies. PLoS ONE 15:e241169CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Carretta E, Bochicchio V, Rucci P, Fabbri G, Laus M, Fantini MP (2011) Hip fracture: effectiveness of early surgery to prevent 30-day mortality. Int Orthop 35:419–424CrossRefPubMed Carretta E, Bochicchio V, Rucci P, Fabbri G, Laus M, Fantini MP (2011) Hip fracture: effectiveness of early surgery to prevent 30-day mortality. Int Orthop 35:419–424CrossRefPubMed
20.
Zurück zum Zitat Verma S, Garg P, Gera M, Agarwal S, Verma A (2022) Complications and Outcomes of Surgical Patients Operated During COVID 19: a Single Centre Study. Indian J Surg 84:1367–1368CrossRefPubMed Verma S, Garg P, Gera M, Agarwal S, Verma A (2022) Complications and Outcomes of Surgical Patients Operated During COVID 19: a Single Centre Study. Indian J Surg 84:1367–1368CrossRefPubMed
21.
Zurück zum Zitat Ruiz-Huerta C, Canto MV, Ruiz C, Gonz I, Lozano-montoya I, Quezada-feijoo M, Francisco JG (2022) COVID-19 Mortality in Patients Aged 80 and over Residing in Nursing Homes—Six Pandemic Waves : OCTA-COVID Study. Int J Env Res Public Heal 19 Ruiz-Huerta C, Canto MV, Ruiz C, Gonz I, Lozano-montoya I, Quezada-feijoo M, Francisco JG (2022) COVID-19 Mortality in Patients Aged 80 and over Residing in Nursing Homes—Six Pandemic Waves : OCTA-COVID Study. Int J Env Res Public Heal 19
22.
Zurück zum Zitat Darwich A, Assaf E, Klein R, Gravius S, Wölfl CG, Jawhar A (2021) Einflussfaktoren auf die Mortalität bei Patienten mit hüft g elenknahen Frakturen an einem re g ionalen Traumazentrum Zusatzmaterial online. Z Gerontol Geriatr: 561–570 Darwich A, Assaf E, Klein R, Gravius S, Wölfl CG, Jawhar A (2021) Einflussfaktoren auf die Mortalität bei Patienten mit hüft g elenknahen Frakturen an einem re g ionalen Traumazentrum Zusatzmaterial online. Z Gerontol Geriatr: 561–570
23.
Zurück zum Zitat Dörr S, Joachim R, Chatzitomaris A, Lobmann R (2023) Risikofaktoren für Outcome und Mortalität bei hospitalisierten geriatrischen Patienten mit SARS-CoV-2-Infektion. Z Gerontol Geriatr: 118–124 Dörr S, Joachim R, Chatzitomaris A, Lobmann R (2023) Risikofaktoren für Outcome und Mortalität bei hospitalisierten geriatrischen Patienten mit SARS-CoV-2-Infektion. Z Gerontol Geriatr: 118–124
24.
Zurück zum Zitat Mohammadpour M, Yazdi H, Bagherifard A et al (2022) Evaluation of early complications, outcome, and mortality in Coronavirus Disease 2019 (COVID-19) infection in patients who underwent orthopedic surgery. BMC Musculoskelet Disord 23:1–9CrossRef Mohammadpour M, Yazdi H, Bagherifard A et al (2022) Evaluation of early complications, outcome, and mortality in Coronavirus Disease 2019 (COVID-19) infection in patients who underwent orthopedic surgery. BMC Musculoskelet Disord 23:1–9CrossRef
25.
Zurück zum Zitat Mezera V, Fekete D, Bureš I (2019) Geriatric scales and rehabilitation after proximal femur fractures. Geriatr a Gerontol, vol 8, pp 107–111 Mezera V, Fekete D, Bureš I (2019) Geriatric scales and rehabilitation after proximal femur fractures. Geriatr a Gerontol, vol 8, pp 107–111
26.
Zurück zum Zitat Kahan BC, Harhay MO (2015) Many multicenter trials had few events per center, requiring analysis via random-effects models or GEEs. J Clin Epidemiol 68:1504–1511CrossRefPubMedPubMedCentral Kahan BC, Harhay MO (2015) Many multicenter trials had few events per center, requiring analysis via random-effects models or GEEs. J Clin Epidemiol 68:1504–1511CrossRefPubMedPubMedCentral
Metadaten
Titel
Proximal femoral fractures in patients with COVID-19
Pneumonia and admission from a nursing home are the strongest predictors of mortality
verfasst von
Petr Kohut
Vojtech Mezera
Ronny Langenhan
Niklas Reimers
Anica Kilper
Publikationsdatum
03.06.2024
Verlag
Springer Medizin
Erschienen in
Zeitschrift für Gerontologie und Geriatrie / Ausgabe 7/2024
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI
https://doi.org/10.1007/s00391-024-02317-0