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Horm Metab Res 2004; 36(10): 696-701
DOI: 10.1055/s-2004-826019
Original Clinical
© Georg Thieme Verlag KG Stuttgart · New York

Insulin-like Growth Factor-I Stimulates Acromegaly-like Specific Mandibular Enlargement in Rats

M.  Iikubo1 , H.  Ikeda2 , A.  Kobayashi1 , I.  Kojima1 , K.  Hashimoto1 , M.  Sakamoto1 , T.  Sasano1
  • 1Department of Oral Diagnosis, Tohoku University Graduate School of Dentistry
  • 2Department of Neurosurgery, Kohnan Hospital
Further Information

Publication History

Received 20 January 2004

Accepted after second revision 2 June 2004

Publication Date:
03 November 2004 (online)

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Abstract

To help us investigate the time course of mandibular enlargement in acromegaly or acrogiantism to determine the most suitable period for occlusal treatment in this disease, our aim was to develop a rat model of acromegaly (acrogiantism). In this study, prominent mandibular enlargement was induced by continuous subcutaneous infusion of human recombinant insulin-like growth factor-I (IGF-I) (640 µg/day) in 10-week-old male rats for 4 weeks (n = 6); the control sham-operated group was injected with saline alone (n = 6). Circulating human IGF-I was clearly detectable in the IGF-I group during the four-week administration period, while endogenous rat IGF-I levels decreased. Total IGF-I (human + rat) increased significantly during administration, returning to control levels afterwards. The length of every bone examined (mandible, maxilla, and femur) showed a significant increase compared to control rats, especially the mandible. Although the mandible did not continue to grow after discontinuation of IGF-I administration, it did not return to control size, unlike the maxilla and femur, and disharmonious jaw size (between maxilla and mandible) persisted even after circulating IGF-I levels normalized. These findings in our rat model suggest that mandibular occlusal treatment should only be considered for acromegalic (acrogiantic) patients after serum IGF-I levels have normalized and bone growth has ceased.

Key words

Acromegaly - Rat Model - IGF-I - Mandibular enlargement - Bone growth

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Dr. M. Iikubo

Department of Oral Diagnosis · Tohoku University Graduate School of Dentistry ·

4-1 Seiryo-machi · Aoba-ku · Sendai 980-8575 · Japan

Phone: +81(22)717-8390

Fax: +81(22)717-8393 ·

Email: machapy@mail.tains.tohoku.ac.jp

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