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Horm Metab Res 2004; 36(10): 662-666
DOI: 10.1055/s-2004-826016
Original Basic
© Georg Thieme Verlag KG Stuttgart · New York

Increase of PTEN Gene Expression in Insulin Resistance

Y.  T.  Lo1 , C.  J.  Tsao2 , I.  M.  Liu3 , S.  S.  Liou3 , J.  T.  Cheng4
  • 1Department of Hospital and Health Care Administration, Chungtai Institute of Health Sciences and Technology, Taichung City, Taiwan, R.O.C.
  • 2Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, R.O.C.
  • 3Department of Pharmacy, Tajen Institute of Technology, Yen-Pou, Ping Tung Shien, Taiwan, R.O.C.
  • 4Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, R.O.C.
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Publication History

Received 9 March 2004

Accepted after revision 20 April 2004

Publication Date:
03 November 2004 (online)

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Abstract

Phosphatase and tensin homologue deleted from chromosome ten (PTEN) has recently been characterized as a regulator of insulin sensitivity in the insulin target tissue. However, whether PTEN gene expression is changed in insulin resistance remains unclear. We observed that both the mRNA and protein level of PTEN in soleus muscle isolated from the obese Zucker rats (fa/fa) were increased compared to the age-matched lean group. Similarly, both the mRNA and protein level of PTEN in soleus muscle of the fructose-fed lean Zucker rats (Fa/Fa) showing the higher glucose-insulin index were higher than that of the regular chow fed group. These results suggest that increase of PTEN gene expression seems to be related to the development of insulin resistance.

Key words

Glucose-insulin index · Insulin resistance · PTEN · Zucker rats

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Prof. J.-T. Cheng

Department of Pharmacology, College of Medicine, National Cheng Kung University

Tainan City · Taiwan · R.O.C.

Phone: +886 (6) 237 27 06

Fax: +886 (6) 238 65 48

Email: jtcheng@mail.ncku.edu.tw

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