Endoscopy 2016; 48(05): v12
DOI: 10.1055/s-0042-106240
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© Georg Thieme Verlag KG Stuttgart · New York

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Publication Date:
26 April 2016 (online)

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Preclinical evaluation of an endoscopic electroporation systemEndoscopy 2016; 48(05): 477-483
DOI: 10.1055/s-0042-101343

Patrick F. Forde et al. Preclinical evaluation of an endoscopic electroporation system


Quality:
Targeted delivery of specific chemotherapeutic drugs into tumors can be achieved by delivering electrical pulses directly to the tumor tissue. In a series of animal models, Forde et al. assessed the efficacy of electroporation delivered through a special device in combination with bleomycin. The authors found that tumor volume reduced significantly, with cell death being induced rapidly, mainly via an apoptotic-type mechanism. This novel therapy may become an addition to the endoscopist’s armamentarium for the treatment of gastrointestinal cancer.