Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter December 13, 2013

Placental chorioangioma: literature review

  • Miaoying Fan EMAIL logo and Daniel W. Skupski

Abstract

Placental chorioangioma is the most common benign non-trophoblastic tumor of the placenta. It is derived from primitive chorionic mesenchyme and is typically vascular. Placenta chorioangiomas occur in approximately 1% of pregnancies. Most placental chorioangiomas are small and are not clinically important. However, those measuring more than 4–5 cm in diameter may be associated with maternal and fetal complications. Early diagnosis, close prenatal surveillance and appropriate intervention may prevent severe complications and perinatal mortality caused by chorioangioma. Here we review the incidence, prenatal diagnosis, complications, the pathophysiological mechanisms of maternal and fetal complications, and the therapeutic possibilities in pregnancies complicated by placental chorioangiomas.


Corresponding author: Miaoying Fan, MD, RDMS, Department of Obstetrics and Gynecology, Columbia University Medical Center, PH12-15, 622W, 168th Street, New York, NY 11355, USA, Tel.: +1-212-305-0911, Fax: +1-212-342-5337, E-mail:

References

[1] Ariel I, Boldes R, Weintraub A, Reinus C, Beller U, Arbel R. Chorangiocarcinoma: a case report and review of the literature. Int J Gynecol Pathol. 2009;28:267–71.10.1097/PGP.0b013e31818f127fSearch in Google Scholar

[2] As AK, Hagen P, Webb JB, Wijesinghe D. Therapeutic amnio-drainage in chorioangioma. J Obstet Gynecol. 1997;17:169–70.10.1080/01443619750113799Search in Google Scholar

[3] Bashiri A, Furman B, Erez O, Wizniter A, Holcberg G, Mazor M. Twelve cases of placental chorioangioma: pregnancy outcome and clinical significance. Arch Gynecol Obstet. 2002;266:53–5.10.1007/PL00007501Search in Google Scholar

[4] Batukan C, Holzgreve W, Danzer E, Bruder E, Hösli I, Tercanli S. Large placental chorioangioma as a cause of sudden intrauterine fetal death. A case report. Fetal Diagn Ther. 2001;16:394–7.10.1159/000053946Search in Google Scholar

[5] Benirschke K. Recent trends in chorioangioma, especially those of multiple and recurrent chorioangiomas. Pediatr Dev Pathol. 1999;2:264–9.10.1007/s100249900122Search in Google Scholar

[6] Bermúdez C, Luengas O, Pérez-Wulff J, Genatios U, García V, Guevara-Zuloaga F, et al. Management of a placental chorioangioma with endoscopic devascularization and intrauterine transfusions. Ultrasound Obstet Gynecol. 2007;29:97–8.10.1002/uog.3903Search in Google Scholar

[7] Braun T, Brauer M, Fuchs I, Czernik C, Dudenhausen JW, Henrich W, et al. Mirror syndrome: a systematic review of fetal associated conditions, maternal presentation and perinatal outcome. Fetal Diagn Ther. 2010;27:191–203.10.1159/000305096Search in Google Scholar

[8] Bromley B, Benacerral BR. Solid masses on the fetal surface of the placenta: differential diagnosis and clinical outcome. J Ultrasound Med. 1994;13:883–6.10.7863/jum.1994.13.11.883Search in Google Scholar

[9] Dorman SL, Cardwell MS. Ballantyne syndrome caused by a large placental chorioangioma. Am J Obstet Gynecol. 1995;173:1632–3.10.1016/0002-9378(95)90666-5Search in Google Scholar

[10] Escribano D, Galindo A, Arbues J, Puente JM, De la Fuente P. Prenatal management of placental chorioangioma: value of the middle cerebral artery peak systolic velocity. Fetal Diagn Ther. 2006;21:489–93.10.1159/000095659Search in Google Scholar PubMed

[11] Faes T, Pecceu A, Van Calenbergh S, Moerman P. Chorangiocarcinoma of the placenta: a case report and clinical review. Placenta. 2012;33:658–61.10.1016/j.placenta.2012.04.012Search in Google Scholar

[12] Gajewska K, Herinckx A, Holoye A, D’Haene N, Massez A, Cassart M, et al. Antenatal embolization of a large chorioangioma by percutaneous Glubran 2 injection. Ultrasound Obstet Gynecol. 2010;36:773–5.10.1002/uog.8806Search in Google Scholar

[13] Galimberti A, Jain S. Placental chorioangioma as a cause of maternal hydrops syndrome. J Obstet Gynaecol. 2000;20:91.10.1080/01443610063633Search in Google Scholar

[14] García-Díaz L, Carreto P, Costa-Pereira S, Antiñolo G. Prenatal management and perinatal outcome in giant placental chorioangioma complicated with hydrops fetalis, fetal anemia and maternal mirror syndrome. Pregnancy Childbirth. 2012;12:72.10.1186/1471-2393-12-72Search in Google Scholar

[15] Gherman RB, Incerpi MH, Wing DA, Goodwin TM. Ballantyne syndrome: is placental ischemia the etiology? J Matern Fetal Med. 1998;7:227–9.10.1002/(SICI)1520-6661(199809/10)7:5<227::AID-MFM3>3.0.CO;2-ISearch in Google Scholar

[16] Ghosh B, Byrd LM. Placental chorioangioma-an unusual cause of acute polyhydramnios with an isolated rise in maternal serum ALT: a clinical marker of disease and/or risk? J Obstet Gynecol. 2011;31:663–4.10.3109/01443615.2011.603771Search in Google Scholar

[17] Guschmann M, Henrich W, Dudenhausen JW. Chorioangiomas–new insights into a well-known problem. II. An immuno-histochemical investigation of 136 cases. J Perinat Med. 2003;31:170–5.10.1515/JPM.2003.023Search in Google Scholar

[18] Haak MC, Oosterhof H, Mouw RJ, Oepkes D, Vandenbussche FP. Pathophysiology and treatment of fetal anemia due to placental chorioangioma. Ultrasound Obstet Gynecol. 1999;14:68–70.10.1046/j.1469-0705.1999.14010068.xSearch in Google Scholar

[19] Hata T, Inubashiri E, Kanenishi K, Akiyama M, Tanaka H, Yanagihara T. Three-dimensional power Doppler angiographic features of placental chorioangioma. J Ultrasound Med. 2004;23:1517–20.10.7863/jum.2004.23.11.1517Search in Google Scholar

[20] Imdad A, Sheikh L, Malik A. A large chorioangioma causing intrauterine foetal demise. J Pak Med Assoc. 2009;59:580–1.Search in Google Scholar

[21] Jauniaux E, Ogle R. Color Doppler imaging in the diagnosis and management of chorioangiomas. Ultrasound Obstet Gynecol. 2000;15:463–7.10.1046/j.1469-0705.2000.00127.xSearch in Google Scholar

[22] Kirkpatric AD, Podberesky DJ, Gray AE, McDermott JH. Best case from AFIP: placental chorioangioma. Radiographics. 2007;27:1187–90.10.1148/rg.274065207Search in Google Scholar

[23] Lau TK, Leung TY, Yu SC, To KF, Leung TN. Prenatal treatment of chorioangioma by microcoil embolization. BJOG. 2003;110:70–3.10.1046/j.1471-0528.2003.02003.xSearch in Google Scholar

[24] Masselli G, Gualdi G. MR imaging of the placenta: what a radiologist should know. Abdom Imaging. 2013;38:573–87.10.1007/s00261-012-9929-8Search in Google Scholar

[25] Mendez-Figueroa H, Papanna R, Popek EJ, Byrd RH, Goldaber K, Moise KJ Jr, et al. Endoscopic laser coagulation following amnioreduction for the management of a large placental chorioangioma. Prenat Diagn. 2009;29:1277–8.10.1002/pd.2400Search in Google Scholar

[26] Nicolini U, Zuliani G, Caravelli E, Fogliani R, Poblete A, Roberts A. Alcohol injection: a new method of treating placental chorioangioma. Lancet. 1999;353:1674–5.10.1016/S0140-6736(99)00781-3Search in Google Scholar

[27] Quarello E, Bernard JP, Leroy B, Ville Y. Prenatal lasers treatment of placenta chorioangioma. Ultrasound Obstet Gynecol. 2005;25:299–301.10.1002/uog.1848Search in Google Scholar

[28] Reshetnikova OS, Burton GJ, Milovanov AP, Fokin EI. Increased incidence of placental chorioangioma in high-altitude pregnancies: hypobaric hypoxia as a possible etiologic factor. Am J Obstet Gynecol. 1996;174:557–61.10.1016/S0002-9378(96)70427-1Search in Google Scholar

[29] Ropacka-Lesiak M, Gruca-Stryjak K, Breborowicz G. Nontrophoblastic placental tumors. Neuro Endocrinol Lett. 2012;33:375–9.Search in Google Scholar

[30] Saksiriwuttho P, Ratanasiri T, Doankum C, Kleebkaew P, Kiatchoosakun P. Prenatal three dimensional ultrasonography and expectant management of placental chorioangioma: a case report. J Med Assoc Thai. 2013;96:496–500.Search in Google Scholar

[31] Sepulveda W, Alcalde JL, Schnapp C, Bravo M. Perinatal outcome after prenatal diagnosis of placental chorioangioma. Obstet Gynecol. 2003;102:1028–30.Search in Google Scholar

[32] Sepulveda W, Aviles G, Carstens E, Corral E, Perez N. Prenatal diagnosis of solid placental masses: the value of color flow imaging. Ultrasound Obstet Gynecol. 2000;16:554–8.10.1046/j.1469-0705.2000.00245.xSearch in Google Scholar PubMed

[33] Sepulveda W, Wong AE, Herrera L, Dezerega V, Devoto JC. Endoscopic laser coagulation of feeding vessels in large placental chorioangiomas: report of three cases and review of invasive treatment options. Prenat Diagn. 2009;9:201–6.10.1002/pd.2197Search in Google Scholar PubMed

[34] Shih JC, Ko TL, Lin MC, Shyu MK, Lee CN. Quantitative three-dimensional Doppler ultrasound predicts the outcome of placenta chorioangioma. Ultrasound Obstet Gynecol. 2004;24:202–6.10.1002/uog.1081Search in Google Scholar PubMed

[35] Tan SA, Yeo SH. Placental chorioangioma: a case report and review. Singapore Med J. 1992;33:816.Search in Google Scholar

[36] Taori K, Patil P, Attarde V, Singh A, Rangankar V. Chorioangioma of placenta: sonographic features. J Clin Ultrasound. 2008;36:113–5.10.1002/jcu.20366Search in Google Scholar PubMed

[37] Wehrens XH, Offermans JP, Snijders M, Peeters LL. Fetal cardiovascular response to large placental chorioangiomas. J Perinat Med. 2004;32:107–12.10.1515/JPM.2004.020Search in Google Scholar PubMed

[38] Wou K, Chen MF, Mallozzi A, Brown RN, Shrim A. Pregnancy outcomes and ultrasonographic diagnosis in patients with histologically-proven placental chorioangioma. Placenta. 2011;32:671–4.10.1016/j.placenta.2011.06.007Search in Google Scholar PubMed

[39] Zalel Y. Role of color Doppler imaging in diagnostic and managing pregnancies complicated by placental chorioangioma. J Clin Ultrasound. 2002;30:264–9.10.1002/jcu.10072Search in Google Scholar PubMed

[40] Zalel Y, Weisz B, Gamzu R, Schiff E, Shalmon B, Achiron R. Chorioangioma of the palcenta: sonographic and Doppler flow characteristics. J Ultrasound Med. 2002;21:909–15.10.7863/jum.2002.21.8.909Search in Google Scholar PubMed

[41] Zanardini C, Papageorghiou A, Bhide A, Thilaganathan B. Giant placental chorioangioma: natural history and pregnancy outcome. Ultrasound Obstet Gynecol. 2010;35:332–6.10.1002/uog.7451Search in Google Scholar PubMed

[42] Zoppini C, Acaia B, Lucci G, Pugni L, Tassis B, Nicolini U. Varying clinical course of large placental chorioangiomas. Report of 3 cases. Fetal Diagn Ther. 1997;12:61–4.10.1159/000264430Search in Google Scholar PubMed

The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2013-7-11
Accepted: 2013-11-18
Published Online: 2013-12-13
Published in Print: 2014-5-1

©2014 by Walter de Gruyter Berlin Boston

Downloaded on 26.4.2024 from https://www.degruyter.com/document/doi/10.1515/jpm-2013-0170/html
Scroll to top button