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Polymorphism 192Q/R of the paraoxonase 1 gene in elderly men and long-lived people of the Tatar ethnic group

  • Genomics. Transcriptomics. Proteomics
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Abstract

To study the molecular genetic basis of human aging and longevity, the allele and genotype frequencies of the 192Q/R polymorphism of PON1 were compared for ethnic Tatars of the younger (1–20 years), middle (21–55 years), elderly (56–74 years), senile (75–89 years), and long-lived (90–109 years) age groups (in total, 1116 people). The PON1 alleles were identified using PCR and restriction enzyme analysis. In the total samples, the frequencies of genotypes Q/Q, Q/R, and R/R were 46.15, 44.35, and 9.5%, respectively, and the frequencies of alleles Q and R were 68.32 and 31.68%, respectively. Some age groups significantly differed from each other in allele and genotype frequencies. The frequency of allele R in the senile group (28.46%) was significantly lower than in the younger group (37.42%, P = 0.009). However, the long-lived displayed significantly higher frequencies of allele R (P = 0.005) and genotype R/R (P = 0.01) as compared with the senile group.

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Authors and Affiliations

  1. Institute of Biochemistry and Genetics, Ufa Research Center, Russian Academy of Sciences, Ufa, Bashkortostan, 4500054, Russia

    V. V. Pauk, I. A. Tuktarova, T. R. Nasibullin, L. P. Zueva, A. Kh. Adelguzhina, E. K. Khusnutdinova & O. E. Mustafina

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  1. V. V. Pauk
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  2. I. A. Tuktarova
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  3. T. R. Nasibullin
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  4. L. P. Zueva
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  7. O. E. Mustafina
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Correspondence to V. V. Pauk.

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Original Russian Text © V.V. Pauk, I.A. Tuktarova, T.R. Nasibullin, L.P. Zueva, A.Kh. Adelguzhina, E.K. Khusnutdinova, O.E. Mustafina, 2007, published in Molekulyarnaya Biologiya, 2007, Vol. 41, No. 4, pp. 601–607.

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Pauk, V.V., Tuktarova, I.A., Nasibullin, T.R. et al. Polymorphism 192Q/R of the paraoxonase 1 gene in elderly men and long-lived people of the Tatar ethnic group. Mol Biol 41, 539–545 (2007). https://doi.org/10.1134/S0026893307040036

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  • DOI: https://doi.org/10.1134/S0026893307040036

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