A discovery metabolomic study was performed in a large cohort of adults to identify circulating biomarkers of frailty. The study found that carnitine and vitamin E pathways were dysregulated in frail compared with non-frail participants. These findings point to dysregulated mitochondrial metabolism as a potential root of age-related frailty.
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The authors acknowledge the support of the Intramural Research Program of the National Institute on Aging.
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Ferrucci, L., Zampino, M. A mitochondrial root to accelerated ageing and frailty. Nat Rev Endocrinol 16, 133–134 (2020). https://doi.org/10.1038/s41574-020-0319-y
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DOI: https://doi.org/10.1038/s41574-020-0319-y
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