Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human Deoxyhaemoglobin

Abstract

DPG has a two-fold effect on human deoxyhaemoglobin. It both stabilizes and slightly distorts the S form, and may therefore affect the solubility.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Benesch, R., and Benesch, R. E., Biochem. Biophys. Res. Commun., 26, 162 (1967).

    Article  CAS  Google Scholar 

  2. Chanutin, A., and Curnish, R. R., Arch. Biochem. Biophys., 121, 96 (1967).

    Article  CAS  Google Scholar 

  3. Benesch, R., Benesch, R. E., and Yu, C. I., Proc. US Nat. Acad. Sci., 59, 526 (1968).

    Article  ADS  CAS  Google Scholar 

  4. Benesch, R., Benesch, R. E., and Enoki, Y., Proc. US Nat. Acad. Sci., 61, 1102 (1968).

    Article  ADS  CAS  Google Scholar 

  5. Bunn, H. F., and Briehl, R. W., J. Clin. Invest., 49, 1088 (1970).

    Article  CAS  Google Scholar 

  6. Tomita, S., and Riggs, A., J. Biol. Chem., 246, 547 (1971).

    CAS  PubMed  Google Scholar 

  7. Caldwell, P. R. B., Nagel, R. L., and Jaffé, E. R., Biochem. Biophys. Res. Commun., 44, 1504 (1971).

    Article  CAS  Google Scholar 

  8. Perutz, M. F., Nature, 228, 734 (1970).

    Article  ADS  CAS  Google Scholar 

  9. Muirhead, H., and Greer, J., Nature, 228, 516 (1970).

    Article  ADS  CAS  Google Scholar 

  10. Perutz, M. F., J. Cryst. Growth, 2, 54 (1968).

    Article  ADS  CAS  Google Scholar 

  11. Benesch, R. E., Benesch, R., and Yu, C. I., Biochemistry, 8, 2567 (1969).

    Article  CAS  Google Scholar 

  12. Bragg, W. L., and Perutz, M. F., Acta Cryst., 5, 277 (1952).

    Article  CAS  Google Scholar 

  13. Monod, J., Wyman, J., and Changeux, J. P., J. Mol. Biol., 12, 88 (1965).

    Article  CAS  Google Scholar 

  14. Bunn, H. F., Science, 172, 1049 (1971).

    Article  ADS  CAS  Google Scholar 

  15. Bailey, J. F., Beetlestone, J. G., and Irvine, D. H., J. Chem. Soc., A, 5, 756 (1970).

    Article  Google Scholar 

  16. Riggs, A., Proc. US Nat. Acad. Sci., 68, 2062 (1971).

    Article  ADS  CAS  Google Scholar 

  17. Carami, A., and Manning, J. M., Proc. US Nat. Acad. Sci., 68, 1180 (1971).

    Article  ADS  Google Scholar 

  18. Murayama, M., Olson, R. A., and Jenning, W. H., Biochim. Biophys. Acta, 94, 194 (1965).

    Article  CAS  Google Scholar 

  19. Beutler, E., Blood (in the press).

  20. Kilmartin, J. V., and Rossi-Benardi, L., Nature, 222, 1243 (1969).

    Article  ADS  CAS  Google Scholar 

  21. Preutz, M. F., New Scientist, 50, 762 (1971).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

ARNONE, A. X-ray Diffraction Study of Binding of 2,3-Diphosphoglycerate to Human Deoxyhaemoglobin. Nature 237, 146–149 (1972). https://doi.org/10.1038/237146a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/237146a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing