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Originalia

Charakterisierung kognitiver Einbußen von Patienten mit “Mild Cognitive Impairment” (MCI) in der CERAD- Screeningbatterie

Published Online:September 01, 2006https://doi.org/10.1024/1016-264X.16.3.139

Abstract

Zusammenfassung: Die frühzeitige Diagnose kognitiver Abbauprozesse ist vor dem Hintergrund der “alternden Gesellschaft” von enormer Bedeutung. In der vorliegenden Arbeit wurde das Potenzial der CERAD-kognitiven Screeningbatterie als Untersuchungsprotokoll zur Diagnostik leichter kognitiver Beeinträchtigungen (MCI, Petersen et al., 1995) sowie als Verlaufsinstrument überprüft. Die Leistungen von 51 MCI-Patienten wurden mit 81 gesunden Kontrollpersonen verglichen. Die Leistungen der MCI-Gruppe unterschied sich in nahezu allen Subtests der CERAD-Batterie signifikant von denen der Kontrollgruppe. In der Verlaufsuntersuchung an einer Teilstichprobe (n = 18) fanden sich hingegen in der CERAD-Batterie keine signifikanten Veränderungen. Zusammenfassend lässt sich feststellen, dass die CERAD-Batterie bei leichten kognitiven Beeinträchtigungen ein ausreichend valides Screeninginstrument darstellt; für Verlaufsuntersuchungen scheint sie hingegen weniger gut geeignet zu sein.


Assessment of Deficits in Subjects with “Mild Cognitive Impairment” (MCI) Using CERAD

Abstract: This study addresses the usefulness of the CERAD cognitive screening battery as an early diagnostic tool to assess mild cognitive impairment (MCI, Petersen et al., 1995) and as instrument for evaluating its progression. The performance of 51 MCI-subjects was compared to 81 healthy age-matched controls. We found significant differences in cognitive performance between the two groups, in particular in verbal memory. In the 19 months follow-up study with 18 MCI-subjects no significant changes were found in the CERAD. In conclusion, the CERAD-Screening battery is a useful and sufficiently valid tool for the assessment of MCI but may have limited value for follow-up studies.

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