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The Toxicology Investigators Consortium Case Registry-the 2018 Annual Report

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Abstract

The Toxicology Investigators Consortium (ToxIC) Registry was established by the American College of Medical Toxicology (ACMT) in 2010. The Registry collects data from participating sites with the agreement that all bedside medical toxicology consultation will be entered. The objective of this ninth annual report is to summarize the Registry’s 2018 data and activity with its additional 7043 cases. Cases were identified for inclusion in this report by a query of the ToxIC database for any case entered from 1 January to 31 December 2018. Detailed data was collected from these cases and aggregated to provide information which included demographics, reason for medical toxicology evaluation, agent and agent class, clinical signs and symptoms, treatments and antidotes administered, mortality, and whether life support was withdrawn. A total of 51.5% of cases were female, 48% were male, and 0.6% transgender. Non-opioid analgesics were the most commonly reported agent class, followed by antidepressants and opioids. Acetaminophen was once again the most common agent reported. There were 106 fatalities, comprising 1.5% of all registry cases. Major trends in demographics and exposure characteristics remained similar to past years’ reports. Sub-analyses were conducted to describe exposures in elderly patients, addiction consultation practices, and risk factors for bupropion-induced seizures. The launch of the ToxIC Qualified Clinical Data Registry (TQCDR) is also described.

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Acknowledgments

Toxicology Investigators Consortium (ToxIC) Study Group Collaborators:

Beauchamp GA, Beuhler MC, Boyle KL, Cannon RD, Carey JL, Carpenter J, Chenoweth JA, Colby DK, Eisenga BH, Fisher E, Ford JB, Fox LM, Ganetsky M, Gorodetsky R, Greene SC, Griswold MK, Harding SA, Hendrickson RG, Horowitz BZ, Hoyte C, Jacob J, Judge BS, Kazzi Z, Kerns WP 2nd, Kim T, Koons A, Leikin JB, Levine M, Liss DB, Marino R, McKay CA, McKeever RG, Meadors K, Moore E, Mullins ME, Nacca N, Nelson ME, Porter L, Riley BD, Ruha AM, Santos C, Schult R, Schwarz ES, Scoccimarro A, Seifert SA, Shafer S, Shah KR, Smolinske SC, Spyres M, Tortora L, Vearrier DJ, Warrick BJ, Weiss S, Wolk BJ, Yanta J.

We also wish to thank study coordinators Andrea Ramirez, D Hopkins, DA Gonzalez, Julie Licata, K Hart, Love Wilson, MD Cook, Melissa Vandenberg, PM Beuhler, T Falter and Tammy Phan.

Funding

The Toxicology Investigators Consortium received funding from the US National Institute of Drug Abuse 1RO1DA037317-02, and data sharing contracts with the U.S. Food and Drug Administration and BTG International, Inc. (North America).

Author information

Authors and Affiliations

  1. Department of Emergency Medicine, Division of Medical Toxicology, University of Southern California, 1200 N State St. Rm 1011, Los Angeles, CA, 90033, USA

    Meghan B. Spyres

  2. Hartford Hospital and University of Connecticut School of Medicine, 80 Seymour Street, Hartford, CT, 06102, USA

    Lynn A. Farrugia

  3. Departments of Medicine and Child Health, University of Arizona College of Medicine–Phoenix, Phoenix, AZ, USA

    A. Min Kang

  4. Department of Medical Toxicology, Banner–University Medical Center, 1012 E Willetta Street, Fl 2, Phoenix, AZ, 85006, USA

    A. Min Kang

  5. New Jersey Medical School, Rutgers, The State University of New Jersey, 140 Bergen Street, Suite G1600, Newark, NJ, 07101-1709, USA

    Diane P. Calello

  6. American College of Medical Toxicology, 10645 N Tatum Blvd., Suite 200-111, Phoenix, AZ, 85028, USA

    Sharan L. Campleman & Shao Li

  7. University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA, 15213, USA

    Anthony Pizon

  8. University of Rochester Medical Center and Strong Memorial Hospital, 601 Elmwood Ave, Rochester, NY, 14642, USA

    Timothy Wiegand

  9. Indiana university school of medicine, 340 West 10th Street, Suite 6200, Indianapolis, IN, 46202, USA

    Louise Kao

  10. Michigan State University College of Human Medicine, 100 Michigan NE MC49, Grand Rapids, MI, 49503, USA

    Brad D. Riley

  11. University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX, 75390, USA

    Paul M. Wax

  12. University of Colorado School of Medicine, 13001 E 17th Pl, Aurora, CO, 80045, USA

    Jeffery Brent

Authors
  1. Meghan B. Spyres
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  2. Lynn A. Farrugia
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  3. A. Min Kang
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  4. Diane P. Calello
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  5. Sharan L. Campleman
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  6. Anthony Pizon
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  7. Timothy Wiegand
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  8. Louise Kao
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  9. Brad D. Riley
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  10. Shao Li
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  11. Paul M. Wax
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  12. Jeffery Brent
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Consortia

On behalf of the Toxicology Investigators Consortium (ToxIC) Study Group

  • G. A. Beauchamp
  • , M. C. Beuhler
  • , K. L. Boyle
  • , R. D. Cannon
  • , J. L. Carey
  • , J. Carpenter
  • , J. A. Chenoweth
  • , D. K. Colby
  • , B. H. Eisenga
  • , E. Fisher
  • , J. B. Ford
  • , L. M. Fox
  • , M. Ganetsky
  • , R. Gorodetsky
  • , S. C. Greene
  • , M. K. Griswold
  • , S. A. Harding
  • , R. G. Hendrickson
  • , B. Z. Horowitz
  • , C. Hoyte
  • , J. Jacob
  • , B. S. Judge
  • , Z. Kazzi
  • , W. P. Kerns
  • , T. Kim
  • , A. Koons
  • , J. B. Leikin
  • , M. Levine
  • , D. B. Liss
  • , R. Marino
  • , C. A. McKay
  • , R. G. McKeever
  • , K. Meadors
  • , K. Moore
  • , M. E. Mullins
  • , N. Nacca
  • , M. E. Nelson
  • , L. Porter
  • , B. D. Riley
  • , C. Santos
  • , R. Schult
  • , E. S. Schwarz
  • , A. Scoccimarro
  • , S. A. Seifert
  • , S. Shafer
  • , K. R. Shah
  • , S. C. Smolinske
  • , M. Spyres
  • , L. Tortora
  • , D. J. Vearrier
  • , B. J. Warrick
  • , S. Weiss
  • , B. J. Wolk
  •  & J. Yanta

Corresponding author

Correspondence to Meghan B. Spyres.

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Supervising Editor: Supervising Editor: Mark B. Mycyk, MD

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Spyres, M.B., Farrugia, L.A., Kang, A.M. et al. The Toxicology Investigators Consortium Case Registry-the 2018 Annual Report. J. Med. Toxicol. 15, 228–254 (2019). https://doi.org/10.1007/s13181-019-00736-9

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  • DOI: https://doi.org/10.1007/s13181-019-00736-9

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