Zusammenfassung
Jährlich erleiden in Deutschland ca. 205.000 Menschen einen akuten Myokardinfarkt. Kernelement der optimalen Behandlung des ST-Hebungsmyokardinfarktes (STEMI) stellt die rasche und vollständige Reperfusion der verschlossenen Koronararterie dar. Zum Erreichen dieses Zieles ist die unverzügliche primäre perkutane Koronarintervention (pPCI) einer Thrombolysetherapie überlegen. Zur Verbesserung der Versorgung von STEMI-Patienten fordern die ESC-Leitlinien nachdrücklich zur Schaffung regionaler Herzinfarktnetzwerke auf, um die Zeit zwischen Symptombeginn und effektiver Reperfusion der verschlossenen Koronararterie kürzestmöglich zu halten. Die genaue Strukturierung von Herzinfarktnetzwerken bedarf vielfältiger formaler, logistischer und inhaltlicher Überlegungen. Derartige „Ausführungshinweise“ sind nicht Teil der Leitlinien und liegen in standardisierter Form bislang nicht vor. Das Positionspapier möchte, basierend auf der verfügbaren Datenlage und den Leitlinien, Empfehlungen zur Implementierung eines optimalen Herzinfarktnetzwerkes geben.
Abstract
In Germany approximately 205,000 patients experience an acute myocardial infarction annually. The main treatment strategy for ST segment elevation myocardial infarction (STEMI) is timely reperfusion of the coronary artery affected, primarily by percutaneous coronary intervention (pPCI), which is in general superior to systemic thrombolysis. In order to achieve these goals the European Society of Cardiology (ESC) guidelines encourage the establishment of regional networks for optimization of treatment and treatment times in STEMI patients. However, detailed information about how to establish and organize myocardial infarction networks are not provided by current guidelines. Therefore, this paper aims to address these gaps and proposes a structure for implementing and maintaining an optimized network according to currently available data.
Abbreviations
- ACC:
-
American College of Cardiology
- ACS:
-
Akutes Koronarsyndrom
- ÄLRD:
-
Ärztlicher Leiter Rettungsdienst
- AHA:
-
American Heart Association
- CBT:
-
Arzterstkontakt-Ballon-Zeit („contact to balloon time“)
- DBT:
-
Krankenhausankunft-Ballon-Zeit („door to ballon time“)
- DGK:
-
Deutsche Gesellschaft für Kardiologie
- DRG:
-
Diagnosis related Groups
- ESC:
-
European Society of Cardiology
- FMC:
-
First Medical Contact
- FITT-STEMI:
-
Feedback intervention and treatment times in STEMI
- IMC:
-
Intermediate Care
- NSTEMI:
-
Nicht-ST-Hebungsmyokardinfarkt
- PCI:
-
Perkutane Koronarintervention
- pPCI:
-
Primäre perkutane Katheterintervention
- PRD:
-
Procedure related delay
- STEMI:
-
ST-Hebungsmyokardinfarkt
Literatur
Löwel H, Meisinger C, Heier M et al (2006) Herzinfarkt und koronare Sterblichkeit in Süddeutschland. Dtsch Ärztebl 103:A616–A622
Sefrin P, Lafontaine B (2004) Prehospital treatment of the acute coronary syndrome in the emergency medical services in Bavaria. Dtsch Med Wochenschr 129(39):2025–2031
Steg PG et al (2012) ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC). Eur Heart J 33(20):2569–2619
Boersma E (2006) Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J 27:779–788
Eagle KA et al (2008) Trends in acute reperfusion therapy for ST-segment elevation myocardial infarction from 1999 to 2006: we are getting better but we have got a long way to go. Eur Heart J 29(5):609–617
Keeley EC, Boura JA, Grines CL (2003) Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 361:13–20
Nallamothu B et al (2007) Relationship of treatment delays and mortality in patients undergoing fibrinolysis and primary percutaneous coronary intervention. the global registry of acute coronary events. Heart 93(12):1552–1555
Stenestrand U, Lindbäck J, Wallentin L (2006) Long-term outcome of primary percutaneous coronary intervention vs prehospital and in-hospital thrombolysis for patients with ST-elevation myocardial infarction. JAMA 296:1749–1756
Tarantini G et al (2010) Acceptable reperfusion delay to prefer primary angioplasty over fibrin-specific thrombolytic therapy is affected (mainly) by the patient’s mortality risk: 1 h does not fit all. Eur Heart J 31(6):676–683
Thilo C, Blüthgen A, von Scheidt W (2013) Efficacy and limitations of a STEMI network: 3 years of experience within the myocardial infarction network of the region of Augsburg – HERA. Clin Res Cardiol 102(12): 905–914
Van de Werf F et al (2008) Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the task force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology. Eur Heart J 29(23):2909–2945
Terkelsen CJ et al (2009) Primary PCI as the preferred reperfusion therapy in STEMI: it is a matter of time. Heart 95(5):362–369
Scheidt W von, Thilo C (2011) As time goes by? The fallacy of thrombolysis in STEMI networks. Clin Res Cardiol 100(10):867–877
Widimsky P (2010) Primary angioplasty vs. thrombolysis: the end of the controversy? Eur Heart J 31(6):634–636
Widimsky P et al (2010) Reperfusion therapy for ST elevation acute myocardial infarction in Europe: description of the current situation in 30 countries. Eur Heart J 31(8):943–957
Kuch B et al (2009) Extent of the decrease of 28-day case fatality of hospitalized patients with acute myocardial infarction over 22 years: epidemiological versus clinical view: the MONICA/KORA Augsburg infarction registry. Circ Cardiovasc Qual Outcomes 2(4):313–319
Bruder O et al (2008) Prognostic impact of contrast-enhanced CMR early after acute ST segment elevation myocardial infarction (STEMI) in a regional STEMI network: results of the „Herzinfarktverbund Essen“. Herz 33(2):136–142
Hailer B et al (2011) Gender-related differences in patients with ST-elevation myocardial infarction: results from the registry study of the ST elevation myocardial infarction network Essen. Clin Cardiol 34(5):294–301
Birkemeyer R et al (2013) Short term cost effectiveness of a regional myocardial infarction network. Health Econ Rev 3(1):10
Schneider H et al (2004) Guideline-conforming interventional treatment of acute ST-segment elevation myocardial infarction in rural areas using network collaboration. Dtsch Med Wochenschr 129(41):2162–2166
Schneider H et al (2005) Interventional therapy of acute ST-elevation myocardial infarction in a regional network. Z Kardiol 94(Suppl 4):IV/85–IV/89
Schneider H et al (2007) Treatment of acute ST elevation myocardial infarction in a regional network („Drip & Ship Network Rostock“). Herz 32(8):635–640
Sefrin P, Maier SK (2011) Arbeitsgemeinschaft der Bayerischen Herzinfarktnetzwerke: Präklinische Standards bei der Herzinfarktbehandlung. Notarzt 27:101–104
Von Scheidt W, Thilo C, Maier SK (2012) Myokardinfarktnetzwerke. Notfall Rettungsmed 15:305–312
Scholz KH et al (2008) Optimizing systems of care for patients with acute myocardial infarction. STEMI networks, telemetry ECG, and standardized quality improvement with systematic data feedback. Herz 33(2):102–109
Maier SKG, Scheidt W von (2012) Konsensus der Arbeitsgemeinschaft der Bayerischen Herzinfarktnetzwerke. www.herzinfarkt-netzwerke.de
Hamm CW et al (2011) ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the task force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 32(23):2999–3054
Antman EM et al (2008) 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association task force on practice guidelines: developed in collaboration with the Canadian Cardiovascular Society endorsed by the American Academy of Family Physicians: 2007 writing group to review new evidence and update the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction, writing on behalf of the 2004 writing committee. Circulation 117(2):296–329
Zahn R et al (1999) Primary angioplasty in acute myocardial infarction: differences between referred patients and those treated in hospitals with on-site facilities? J Invasive Cardiol 11(4):213–219
Zahn R et al (1999) Spectrum of reperfusion strategies and factors influencing the use of primary angioplasty in patients with acute myocardial infarction admitted to hospitals with the facilities to perform primary angioplasty. Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) Study Group. Heart 82(4):420–425
Gottwik M et al (2001) Differences in treatment and outcome of patients with acute myocardial infarction admitted to hospitals with compared to without departments of cardiology. Results from the pooled data of the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA 1 + 2) Registries and the Myocardial Infarction Registry (MIR). Eur Heart J 22(19):1794–1801
Zahn R et al (2009) Reperfusion therapy for acute ST-elevation and non ST-elevation myocardial infarction: what can be achieved in daily clinical practice in unselected patients at an interventional center? Acute Card Care 11:92–98
Bauer T et al (2009) Efficacy of a 24-h primary percutaneous coronary intervention service on outcome in patients with ST elevation myocardial infarction in clinical practice. Clin Res Cardiol 98(3):171–178
Bonzel T et al (2008) Leitlinie Interventionelle Koronartherapie. Clin Res Cardiol 97:513–547
Allaqaband S et al (2010) Impact of 24-hr in-hospital interventional cardiology team on timeliness of reperfusion for ST-segment elevation myocardial infarction. Catheter Cardiovasc Interv 75(7):1015–1023
Scholz KH et al (2012) Reduction in treatment times through formalized data feedback: results from a prospective multicenter study of ST-segment elevation myocardial infarction. JACC Cardiovasc Interv 5(8):848–857
Brown JP et al (2008) Effect of prehospital 12-lead electrocardiogram on activation of the cardiac catheterization laboratory and door-to-balloon time in ST-segment elevation acute myocardial infarction. Am J Cardiol 101(2):158–161
Dhruva VN et al (2007) ST-Segment Analysis Using Wireless Technology in Acute Myocardial Infarction (STAT-MI) trial. J Am Coll Cardiol 50(6):509–513
Rao A et al (2010) Impact of the prehospital ECG on door-to-balloon time in ST elevation myocardial infarction. Catheter Cardiovasc Interv 75(2):174–178
Scholz KH et al (2011) Umgehung der Notaufnahme führt zu erheblicher Verkürzung der Revaskularisationszeiten und besserer Prognose bei STEMI-Patienten – Ergebnisse aus dem FITT-STEMI-Gesamtprojekt. Clin Res Cardiol 100, Suppl 1, April 2011, P1643
Garvey JL et al (2012) Rates of cardiac catheterization cancelation for ST-segment elevation myocardial infarction after activation by emergency medical services or emergency physicians. Circulation 125(2):308–313
Alexander KP et al (2007) Acute coronary care in the elderly, part II. ST-segment elevation myocardial infarction. Circulation 115:2570–2589
Larson DM et al (2012) Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation myocardial infarction patients with expected delays due to long-distance transfers. Eur Heart J 33(10):1232–1240
Wang TY et al (2011) Association of door-in to door-out time with reperfusion delays and outcomes among patients transferred for primary percutaneous coronary intervention. JAMA 305(24):2540–2547
Thiele H (2010) Door to balloon times in acute myocardial infarction. http://www.uni-leipzig.de/~kard/d2bt/. (Zugegriffen: 02. Feb. 2012)
Scholz KH et al (2008) Contact-to-balloon time and door-to-balloon time after initiation of a formalized data feedback in patients with acute ST-elevation myocardial infarction. Am J Cardiol 101(1):46–52
Rustige J et al (1997) The 60 min myocardial infarction project. Treatment and clinical outcome of patients with acute myocardial infarction in Germany. Eur Heart J 18(9):1438–1446
Gitt AK et al (2010) The role of cardiac registries in evidence-based medicine. Eur Heart J 31(5):525–529
Bradley EH et al (2006) Strategies for reducing the door-to-balloon time in acute myocardial infarction. N Engl J Med 355(22):2208–2220
Krumholz HM et al (2011) Improvements in door-to-balloon time in the United States, 2005 to 2010. Circulation 124(9):1038–1045
Boersma E et al (1996) Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour. Lancet 348:771–775
Wijns W et al (2010) Guidelines on myocardial revascularization: the task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 31:2501–2555
Ting HH et al (2007) Regional systems of care to optimize timeliness of reperfusion therapy for ST-elevation myocardial infarction. Circulation 116:729–736
Zahn R et al (2005) In-hospital time to treatment of patients with acute ST elevation myocardial infarction treated with primary angioplasty: determinants and outcome. Results from the registry of percutaneous coronary interventions in acute myocardial infarction of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte. Heart 91(8):1041–1046
Brodie BR et al (2010) When is door-to-balloon time critical? Analysis from the HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) and CADILLAC (Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications) trials. J Am Coll Cardiol 56:407–413
Brodie BR et al (2002) Effect of treatment delay on outcomes in patients with acute myocardial infarction transferred from community hospitals for primary percutaneous coronary intervention. Am J Cardiol 89:1243–1247
Einhaltung ethischer Richtlinien
Interessenkonflikt. S.K.G. Maier, H. Thiele, R. Zahn, P. Sefrin, C.K. Naber, K.H. Scholz und W. von Scheidt geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.
Author information
Authors and Affiliations
Corresponding author
Zusatzmaterial online
Rights and permissions
About this article
Cite this article
Maier, S., Thiele, H., Zahn, R. et al. Empfehlungen zur Organisation von Herzinfarktnetzwerken. Kardiologe 8, 36–44 (2014). https://doi.org/10.1007/s12181-013-0540-1
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12181-013-0540-1