Skip to main content
Log in

Empfehlungen zur Organisation von Herzinfarktnetzwerken

Recommendations for the organization of acute myocardial infarction networks

  • Empfehlungen
  • Published:
Der Kardiologe Aims and scope

Zusammenfassung

Jährlich erleiden in Deutschland ca. 205.000 Menschen einen akuten Myokardinfarkt. Kernelement der optimalen Behandlung des ST-Hebungsmyokardinfarktes (STEMI) stellt die rasche und vollständige Reperfusion der verschlossenen Koronararterie dar. Zum Erreichen dieses Zieles ist die unverzügliche primäre perkutane Koronarintervention (pPCI) einer Thrombolysetherapie überlegen. Zur Verbesserung der Versorgung von STEMI-Patienten fordern die ESC-Leitlinien nachdrücklich zur Schaffung regionaler Herzinfarktnetzwerke auf, um die Zeit zwischen Symptombeginn und effektiver Reperfusion der verschlossenen Koronararterie kürzestmöglich zu halten. Die genaue Strukturierung von Herzinfarktnetzwerken bedarf vielfältiger formaler, logistischer und inhaltlicher Überlegungen. Derartige „Ausführungshinweise“ sind nicht Teil der Leitlinien und liegen in standardisierter Form bislang nicht vor. Das Positionspapier möchte, basierend auf der verfügbaren Datenlage und den Leitlinien, Empfehlungen zur Implementierung eines optimalen Herzinfarktnetzwerkes geben.

Abstract

In Germany approximately 205,000 patients experience an acute myocardial infarction annually. The main treatment strategy for ST segment elevation myocardial infarction (STEMI) is timely reperfusion of the coronary artery affected, primarily by percutaneous coronary intervention (pPCI), which is in general superior to systemic thrombolysis. In order to achieve these goals the European Society of Cardiology (ESC) guidelines encourage the establishment of regional networks for optimization of treatment and treatment times in STEMI patients. However, detailed information about how to establish and organize myocardial infarction networks are not provided by current guidelines. Therefore, this paper aims to address these gaps and proposes a structure for implementing and maintaining an optimized network according to currently available data.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1

Abbreviations

ACC:

American College of Cardiology

ACS:

Akutes Koronarsyndrom

ÄLRD:

Ärztlicher Leiter Rettungsdienst

AHA:

American Heart Association

CBT:

Arzterstkontakt-Ballon-Zeit („contact to balloon time“)

DBT:

Krankenhausankunft-Ballon-Zeit („door to ballon time“)

DGK:

Deutsche Gesellschaft für Kardiologie

DRG:

Diagnosis related Groups

ESC:

European Society of Cardiology

FMC:

First Medical Contact

FITT-STEMI:

Feedback intervention and treatment times in STEMI

IMC:

Intermediate Care

NSTEMI:

Nicht-ST-Hebungsmyokardinfarkt

PCI:

Perkutane Koronarintervention

pPCI:

Primäre perkutane Katheterintervention

PRD:

Procedure related delay

STEMI:

ST-Hebungsmyokardinfarkt

Literatur

  1. Löwel H, Meisinger C, Heier M et al (2006) Herzinfarkt und koronare Sterblichkeit in Süddeutschland. Dtsch Ärztebl 103:A616–A622

    Google Scholar 

  2. Sefrin P, Lafontaine B (2004) Prehospital treatment of the acute coronary syndrome in the emergency medical services in Bavaria. Dtsch Med Wochenschr 129(39):2025–2031

    Article  CAS  PubMed  Google Scholar 

  3. Steg PG et al (2012) ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC). Eur Heart J 33(20):2569–2619

    Article  CAS  PubMed  Google Scholar 

  4. Boersma E (2006) Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J 27:779–788

    Article  PubMed  Google Scholar 

  5. Eagle KA et al (2008) Trends in acute reperfusion therapy for ST-segment elevation myocardial infarction from 1999 to 2006: we are getting better but we have got a long way to go. Eur Heart J 29(5):609–617

    Article  PubMed  Google Scholar 

  6. Keeley EC, Boura JA, Grines CL (2003) Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 361:13–20

    Article  PubMed  Google Scholar 

  7. Nallamothu B et al (2007) Relationship of treatment delays and mortality in patients undergoing fibrinolysis and primary percutaneous coronary intervention. the global registry of acute coronary events. Heart 93(12):1552–1555

    Article  CAS  PubMed  Google Scholar 

  8. Stenestrand U, Lindbäck J, Wallentin L (2006) Long-term outcome of primary percutaneous coronary intervention vs prehospital and in-hospital thrombolysis for patients with ST-elevation myocardial infarction. JAMA 296:1749–1756

    Article  CAS  PubMed  Google Scholar 

  9. Tarantini G et al (2010) Acceptable reperfusion delay to prefer primary angioplasty over fibrin-specific thrombolytic therapy is affected (mainly) by the patient’s mortality risk: 1 h does not fit all. Eur Heart J 31(6):676–683

    Article  PubMed  Google Scholar 

  10. Thilo C, Blüthgen A, von Scheidt W (2013) Efficacy and limitations of a STEMI network: 3 years of experience within the myocardial infarction network of the region of Augsburg – HERA. Clin Res Cardiol 102(12): 905–914

    Article  PubMed  Google Scholar 

  11. Van de Werf F et al (2008) Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the task force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology. Eur Heart J 29(23):2909–2945

    Article  Google Scholar 

  12. Terkelsen CJ et al (2009) Primary PCI as the preferred reperfusion therapy in STEMI: it is a matter of time. Heart 95(5):362–369

    Article  CAS  PubMed  Google Scholar 

  13. Scheidt W von, Thilo C (2011) As time goes by? The fallacy of thrombolysis in STEMI networks. Clin Res Cardiol 100(10):867–877

    Article  Google Scholar 

  14. Widimsky P (2010) Primary angioplasty vs. thrombolysis: the end of the controversy? Eur Heart J 31(6):634–636

    Article  PubMed  Google Scholar 

  15. Widimsky P et al (2010) Reperfusion therapy for ST elevation acute myocardial infarction in Europe: description of the current situation in 30 countries. Eur Heart J 31(8):943–957

    Article  PubMed  Google Scholar 

  16. Kuch B et al (2009) Extent of the decrease of 28-day case fatality of hospitalized patients with acute myocardial infarction over 22 years: epidemiological versus clinical view: the MONICA/KORA Augsburg infarction registry. Circ Cardiovasc Qual Outcomes 2(4):313–319

    Article  PubMed  Google Scholar 

  17. Bruder O et al (2008) Prognostic impact of contrast-enhanced CMR early after acute ST segment elevation myocardial infarction (STEMI) in a regional STEMI network: results of the „Herzinfarktverbund Essen“. Herz 33(2):136–142

    Article  PubMed  Google Scholar 

  18. Hailer B et al (2011) Gender-related differences in patients with ST-elevation myocardial infarction: results from the registry study of the ST elevation myocardial infarction network Essen. Clin Cardiol 34(5):294–301

    Article  PubMed  Google Scholar 

  19. Birkemeyer R et al (2013) Short term cost effectiveness of a regional myocardial infarction network. Health Econ Rev 3(1):10

    Article  PubMed Central  PubMed  Google Scholar 

  20. Schneider H et al (2004) Guideline-conforming interventional treatment of acute ST-segment elevation myocardial infarction in rural areas using network collaboration. Dtsch Med Wochenschr 129(41):2162–2166

    Article  CAS  PubMed  Google Scholar 

  21. Schneider H et al (2005) Interventional therapy of acute ST-elevation myocardial infarction in a regional network. Z Kardiol 94(Suppl 4):IV/85–IV/89

    Article  PubMed  Google Scholar 

  22. Schneider H et al (2007) Treatment of acute ST elevation myocardial infarction in a regional network („Drip & Ship Network Rostock“). Herz 32(8):635–640

    Article  PubMed  Google Scholar 

  23. Sefrin P, Maier SK (2011) Arbeitsgemeinschaft der Bayerischen Herzinfarktnetzwerke: Präklinische Standards bei der Herzinfarktbehandlung. Notarzt 27:101–104

    Article  Google Scholar 

  24. Von Scheidt W, Thilo C, Maier SK (2012) Myokardinfarktnetzwerke. Notfall Rettungsmed 15:305–312

    Google Scholar 

  25. Scholz KH et al (2008) Optimizing systems of care for patients with acute myocardial infarction. STEMI networks, telemetry ECG, and standardized quality improvement with systematic data feedback. Herz 33(2):102–109

    Article  PubMed  Google Scholar 

  26. Maier SKG, Scheidt W von (2012) Konsensus der Arbeitsgemeinschaft der Bayerischen Herzinfarktnetzwerke. www.herzinfarkt-netzwerke.de

  27. Hamm CW et al (2011) ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: the task force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 32(23):2999–3054

    Article  PubMed  Google Scholar 

  28. Antman EM et al (2008) 2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association task force on practice guidelines: developed in collaboration with the Canadian Cardiovascular Society endorsed by the American Academy of Family Physicians: 2007 writing group to review new evidence and update the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction, writing on behalf of the 2004 writing committee. Circulation 117(2):296–329

    Article  PubMed  Google Scholar 

  29. Zahn R et al (1999) Primary angioplasty in acute myocardial infarction: differences between referred patients and those treated in hospitals with on-site facilities? J Invasive Cardiol 11(4):213–219

    CAS  PubMed  Google Scholar 

  30. Zahn R et al (1999) Spectrum of reperfusion strategies and factors influencing the use of primary angioplasty in patients with acute myocardial infarction admitted to hospitals with the facilities to perform primary angioplasty. Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) Study Group. Heart 82(4):420–425

    CAS  PubMed  Google Scholar 

  31. Gottwik M et al (2001) Differences in treatment and outcome of patients with acute myocardial infarction admitted to hospitals with compared to without departments of cardiology. Results from the pooled data of the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA 1 + 2) Registries and the Myocardial Infarction Registry (MIR). Eur Heart J 22(19):1794–1801

    Article  CAS  PubMed  Google Scholar 

  32. Zahn R et al (2009) Reperfusion therapy for acute ST-elevation and non ST-elevation myocardial infarction: what can be achieved in daily clinical practice in unselected patients at an interventional center? Acute Card Care 11:92–98

    Article  PubMed  Google Scholar 

  33. Bauer T et al (2009) Efficacy of a 24-h primary percutaneous coronary intervention service on outcome in patients with ST elevation myocardial infarction in clinical practice. Clin Res Cardiol 98(3):171–178

    Article  PubMed  Google Scholar 

  34. Bonzel T et al (2008) Leitlinie Interventionelle Koronartherapie. Clin Res Cardiol 97:513–547

    Article  PubMed  Google Scholar 

  35. Allaqaband S et al (2010) Impact of 24-hr in-hospital interventional cardiology team on timeliness of reperfusion for ST-segment elevation myocardial infarction. Catheter Cardiovasc Interv 75(7):1015–1023

    PubMed  Google Scholar 

  36. Scholz KH et al (2012) Reduction in treatment times through formalized data feedback: results from a prospective multicenter study of ST-segment elevation myocardial infarction. JACC Cardiovasc Interv 5(8):848–857

    Article  PubMed  Google Scholar 

  37. Brown JP et al (2008) Effect of prehospital 12-lead electrocardiogram on activation of the cardiac catheterization laboratory and door-to-balloon time in ST-segment elevation acute myocardial infarction. Am J Cardiol 101(2):158–161

    Article  PubMed  Google Scholar 

  38. Dhruva VN et al (2007) ST-Segment Analysis Using Wireless Technology in Acute Myocardial Infarction (STAT-MI) trial. J Am Coll Cardiol 50(6):509–513

    Article  PubMed  Google Scholar 

  39. Rao A et al (2010) Impact of the prehospital ECG on door-to-balloon time in ST elevation myocardial infarction. Catheter Cardiovasc Interv 75(2):174–178

    Article  PubMed  Google Scholar 

  40. Scholz KH et al (2011) Umgehung der Notaufnahme führt zu erheblicher Verkürzung der Revaskularisationszeiten und besserer Prognose bei STEMI-Patienten – Ergebnisse aus dem FITT-STEMI-Gesamtprojekt. Clin Res Cardiol 100, Suppl 1, April 2011, P1643

  41. Garvey JL et al (2012) Rates of cardiac catheterization cancelation for ST-segment elevation myocardial infarction after activation by emergency medical services or emergency physicians. Circulation 125(2):308–313

    Article  PubMed  Google Scholar 

  42. Alexander KP et al (2007) Acute coronary care in the elderly, part II. ST-segment elevation myocardial infarction. Circulation 115:2570–2589

    Article  PubMed  Google Scholar 

  43. Larson DM et al (2012) Safety and efficacy of a pharmaco-invasive reperfusion strategy in rural ST-elevation myocardial infarction patients with expected delays due to long-distance transfers. Eur Heart J 33(10):1232–1240

    Article  CAS  PubMed  Google Scholar 

  44. Wang TY et al (2011) Association of door-in to door-out time with reperfusion delays and outcomes among patients transferred for primary percutaneous coronary intervention. JAMA 305(24):2540–2547

    Article  CAS  PubMed  Google Scholar 

  45. Thiele H (2010) Door to balloon times in acute myocardial infarction. http://www.uni-leipzig.de/~kard/d2bt/. (Zugegriffen: 02. Feb. 2012)

  46. Scholz KH et al (2008) Contact-to-balloon time and door-to-balloon time after initiation of a formalized data feedback in patients with acute ST-elevation myocardial infarction. Am J Cardiol 101(1):46–52

    Article  PubMed  Google Scholar 

  47. Rustige J et al (1997) The 60 min myocardial infarction project. Treatment and clinical outcome of patients with acute myocardial infarction in Germany. Eur Heart J 18(9):1438–1446

    Article  CAS  PubMed  Google Scholar 

  48. Gitt AK et al (2010) The role of cardiac registries in evidence-based medicine. Eur Heart J 31(5):525–529

    Article  PubMed  Google Scholar 

  49. Bradley EH et al (2006) Strategies for reducing the door-to-balloon time in acute myocardial infarction. N Engl J Med 355(22):2208–2220

    Article  Google Scholar 

  50. Krumholz HM et al (2011) Improvements in door-to-balloon time in the United States, 2005 to 2010. Circulation 124(9):1038–1045

    Article  PubMed Central  PubMed  Google Scholar 

  51. Boersma E et al (1996) Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour. Lancet 348:771–775

    Article  CAS  PubMed  Google Scholar 

  52. Wijns W et al (2010) Guidelines on myocardial revascularization: the task force on myocardial revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 31:2501–2555

    Article  PubMed  Google Scholar 

  53. Ting HH et al (2007) Regional systems of care to optimize timeliness of reperfusion therapy for ST-elevation myocardial infarction. Circulation 116:729–736

    Article  PubMed  Google Scholar 

  54. Zahn R et al (2005) In-hospital time to treatment of patients with acute ST elevation myocardial infarction treated with primary angioplasty: determinants and outcome. Results from the registry of percutaneous coronary interventions in acute myocardial infarction of the Arbeitsgemeinschaft Leitender Kardiologischer Krankenhausarzte. Heart 91(8):1041–1046

    Article  CAS  PubMed  Google Scholar 

  55. Brodie BR et al (2010) When is door-to-balloon time critical? Analysis from the HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) and CADILLAC (Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications) trials. J Am Coll Cardiol 56:407–413

    Article  PubMed  Google Scholar 

  56. Brodie BR et al (2002) Effect of treatment delay on outcomes in patients with acute myocardial infarction transferred from community hospitals for primary percutaneous coronary intervention. Am J Cardiol 89:1243–1247

    Article  PubMed  Google Scholar 

Download references

Einhaltung ethischer Richtlinien

Interessenkonflikt. S.K.G. Maier, H. Thiele, R. Zahn, P. Sefrin, C.K. Naber, K.H. Scholz und W. von Scheidt geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S.K.G. Maier.

Zusatzmaterial online

Rights and permissions

Reprints and permissions

About this article

Cite this article

Maier, S., Thiele, H., Zahn, R. et al. Empfehlungen zur Organisation von Herzinfarktnetzwerken. Kardiologe 8, 36–44 (2014). https://doi.org/10.1007/s12181-013-0540-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12181-013-0540-1

Schlüsselwörter

Keywords

Navigation