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Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening

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Abstract

Lipid peroxidation due to oxidative stress (OS) may play an important role in the pathogenesis of chronic systemic inflammatory diseases such as multiple sclerosis (MS). Telomeres, repeated sequences that cap chromosome ends, undergo shortening with each cycle of cell division, resulting in cellular senescence. Research regarding telomere shortening has provided novel insight into the pathogenesis of various diseases. We hypothesized that OS damage leads to inflammatory reactions, which subsequently shortens the telomere length in MS. We enrolled 59 patients with MS, and age- and gender-matched 60 healthy controls. We divided MS subjects into three groups matched for age and gender according to the severity of disability: relatively benign course (BMS), secondary progressive MS, and primary progressive MS (PPMS). We analyzed the telomere length in peripheral blood mononuclear cells and the 8-iso-PGF2α concentration in urine, a reliable and stable marker of lipid peroxidation in vivo. The data showed significant higher levels of urinary 8-iso-PGF2α in MS subjects than in the controls. The lag-time, which represents the direct measurement of the resistance of low-density lipoprotein to oxidation, was shorter in the PPMS subjects than in the groups. Compared to that observed in the controls, the mean telomere length was significantly shorter in the PPMS group, whereas no significant telomere shortening was found between the controls and other subjects. Our data suggest that a decreased telomere length and enhanced lipid peroxidation reflects the severest stage of MS.

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Acknowledgments

This work was supported by grants from the National Natural. Science Fund (NSFC) (81170329/H2501), and 2012 Health and Labour Sciences Research Grants Comprehensive Research on Life-Style Related Diseases including Cardiovascular Diseases and Diabetes Mellitus, and the Ministry of Education, Science, and Culture of Japan (#23590885).

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Authors and Affiliations

  1. The 309th Hospital of Chinese People’s Liberation Army, Beijing, China

    Jing-Zhi Guan, Xie Guoqing & Wan GuangZhi

  2. Nanlou Neurology Department, Chinese People’s Liberation Army General Hospital, Beijing, China

    Wei-Ping Guan

  3. Department of Cardiovascular Respiratory, and Geriatric Medicine, Kyushu University Beppu Hospital, Tsurumihara 4546, Beppu, Oita, 874-0838, Japan

    Toyoki Maeda & Naoki Makino

Authors
  1. Jing-Zhi Guan
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  2. Wei-Ping Guan
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  3. Toyoki Maeda
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  4. Xie Guoqing
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  5. Wan GuangZhi
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  6. Naoki Makino
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Correspondence to Toyoki Maeda.

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Jing-Zhi Guan, Wei-Ping Guan and Toyoki Maeda have equally contributed to this work.

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Guan, JZ., Guan, WP., Maeda, T. et al. Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening. Mol Cell Biochem 400, 183–187 (2015). https://doi.org/10.1007/s11010-014-2274-1

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  • DOI: https://doi.org/10.1007/s11010-014-2274-1

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