Skip to main content
Log in

Das Inhalationstrauma bei Verbrennungspatienten: Diagnostik und Therapie

Inhalation injury in burn patients: diagnosis and therapy

  • ÜBERSICHT
  • Published:
Intensivmedizin und Notfallmedizin

Summary

Inhalation injury/trauma of the lung (IHT) provides a variable picture of the consequences from the complex array of harmful gases. Approximately 30% of burn patients suffer from accompanying inhalation injury that negatively effect the prognosis of burn injuries. Presented in this survey work will be diagnosis of and therapy for thermal and chemical IHT. The physiological effects of carbon monoxide and cyanide (HCN) as well as the symptoms and therapy for inhalation poisoning will be examined. Therapy for and prognosis of different forms of IHT will be described. A severe IHT leading to cutaneous burns can result in adult respiratory distress syndrome (ARDS). The present state of respiratory therapy for burn patients with concomitant IHT will be discussed in this context.

Zusammenfassung

Das Inhalationstrauma (IHT) der Lunge bietet ein variables Erscheinungsbild als Folge der Komplexität der verschiedenen schädigenden Rauchgase. Etwa 30% der Verbrennungspatienten erleiden ein begleitendes Inhalationstrauma, welches die Prognose des Brandverletzten erheblich verschlechtert.

In dieser Übersichtsarbeit werden Vorkommen, Diagnostik und Therapie des thermischen und des chemischen IHT dargestellt. Die physiologischen Wirkungen von Kohlenmonoxid (CO) und Cyanid (HCN) sowie Symptome und Therapie der systemischen Inhalationsvergiftung mit diesen Substanzen werden erläutert.

Die Therapie und die Prognose der verschiedenen Formen des IHT werden beschrieben. Ein schweres IHT begleitend zur kutanen Verbrennung kann ein ARDS (adult respiratory distress syndrome) hervorrufen. In diesem Zusammenhang wird der aktuelle Stand der Respiratortherapie bei dem Verbrennungspatienten mit IHT diskutiert.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Terrill JB, Montgomery RR, Reinhardt CF (1978) Toxic gases from fires. Science 200:1343–1347

    CAS  PubMed  Google Scholar 

  2. Clark WR, Nieman GF (1988) Smoke inhalation. Burns 14(6):473–494

    Google Scholar 

  3. Prien T, Traber DL (1988) Toxic smoke compounds and inhalation injury—a review. Burns 14(6):451–460

    CAS  Google Scholar 

  4. Thompson PB, Herndon DN, Abston S (1986) Effect of inhalation injury on mortality. J Trauma 26:163–169

    CAS  PubMed  Google Scholar 

  5. Herndon DN, Barrow RE, Linares HA, Rutan RL, Prien T, Traber L, Traber D (1988) Inhalation injury in burned patients: effects and treatment. Burns 14:349–356

    CAS  Google Scholar 

  6. Rue LW, Cioffi MW, Mason AD, McManus WF, Pruitt BA (1993) Improved survival of burned patients with inhalation injury. Arch Surg 128:772–780

    PubMed  Google Scholar 

  7. Kohn (2000) Der Anaesthesist 49:349–370

    Article  PubMed  Google Scholar 

  8. Herndon DN, Barrow RE, Traber DL (1987) Extravascular lungwater changes following smoke inhalation injury in massive burns. Surgery 102:341–347

    CAS  PubMed  Google Scholar 

  9. Zawacki BE, Azen SP, Imbus SH, Chang YC (1979) Multifactorial probit analysis of mortality in burned patients. Ann Surg 189:1–9

    CAS  PubMed  Google Scholar 

  10. Klose R (2003) Zur Prognose des Brandverletzten. Anästhesiol Intensivmed Notfallmed Schmerzther 38:141–142

    Article  CAS  PubMed  Google Scholar 

  11. Haponik EF (1993) Clinical smoke inhalation injury: pulmonary effects. J Occup Med 8:431–468

    Google Scholar 

  12. Voeltz P (1995) Inhalationstrauma. Unfallchirurg 98:187–192

    CAS  PubMed  Google Scholar 

  13. Smith DL, Cairns BA, Ramadan F, Dalston JS, Fakhry SM, Rutlege R, Meyer A, Peterson HD (1994) Effect of inhalation injury, burn size, and age on mortality: study of 1447 consecutive burn patients. J Trauma 37 84:655–659

    CAS  PubMed  Google Scholar 

  14. Pruitt, BA (1984) The diagnosis and treatment of infection in the burn patient. Burns 11:79–91

    Google Scholar 

  15. Shirani KZ, Pruitt BA, Mason AD (1986) The influence of inhalation injury and pneumonia on burn mortality. Ann Surg 205(1):82–87

    Google Scholar 

  16. Cope O, Rhinelander FW (1943) The problem of burn shock complicated by pulmonary damage. Ann Surg 117:915–918

    Google Scholar 

  17. Phillips AW, Cope O (1962) Burn Therapy II. The revelation of respiratory tract damage as a principal killer of the burned patient. Ann Surg 155:1–10

    CAS  PubMed  Google Scholar 

  18. Prien T (1984) Die Inhalationsverletzung der Lunge. Anästh Intensivther Notfallmed 19:161–167

    CAS  PubMed  Google Scholar 

  19. Zawacki BE, Jung RC, Joyce J, Rincon E (1977) Smoke, burns, and the natural history of inhalation injury in fire victims. Ann Surg 185:100–105

    Google Scholar 

  20. Moritz AR, Henriques FC, McLean R (1945) The effect of inhaled heat on the air passages and lungs. Am J Pathol 24:311–315

    Google Scholar 

  21. Reed GF, Camp HL (1969) Upper airway problems in severely burned patients. Ann Otol 78:741

    CAS  Google Scholar 

  22. Heimbach DM, Waeckerle, JF: Inhalation injuries. Ann Emerg Med 17:1316–1320

  23. Pruitt BA, Cioffi WG (1995) Diagnosis and treatment of smoke inhalation. J Intensive Care Med 10:117–127

    PubMed  Google Scholar 

  24. Muehlberger T, Kunar D, Munster AM, Couch M (1998) Efficacy of fiberoptic laryngoscopy in the diagnosis of inhalation injuries. Arch Otolaryngol Head Neck Surg 124:1003–1007

    CAS  PubMed  Google Scholar 

  25. Hoppe U (2002) Beatmung des Brandverletzten. In: Bruck JC, Müller FE, Steen M (Hrsg) Handbuch der Verbrennungstherapie. Ecomed, Landsberg, S 209–222

  26. Achauer BM, Allyn PA, Furnas DW, Bartlett RH (1975) Pulmonary complications of burns: the major threat to the burn patient. Ann Surg 177:311–315

    Google Scholar 

  27. Weiss S, Lakshminarayan S (1994) Acute inhalation injury. Clin Chest Med, pp 103–116

  28. Murakami K, Traber DL (2003) Pathophysiological basis of smoke inhalation injury. News Physiol Sci 18:125–129

    CAS  PubMed  Google Scholar 

  29. Garnier R (1998) Acute toxic pneumopathies. Rev Prat 48:1319–1323

    CAS  PubMed  Google Scholar 

  30. Haponik EF, Munster AM (1990) Respiratory Injury—Smoke inhalation and burns. Mc Graw Hill, New York, pp 34–42

  31. Remarque EM (1929) Im Westen nichts Neues. Kiepenheuer & Witsch, Köln, S 123

  32. Konrad F, Schreiber T, Hähnel J, Kilian J, Georgieff M (1994) Einfluss von Theophyllin auf die mukoziliare Klärfunktion beatmeter Intensivpatienten. Anästhesist 43:101–106

    CAS  Google Scholar 

  33. Skornik WA, Dressler DP (1974) The effects of short-term steroid therapy on lung bacterial clearance and survival in rats. Ann Surg 179:415–421

    CAS  PubMed  Google Scholar 

  34. Seinfeld H, Guilani V. Merzel D (1975) Corticosteroid derivates in the treatment of inhalation burns. Burns incl Therm Inj 1:261–263

    Google Scholar 

  35. Hennes HJ (1998) Thermische Schäden—Verbrennungen und Verbrühungen. Notfallmedizin 24:31–37

    Google Scholar 

  36. Steen M (2002) Inhalationstrauma. In: Bruck JC, Müller FE, Steen M (Hrsg) Handbuch der Verbrennungstherapie. Ecomed, Landsberg, S 450–463

  37. Möllmann HW, Barth J, Schött D, Ulmer WT, Derendorf H, Hochhaus G (1989) Differentialtherapeutische Aspekte zum Einsatz von Glukokortikoiden nach Reizgasvergiftungen. Intensivmed 26:2–15

    Google Scholar 

  38. Vogt PM, Lahoda LU, Köller M (2002) Sepsis und Organversagen. In: Bruck JC, Müller FE, Steen M (Hrsg) Handbuch der Verbrennungstherapie. Ecomed, Landsberg, S 126–150

  39. Leach CL (1998) Improved delivery of inhaled steroids to the large and small airways. Respir Med 92(Suppl A):3–8

    Article  PubMed  Google Scholar 

  40. Levine BA, Petroff PA, Slade CL, Pruitt BA (1978) Prospective trials of dexamethasone and aerolized gentamicin in the treatment of inhalation injury in the burned patient. J Trauma 18(3):188–193

    CAS  PubMed  Google Scholar 

  41. Moylan JA, Alexander LG (1978) Diagnosis and treatment of inhalation injury. World J Surg 2:185–191

    Article  CAS  PubMed  Google Scholar 

  42. Deitch EA (1990) The management of burns. New Engl J Med 323:1249–1253

    CAS  PubMed  Google Scholar 

  43. Hoppe U, Klose R (1998) Keine generelle Empfehlung für Corticoide beim Inhalationstrauma. Notfallmedizin 24:338–339

    Google Scholar 

  44. Robinson NB, Hudson LD, Riem M, Miller E, Willoughby J, Ravenholt O, Carrico CL, Heimbach DM (1982) Steroid therapy following isolated smoke inhalation injury. J Trauma 22 (10):876– 879

    CAS  PubMed  Google Scholar 

  45. Lechleuthner A, Steffens W (1999) Cortison bei Reizgasinhalation. www.medizinimdialog.com

  46. Coburn R (1979) Mechanism of carbon monoxide toxicity. PrevMed 8:310–322

    CAS  Google Scholar 

  47. Breen P (1995) Combined carbon monoxide and cyanide poisoning: a place for treatment? Anesth Analg 80:671–677

    Article  CAS  PubMed  Google Scholar 

  48. Sharar SR, Heimbach DM (1991) Inhalation injury: Current concepts and controversies. In: Advances in Trauma and Critical Care, Vol 6. Mosby Year Book, St. Louis

  49. Zimmermann M, Ittner KP (2000) Die Kohlenmonoxidvergiftung in der Notfallmedizin. Anästhesiologie & Intensivmedizin 41:239–244

    Google Scholar 

  50. Meyer-Witting M (1991) Acute carbon monoxide exposure and cerebral blood flow in rats. Anesth Intens Care 19:373–377

    CAS  Google Scholar 

  51. Thom SR (1992) Dehydrogenase conversion to oxidase and lipid peroxidation in brain after carbon monoxide poisoning. J Appl Physiol 73:1584–1589

    CAS  PubMed  Google Scholar 

  52. Thom SR (1993) Leucocytes in carbon monoxide-mediated brain oxidative injury. Toxicol Appl Pharmacol 123:234–247

    Article  CAS  PubMed  Google Scholar 

  53. Brown S, Piantadosi C (1990) In vivo binding of carbon monoxide to cytochrome c oxidase in rat brain. J Appl Physiol 68:604–610

    CAS  PubMed  Google Scholar 

  54. Bratzke H, Maxeiner H (1985) Kohlenmonoxidvergiftungen: immer häufiger werden sie verkannt. Notfallmedizin 11:1395–1408

    Google Scholar 

  55. Stout D (1995) Man indicted in the death of Gerulaitis. The New York Times 1995, May 23, B1

  56. Silvers SM, HampsonNB (1995) Carbon monoxide poisoning among recreational boaters. JAMA 274:1614–1616

    Article  CAS  PubMed  Google Scholar 

  57. Miller F (1996) Carbon monoxide poisoning at an indoor ice arena and bingo hall. JAMA 275:1468–1469

    Article  PubMed  Google Scholar 

  58. Hausberg M, Sommers V (1997) Neural circulatory responses to carbon monoxide in healthy humans. Hypertension 29:1114–1118

    CAS  PubMed  Google Scholar 

  59. Pankow D (1981) Toxikologie des Kohlenmonoxids. VEB Verlag Volk und Gesundheit, Berlin

  60. Jaeger R (1981) Carbon monoxide in houses and vehicles. Bull NY Acad Med 57:860–872

    CAS  Google Scholar 

  61. Fisher J (1999) Carbon monoxide poisoning: a disease of a thousand faces. Chest 115:322–323

    Article  CAS  PubMed  Google Scholar 

  62. Statistisches Bundesamt (2004) Todesursachenstatistik

  63. Cobb N, Etzel RA (1991) Unintentional carbon monoxide related deaths in the United States, 1979 through 1988. JAMA 266 (5):659–663

    Article  CAS  PubMed  Google Scholar 

  64. Mathieu D, Wattel F, Neviere R, Mathieu-Nolf M (1992) Carbon monoxide poisoning. Acta Anaesth Italica 43:167–176

    Google Scholar 

  65. Tetzlaff K, Bettinghausen E, Urbach W (1995) Akute Kohlenmonoxid-Vergiftung: Indikation für hyperbaren Sauerstoff. Anästh Intensivmed 36:336–342

    Google Scholar 

  66. Thom SR, Keim L (1989) Carbon monoxide poisoning. A review. Epidemiology, pathophysiology, clinical features and treatment options including hyperbaric oxygen therapy. Clinical Toxicology 27:141–156

    CAS  PubMed  Google Scholar 

  67. Born M, Russ N, Ellinger K (2000) CO-Intoxikation. Der Notarzt 16:108–111

    Article  Google Scholar 

  68. Kelley J (1978) Retinal hemorrhages in subacute carbon monoxide poisoning. Exposures in homes with blocked furnace flues. JAMA 239:1515–1517

    Article  CAS  PubMed  Google Scholar 

  69. Ernst A, Zibrak JD (1998) Carbon monoxide poisoning. N Engl J Med 339(22):1603–1608

    Article  CAS  PubMed  Google Scholar 

  70. Glaß F, Mallach H, Wojahn H (1966) Über den CO-Gehalt des Blutes bei akuter Kohlenmonoxid-Vergiftung. Arzneimittel Forschg 16:1553–1555

    Google Scholar 

  71. Mertzlufft F (1990) Was die Pulsoximetrie für die Notfallmedizin bringt. Notfallmedizin 16:637–643

    Google Scholar 

  72. Buckley RG, Aks SE, Eshorn JL, Rydmann R, Schaider J, Shayne P (1994) The pulse oximetry gap in carbon monoxide intoxication. Ann Emerg Med 24:252–255

    CAS  PubMed  Google Scholar 

  73. Hampson NB (1998) Pulse oximetry in severe carbon monoxide poisoning. Chest 114:1036–1041

    CAS  PubMed  Google Scholar 

  74. Kindwall, E (1983) Carbon monoxide poisoning. In: Hamilton R, Peirce E (Ed) Hyperbaric oxygen emergency medical care. Undersea Medical Society; 14–22

  75. Myers R, Britten J (1989) Are arterial blood gases of value in treatment decisions for carbon monoxide poisoning? Crit Care Med 17:139–142

    CAS  PubMed  Google Scholar 

  76. Giessler GA, Deb R, Germann G, Sauerbier M (2004) Chirurg 75:560–567

    Article  CAS  PubMed  Google Scholar 

  77. Norkool D, Kirkpatrick J (1985) Treatment of acute carbon monoxide poisoning with hyperbaric oxygen: a review of 115 cases. Ann Emerg Med 14:1168–1171

    CAS  PubMed  Google Scholar 

  78. Shimosegawa E (1992) Cerebral blood flow and glucose metabolism measurements in a patient surviving one year after carbon monoxide intoxication. J Nucl Med 33(9):1696–1698

    CAS  PubMed  Google Scholar 

  79. Raub JA, Mathieu-Nolf M, Hampson NB, Thom SR (2000) Carbon-monoxide poisoning—a public health perspective. Toxicology 145:1–14

    Article  CAS  PubMed  Google Scholar 

  80. Thom SR, Taber RL, Mendiguren I, Clark JM, Hardy KR, Fisher AB (1995) Delayed neuro-psycholgical sequelae after carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen. Ann Emerg Med 25:474–480

    CAS  PubMed  Google Scholar 

  81. Kim K, Weinberg P, Suh J (1980) Acute carbon monoxide poisoning: computed tomography of the brain. Am J Neuroradiol 1:399–402

    Google Scholar 

  82. Sawada Y, Takahashi H, Ohashi H (1980) Computerised tomography as an indication of longterm outcome after acute carbon monoxide poisoning. Lancet 1:783–784

    CAS  PubMed  Google Scholar 

  83. Taylor R, Holgate R (1988) Carbon monoxide poisoning. Asymmetric and unilateral changes on CT. American Journal of Neuroradiology 9:975–977

    CAS  PubMed  Google Scholar 

  84. Silver DA, Cross M, Fox B, Paxton RM (1996) Computed tomography of the brain in acute carbon monoxide poisoning. Clin Radiol 51:480–483

    Article  CAS  PubMed  Google Scholar 

  85. Mathieu D (1985) Acute carbon monoxide poisoning—risk of late sequelae and treatment by hyperbaric oxygen. Clin Toxicol 23:315–324

    CAS  Google Scholar 

  86. Smith J, Brandon S (1973) Morbidity from acute carbon monoxide poisoning at three-year follow-up. B Med J 1:318–321

    CAS  Google Scholar 

  87. Gorman D, Clayton D, Gilligan JE, Webb RK (1992) A longitudinal study of 100 consecutive admissions of carbon monoxide poisoning to the Royal Adelaide Hospital. Anaesth Intens Care 20(3):311–316

    CAS  Google Scholar 

  88. Goulon M, Barois M, Rapin M (1986) Carbon monoxide poisoning and acute anoxia due to breathing coal gas and hydrocarbons. Journal of hyperbaric medicine 1:23–41

    Google Scholar 

  89. Muggenthaler KH, Busch R, Helm M, Lackner C (1999) Akute Kohlenmonoxidvergiftung. Notfall & Rettungsmedizin 2:51–59

    Google Scholar 

  90. Shimazu, T (2001) Half-life of blood carboxyhemoglobin. Chest 119:661–662

    Article  CAS  PubMed  Google Scholar 

  91. Ducasse JL, Celsis P, Marc-Vergnes JP (1995) Non-comatose patients with acute carbon monoxide poisoning: hyperbaric or normobaric oxygenation? Undersea Hyperb Med 22:9–15

    CAS  PubMed  Google Scholar 

  92. Myers R (1985) Subacute sequelae of carbon monoxide poisoning. Ann Emerg Med 14:1163–1167

    CAS  PubMed  Google Scholar 

  93. Jaeger K, Jüttner B (2003) Hyperbare Sauerstofftherapie. Anästhesiologie & Intensivmedizin 44:187–202

    Google Scholar 

  94. Undersea and Hyperbaric Medical Society. http://www.uhms.org

  95. Tibbles PM, Perrotta PL (1994) Treatment of carbon monoxide poisoning: a critical review of human outcome studies comparing normobaric oxygen with hyperbaric oxygen. Ann Emerg Med 24:269–276

    CAS  PubMed  Google Scholar 

  96. Dean BS, Verdile VP, Krenzelok EP (1993) Coma reversal with cerebral dysfunction recovery after repetitive hyperbaric oxygen therapy for severe carbon monoxide poisoning. AM J Emerg Med 11:616–618

    Article  CAS  PubMed  Google Scholar 

  97. Jiang J, Tyssebotn I (1997) Cerebrospinal fluid pressure changes after acute carbon monoxide poisoning and therapeutic effects of normobaric and hyperbaric oxygen in conscious rats. Undersea Hyper Med 24:245–254

    CAS  Google Scholar 

  98. Hampson NB, Mathieu D, Piantadosi CA, Thom SR, Weaver LK (2001) Carbon monoxide poisoning: interpretation of randomized clinical trials and unresolved treatment issues. Undersea Hyperb Med 28:157–164

    CAS  PubMed  Google Scholar 

  99. Weaver LK, Hopkins RO, Chan KJ (2002) Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med 2002:1057–1067

    Google Scholar 

  100. Leischker AH (2003) Hyperbare Sauerstofftherapie kann neurologische Spätschäden bei Kohlenmonoxidintoxikationen verhindern. Eine neue Studie zu einem alten Problem. Intensivmed 40:181–183

    Article  Google Scholar 

  101. Jaeger K, Ruschulte H, Heine J, Piepenbrock S (2000) Kohlenmonoxidvergiftung. Anaesthesiol Reanim 25:74–77

    CAS  PubMed  Google Scholar 

  102. Koren G (1985) A multicenter, prospective study of fetal outcome following accidental carbon monoxide poisoning in pregnancy. Reprod Toxicol 23:(5):397–403

    Google Scholar 

  103. Friedrich G (1986) Toxikologie und postmortale Biochemie. Cyanwasserstoff (Blausäure) und Cyanide. In: Forster B (Hrsg) Praxis der Rechtsmedizin. Thieme, Stuttgart, S 701–705

  104. Eyer P (1997) Gasförmige Verbindungen. In: Marquardt H, Schäfer SG (Hrsg) Lehrbuch der Toxikologie. Spektrum Akademischer Verlag, Heidelberg Berlin Oxford

  105. Yen D (1995) The clinical experience of acute cyanide poisoning. Am J Emerg Med 13:524–528

    Article  CAS  PubMed  Google Scholar 

  106. Goenechea S (1982) Cyanidverluste bei der Aufbewahrung von Blutproben. Z Rechtsmed 88:97–101

    Article  CAS  PubMed  Google Scholar 

  107. Heintz B (1990) Cyanid-Intoxikation: Behandlung mit Hyperoxigenation und Natriumthiosulfat. DMW 115:1100–1103

    CAS  Google Scholar 

  108. Silverman S (1988) Cyanide toxicity in burned patients. J Trauma 28:171–176

    CAS  PubMed  Google Scholar 

  109. Harloff M (1987) Antidota in der Prähospitalphase. Intensivmed 24:433–436

    Google Scholar 

  110. Clark C (1981) Blood carboxy-hemoglobin and cyanide levels in fire survivors. Lancet 1332–1337

  111. Moore S (1987) Antidotal use of methemoglobin forming cyanide antagonists in concurrent carbon monoxide/cyanide intoxication. J Pharmacol Exper Ther 242:70–73

    CAS  Google Scholar 

  112. Baud, F, Barriot P, Toffis V, Riou B, Vicaut E, Lecarpentier Y, Bismuth C (1991) Elevated blood cyanide concentrations in victims of smoke inhalation. N Engl J Med 325:1761–1766

    CAS  PubMed  Google Scholar 

  113. Norris J (1986) Synergistic lethality induced by the combination of carbon monoxide and cyanide. Toxicology 40:121–129

    Article  CAS  PubMed  Google Scholar 

  114. Moore S (1987) Severe hypoxia produced by concomitant intoxication with subletal doses of carbon monoxide and cyanide. Toxicol Appl Pharmacol 109:412–420

    Article  Google Scholar 

  115. Gall T, Hoppe U, Wresch P, Klose R (2000) Problematik der präklinischen Zyanid-Antidottherapie bei Brandverletzten mit Rauchgasinhalation. Der Notarzt 16:56–60

    Article  Google Scholar 

  116. Medau H, Beyer G (1992) Suizidale schwere Cyanid-Intoxikation, rechtzeitige Behandlung lebensrettend. Intensivmed 29:309–312

    Google Scholar 

  117. Gebrauchsinformation Natriumthiosulfat. Dr. F. Köhler Chemie GmbH

  118. Gebrauchsinformation Cyanokit. Orphan Europe GmbH

  119. American Burn Association (2003) Inhalation injury: diagnosis. J Am Coll Surg 196(2):307–312

    PubMed  Google Scholar 

  120. Peitzman AB, Shires GT, Teixidor HS, Curreri PW, Shires GT (1989) Smoke inhalation injury: Evaluation of radiographic manifestations and pulmonary dysfunction. J Trauma 29(9):1232–1239

    CAS  PubMed  Google Scholar 

  121. Khoo AK, Lee ST, Poh WT (1997) Tracheobronchial cytology in inhalation injury. J Trauma 42(1):81–85

    CAS  PubMed  Google Scholar 

  122. Masanes MJ, Legendre C, Lioret N, Saizy R, Lebeau B (1995) Using bronchoscopy and biopsy to diagnose early inhalation injury. Chest 107 (5):1365–1369

    CAS  PubMed  Google Scholar 

  123. Schneider W, Berger A, Mailänder P, Tempka A (1988) Diagnostic and therapeutic possibilities for fiberoptic bronchoscopy in inhalation injury. Burns 14(1):53–57

    Article  CAS  Google Scholar 

  124. Steen M, Wresch KP (1993) Präklinische Diagnostik und Erstversorgung bei Notfallpatienten mit Verbrennungen. Notfallmedizin 19:17–23

    Google Scholar 

  125. Lund T, Bert JL, Onarheim H, Bowen BD, Reed RK (1989) Microvascular exchange during burn injury—a review. Circulatory Shock 28:179–197

    CAS  PubMed  Google Scholar 

  126. Krueger WA, Daschner FD (2003) Beatmungsassoziierte Pneumonien. Anaesthesist 52:265–296

    Article  CAS  PubMed  Google Scholar 

  127. Nguyen T, Gilpin DA, Meyer N, Herndon DN (1996) Current treatment of severely burned patients. Ann Surg 223(1)14–25

    Article  CAS  PubMed  Google Scholar 

  128. Brigham KL, Bowers R, Haynes J (1979) Increased sheep lung vascular permeability caused by Escherichia coli endotoxin. Circ Res 45:292–297

    CAS  PubMed  Google Scholar 

  129. Dehring DJ, Lubbesmeyer HJ, Fader RC, Traber LD, Traber DL (1993) Ex-aggerated cardiopulmonary response after bacteremia in sheep with week-old-thermal-injury. Crit Care Med 21:888–893

    CAS  PubMed  Google Scholar 

  130. Demling RG, Wong C, Jin LJ, Hechtman H, Lalonde C, West K (1985) Early lung dysfunction after major burns: role of edema and vasoactive mediators. J Trauma 25(10):959–966

    CAS  PubMed  Google Scholar 

  131. Demling RH, Will JA, Belzer FO (1978) Effect of major thermal injury on the pulmonary microcirculation. Surgery 83:746–751

    CAS  PubMed  Google Scholar 

  132. Arturson G (1979) Microvascular permeability to macromolecules in thermal injury. Acta Physiol Scand 463 (S):111–222

    CAS  Google Scholar 

  133. Pallua N, Noah EM, Radke A (2000) Inhalationstrauma bei Verbrennungen. Intensivmed 37:284–292

    Article  Google Scholar 

  134. Kowal-Vern A, Walenga JM, Sharp-Pucci M, Hoppenstaedt D, Garnelli RL (1997) Postburn edema and related changes in interleucin-2, leucocytes, platelet activation, endothelin-1, and C1 esterase inhibitor. J Burn Care Rehabil 18:99–103

    CAS  PubMed  Google Scholar 

  135. Khorram-Sefat R, Goldmann C, Radke A, Lennartz A, Montaghy K, Afify M, Küpper W, Klosterhalfen B (1998) The therapeutic effect of C1-Inhibitor on gut-derived bacterial translocation following thermal injury. Shock 9(2):101–108

    CAS  PubMed  Google Scholar 

  136. Zilow G, Sturm JA, Rother U, Kirschfink M (1990) Complement activation and the prognostic value of C3a in patients at risk of adult respiratory distress syndrome. Clin Exp Immunol 79:151–157

    CAS  PubMed  Google Scholar 

  137. Clark WR (1990) Death due to thermal trauma. In: Dolecek R, Brizio-Molteni L, Molteni A, Traber D (Hrsg) Endocrinology of thermal trauma. Lea & Febiger, Philadelphia PA, pp 6–27

  138. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, LeGall JR, Morris A, Spragg R (1994) The Consensus Committee: Report of the American-European Consenus-Conference on ARDS. Int Care Med 20:225–232

    Article  CAS  Google Scholar 

  139. Marini (1998) Roundtable conference: acute lung injury. March 1997, Brussels, Belgium. Intensive Care Med 248(8):878–883

    Article  Google Scholar 

  140. Gommers D, Lachmann B (1993) Surfactant therapy: does it have a role in adults? Clin Int Care 4:284–295

    Google Scholar 

  141. Picone A, Gatto LA, Nieman GF, Paskanik AM, Lutz C (1996) Pulmonary surfactant function following endotoxin: effects of exogenous surfactant treatment. Shock 5(4):304–310

    CAS  PubMed  Google Scholar 

  142. Pruitt BA, Erickson DR, Morris A (1975) Progressive pulmonary insufficiency and other pulmonary complications of thermal injury. J Trauma 15:369–379

    PubMed  Google Scholar 

  143. Henzler D, Dembinski R, Kopp R (2003) Therapie des akuten Lungenversagens in einem Behandlungszentrum: Der Erfolg ist abhängig von der Indikationsstellung. Anaesthesist 53 (3):235–243

    Article  Google Scholar 

  144. Pulmonary Artery Catheter Consensus Conference (1997) Crit Care Med 25

  145. Slutsky AS (1994) Consensus Conference on mechanical ventilation—January 28–30, 1993 at Northbrook, Illinois, USA, Part I. Intensive Care Med 20:64–79

    Article  CAS  PubMed  Google Scholar 

  146. Slutsky AS (1994) Consensus Conference on mechanical ventilation—January 28–30, 1993 at Northbrook, Illinois, USA, Part II. Intensive Care Med 20:150–162

    Article  CAS  PubMed  Google Scholar 

  147. Suter PM, Failey B, Isenberg M (1975) Optimum end-exspiratory airway pressure in patients with acute pulmonary failure. N Engl J Med 292:284–289

    CAS  PubMed  Google Scholar 

  148. Jürgens E, Kuhlen R, Max M, Roissant R (2001) Beatmungsstrategien beim akuten Lungenversagen. Intensivmed 38:601–610

    Article  Google Scholar 

  149. Acute Respiratory Distress Syndrome Network (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342:1301–1308

    Article  PubMed  Google Scholar 

  150. Amato MB, Barabas CS, Medeiros DM (1998) Effect of a protective ventilation strategy on mortality in the acute respiratory distress syndrome N Engl J Med 338:347–354

    Article  CAS  PubMed  Google Scholar 

  151. Kumar A, Falke K, Geffin B (1970) Continuous positive-pressure ventilation in acute respiratory failure. N Engl J Med 238:1430–1436

    Google Scholar 

  152. Gattinoni L, Pesenti A, Bombino M, Baglioni S, Rivolta M, Rossi F, Rossi G, Fumagalli R, Marcolin R, Mascheroni D, Torresin A (1988) Relationship between lung computed density, gas exchange, and PEEP in acute respiratory failure. Anaesthesiology 69:824–832

    CAS  Google Scholar 

  153. Sydow M, Buchardi H, Ephraim E, Zielmann S, Crozier T (1994) Longterm effects of two different ventilatory modes on oxygenation in acute lung injury. Comparison of airway pressure release ventilation and volume controlled inverse ratio ventilation. Am J Respir Crit Care Med 149:1550–1556

    CAS  PubMed  Google Scholar 

  154. Esteban A, Alia I, Gordo F, Pablo R, Suarez J, Gonzalez G, Blanco J (2000) Prospective randomised trial comparing pressure-controlled ventilation and volume-controlled ventilation in ARDS. Chest 117:1690–1696

    Article  CAS  PubMed  Google Scholar 

  155. Lachmann B (1992) Open up the lung and keep the lung open. Intensive Care Med 118:319–321

    Article  Google Scholar 

  156. Böhm S, Vazquez de Anda GF, Lachmann B (1998) “The open lung concept”. In: Vincent JL (ed) Yearbook of Intensive Care and Emergency Medicine. Springer, Berlin Heidelberg New York, pp 430–440

  157. Cioffi WG, Graves TA, McManus WF, Pruitt BA (1989) High-frequency percussive ventilation in patients with inhalation injury. J Trauma 29:350–354

    CAS  PubMed  Google Scholar 

  158. Derdak SD (2003) High-frequeny oscillatory ventilation for acute respiratory distress syndrome in adult patients. Crit Care Med 31(4):(S)317–(S)323

    Google Scholar 

  159. Reper P, Wibaux O, Van Laeke P, Vandeenen D, Duinslaeger L, Vanderkelen A (2002) High frequency percussive ventilation and conventional ventilation after smoke inhalation: a randomised study. Burns 28:503–508

    Article  CAS  PubMed  Google Scholar 

  160. Jackson MP, Philp B, Murdoch LJ, Powell BW (2002) High frequency oscillatory ventilation successfully used to treat a severe paediatric inhalation injury. Burns 28:509–511

    Article  CAS  PubMed  Google Scholar 

  161. Gattinoni L, Pelosi P, Vitale G, Pesenti A, D’Andrea L, Mascheroni D (1991) Body position changes redistribute lung computed-tomographic density in patients with acute respiratory failure. Anaesthesiology 74:15–23

    CAS  Google Scholar 

  162. Mutoh T, Guest RJ, Lamm WJ, Albert RK (1992) Prone position alters the effect of volume overload and regional pleural pressures and improves hyperoxemia in pigs in vivo. Am Rev Respir Dis 146:300–306

    CAS  PubMed  Google Scholar 

  163. Hörmann C, Benzer H, Baum M, Wicke K, Putensen C, Putz G (1994) The prone position in ARDS. A successful therapeutic strategy. Anaestesist 43:454–462

    Article  Google Scholar 

  164. Gattinoni L, Tognoni G, Pesenti A, Taccone P, Mascheroni D, Labarta V, Malacrida R, Di Giulio P, Fumagalli R, Pelosi P, Brazzi L, Latini R, the Prone-Supine Study Group (2001) Effect of prone positioning on the survival of patients with acute respitatory failure. N Engl J Med 345:568–573

    CAS  PubMed  Google Scholar 

  165. Fishman A (1981) Down with the good lung. N Engl J Med 304(9):537–538

    CAS  PubMed  Google Scholar 

  166. Pape HC, Weinberg A, Graf B, Reilmann H, Tscherne H, Regel G (1997) Kontinuierlicher axialer Lagewechsel bei posttraumatischem Lungenversagen—prophylaktisch oder therapeutisch induziert? AINS 32:245–249

    CAS  PubMed  Google Scholar 

  167. Bein T (1998) Patientenlagerung—Kinetische Therapie in der Intensivmedizin. Anaesthesist 47:74–80

    Article  CAS  PubMed  Google Scholar 

  168. Jürgens E, Roissant R (2000) Invasive Beatmung beim hypoxämischen Lungenversagen—State of the Art. Intensivmed 37:257–264

    Article  Google Scholar 

  169. Roissant R, Falke K, Lopez F, Slama K, Pison U, Zapol W (1993) Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328:399–405

    CAS  PubMed  Google Scholar 

  170. Lundin S, Mang H, Smithies M (1999) Inhalation of nitric oxide in acute lung injury: results of a European multicentre study. Intensive Care Med 25(9):911–919

    CAS  PubMed  Google Scholar 

  171. Roissant R, Gerlach H, Schmidt-Ruhnke H, Pappert D, Lewandowsky K, Steudel W, Falke K (1995) Efficacy of inhaled nitric oxide in patients with severe ARDS. Chest 107:1107–1115

    PubMed  Google Scholar 

  172. Kornberger E, Mair P, Oswald E, Hörmann C, Öhler K, Balogh D (1997) Inhalation injury treated with extracorporeal CO2 elimination. Burns 23(4):354–359

    Article  CAS  PubMed  Google Scholar 

  173. Brown M, Traber DL, Herndon DN, Oldham KT, Traber LD (1987) The use of venovenous extracorporeal membrane oxygenation in sheep receiving severe smoke inhalation injury. Burns 13(1):34–38

    CAS  Google Scholar 

  174. Alliance Pharmaceutical Corporation announces preliminary results of LiquiVent Phase 2–3 Clinical Study (2001) www.allp.com

Download references

Author information

Authors and Affiliations

Authors

Additional information

Serie: Die Notfalltherapie und Intensivtherapie beim Verbrennungstrauma Herausgegeben von B. Hartmann (Berlin)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hoppe, U., Klose, R. Das Inhalationstrauma bei Verbrennungspatienten: Diagnostik und Therapie. Intensivmed 42, 425–439 (2005). https://doi.org/10.1007/s00390-005-0611-z

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00390-005-0611-z

Key words

Schlüsselwörter

Navigation