Skip to main content
Log in

Depressionshäufigkeit in Abhängigkeit von verschiedenen Erkrankungen bei geriatrischen Patienten

Relation between certain diseases and frequency of depression in geriatric patients

  • Originalien
  • Published:
Der Nervenarzt Aims and scope Submit manuscript

Zusammenfassung

Im Zusammenhang mit bestimmten Erkrankungen und bei älteren Menschen wird eine erhöhte Prävalenz von Depression diskutiert. Je nach Erhebungsmethodik bestehen dabei große Unterschiede. Eine Definition von Risikogruppen ist nur möglich, wenn die Erkrankungen und andere Einflussfaktoren einheitlich erfasst werden. Bei 1208 geriatrischen Patienten des ZAGF am Klinikum Neuperlach wurden die Zieldiagnosen Parkinson, Hirn- und Myokardinfarkt, Krebs, Diabetes mellitus, chronisches Schmerzsyndrom, Multiinfarktsyndrom, Alzheimer-Demenz oder Demenz vom Mischtyp erfasst. Mit Hilfe logistischer Regression wurde chronischer Schmerz als wichtigster Kofaktor für eine Assoziation mit Depression (klinische Diagnose mittels ICD-10) und depressiven Symptomen (Geriatrische Depressionsskala, GDS) identifiziert. Dieser Zusammenhang bestand auch bei multimorbiden Patienten mit chronischem Schmerz. Eine Beeinträchtigung der Aktivitäten des täglichen Lebens und das klinische Setting waren weitere wichtige Kofaktoren. Schmerzpatienten stellen somit eine Hochrisikogruppe für Depression dar.

Summary

The higher prevalence of depression in specific diseases and older persons is discussed. This prevalence varies greatly according to the method used to collect data. A risk group can only be defined if information on diseases and other influencing factors are collected uniformly. The target diagnoses Parkinson’s disease, stroke, myocardial infarction, cancer, diabetes mellitus, chronic pain, multiple infarct syndrome, Alzheimer’s and other dementia were recorded from 1208 geriatric patients of the ZAGF municipal hospital in Munich, Germany. Logistic regression was used to identify chronic pain as the main cofactor for an association with depression (clinical diagnoses by ICD-10) and depressive symptoms (via GDS [Geriatric Depression Scale]). This association was also found for multimorbid patients with chronic pain. Impairment of the activities of daily living and the clinical setting were important additional cofactors. Pain patients are therefore at higher risk for depression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3

Literatur

  1. Aben I, Verhey F, Strik J et al. (2003) A comparative study into the one year cumulative incidence of depression after stroke and myocardial infarction. J Neurol Neurosurg Psychiatry 74:581–585

    Article  PubMed  CAS  Google Scholar 

  2. Akechi T, Okuyama T, Sugawara Y et al. (2004) Major depression, adjustment disorders, and post-traumatic stress disorder in terminally ill cancer patients: associated and predictive factors. J Clin Oncol 22:1957–1965

    Article  PubMed  Google Scholar 

  3. Bair MJ, Robinson RL, Katon W et al. (2003) Depression and pain comorbidity: a literature review. Arch Intern Med 163:2433–2445

    Article  PubMed  Google Scholar 

  4. Baldwin RC (2002) Research into depressive disorder in later life: who is doing what? A literature search from 1998–2001. Int Psychogeriatr 14:335–346

    Article  PubMed  Google Scholar 

  5. Ballard C, Neill D, O’Brien J et al. (2000) Anxiety, depression and psychosis in vascular dementia: prevalence and associations. J Affect Disord 59:97–106

    Article  PubMed  CAS  Google Scholar 

  6. Bisschop MI, Kriegsman DM, Deeg DJ et al. (2004) The longitudinal relation between chronic diseases and depression in older persons in the community: the longitudinal aging study Amsterdam. J Clin Epidemiol 57:187–194

    Article  PubMed  Google Scholar 

  7. Block S (2000) Assessing and managing depression in the terminally ill patient. Ann Intern Med 132:209–218

    PubMed  CAS  Google Scholar 

  8. Brodaty H, Luscombe G (1996) Depression in persons with dementia. Int Psychogeriatr 8:609–622

    Article  PubMed  CAS  Google Scholar 

  9. Cano A, Gillis M, Heinz W et al. (2004) Marital functioning, chronic pain, and psychological distress. Pain 107:99–106

    Article  PubMed  Google Scholar 

  10. Copeland MP, Daly E, Hines V et al. (2003) Psychiatric symptomatology and prodromal Alzheimer’s disease. Alzheimer Dis Assoc Disord 17:1–8

    Article  PubMed  Google Scholar 

  11. Currie SR, Wang J (2004) Chronic back pain and major depression in the general Canadian population. Pain 107:54–60

    Article  PubMed  Google Scholar 

  12. D’Ath P, Katona P, Mullan E et al. (1994) Screening detection and management of depression in elderly primary care attenders. I. The acceptability and performance of the 15 item Geriatric Depression Scale (GDS15) and the development of short versions. Fam Pract 11:260–266

    Article  Google Scholar 

  13. Dennis M, O’Rourke S, Lewis S et al. (2000) Emotional outcomes after stroke: factors associated with poor outcome. J Neurol Neurosurg Psychiatry 68:47–52

    Article  PubMed  CAS  Google Scholar 

  14. Folstein MF, Folstein SE, McHugh PR (1975) “Mini-Mental State’: a practical method for grading cognitive state of patients for the clinician. J Psychiatr Res 12:189–196

    Article  PubMed  CAS  Google Scholar 

  15. Gallo JJ, Rabins PV (1999) Depression without sadness: alternative presentations of depression in late life. Am Fam Physician 60:820–826

    PubMed  CAS  Google Scholar 

  16. Gareri P, De Fazio P, De Sarro G (2002) Neuropharmacology of depression in aging and age-related diseases. Ageing Res Rev 1:113–134

    Article  PubMed  CAS  Google Scholar 

  17. Gavard JA, Lustman PJ, Clouse RE (1993) Prevalence of depression in adults with diabetes. An epidemiological evaluation. Diabetes Care 16:1167–1178

    Article  PubMed  CAS  Google Scholar 

  18. Gostynski M, Ajdacic-Gross V, Gutzwiller F et al. (2002) Depression bei Betagten in der Schweiz. Nervenarzt 73:851–860

    Article  PubMed  CAS  Google Scholar 

  19. Greenland S (1994) Alternative models for ordinal logistic regression. Stat Med 13:1665–1677

    Article  PubMed  CAS  Google Scholar 

  20. Greenland S (1998) Introduction to regression models. In: Rothman KJ, Greenland S (eds) Modern epidemiology, 2nd edn. Lippincott, Philadelphia, pp 359–399

  21. Gupta A, Bhatia S (2000) Psychological functioning in patients with Parkinson’s disease. Parkinsonism Relat Disord 6:185–190

    Article  PubMed  Google Scholar 

  22. Gureje O, Simon GE, Von Korff M (2001) A cross-sectional study of the course of persistent pain in primary care. Pain 92:195–200

    Article  PubMed  CAS  Google Scholar 

  23. Hansson P (2004) Post-stroke pain case study: clinical characteristics, therapeutic options and long-term follow-up. Eur J Neurol 11(Suppl 1):22–30

    Article  PubMed  Google Scholar 

  24. Hotopf M, Chidgey J, Addington-Hall J et al. (2002) Depression in advanced disease: a systematic review. Part 1: prevalence and case finding. Palliat Med 16:81–97

    Article  PubMed  CAS  Google Scholar 

  25. Iosifescu DV, Bankier B, Fava M (2004) Impact of medical comorbid disease on antidepressant treatment of major depressive disorder. Curr Psychiatry Rep 6:193–201

    Article  PubMed  Google Scholar 

  26. Katz IR, Streim J, Parmeles P (1994) Prevention of depression, recurrence and complications in late life. Prev Med 23:743–750

    Article  PubMed  CAS  Google Scholar 

  27. Kuopio AM, Marttila RJ, Helenius H et al. (2000) The quality of life in Parkinson’ disease. Mov Disord 15:216–223

    Article  PubMed  CAS  Google Scholar 

  28. Larson SL, Clark MR, Eaton WW (2004) Depressive disorder as a long-term antecedent risk factor for incident back pain: a 13-yar follow-up study from the Baltimore Epidemiological Catchment Area sample. Psychol Med 34:211–219

    Article  PubMed  CAS  Google Scholar 

  29. Leentjens AF, Van den Akker M, Metsemakers JF et al. (2003) Higher incidence of depression preceding the onset of Parkinson’s disease: a register study. Mov Disord 18:414–418

    Article  PubMed  Google Scholar 

  30. Li YS, Meyer JS, Thornby J (2001) Longitudinal follow-up of depressive symptoms among normal vs. cognitively impaired elderly. Int J Geriatr Psychiatry 16:718–727

    Article  PubMed  CAS  Google Scholar 

  31. Linden M, Kurtz G, Baltes MM et al. (1998) Depression bei Hochbetagten. Ergebnisse der Berliner Altersstudie. Nervenarzt 69:27–37

    Article  PubMed  CAS  Google Scholar 

  32. Liu CY, Wang SJ, Fuh JL et al. (1997) The correlation of depression with functional activity in Parkinson’s disease. J Neurol 244:493–498

    Article  PubMed  CAS  Google Scholar 

  33. Livingston G, Watkin V, Milne B et al. (2000) Who becomes depressed? The Islington community study of older people. J Affect Disord 58:125–133

    Article  PubMed  CAS  Google Scholar 

  34. Lyketsos CG, Steele C, Baker L et al. (1997) Major and minor depression in Alzheimer’s disease: prevalence and impact. J Neuropsychiatry Clin Neurosci 9:556–561

    PubMed  CAS  Google Scholar 

  35. Mahoney FI, Barthel DW (1965) Functional evaluation: the Barthel index. Md State Med J 14:61–65

    PubMed  CAS  Google Scholar 

  36. McCullagh P, Nelder JA (1989) Generalized linear models, 2nd edn. Chapman & Hall, New York

  37. McGivney SA, Mulvihill M, Taylor B (1994) Validating the GDS depression screen in the nursing home. J Am Geriatr Soc 42:490–492

    PubMed  CAS  Google Scholar 

  38. Newman S (2003) The psychological perspective: a professional view. Heart 89(Suppl II):ii16–ii18

    Article  PubMed  Google Scholar 

  39. Nightingale S, Holmes J, Mason J et al. (2001) Psychiatric illness and mortality after hip fracture. Lancet 357:1264–1265

    Article  PubMed  CAS  Google Scholar 

  40. Nilsson FM, Kessing LV, Sorensen TM et al. (2002) Major depressive disorder in Parkinson’s disease: a register-based study. Acta Psychiatr Scand 106:202–211

    Article  PubMed  Google Scholar 

  41. Ohayon MM, Schatzberg AF (2003) Using chronic pain to predict depressive morbidity in the general population. Arch Gen Psychiatry 60:39–47

    Article  PubMed  Google Scholar 

  42. Olin JT, Katz IR, Meyers BS et al. (2002) Provisional diagnostic criteria for depression of Alzheimer’s disease: rationale and background. Am J Geriatr Psychiatry 10:129–141

    Article  PubMed  Google Scholar 

  43. Ong KS, Keng SB (2003) The biological, social, and psychological relationship between depression and chronic pain. Cranio 21:286–294

    PubMed  CAS  Google Scholar 

  44. Parikh SV, Lam RW (2001) Clinical guidelines for treatment of depressive disorders I. Definitions, prevalence, and health burden. Can J Psychialtry 46(Suppl 1):13–28

    Google Scholar 

  45. Patten SB (2001) Long-term medical conditions and major depression in a Canadian population study at waves 1 and 2. J Affect Disord 63:35–41

    Article  PubMed  CAS  Google Scholar 

  46. Payne JL, Sheppard JM, Steinberg M et al. (2002) Incidence, prevalence, and outcomes of depression in residents of a long-term care facility with dementia. Int J Geriatr Psychiatry 17:247–253

    Article  PubMed  Google Scholar 

  47. Penninx B, van Tilburg T, Boeke AJ et al. (1998) Effects of social support and personal coping resources on depressive symptoms: Different for various chronic diseases? Health Psychol 17:551–558

    Article  PubMed  CAS  Google Scholar 

  48. Pohjasvaara T, Leppavuori A, Siira I et al. (1998) Frequency and clinical determinants of poststroke depression. Stroke 29:2311–2317

    PubMed  CAS  Google Scholar 

  49. Rabheru K (2004) Special issues in the management of depression in older patients. Can J Psychiatry 49(3 Suppl 1):41S–50S

    PubMed  Google Scholar 

  50. Rojo A, Aguilar M, Garolera MT et al. (2003) Depression in Parkinson’s disease: clinical correlates and outcome. Parkinsonism Relat Disord 10:23–28

    Article  PubMed  CAS  Google Scholar 

  51. Sartorius N (2003) Physical symptoms of depression as a public health concern. J Clin Psychiatry 64(Suppl 7):3–4

    PubMed  Google Scholar 

  52. Sheikh JI, Yesavage JA (1986) Geriatric Depression Scale (GDS): recent evidence and development of a shorter version. In: Brink TL (ed) Clinical gerontology: a guide to assessment and intervention. Haworth Press, New York, pp 165–173

  53. Spiegel D, Giese-Davis J (2003) Depression and cancer: mechanisms and disease progression. Biol Psychiatry 54:269–282

    Article  PubMed  Google Scholar 

  54. Thomas AJ, Kalaria RN, O’Brien JT (2004) Depression and vascular disease: what is the relationship? J Affect Disord 79:81–95

    Article  PubMed  Google Scholar 

  55. Tractenberg RE, Weiner MF, Patterson MB et al. (2003) Comorbidity of psychopathological domains in community-dwelling persons with Alzheimer’s disease. J Geriatr Psychiatry Neurol 16:94–99

    Article  PubMed  Google Scholar 

  56. Vastag B (2003) Scientists find connections in the brain between physical and emotional pain. JAMA 290:2389–2390

    Article  PubMed  Google Scholar 

  57. Weiner MF, Doody RS, Sairam R et al. (2002) Prevalence and incidence of major depressive disorder in Alzheimer’s disease: findings from two databases. Dement Geriatr Cogn Disord 13:8–12

    Article  PubMed  Google Scholar 

  58. Weintraub D, Moberg PJ, Duda JE (2004) Effect of psychiatric and other nonmotor symptoms on disability in Parkinson’s disease. J Am Geriatr Soc 52:784–788

    Article  PubMed  Google Scholar 

  59. Whyte EM, Mulsant BH (2002) Post stroke depression: epidemiology, pathophysiology, and biological treatment. Biol Psychiatry 52:253–264

    Article  PubMed  Google Scholar 

  60. Whyte EM, Mulsant BH, Vanderbilt J et al. (2004) Depression after stroke: a prospective epidemiological study. J Am Geriatr Soc 52:774–778

    Article  PubMed  Google Scholar 

  61. World Health Organization (1992) The ICD-10 classification of mental and behavioural disorders. Clinical descriptions and diagnostic guidelines. World Health Organization, Geneva

  62. Zubenko GS, Zubenko WN, McPherson S et al. (2003) A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer’s disease. Am J Psychiatry 160:857–866

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. Kwetkat.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zietemann, V., Zietemann, P., Weitkunat, R. et al. Depressionshäufigkeit in Abhängigkeit von verschiedenen Erkrankungen bei geriatrischen Patienten. Nervenarzt 78, 657–664 (2007). https://doi.org/10.1007/s00115-006-2106-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00115-006-2106-y

Schlüsselwörter

Keywords

Navigation