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Ventrikuläre Tachykardien

Diagnostisches Spektrum und therapeutische Möglichkeiten

Ventricular tachycardia

Diagnostic spectrum and therapeutic measures

  • Schwerpunkt: Herzrhythmusstörungen
  • Published:
Der Internist Aims and scope Submit manuscript

Zusammenfassung

Der Ursprung ventrikulärer Tachyarrhythmien liegt unterhalb der Ventilebene des Herzens und umfasst verschiedene Erscheinungsformen wie monomorphe und polymorphe Kammertachykardien, Kammerflattern und Kammerflimmern. Da Übergänge zwischen den einzelnen Formen ventrikulärer Tachyarrhythmien häufig sind, sind ventrikuläre Tachyarrhythmien als prinzipiell bedrohlich anzusehen. Neben unterschiedlichen elektrophysiologischen Mechanismen wie Kreiserregung oder fokale Impulsbildung spielt sich das Auftreten von ventrikulären Tachyarrhythmien in einem individuellen biologischen Kontext ab: So treten ventrikuläre Tachyarrhythmien als Folge struktureller Herzerkrankungen auf oder sind bedingt durch primär elektrische Erkrankungen. Des Weiteren unterscheidet man ventrikuläre Tachyarrhythmien ohne fassbare strukturelle oder elektrische Grunderkrankung. Die Einordnung der Arrhythmie in diesen biologischen Zusammenhang ist für die Prognose, Differenzialtherapie und Langzeitbetreuung des Patienten von entscheidender Bedeutung.

Abstract

The origin of ventricular tachycardia lies in the ventricular tissue and includes a variety of symptoms such as monomorphic and polymorphic ventricular tachyarrhythmia (VT), ventricular flutter and ventricular fibrillation. Due to transitions of one form of VT to another, any form of VT incurs in principal the risk of cardiac failure. Apart from different electrophysiologic mechanisms such as reentry or triggered activity, any occurrence of VT has to be considered in an individual context: VT can be caused by structural heart disease such as coronary artery disease or dilative cardiomyopathy, or primary electrical disease such as long or short QT syndromes or can even occur without any detectable cause (idiopathic VT). Correct identification of the underlying cause of the arrhythmia is essential for the prognosis, differential therapy and long-term treatment of patients.

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Literatur

  1. Antzelevitch C, Brugada P, Borggrefe M et al. (2005) Brugada syndrome: report of the second consensus conference. Heart Rhythm 4: 429–440

    Google Scholar 

  2. Bänsch D, Antz M, Boczor S et al. (2002) Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: the Cardiomyopathy Trial (CAT). Circulation 105: 1453–1458

    Article  PubMed  Google Scholar 

  3. Bollmann A, Husser D, Cannom DS (2005) Antiarrhythmic drugs in patients with implantable cardioverter-defibrillators. Am J Cardiovasc Drugs 5: 371–378

    Article  PubMed  Google Scholar 

  4. Connolly SJ, Gent M, Roberts RS et al. (2000) Canadian implantable defibrillator study (CIDS): a randomized trial of the implantable cardioverter defibrillator against amiodarone. Circulation 101: 1297–1302

    PubMed  Google Scholar 

  5. Connolly SJ, Dorian P, Roberts RS et al. (2006) Comparison of ß-blockers, amiodarone plus ß-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators. JAMA 295: 165–171

    Article  PubMed  Google Scholar 

  6. Dorian P, Borggrefe M, Al-Khalidi HR et al. (2004) Placebo-controlled, randomized clinical trial of azimilide for prevention of ventricular tachyarrhythmias in patients with an implantable cardioverter defibrillator. Circulation 110: 3646–3654

    Article  PubMed  Google Scholar 

  7. Francis J, Sankar V, Nair VL, Priori S (2005) Catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm 2: 550–554

    Article  PubMed  Google Scholar 

  8. Gaita F, Giustetto C, Bianchi F et al. (2003) Short QT syndrome: a familial cause of sudden death. Circulation 108: 965–970

    Article  PubMed  Google Scholar 

  9. Gussak I, Brugada P, Brugada J et al. (2000) Idiopathic short QT interval: a new clinical syndrome? Cardiology 94: 99–102

    Article  PubMed  Google Scholar 

  10. Gregoratos G, Abrams J, Epstein AE et al. (2002) ACC/AHA/NASPE 2002 guideline update for implantation of cardiac pacemakers and antiarrhythmia devices: summary article: a report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines. Circulation 106: 2145–2161

    Article  PubMed  Google Scholar 

  11. Ito S, Tada H, Naito S et al. (2003) Development and validation of an ECG algorithm for identifying the optimal ablation site for idiopathic ventricular outflow tract tachycardia. J Cardiovasc Electrophysiol 14: 1260–1286

    Article  Google Scholar 

  12. Joshi S, Wilber DJ (2005) Ablation of idiopathic right ventricular outflow tract tachycardia: current perspective. J Cardiovasc Electrophysiol 16 [Suppl 1]: S52–58

    Google Scholar 

  13. Knight BP, Goyal R, Pelosi F et al. (1999) Outcome of patients with nonischemic dilated cardiomyopathyand unexplained syncope treated with an implantable defibrillator. J Am Coll Cardiol 33: 1964–1970

    Article  PubMed  Google Scholar 

  14. Kuck KH, Cappato R, Siebels J et al. (2000) Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest: the Cardiac Arrest Study Hamburg (CASH). Circulation 102: 748–754

    PubMed  Google Scholar 

  15. Kurzidim K, Neumann T, Vukajlovic D et al. (2002) Gekühlte HF-Stromkatheterablation epikardialer Ausflusstrakttachykardien über die sinus valsalvae der Aorta. Z Kardiol 91: 796–805

    Article  PubMed  Google Scholar 

  16. Lehnart SE, Terrenoire C, Reiken S et al. (2006) Stabilisation of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci 103: 7906–7910

    Article  PubMed  Google Scholar 

  17. Lin FC, Finley CD, Rahimtoola SH et al. (1983) Idiopathic paroxysmal ventricular tachycardia with a QRS pattern of right bundle branch block and left axis deviation: A unique clinical entity with specific properties. Am J Cardiol 52: 95–100

    Article  PubMed  Google Scholar 

  18. Moss AJ, Kass RS (2005) Long QT syndrome: from channels to cardiac arrhythmias. J Clin Invest 115: 2018–2024

    Article  PubMed  Google Scholar 

  19. Moss AJ, Windle JR, Hall WJ et al. (2005) Safety and efficacy of flecainide in subjects with Long QT-3 syndrome (DeltaKPQmutation): a randomised, double-blind, placebo-controlled clinical trial. Ann Noninvasive Electrocardiol 10: 59–66

    Article  PubMed  Google Scholar 

  20. Ouyang F, Cappato R, Ernst S et al. (2002) Electroanatomical substrate of idiopathic left ventricular tachycardia. Unidirectional block and macroreentry within the Purkinje network. Circulation 105: 462–469

    Article  PubMed  Google Scholar 

  21. Ouyang F, Fotuhi P, Ho SY et al. (2002) Repetitive monomorphic ventricular tachycardia originating from the aortic sinus cusp. J Am Coll Cardiol 39: 500–508

    Article  PubMed  Google Scholar 

  22. Paul M, Schulze-Bahr E, Eckhardt L et al. (2005) Rechtsventrikuläre Tachyarrhythmien – Diagnostik und Therapie. Herzschr Elektrophys 16: 260–269

    Article  Google Scholar 

  23. Priori SG, Napolitano C, Schwartz PJ et al. (2004) Association of long QT syndrome loci and cardiac events among patients treated with ß-blockers. JAMA 292: 1341–1344

    Article  PubMed  Google Scholar 

  24. Roberts R (2006) Genomics and cardiac arrhythmias. J Am Coll Cardiol 47: 9–21

    Article  PubMed  Google Scholar 

  25. Swan H, Laitinen P, Kontula K et al. (2005) Calcium channel antagonism reduces exercise-induced ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia patients with RyR2 mutations. J Cardiovasc Electrophysiol 16: 162–166

    Article  PubMed  Google Scholar 

  26. Sheldon R, Connolly S, Krahn A et al. (2000) Identification of patients most likely to benefit from implantable cardioverter-defibrillator therapy: the Canadian Implantable Defibrillator Study. Circulation 101: 1660–1664

    PubMed  Google Scholar 

  27. Shimlizul W, Aiba T, Antzelevitch C (2005) Specific therapy based on the genotype and cellular mechanisms in inherited cardiac arrhythmias. Long QT syndrome and Brugada Syndrome. Curr Pharm Des 11: 1561–1572

    Article  PubMed  Google Scholar 

  28. Shimoike E, Ohnishi Y, Ueda N et al. (1999) Radiofrequency catheter ablation of the left ventricular outflow tachycardia from the coronary cusp: a new approach to the tachycardia focus. J Cardiovasc Electrophysiol 10: 1005–1009

    PubMed  Google Scholar 

  29. Scheinman MM, Lam J (2006) Exercise-induced ventricular arrhythmias in patients with no structural cardiac disease. Annu Rev Med 57: 473–484

    Article  PubMed  Google Scholar 

  30. Schwartz PJ, Vincent GM, Moss AF, Crampton RS (1993) Diagnostic criteria for the long QT syndrome – an update. Circulation 88: 782–784

    PubMed  Google Scholar 

  31. Tada H, Ito S, Naito S et al. (2005) Idiopathic ventricular arrhythmia arising from the mitral annulus. J Am Coll Cardiol 45: 877–886

    Article  PubMed  Google Scholar 

  32. Tanner H, Wolber T, Schwick N et al. (2005) Electrocardiographic pattern as a guide for management and radiofrequency ablation of idiopathic ventricular tachycardia. Cardiology 103: 30–36

    Article  PubMed  Google Scholar 

  33. Tchou P, Mehdirad AA (1995) Bundle branch reentry ventricular tachycardia. PACE 18: 1427–1437

    PubMed  Google Scholar 

  34. Wolpert C, Schimpf R, Giustetto C et al. (2005) Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol 16: 54–58

    Article  PubMed  Google Scholar 

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Lewalter, T., Schwab, J.O. & Nickenig, G. Ventrikuläre Tachykardien. Internist 47, 1001–1012 (2006). https://doi.org/10.1007/s00108-006-1708-6

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  • DOI: https://doi.org/10.1007/s00108-006-1708-6

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