Zusammenfassung
Hintergrund
Drei Jahre nach Veröffentlichung der S3-Leitlinie Polytrauma/Schwerverletzten-Behandlung müssen die enthaltenen Kernaussagen weiterhin implementiert werden.
Ziel der Arbeit
Der vorliegende Beitrag soll einerseits einige der wesentlichen Kernaussagen der S3-Leitlinie repetieren und andererseits einen Überblick über neuere wissenschaftliche Studien geben.
Material und Methoden
In einer selektionierten Literaturrecherche wurden neue Studien zu den Themen Atemwegsmanagement, traumaassoziierter Herz-Kreislauf-Stillstand, Schockklassifikationen, Gerinnungstherapie, Ganzkörpercomputertomographie sowie Luftrettung und Zielklinik identifiziert. Die dabei gewonnenen Erkenntnisse werden vor dem Hintergrund der bestehenden Kernaussagen der S3-Leitlinie Polytrauma/Schwerverletzten-Behandlung diskutiert.
Ergebnisse
Die in der S3-Leitlinie bestehenden Empfehlungen zum Atemwegsmanagement sind weiterhin aktuell. Jedoch sollten Empfehlungen zur Beurteilung eines schwierigen Atemwegs (z. B. „LEMON law“) ergänzt werden. Als wesentlicher Qualitätsparameter wird zukünftig der „first pass success“ (Intubationserfolg im 1. Versuch) berücksichtigt werden müssen. Die Videolaryngoskopie stellt hierbei ein zukunftweisendes Instrument zur Umsetzung dieses Ziels dar. Aktuell ermittelte Lernkurven für die endotracheale Intubation und supraglottische Atemwegshilfen sollten bei der Erstellung von Qualifikationsanforderungen berücksichtigt werden. Lebensrettende invasive Notfalltechniken müssen prähospital durchgeführt werden und verlängern nicht die Gesamtversorgungsdauer schwerverletzter Patienten bis zum Abschluss der Schockraumphase. Die Behandlungsergebnisse bei traumaassoziierten Herz-Kreislauf-Stillständen sind besser als erwartet. Aktuell entwickelte Reanimationsalgorithmen für Traumapatienten müssen implementiert werden. Die „Prehospital-trauma-life-support“(PHTLS)/“Advanced-trauma-life-support“(ATLS)-Schockkriterien haben sich als nicht realitätsnah herausgestellt, daher schlagen neuere Untersuchungen die Beachtung der Laktatkonzentration, der Laktat-Clearance und des Basendefizits für die Evaluation eines Schockzustands im Schockraum vor. Im Gerinnungsmanagement hat sich Tranexamsäure als einfach zu applizierende, sichere und effektive antifibrinolytische Substanz herausgestellt, deren Einsatz jedoch nicht nur den am schwersten verletzten Patienten vorbehalten sein sollte. Zahlreiche Studien legen einen positiven Effekt der Ganzkörpercomputertomographie auf die Versorgungszeit und das Überleben nahe. Ungeklärt sind hierbei die Indikatoren, die die Notwendigkeit einer Durchführung einer Ganzkörpercomputertomographie anzeigen. Weitere Untersuchungen unterstützen die Einschätzung eines positiven Effekts der Luftrettung auf das Behandlungsergebnis von Traumapatienten.
Schlussfolgerung
Die in der S3-Leitlinie „Polytrauma/Schwerverletzten-Behandlung“ bestehenden Empfehlungen zum interdisziplinären Traumamanagement sollten in den klinischen Alltag übertragen werden. Daneben ist die Kenntnis neuerer wissenschaftlicher Studien für den Anästhesisten und Notarzt wichtig, um die Kernaussagen der S3-Leitlinie „Polytrauma/Schwerverletzten-Behandlung“ adäquat umsetzen zu können.
Abstract
Background
The recommendations still have to be implemented 3 years after publication of the S3 guidelines on the treatment of patients with severe and multiple injuries.
Aim
This article reiterates some of the essential core statements of the S3 guidelines and also gives an overview of new scientific studies.
Material and methods
In a selective literature search new studies on airway management, traumatic cardiac arrest, shock classification, coagulation therapy, whole-body computed tomography, air rescue and trauma centers were identified and are discussed in the light of the S3 guideline recommendations.
Results
The recommendations on airway management are up to date; however, recommendations on difficult airway evaluation tools, e.g. the LEMON law, should be included. The first pass success (i.e. intubation success at the first attempt) must be considered as a quality marker in the future. Video laryngoscopy is identified as a leading airway procedure in order to reach this aim. Recently estimated learning curves for endotracheal intubation and supraglottic airway devices should be implemented in qualification statements. Life-saving emergency interventions have to be performed in the prehospital setting as they do not prolong the complete treatment period for severely injured patients up to discharge from the resuscitation room. The outcome of patients suffering from traumatic cardiac arrest is better than expected. Recently developed algorithms for trauma patients have to be implemented. The prehospital trauma life support (PHTLS) and advanced trauma life support (ATLS) shock classification does not reflect the clinical reality; therefore, lactate, lactate clearance and base deficit should be used for evaluating the shock state in the resuscitation room. Concerning coagulation therapy, tranexamic acid is easy to administer, safe and effective as an antifibrinolytic therapy and should not be restricted to the most severely injured patients. Numerous studies have shown the positive effect of whole-body computed tomography on treatment time and outcome; however, clear indications for the use of whole-body computed tomography are lacking. Further investigations supported the positive effects of air rescue on the treatment outcome of trauma patients.
Conclusion
The recommendations on interdisciplinary trauma management contained in the S3 guidelines on the treatment of patients with severe and multiple injuries should be implemented into the clinical routine. Additionally, the knowledge gained from more recent scientific studies is necessary for anesthetists and emergency physicians to be able to adequately implement the core statements of the S3 guidelines for the treatment of patients with severe and multiple injuries.
Literatur
Alberts SG, Ariyan S, Rather A (2010) The effect of etomidate on adrenal function in critical illness: a systematic review. Intensive Care Med 37:901–910
Andruszkow H, Lefering R, Frink M et al (2013) Survival benefit of helicopter emergency medical services compared to ground emergency medical services in traumatized patients. Crit Care 17:R124
Ballow SL, Kaups KL, Anderson S, Chang M (2012) A standardized rapid sequence intubation protocol facilitates airway management in critically injured patients. J Trauma Acute Care Surg 73:1401–1405
Bernhard M, Matthes G, Kanz KG et al (2011) Notfallnarkose, Atemwegsmanagement und Beatmung beim Polytrauma. Hintergrund und Kernaussagen der interdisziplinären S3-Leitlinie Polytrauma. Anaesthesist 60:1027–1040
Bernhard M, Mohr S, Weigand MA et al (2012) Developing the skill of endotracheal intubation: implication for emergency medicine. Acta Anaesthesiol Scand 56:164–171
CRASH 2 trial collaborators (2010) Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 376:23–32
CRASH 2 trial collaborators (2011) The importance of the early treatment of tranexamic acid in bleeding trauma patients: a exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 377:1096–1101
CRASH 2 trial collaborators (2011) Effects of tranexamic acid in traumatic brain injury: a nested randomised, placebo-controlled trial (CRASH-2 Intracranial Bleeding Study). BMJ 343:d3795
Cavus E, Callies A, Doerges V et al (2011) The C-MAC videolaryngoscope for prehospital emergency intubation: a prospective, multicentre, observational study. Emerg Med J 28:650–653
Chen CY, Lin YR, Zhao LL et al (2013) Epidemiology and outcome analysis of children with traumatic out-of-hospital cardiac arrest compared to nontraumatic cardiac arrest. Pediatr Surg Int 29:471–477
De Jong A, Molinari N, Conseil M et al (2014) Video laryngoscopy versus direct laryngoscopy for orotracheal intubation in the intensive care unit: a systematic review and meta-analysis. Intensive Care Med 40:629–639
De Jong A, Claviers N, Conseil M et al (2013) Implementation of a combo videolaryngoscope for intubation in critically ill patients: a before-after comparative study. Intensive Care Med 39:2144–2152
Desmettre T, Yeguiayan JM, Coadou H et al (2012) Impact of emergency medical helicopter transport directly to a university hospital trauma center on mortality of severe blunt trauma patients until discharge. Crit Care 16:R170
Deutsche Gesellschaft für Unfallchirurgie (2012) Weißbuch Schwerverletztenversorgung DGU, 2. Aufl. Thieme, Stuttgart
Deutsche Gesellschaft für Unfallchirurgie. Jahresbericht 2013. http://www.dgn.de
Dunham CM, Barraco RD, Clark DE et al (2003) Guidelines for emergency tracheal intubation immediately after traumatic injury. J Trauma 55:162–179
Galvagno SM, Haut ER, Zafar SN et al (2012) Association between helicopter vs. ground emergency medical services and survival for adults with major trauma. JAMA 307:1602–1610
Gräsner JT, Wnent J, Seewald S et al (2011) Cardiopulmonary resuscitation cardiac arrest – there are survivors. An analysis of two national emergency registries. Crit Care 15:R276
Grottke O, Frietsch T, Maas M (2013) Dealing with massive bleeding and associated perioperative coagulopathy: recommendations for action of the German Society of Anaesthesiology and Intensive Care Medicine. Anaesthesist 62:213–222
Guly HR, Bouamra O, Little R et al (2010) Testing the validity of the ATLS classification of hypovolaemic shock. Resuscitation 81:1142–1147
Guly HR, Bouamra O, Spiers M et al (2011) Vital signs and estimated blood loss in patients with major trauma: testing the validity of the ATLS classification of hypovolaemic shock. Resuscitation 82:556–559
Hampton DA, Fabricant LJ, Differding J et al (2013) Prehospital intravenous fluid is associated with increased survival in trauma patients. J Trauma Acute Care Surg 74:S9–S15
Hsiao KH, Dinh MM, McNamara KP et al (2013) Whole-body computed tomography in the initial assessment of trauma patients: is there optimal criteria for patient selection? Emerg Med Australas 25:182–191
Hohl CM, Kelly-Smith CH, Yeung TC et al (2010) The effect of a bolus dose of etomidate on cortisol levels, mortality, and health services utilization: a systematic review. Ann Emerg Med 56:105–13.e5
Huber-Wagner S, Biberthaler P, Häberle S et al (2013) Whole-body CT in haemodynamically unstable severely injured patients-a retrospective, multicentre study. PLoS One 8:e68880
Hussmann B, Lefering R, Waydhas C et al (2011) Prehospital intubation of the moderately injured patient: a cause of morbidity? A matched-pairs analysis of 1,200 patients from the DGU Trauma Registry. Crit Care 15:R207
Hutter M, Woltmann A, Hierholzer C et al (2011) Association between a single-pass whole-body computed tomography policy and survival after blunt major trauma: a retrospective cohort study. Scand J Trauma Resusc Emerg Med 19:73
Jones AE (2012) Lactate clearance in the acutely traumatized patient. Anesthesiology 117:1162–1164
Kanz KG, Paul AO, Lefering R et al (2010) Trauma management incorporating focused assessment with computed tomography in trauma (FACTT) – potential effect on survival. J Trauma Manag Outcomes 4:4
Kimura A, Tanaka N (2013) Whole-body computed tomography is associated with decreased mortality in blunt trauma patients with moderate-to-severe consciousness disturbance: a multicenter, retrospective study. J Trauma Acute Care Surg 75:202–206
Kleber C, Gisecke MT, Lindner T et al (2014) Requirement for a structured algorithm in cardiac arrest following major trauma: epidemiology, management errors, and preventability of traumatic deaths in Berlin. Resuscitation 85:405–410
Kill C, Risse J, Wallot P et al (2013) Videolaryngoscopy with Glidescope reduces cervical spine movement in patients with unsecured cervical spine. J Emerg Med 44:750–756
Komatsu R, You J, Mascha EJ et al (2013) Anesthetic induction with etomidate, rather than propofol, is associated with increased 30-day mortality and cardiovascular morbidity after noncardiac surgery. Anesth Analg 117:1329–1337
Kory P, Guevarra K, Mathew JP et al (2013) The impact of video laryngoscopy use during urgent endotracheal intubation in the critically ill. Anesth Analg 117:144–149
Kulla M, Helm M, Lefering R, Walcher F (2012) Prehospital endotracheal intubation and chest tubing does not prolong the overall resuscitation time of severely injured patients: a retrospective, multicentre study of the Trauma Registry of the German Society of Trauma Surgery. Emerg Med J 29:497–501
Lawton LD, Roncal S, Leonard E et al (2014) The utility of Advanced Trauma Life Support (ATLS) shock grading in assessment of trauma. Emerg Med J 31:384–389
Leis CC, Hernandez CC, Blanco MJ et al (2013) Traumatic cardiac arrest: should advanced life support be initiated? J Trauma Acute Care Surg 74:634–638
Levy JH (2010) Antifibrinolytic therapy: new data and new concepts. Lancet 376:3–4
Lier H, Böttier BW, Hinkelbein J et al (2011) Coagulation management in multiple trauma: a systematic review. Intensive Care Med 37:572–582
Lockey DJ, Lyon RM, Davis GE (2013) Development of a simple algorithm to guide the effective management of traumatic cardiac arrest. Resuscitation 84:738–742
Lunde J, Stensballe J, Wikkelsø A et al (2014) Fibrinogen concentrate for bleeding – a systematic review. Acta Anaesthesiol Scand. DOI 10.1111/aas.12370
Mayglothing J, Duane TM, Gibbs M et al (2012) Emergency tracheal intubation immediately following traumatic injury: an Eastern Association for the Surgery of Trauma practice management guideline. J Trauma Acute Care Surg 73:S333–S340
Meyer MA, Ostrowski SR, Windeløv NA et al (2011) Fibrinogen concentrates for bleeding trauma patients: what is the evidence? Vox Sang 101:185–190
Mohr S, Weigand MA, Hofer S et al (2013) Developing the skill of laryngeal mask insertion: prospective single center study. Anaesthesist 62:447–452
Mosier JM, Stolz U, Chiu S, Sakles JC (2012) Difficult airway management in the emergency department: Glidescope videolaryngoscopy compared to direct laryngoscopy. J Emerg Med 42:629–634
Mutschler M, Nienaber U, Brockamp T et al (2013) A critical reappraisal of the ATLS classification of hypovolaemic shock: does it really reflect clinical reality? Resuscitation 84:309–313
Mutschler M, Nienaber U, Münzberg M et al (2014) Assessment of hypovolaemic shock at scene: is the PHTLS classification of hypovolaemic shock really valid? Emerg Med J 31:35–40
Mutschler M, Nienaber U, Brockamp T et al (2013) Renaissance of base deficit for the initial assessment of trauma patients: a base deficit-based classification for hypovolaemic shock developed on data from 16,305 patients derived from the TraumaRegister DGU. Crit Care 17:R42
Noppens RR, Geimer S, Eisel N et al (2012) Endotracheal intubation using the C-MAC® video laryngoscope or the Macintosh laryngoscope: a prospective, comparative study in the ICU. Crit Care 16:R103
Peiniger S, Paffrath T, Mutschler M et al (2012) The trauma patient in hemorrhagic shock: how is the C-priority addressed between emergency and ICU admission? Scand J Trauma Resusc Emerg Med 20:78
Regnier MA, Raux M, Le Manach Y et al (2012) Prognostic significance of blood lactate and lactate clearance in trauma patients. Anesthesiology 117:1276–1288
Roberts I, Perel P, Prieto-Merino D et al (2012) Effect of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trail. BMJ 345:e5839
Rognas K, Hansen TM, Kirkegaard H, Tonnesen E (2013) Pre-hospital advanced airway management by experienced anaesthesiologists: a prospective descriptive study. Scand J Trauma Resusc Emerg Med 21:58
S3-Leitlinie: „Polytrauma/Schwerverletzten-Behandlung. AWMF-Register Nr.: 012/019. http://www.awmf.de
Sakles JC, Mosier J, Chiu S et al (2012) A comparison of the C-MAC video laryngoscope to the Macintosh direct laryngoscope for intubation in the emergency department. Ann Emerg Med 60:739–748
Sierink JC, Saltzherr TP, Reitsma JB et al (2012) Systematic review and meta-analysis of immediate total-body computed tomography compared with selective radiological imaging of injured patients. Br J Surg 99(Suppl 1):52–58
Sierink JC, Saltzherr TP, Russchen MJ et al (2014) Incidental findings on total-body CT scans in trauma patients. Injury 45:840–844
Sierink JC, Saltzherr TP, Beenen LF et al (2014) A case-matched series of immediate total-body CT scanning versus the standard radiological work-up in trauma patients. World J Surg 38:795–802
Sollid SJ, Lossius HM, Soreide E (2010) Pre-hospital intubation by anaesthesiologists in patients with severe trauma: an audit of a Norwegian helicopter emergency medical service. Scand J Trauma Resusc Emerg Med 18:30
Spahn DR, Bouillon B, Cerny V et al (2013) Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care 17(2):R76
Timmermann A, Byhahn C, Wenzel V et al (2012) Handlungsempfehlung für das präklinische Atemwegsmanagement. Für Notärzte und Rettungsdienstpersonal. Anaesth Intensivmed 53:294–308
Van den Heuvel I, Wurmb TE, Böttiger BW, Bernhard M (2013) Pros and cons of etomidate – more discussion than evidence? Curr Opin Anaesthesiol 26:404–408
Venugopal K, Kinghorn AF, Emordi CE et al (2012) An evaluation of the use of whole-body computed tomography in trauma patients at a United Kingdom trauma centre. Eur J Emerg Med 19:193–195
Heymann C von, Kaufner L (2014) Differentiated therapy of acute bleeding – haemostasis, haemotherapy and haemodynamics. Anaesth Intensivmed 55:58–67
Wada D, Nakamori Y, Yamakawa K et al (2013) Impact on survival of whole-body computed tomography before emergency bleeding control in patients with severe blunt trauma. Crit Care 17(4):R178
Wurmb TE, Quaisser C, Balling H et al (2011) Whole-body multislice computed tomography (MSCT) improves trauma care in patients requiring surgery after multiple trauma. Emerg Med J 28:300–304
Wurmb TE, Frühwald P, Hopfner W et al (2007) Whole-body multislice computed tomography as the primary and sole diagnostic tool in patients with blunt trauma: searching for its appropriate indication. Am J Emerg Med 25:1057–1062
Wyen H, Lefering R, Maegele M et al (2013) The golden hour of shock – how time is running out: prehospital time intervals in Germany – a multivariate analysis of 15,103 patients from the TraumaRegister DGU. Emerg Med J 30:1048–1055
Yeatts DJ, Dutton RP, HU PF et al (2013) Effect of video laryngoscopy on trauma patient survival: a randomized controlled trial. J Trauma Acute Care Surg 75:212–219
Einhaltung ethischer Richtlinien
Interessenkonflikt. B. Donaubauer, J. Fakler, A. Gries, U.X. Kaisers, C. Josten, M. Bernhard geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Donaubauer, B., Fakler, J., Gries, A. et al. Interdisziplinäres Traumamanagement. Anaesthesist 63, 852–864 (2014). https://doi.org/10.1007/s00101-014-2375-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00101-014-2375-y