Skip to main content
Log in

Anästhesie bei geriatrischen Patienten

Teil 1: Alter, Organfunktion und typische Erkrankungen

Anesthesia for geriatric patients

Part 1: age, organ function and typical diseases

  • CME Weiterbildung · Zertifizierte Fortbildung
  • Published:
Der Anaesthesist Aims and scope Submit manuscript

An Erratum to this article was published on 15 December 2015

Zusammenfassung

Aufgrund der demografischen Entwicklung wird sich der Anteil der über 80-Jährigen in Deutschland in den nächsten 30 Jahren von heute 4 Mio. auf ca. 10 Mio. mehr als verdoppeln. Dies wird zu einer Zunahme an multimorbiden, chronisch-kranken Patienten führen. Auch wenn ältere Menschen nicht von Erkrankungen betroffen sind, reagieren sie auf die perioperativen Veränderungen der Homöostase, die pharmakologischen Interventionen und die operativen Prozeduren viel empfindlicher als jüngere Patienten. Die Erholung nach einem operativen Eingriff ist oft verlängert und resultiert nicht immer in einer „Restitutio ad integrum“. In Teil 1 dieses Weiterbildungsbeitrags werden die Zusammenhänge zwischen Alter und Organfunktion dargestellt und zudem typische Erkrankungen besprochen, die perioperativ bei der Versorgung geriatrischer Patienten bedeutsam sind. Die Besonderheiten von Anästhetika und Anästhesieführung im Alter werden in Teil 2 dargestellt.

Abstract

Due to demographic changes in the population of industrial nations the number of elderly patients undergoing elective or emergency procedures will rise significantly in the coming years. Anesthesia for geriatric patients is challenging for the anesthesiologist in many ways: with increasing age numerous physiological changes occur which all lead to a subsequent reduction of physical performance and compensatory capacity of the organism, in many cases additionally aggravated by chronic illness. Subsequently, these age-dependent changes (with or without  chronic illness) increase the risk for admission to intensive care units, perioperative death, treatment costs and a prolonged length of hospital stay. Therefore, subtle preoperative assessment and tailored anesthetic management are essential in elderly patients. Part 1 of this continuous education article covers the influence of age on organ functions and describes typical comorbidities which are of high relevance for the perioperative care of geriatric patients. The special features of anesthetic agents and anesthesia management in the elderly will be presented in part 2.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6
Abb. 7

Literatur

  1. Akça O (2006) Optimizing the intraoperative management of carbon dioxide concentration. Curr Opin Anaesthesiol 19:19–25

    Article  PubMed  Google Scholar 

  2. Bettelli G (2011) Preoperative evaluation in geriatric surgery: comorbidity, functional status and pharmacological history. Minerva Anestesiol 77:1–10

    Google Scholar 

  3. Bijker JB, Klei WA van, Kappen TH et al (2007) Incidence of intraoperative hypotension as a function of the chosen definition: literature definitions applied to a retrospective cohort using automated data collection. Anesthesiology 107:213–220

    Article  PubMed  Google Scholar 

  4. Bijker JB, Klei WA van, Vergouwe Y et al (2009) Intraoperative hypotension and 1-year mortality after noncardiac surgery. Anesthesiology 111:1217–1226

    Article  PubMed  Google Scholar 

  5. Bräuer A, Perl T, Quintel M (2006) Perioperatives Wärmemanagement. Anaesthesist 55:1321–1340

    Article  PubMed  Google Scholar 

  6. Burris JM, Subramanian A, Sansgiry S et al (2010) Perioperative atrial arrhythmias in noncardiothoracic patients: a review of risk factors and treatment strategies in the veteran population. Am J Surg 200:601–605

    Article  PubMed  Google Scholar 

  7. Camm AJ, Kirchhof P, Lip GY et al (2010) Guidelines for the management of atrial fibrillation: the task force for the management of atrial fibrillation of the European Society of Cardiology (ESC). Eur Heart J 31:2369–2429

    Article  PubMed  Google Scholar 

  8. Coburn M, Fahlenkamp A, Zoremba N, Schaelte G (2010) Postoperative kognitive Dysfunktion. Anaesthesist 59:177–185

    Article  PubMed  CAS  Google Scholar 

  9. Damm M, Hübler A, Heller AR (2011) Kardioprotektion. Anaesthesist 60:1065–1082

    Article  PubMed  CAS  Google Scholar 

  10. Devereaux PJ, Yang H, Yusuf S et al (2008) Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet 371:1839–1847

    Article  PubMed  CAS  Google Scholar 

  11. Dickstein DL, Kabaso D, Rocher AB et al (2007) Changes in the structural complexity of aged brain. Aging Cell 6:275–284

    Article  PubMed  CAS  Google Scholar 

  12. Dodds C, Kumar CM, Servin F (2007) Anaesthesia for the elderly patient. Oxford University Press, Oxford

  13. Ebihara S, Saito H, Kanda A et al (2003) Impaired efficacy of cough in patients with Parkinson disease. Chest 124:1009–1015

    Article  PubMed  Google Scholar 

  14. Ekberg O, Feinberg MJ (1991) Altered swallowing function in elderly patients without dysphagia: radiologic findings in 56 cases. AJR Am J Roentgenol 156:1181–1184

    PubMed  CAS  Google Scholar 

  15. Epstein M (1996) Aging and the kidney. J Am Soc Nephrol 7:1106–1122

    PubMed  CAS  Google Scholar 

  16. Frank SM, El-Rahmany HK, Cattaneo CG, Barnes RA (2000) Predictors of hypothermia during spinal anesthesia. Anesthesiology 92:1330–1334

    Article  PubMed  CAS  Google Scholar 

  17. Frank SM, Fleisher LA, Breslow MJ et al (1997) Perioperative maintenance of normothermia reduces the incidence of morbid cardiac events. JAMA 277:1127–1134

    Article  PubMed  CAS  Google Scholar 

  18. Garcia-Rio F, Villamor A, Gomez-Mendieta A et al (2007) The progressive effects of aging on chemosensitivity in healthy subjects. Respir Med 101:2192–2198

    Article  PubMed  Google Scholar 

  19. Graf M, Sinner B, Zink W (2010) Anästhesie bei alten Menschen. Thieme, Stuttgart

  20. Gupta AK, Meheshwari A, Tresch DD et al (2002) Cardiac arrhythmias in the elderly. Card Electrophysiol Rev 6:120–128

    Article  PubMed  Google Scholar 

  21. Hager H, Reddy D, Mandadi G et al (2006) Hypercapnia improves tissue oxygenation in morbidly obese surgical patients. Anesth Analg 103:677–681

    Article  PubMed  Google Scholar 

  22. Hardie JA, Vollmer WM, Buist AS et al (2004) Reference values for arterial blood gases in the elderly. Chest 125:2053–2060

    Article  PubMed  Google Scholar 

  23. Herminghaus A, Wachowiak M, Wilhelm W et al (2011) Intravenöses Lidocain zur perioperativen Schmerztherapie – eine Übersicht und praktische Handlungsempfehlungen. Anaesthesist 60:152–160

    Article  PubMed  CAS  Google Scholar 

  24. Hoch CC, Reynolds CF 3rd, Monk TH et al (1990) Comparison of sleep-disordered breathing among healthy elderly in the seventh, eighth, and ninth decades of life. Sleep 13:502–511

    PubMed  CAS  Google Scholar 

  25. Ihrig A, Haken R von, Mieth M et al (2011) Langzeitfolgen eines postoperativen Delirs. Anaesthesist 60:735–739

    Article  PubMed  CAS  Google Scholar 

  26. Janssens JP, Pache JC, Nicod LP (1999) Physiological changes in respiratory function associated with ageing. Eur Respir J 13:197–205

    Article  PubMed  CAS  Google Scholar 

  27. Keefover RW (1998) Aging and cognition. Neurol Clin 16:635–648

    Article  PubMed  CAS  Google Scholar 

  28. Khan F, Spence VA, Belch JJ (1992) Cutaneous vascular responses and thermoregulation in relation to age. Clin Sci (Lond) 82:521–528

    Google Scholar 

  29. Kikura M, Bateman B, Tanaka K (2010) Perioperative ischemic stroke in non-cardiovascular surgery patients. J Anesth 24:733–738

    Article  PubMed  Google Scholar 

  30. Kohli HS, Bhaskaran C, Muthukumar T et al (2000) Treatment-related acute renal failure in the elderly: a hospital-based prospective study. Nephrol Dial Transplant 15:212–217

    Article  PubMed  CAS  Google Scholar 

  31. Kratz CD, Schleppers A, Iber T, Geldner G (2005) Pharmakologische Besonderheiten und Probleme des älteren Patienten. Anaesthesist 54:467–475

    Article  PubMed  CAS  Google Scholar 

  32. Kurz A, Plattner O, Sessler DI et al (1993) The threshold for thermoregulatory vasoconstriction during nitrous oxide/isoflurane anesthesia is lower in elderly than in young patients. Anesthesiology 79:465–469

    Article  PubMed  CAS  Google Scholar 

  33. Laffey JG, Kavanagh BP (2002) Hypocapnia. N Engl J Med 347:43–53

    Article  PubMed  CAS  Google Scholar 

  34. Lee TH, Marcantonio ER, Mangione CM et al (1999) Derivation and prospective validation of a simple index for prediction of cardiac risk of major noncardiac surgery. Circulation 100:1043–1048

    PubMed  CAS  Google Scholar 

  35. Lenhardt R, Marker E, Goll V et al (1997) Mild intraoperative hypothermia prolongs postanesthetic recovery. Anesthesiology 87:1318–1323

    Article  PubMed  CAS  Google Scholar 

  36. Liu L, Bopp MM, Roberson PK et al (2002) Undernutrition and risk of mortality in elderly patients within 1 year of hospital discharge. J Gerontol A Biol Sci Med Sci 57:741–746

    Article  Google Scholar 

  37. Mayson SE, Greenspon AJ, Adams S et al (2007) The changing face of postoperative atrial fibrillation prevention: a review of current medical therapy. Cardiol Rev 15:231–241

    Article  PubMed  Google Scholar 

  38. Melling AC, Ali B, Scott EM, Leaper DJ (2001) Effects of preoperative warming on the incidence of wound infection after clean surgery: a randomized, controlled trial. Lancet 358:876–880

    Article  PubMed  CAS  Google Scholar 

  39. Muhlberg W, Platt D (1999) Age-dependent changes of the kidneys: pharmacological implications. Gerontology 45:243–253

    Article  PubMed  CAS  Google Scholar 

  40. Müller C, Zwißler B (2012) Der geriatrische Patient. In: Rossaint R, Werner C, Zwißler B (Hrsg) Die Anästhesiologie, 3. Aufl. Springer Medizin, Heidelberg

  41. Münzer T (2010) Sarkopenie im Alter. Schweiz Med Forum 10:188–190

    Google Scholar 

  42. Raine JM, Bishop JM (1963) A-a difference in O2 tension and physiological dead space in normal man. J Appl Physiol 18:284–288

    PubMed  CAS  Google Scholar 

  43. Rajagopalan S, Mascha E, Na J, Sessler DI (2008) The effects of mild perioperative hypothermia on blood loss and transfusion requirement. Anesthesiology 108:71–77

    Article  PubMed  Google Scholar 

  44. Raz N, Lindenberger U, Rodrigue KM (2005) Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex 15:1676–1689

    Article  PubMed  Google Scholar 

  45. Rivera R, Antognini JF (2009) Perioperative drug therapy in elderly patients. Anesthesiology 110:1176–1181

    Article  PubMed  Google Scholar 

  46. Rudolph JL, Marcantonio ER (2011) Postoperative delirium: acute change with long-term implications. Anesth Analg 112:1202–1211

    Article  PubMed  Google Scholar 

  47. Sabaté S, Mases A, Guilera N et al (2011) Incidence and predictors of major perioperative adverse cardiac and cerebrovascular events in non-cardiac surgery. Br J Anaesth 107:879–890

    Article  PubMed  Google Scholar 

  48. Selkoe DJ (1992) Aging brain, aging mind. Sci Am 267:134–142

    Article  PubMed  CAS  Google Scholar 

  49. Siu CW, Tung HM, Chu KW et al (2005) Prevalence and predictors of new-onset atrial fibrillation after elective surgery for colorectal cancer. Pacing Clin Electrophysiol 28:120–123

    Article  Google Scholar 

  50. Silverstein JH, Rooke GA, Reves JG, McLeskey CH (2008) Geriatric anesthesiology. Springer, Berlin Heidelberg New York Tokio

  51. Statistisches Bundesamt, http://www.destatis.de/jetspeed/portal/cms/, Zugriff am: 15.12.2011

  52. Sutton-Tyrrell K, Najjar SS, Boudreau RM et al (2005) Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 111:3384–3390

    Article  PubMed  Google Scholar 

  53. Tolep K, Higgins N, Muza S et al (1995) Comparison of diaphragm strength between healthy adult elderly and young men. Am J Respir Crit Care Med 152:677–682

    PubMed  CAS  Google Scholar 

  54. Vassilieff N, Rosencher N, Sessler DI, Conseiller C (1995) Shivering threshold during spinal anesthesia is reduced in elderly patients. Anesthesiology 83:1162–1166

    Article  PubMed  CAS  Google Scholar 

  55. Haken R von, Gruß M, Plaschke K et al (2010) Delir auf der Intensivstation. Anaesthesist 59:235–247

    Article  Google Scholar 

  56. Wax DB, Lin HM, Hossain S, Porter SB (2010) Intraoperative carbon dioxide management and outcomes. Eur J Anaesthesiol 27:819–823

    Article  PubMed  Google Scholar 

  57. Zaugg M, Lucchinetti E (2000) Respiratory function in the elderly. Anesthesiol Clin North America 18:47–58

    Article  PubMed  CAS  Google Scholar 

  58. Zwissler B, Wappler F, Mertens E et al (2010) Präoperative Evaluation erwachsener Patienten vor elektiven, nichtkardiochirurgischen Eingriffen. Anaesthesist 59:1041–1050

    Article  Google Scholar 

Download references

Interessenkonflikt

Die Autoren weisen auf folgende Beziehungen hin: A.H. und S.L. haben keine Industriekontakte mit potenziellem Interessenkonflikt. W.W. hat für die Firmen Aspect, AstraZeneca, Baxter, B. Braun Melsungen, Dräger, Essex Pharma, Fresenius, GlaxoSmithKline, Narcotrend Monitortechnik, Storz, Transmed u. a. Vorträge gehalten und/oder Consulting durchgeführt.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. Herminghaus DESA.

Additional information

Ein Erratum zu diesem Beitrag ist unter http://dx.doi.org/10.1007/s00101-015-0116-5 zu finden.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Herminghaus, A., Löser, S. & Wilhelm, W. Anästhesie bei geriatrischen Patienten. Anaesthesist 61, 163–176 (2012). https://doi.org/10.1007/s00101-012-1978-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00101-012-1978-4

Schlüsselwörter

Keywords

Navigation