Skip to main content

Reconsolidation and Trauma Memory

  • Chapter
  • First Online:
Cognitive Neuroscience of Memory Consolidation

Abstract

This chapter highlights how advances in reconsolidation research could lead to the development of novel treatments to influence traumatic memories. Patients with Posttraumatic Stress Disorder (PTSD) suffer from recurrent intrusive memories of the traumatic event(s). The concept of reconsolidation implies that already consolidated memories can be changed after reactivating them and applying an update to the original memory trace. This chapter briefly reviews the relevant literature on (mainly human) reconsolidation research. Afterwards, PTSD is explained as a disorder of memory. Finally, first approaches are described that make use of postulated reconsolidation-update mechanisms in order to change traumatic memories.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Agren T, Engman J, Frick A, Björkstrand J, Larsson E-M, Furmark T, Fredrikson M (2012) Disruption of reconsolidation erases a fear memory trace in the human amygdala. Science 337(6101):1550–1552. doi:10.1126/science.1223006

    Article  PubMed  Google Scholar 

  • American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders. 5th edn. American Psychiatric Publishing

    Google Scholar 

  • Arntz A (2012) Imagery rescripting as a therapeutic technique: review of clinical trials, basic studies, and research agenda. J Exp Psychopathol 3(2):189–208

    Article  Google Scholar 

  • Axmacher N, Do Lam AT, Kessler H, Fell J (2010) Natural memory beyond the storage model: repression, trauma, and the construction of a personal past. Front Hum Neurosci 4:211

    Article  PubMed  PubMed Central  Google Scholar 

  • Bartlett FC (1932) Remembering: a study in experimental and social psychology. Cambridge University Press, Cambridge

    Google Scholar 

  • Besnard A, Caboche J, Laroche S (2012) Reconsolidation of memory: a decade of debate. Prog Neurobiol 99:61–80

    Article  PubMed  Google Scholar 

  • Brewin CR (2003) Posttraumatic stress disorder: malady or myth?. Yale University Press, New Haven

    Google Scholar 

  • Brewin CR (2014) Episodic memory, perceptual memory and their interaction: foundations for a theory of posttraumatic stress disorder. Psychol Bull 140:69–97. doi:10.1037/a0033722

    Article  PubMed  Google Scholar 

  • Brunet A, Orr SP, Tremblay J, Robertson K, N K, Pitman RK (2008) Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder. J Psychiatr Res 42(6):503–506. doi:10.1016/j.jpsychires.2007.05.006

    Article  PubMed  Google Scholar 

  • Brunet A, Ashbaugh AR, Saumier D, Nelson M, Pitman RK, Tremblay J et al (2011a) Does reconsolidation occur in humans: a reply. Front Behav Neurosci 5:74

    Article  PubMed  PubMed Central  Google Scholar 

  • Brunet A, Poundja J, Tremblay J, Bui E, Thomas E, Orr SP et al (2011b) Trauma reactivation under the influence of propranolol decreases posttraumatic stress symptoms and disorder: 3 open-label trials. J Clin Psychopharmacol 31(4):547–550. doi:10.1097/JCP.0b013e318222f360

    Article  PubMed  Google Scholar 

  • Brunet A, Thomas É, Saumier D, Ashbaugh AR, Azzoug A, Pitman RK et al (2014) Trauma reactivation plus propranolol is associated with durably low physiological responding during subsequent script-driven traumatic imagery. Can J Psychiatry (Revue Canadienne de Psychiatrie) 59(4):S228–232

    Google Scholar 

  • Chan JC, LaPaglia JA (2013) Impairing existing declarative memory in humans. Proc Natl Acad Sci U S A 110:9309–9313

    Article  PubMed  PubMed Central  Google Scholar 

  • de Quervain D (2007) Preventive effect of β-adrenoceptor blockade on glucocorticoid-induced memory retrieval deficits. Am J Psychiatry 164(6):967. doi:10.1176/appi.ajp.164.6.967

    Article  PubMed  Google Scholar 

  • Ehlers A, Clark DM (2000) A cognitive model of posttraumatic stress disorder. Behav Res Ther 38:319–345

    Article  PubMed  Google Scholar 

  • Finnie PSB, Nader K (2012) The role of metaplasticity mechanisms in regulating memory destabilization and reconsolidation. Neurosci Biobehav Rev 36:1667–1707

    Article  PubMed  Google Scholar 

  • Forcato C, Rodriguez ML, Pedreira ME (2011) Repeated labilization-reconsolidation processes strengthen declarative memory in humans. PLoS ONE 6:e23305

    Article  PubMed  PubMed Central  Google Scholar 

  • Freud S, Breuer J (1895) Studien über hysterie. Fischer, Frankfurt a. M

    Google Scholar 

  • Gahr M, Schonfeldt-Lecuona C, Spitzer M, Graf H (2014) Electroconvulsive therapy and posttraumatic stress disorder: first experience with conversation-based reactivation of traumatic memory contents and subsequent ECT-mediated impairment of reconsolidation. J Neuropsychiatry Clin Neurosci 26(3):E38–9. doi:10.1176/appi.neuropsych.13070159

    Article  PubMed  Google Scholar 

  • Giustino TF, Fitzgerald PJ, Maren S (2016) Revisiting propranolol and PTSD: memory erasure or extinction enhancement? Neurobiol Learn Mem 130:26–33. doi:10.1016/j.nlm.2016.01.009

    Article  PubMed  Google Scholar 

  • Golkar A, Bellander M, Olsson A, Ohman A (2012) Are fear memories erasable?-reconsolidation of learned fear with fear-relevant and fear-irrelevant stimuli. Front Behav Neurosci 6:80

    Article  PubMed  PubMed Central  Google Scholar 

  • Holmes EA, Craske MG, Graybiel AM (2014) A call for mental-health science. Clinicians and neuroscientists must work together to understand and improve psychological treatments [Comment]. Nature 511:287–289. doi:10.1038/511287a

    Article  PubMed  Google Scholar 

  • Hupbach A, Gomez R, Hardt O, Nadel L (2007) Reconsolidation of episodic memories: a subtle reminder triggers integration of new information. Learn Mem 14:47–53

    Article  PubMed  PubMed Central  Google Scholar 

  • James W (1892) Psychology: the briefer course. Harper, Torchbooks, New York

    Book  Google Scholar 

  • James EL et al (2015) Computer game play reduces intrusive memories of experimental trauma via reconsolidation update mechanisms. Psychol Sci 1–15. doi:10.1177/0956797615583071 (OnlineFirst)

  • James EL, Lau-Zhu A, Clark IA, Visser RM, Hagenaars MA, & Holmes EA (2016) The trauma film paradigm as an experimental psychopathology model of psychological trauma: intrusive memories and beyond. Clin Psychol Rev 47:106–142. doi:10.1016/j.cpr.2016.04.010

  • Janet P (1894) Der Geisteszustand der Hysterischen. Deuticke, Leipzig/Wien

    Google Scholar 

  • Kindt M, Soeter M, Vervliet B (2009) Beyond extinction: erasing human fear responses and preventing the return of fear. Nat Neurosci 12:256–258. doi:http://www.nature.com/neuro/journal/v12/n3/full/nn.2271.html

  • Kroes MCW, Strange BA, Dolan RJ (2010) Beta-adrenergic blockade during memory retrieval in humans evokes a sustained reduction of declarative emotional memory enhancement. J Neurosci Official J Soc Neurosci 30(11):3959–3963. doi:10.1523/JNEUROSCI.5469-09.2010

    Article  Google Scholar 

  • Kroes MCW et al (2014) An electroconvulsive therapy procedure impairs reconsolidation of episodic memories in humans. Nat Neurosci 17:204–2016. doi:10.1038/nn.3609

    Article  PubMed  Google Scholar 

  • Lane RD, Ryan L, Nadel L, & Greenberg L (2015) Memory reconsolidation, emotional arousal, and the process of change in psychotherapy: new insights from brain science. Behav Brain Sci, 38, e1

    Google Scholar 

  • Lewis DJ (1969) Sources of experimental amnesia. Psychol Rev 76:461–472

    Article  PubMed  Google Scholar 

  • Loftus EF (2005) Planting misinformation in the human mind: a 30-year investigation of the malleability of memory. Learn Mem 12:361–366

    Article  PubMed  Google Scholar 

  • Lonergan MH, Olivera-Figueroa LA, Pitman RK, Brunet A (2013) Propranolol’s effects on the consolidation and reconsolidation of long-term emotional memory in healthy participants: a meta-analysis. J Psychiatry Neurosci JPN 38(4):222–231. doi:10.1503/jpn.120111

    Article  PubMed  Google Scholar 

  • Marks EH, Zoellner LA (2014) Attenuating fearful memories: effect of cued extinction on intrusions. Emotion (Washington, DC) 14(6):S1143–1154. doi:10.1037/a0037862

  • McNally RJ (2003) Remembering trauma. Harvard University Press. Traumatic experiences are unforgettable, Cambridge, MA

    Google Scholar 

  • Merlo E, Milton AL, Goozée ZY, Theobald DE, Everitt BJ (2014) Reconsolidation and extinction are dissociable and mutually exclusive processes: behavioral and molecular evidence. J Neurosci Official J Soc Neurosci 34(7):2422–2431. doi:10.1523/JNEUROSCI.4001-13.2014

    Article  Google Scholar 

  • Milekic MH, Alberini CM (2002) Temporally graded requirement for protein synthesis following memory reactivation. Neuron 36(3):521–525. doi:10.1016/S0896-6273(02)00976-5

    Article  PubMed  Google Scholar 

  • Misanin JR, Miller RR, Lewis DJ (1968) Retrograde amnesia produced by electroconvulsive shock after reactivation of a consolidated memory trace. Science 160:554–555

    Article  PubMed  Google Scholar 

  • Nadel L, Hupbach A, Gomez R, Newman-Smith K (2012) Memory formation, consolidation and transformation. Neurosci Biobehav Rev 36:1640–1645

    Article  PubMed  Google Scholar 

  • Nader K, Hardt O (2009) A single standard for memory: the case for reconsolidation. Nat Rev Neurosci 10:224–234

    Article  PubMed  Google Scholar 

  • Nader K, Schafe G, LeDoux J (2000a) The labile nature of consolidation theory. Nat Rev Neurosci 1:216–219

    Article  PubMed  Google Scholar 

  • Nader K, Schafe GE, LeDoux JE (2000b) Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature 406:722–726

    Article  PubMed  Google Scholar 

  • National Institute for Health and Clinical Excellence (2005) Post-traumatic stress disorder (PTSD): the management of PTSD in adults and children in primary and secondary care. Report No. CG026. National Institute for Health and Clinical Excellence, London

    Google Scholar 

  • Oyarzun JP, Lopez-Barroso D, Fuentemilla L, Cucurell D, Pedraza C, Rodriguez-Fornells A, de Diego-Balaguer R (2012) Updating fearful memories with extinction training during reconsolidation: a human study using auditory aversive stimuli. PLoS ONE 7(6):e38849

    Article  PubMed  PubMed Central  Google Scholar 

  • Pitman RK (1989) Post-traumatic stress disorder, hormones, and memory. Biol Psychiatry 26:221–223

    Article  PubMed  Google Scholar 

  • Pitman RK, Delahanty DL (2005) Conceptually driven pharmacologic approaches to acute trauma. CNS Spectr 10(2):99–106

    Article  PubMed  Google Scholar 

  • Przybyslawski J, Roullet P, Sara SJ (1999) Attenuation of emotional and nonemotional memories after their reactivation, role of beta adrenergic receptors. J Neurosci 19:6623–6628

    PubMed  Google Scholar 

  • Sara SJ (2000) Retrieval and reconsolidation: toward a neurobiology of remembering. Learn Mem 7:73–84

    Article  PubMed  Google Scholar 

  • Schiller D, Phelps EA (2011) Does reconsolidation occur in humans? Front Behav Neurosci 5:24

    Article  PubMed  PubMed Central  Google Scholar 

  • Schiller D et al (2010) Preventing the return of fear in humans using reconsolidation update mechanisms. Nature 463:49–53

    Article  PubMed  Google Scholar 

  • Schwabe L, Nader K, Wolf OT, Beaudry T, Pruessner JC (2012) Neural signature of reconsolidation impairments by propranolol in humans. Biol Psychiatry 71(4):380–386. doi:10.1016/j.biopsych.2011.10.028

    Article  PubMed  Google Scholar 

  • Schwabe L, Nader K, Pruessner JC (2014) Reconsolidation of human memory: Brain mechanisms and clinical relevance. Biol Psychiatry 76(4):274–280

    Article  PubMed  Google Scholar 

  • Sevenster D, Beckers T, Kindt M (2012) Retrieval per se is not sufficient to trigger reconsolidation of human fear memory. Neurobiol Learn Mem 97(3):338–345. doi:10.1016/j.nlm.2012.01.009

    Article  PubMed  Google Scholar 

  • Shapiro F (2001) Eye movement desensitization and reprocessing: Basic principles, protocols and procedures, 2nd edn. Guilford, New York

    Google Scholar 

  • Soeter M, Kindt M (2010) Dissociating response systems: erasing fear from memory. Neurobiol Learn Mem 94(1):30–41. doi:10.1016/j.nlm.2010.03.004

    Article  PubMed  Google Scholar 

  • Soeter M, Kindt M (2011) Disrupting reconsolidation: pharmacological and behavioral manipulations. Learn Mem 18(6):357–366

    Article  PubMed  Google Scholar 

  • Suzuki A, Josselyn SA, Frankland PW, Masushige S, Silva AJ, Kida S (2004) Memory reconsolidation and extinction have distinct temporal and biochemical signatures. J Neurosci Official J Soc Neurosci 24(20):4787–4795. doi:10.1523/JNEUROSCI.5491-03.2004

    Article  Google Scholar 

  • Tollenaar MS, Elzinga BM, Spinhoven P, Everaerd W (2009a) Immediate and prolonged effects of cortisol, but not propranolol, on memory retrieval in healthy young men. Neurobiol Learn Mem 91(1):23–31. doi:10.1016/j.nlm.2008.08.002

    Article  PubMed  Google Scholar 

  • Tollenaar MS, Elzinga BM, Spinhoven P, Everaerd W (2009b) Psychophysiological responding to emotional memories in healthy young men after cortisol and propranolol administration. Psychopharmacology 203(4):793–803. doi:10.1007/s00213-008-1427-x

    Article  PubMed  Google Scholar 

  • van den Hout M, Engelhard IM (2012) How does EMDR work? J Exp Psychopathol 3(5):724–738

    Article  Google Scholar 

  • Van der Kolk BA (2007) The history of trauma in psychiatry. In: Friedman MJ, Keane TM, Resick PA (eds) Handbook of PTSD: science and practice. Guilford Press, New York, pp 19–36

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Henrik Kessler .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Kessler, H., Blackwell, S.E., Kehyayan, A. (2017). Reconsolidation and Trauma Memory. In: Axmacher, N., Rasch, B. (eds) Cognitive Neuroscience of Memory Consolidation. Studies in Neuroscience, Psychology and Behavioral Economics. Springer, Cham. https://doi.org/10.1007/978-3-319-45066-7_22

Download citation

Publish with us

Policies and ethics