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Monogene Adipositas

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Adipositas bei Kindern und Jugendlichen

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Zusammenfassung

Das Wissen über monogene Adipositasformen hat in den letzten Jahren enorm zugenommen und gewinnt zunehmend an Bedeutung in der pädiatrischen Endokrinologie. Zum einen kann es für die Betroffenen eine ausgeprägte Erleichterung bedeuten, die Ursache ihrer Adipositas zu verstehen. Außerdem kann einigen wenigen Patienten kann sogar eine kausale oder zumindest optimierte Therapie angeboten werden. Selten vorkommende biallelische Varianten im Leptin-Melanokortin-Signalweg führen zu einer schweren frühkindlichen Adipositas. Bei Patienten mit extremer Hyperphagie und einem BMI über 25 kg/m2 im 2. Lebensjahr oder von >30 kg/m2 im 5. Lebensjahr bzw. einem BMI-SDS >4 sollte auf jeden Fall eine Diagnostik hinsichtlich einer monogenen Adipositas eingeleitet werden.

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Authors and Affiliations

  1. Sektion Pädiatrische Endokrinologie u. Diabetologie, Universitätsklinik für Kinder- und Jugendmedizin, Ulm, Deutschland

    Julia von Schnurbein & Martin Wabitsch

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  1. Julia von Schnurbein
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  2. Martin Wabitsch
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Correspondence to Julia von Schnurbein .

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Editors and Affiliations

  1. Sektion Pädiatrische Endokrinologie u. Diabetologie, Universitätsklinik für Kinder- und Jugendmedizin, Ulm, Deutschland

    Martin Wabitsch

  2. Kinder- und Jugendpsychiatrie, Rheinische Kliniken der Universität Duisburg-Essen, Essen, Deutschland

    Johannes Hebebrand

  3. Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Leipzig, Leipzig, Deutschland

    Wieland Kiess

  4. Endokrinologie und Diabetologie, Vestische Kinderklinik, Datteln, Deutschland

    Thomas Reinehr

  5. Sozialpädiatrisches Zentrum, Charité – Universitätsmedizin Berlin, Berlin, Deutschland

    Susanna Wiegand

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von Schnurbein, J., Wabitsch, M. (2022). Monogene Adipositas . In: Wabitsch, M., Hebebrand, J., Kiess, W., Reinehr, T., Wiegand, S. (eds) Adipositas bei Kindern und Jugendlichen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-59216-8_6

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