Skip to main content
SpringerLink
Log in

Entwicklung und Regulation des weißen Fettgewebes

  • Chapter
  • First Online:
Adipositas bei Kindern und Jugendlichen

  • 4201 Accesses

Zusammenfassung

Klassischerweise unterscheidet man zwei Arten des Fettgewebes. Das weiße Fettgewebe besteht aus weißen, univakuolären Adipozyten und ist für die Speicherung und Bereitstellung von Energie verantwortlich. Im thermogenen, braunen Fettgewebe findet man hingegen multivakuoläre, mitochondrienreiche, braune Adipozyten. Erst vor kurzem wurde ein dritter Fettgewebstyp beschrieben, dem die Farbe beige zugeordnet wurde. Beige Adipozyten entstehen in weißen Fettgewebsdepots durch anhaltende Kälteexposition oder adrenerge Stimulation und zeigen eine Morphologie ähnlich den braunen Adipozyten, unterscheiden sich aber von ihnen anhand ihres Genexpressionsprofil. Dieses Kapitel behandelt die Entwicklung und das Wachstum des weißen Fettgewebes im Kindes- und Jugendalter und gibt einen Einblick in zelluläre und metabolische Prozesse, die die Fettmasse beeinflussen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Ameer F, Scandiuzzi L, Hasnain S, Kalbacher H, Zaidi N (2014) De novo lipogenesis in health and disease. Metabolism 63:895–902

    Article  CAS  Google Scholar 

  • Arner E et al (2010) Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 59:105–109

    Article  CAS  Google Scholar 

  • Arner P, Langin D (2014) Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance. Trends Endocrinol Metab 25:255–262

    Article  CAS  Google Scholar 

  • Berry DC, Stenesen D, Zeve D, Graff JM (2013) The developmental origins of adipose tissue. Development 140:3939–3949

    Article  CAS  Google Scholar 

  • Billon N et al (2007) The generation of adipocytes by the neural crest. Development 134:2283–2292

    Article  CAS  Google Scholar 

  • Cao Y (2007) Angiogenesis modulates adipogenesis and obesity. J Clin Invest 117:2362–2368

    Article  CAS  Google Scholar 

  • Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB (2016) Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Cell Endocrinol 30. https://doi.org/10.3389/fendo.2016.00030

  • Choi SM et al (2010) Insulin regulates adipocyte lipolysis via an akt-independent signaling pathway. Mol Cell Biol 30:5009–5020

    Article  CAS  Google Scholar 

  • Cinti S (2005) Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46:2347–2355

    Article  CAS  Google Scholar 

  • Cook A, Cowan C (2009) Adipose. In: StemBook. Harvard Stem Cell Institute, Cambridge, MA

    Google Scholar 

  • Crandall DL, Hausman GJ, Kral JG (1997) A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 4:211–232

    Article  CAS  Google Scholar 

  • Der Stratz C (1903) Körper des Kindes und seine Pflege. Enke, Stuttgart

    Google Scholar 

  • DiGirolamo M, Newby FD, Lovejoy J (1992) Lactate production in adipose tissue: a regulated function with extra-adipose implications. FASEB J 6:2405–2412

    Article  CAS  Google Scholar 

  • Dugdale AE, Payne PR (1975) Pattern of fat and lean tissue deposition in children. Nature 256:725–727

    Article  CAS  Google Scholar 

  • Engfeldt P, Arner P (1988) Lipolysis in human adipocytes, effects of cell size, age and of regional differences. Horm Metab Res Suppl 19:26–29

    CAS  PubMed  Google Scholar 

  • Farmer SR (2006) Transcriptional control of adipocyte formation. Cell Metab 4:263–273

    Article  CAS  Google Scholar 

  • Garn SM, Haskell JA (1959) Fat changes during adolescence. Science 129:1615–1616

    Article  CAS  Google Scholar 

  • Gupta RK et al (2010) Transcriptional control of preadipocyte determination by Zfp423. Nature 464:619–623

    Article  CAS  Google Scholar 

  • Häger A, Sjöström L, Arvidsson B, Björntorp P, Smith U (1977) Body fat and adipose tissue cellularity in infants: a longitudinal study. Metabolism 26:607–614

    Article  Google Scholar 

  • Jernås M et al (2006) Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression. FASEB J Off Publ Fed Am Soc Exp Biol 20:1540–1542

    Google Scholar 

  • Kersten S (2001) Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Rep 2:282–286

    Article  CAS  Google Scholar 

  • Knittle JL, Timmers K, Ginsberg-Fellner F, Brown RE, Katz DP (1979) The growth of adipose tissue in children and adolescents. Cross-sectional and longitudinal studies of adipose cell number and size. J Clin Invest 63:239–246

    Article  CAS  Google Scholar 

  • Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117:175–184

    Article  CAS  Google Scholar 

  • McLaren DSA (1987) Fresh look at some perinatal growth and nutritional standards. In: Nutrition and the quality of life, Bd 49. Karger Publishers, Basel, S 87–120

    Google Scholar 

  • Napolitano L (1963) The differentiation of white adipose cells. An electron microscope study. J Cell Biol 18:663–679

    Article  CAS  Google Scholar 

  • Poissonnet CM, Burdi AR, Bookstein FL (1983) Growth and development of human adipose tissue during early gestation. Early Hum Dev 8:1–11

    Article  CAS  Google Scholar 

  • Poissonnet CM, Burdi AR, Garn SM (1984) The chronology of adipose tissue appearance and distribution in the human fetus. Early Hum Dev 10:1–11

    Article  CAS  Google Scholar 

  • Rodeheffer MS, Birsoy K, Friedman JM (2008) Identification of white adipocyte progenitor cells in vivo. Cell 135:240–249

    Article  CAS  Google Scholar 

  • Rosen ED, Spiegelman BM (2014) What we talk about when we talk about fat. Cell 156:20–44

    Article  CAS  Google Scholar 

  • Rydén M et al (2015) Transplanted bone marrow-derived cells contribute to human adipogenesis. Cell Metab 22:408–417

    Article  Google Scholar 

  • Spalding KL et al (2008) Dynamics of fat cell turnover in humans. Nature 453:783–787

    Article  CAS  Google Scholar 

  • Sun K, Tordjman J, Clément K, Scherer PE (2013) Fibrosis and adipose tissue dysfunction. Cell Metab 18:470–477

    Article  CAS  Google Scholar 

  • Tang QQ, Lane MD (2012) Adipogenesis: from stem cell to adipocyte. Annu Rev Biochem 81:715–736

    Article  CAS  Google Scholar 

  • Taylor RW, Jones IE, Williams SM, Goulding A (2002) Body fat percentages measured by dual-energy X-ray absorptiometry corresponding to recently recommended body mass index cutoffs for overweight and obesity in children and adolescents aged 3–18 y. Am J Clin Nutr 76:1416–1421

    Article  CAS  Google Scholar 

  • Traktuev DO et al (2009) Robust functional vascular network formation in vivo by cooperation of adipose progenitor and endothelial cells. Circ Res 104:1410–1420

    Article  CAS  Google Scholar 

  • Trayhurn P (2013) Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev 93:1–21

    Article  CAS  Google Scholar 

  • Wang F, Mullican SE, DiSpirito JR, Peed LC, Lazar MA (2013) Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR. Proc Natl Acad Sci 110:18656–18661

    Article  CAS  Google Scholar 

  • Weisberg SP et al (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–1808

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sektion Pädiatrische Endokrinologie u. Diabetologie, Universitätsklinik für Kinder- und Jugendmedizin, Ulm, Deutschland

    Pamela Fischer-Posovszky, Julian Roos, Jan-Bernd Funcke & Martin Wabitsch

Authors
  1. Pamela Fischer-Posovszky
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Julian Roos
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jan-Bernd Funcke
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Martin Wabitsch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pamela Fischer-Posovszky .

Editor information

Editors and Affiliations

  1. Sektion Pädiatrische Endokrinologie u. Diabetologie, Universitätsklinik für Kinder- und Jugendmedizin, Ulm, Deutschland

    Martin Wabitsch

  2. Kinder- und Jugendpsychiatrie, Rheinische Kliniken der Universität Duisburg-Essen, Essen, Deutschland

    Johannes Hebebrand

  3. Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Leipzig, Leipzig, Deutschland

    Wieland Kiess

  4. Endokrinologie und Diabetologie, Vestische Kinderklinik, Datteln, Deutschland

    Thomas Reinehr

  5. Sozialpädiatrisches Zentrum, Charité – Universitätsmedizin Berlin, Berlin, Deutschland

    Susanna Wiegand

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Fischer-Posovszky, P., Roos, J., Funcke, JB., Wabitsch, M. (2022). Entwicklung und Regulation des weißen Fettgewebes. In: Wabitsch, M., Hebebrand, J., Kiess, W., Reinehr, T., Wiegand, S. (eds) Adipositas bei Kindern und Jugendlichen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-59216-8_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-59216-8_12

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-59215-1

  • Online ISBN: 978-3-662-59216-8

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation