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Hemmstoffe des Renin-Angiotensin-Systems

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Arzneiverordnungs-Report 2017

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Zusammenfassung

ACE-Hemmer, Angiotensinrezeptorantagonisten und Renininhibitoren sind Hemmstoffe des Renin-Angiotensin-Systems. Wichtigster Mediator dieses Systems ist das stark vasokonstriktorisch wirkende Angiotensin II, das über Kurz- und Langzeiteffekte maßgeblich an der Blutdruckregulation beteiligt ist. Zusätzlich hat es zahlreiche indirekte Gefäßeffekte, da es die Freisetzung von Noradrenalin, die adrenale Aldosteronsynthese, die tubuläre Natriumrückresorption und die Bildung von Wachstumsfaktoren (Herzhypertrophie, Remodeling) erhöht.

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Authors and Affiliations

  1. Thiemannstraße 18, 45219, Essen, Deutschland

    Franz Weber

  2. Friedrich-Plettke-Weg 12, 27570, Bremerhaven, Deutschland

    Manfred Anlauf

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  1. Franz Weber
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Correspondence to Franz Weber .

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  1. Pharmakologisches Institut Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg, Deutschland

    Ulrich Schwabe

  2. Bachstraße 29, 50858, Köln, Deutschland

    Dieter Paffrath

  3. Arzneimittelkommission der deutschen Ärzteschaft, Herbert-Lewin-Platz 1, 10623, Berlin, Deutschland

    Wolf-Dieter Ludwig

  4. Wissenschaftliches Institut der AOK (WIdO), Rosenthaler Straße 31, 10178, Berlin, Deutschland

    Jürgen Klauber

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Weber, F., Anlauf, M. (2017). Hemmstoffe des Renin-Angiotensin-Systems. In: Schwabe, U., Paffrath, D., Ludwig, WD., Klauber, J. (eds) Arzneiverordnungs-Report 2017. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54630-7_8

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