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Hämatologische Probleme

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Neugeborenenintensivmedizin

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Zusammenfassung

Um Störungen des hämatopoietischen Systems bewerten zu können, müssen die alters- und reifespezifischen Referenzwerte bekannt sein. In diesem Kapitel werden Maßnahmen zur Verhinderung und Behandlung der bei Frühgeborenen regelhaft auftretenden Anämie beschrieben. Auf die Schwierigkeiten bei der Indikationsstellung und die Besonderheiten bei der Durchführung von Transfusionen in der Neonatalperiode wird eingegangen. Zu den durch konsequente Vitamin-K-Substitution leicht zu verhindernden Gerinnungsstörungen zählt der Morbus haemorrhagicus neonatorum. Thrombozytopenien sind in der Neonatalperiode häufig und müssen differenzialdiagnostisch abgeklärt werden.

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Literatur

  1. Aher SM, Ohlsson A (2014) Late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev:CD004868

    Google Scholar 

  2. Amin SC, Remon JI, Subbarao GC, Maheshwari A (2012) Association between red cell transfusions and necrotizing enterocolitis. J Matern Fetal Neonatal Med 25(Suppl 5):85–9

    Google Scholar 

  3. Andrew M, Paes B, Milner R, Johnston M, Mitchell L, Tollefsen DM, Castle V, Powers P (1988) Development of the human coagulation system in the healthy premature infant. Blood 72:1651–7

    Google Scholar 

  4. Backes CH, Rivera BK, Haque U, Bridge JA, Smith CV, Hutchon DJ, Mercer JS (2014) Placental transfusion strategies in very preterm neonates: a systematic review and meta-analysis. Obstet Gynecol 124:47–56

    Google Scholar 

  5. Bakchoul T, Bassler D, Heckmann M, Thiele T, Kiefel V, Gross I, Arnold DM, DiTomasso J, Smith JW, Paes B, Greinacher A (2014) Management of infants born with severe neonatal alloimmune thrombocytopenia: the role of platelet transfusions and intravenous immunoglobulin. Transfusion 54:640–5

    Google Scholar 

  6. Bell EF, Strauss RG, Widness JA, Mahoney LT, Mock DM, Seward VJ, Cress GA, Johnson KJ, Kromer IJ, Zimmerman MB (2005) Randomized trial of liberal versus restrictive guidelines for red blood cell transfusion in preterm infants. Pediatrics 115:1685–91

    Google Scholar 

  7. Brunskill SJ, Wilkinson KL, Doree C, Trivella M, Stanworth S (2015) Transfusion of fresher versus older red blood cells for all conditions. Cochrane Database Syst Rev:CD010801

    Google Scholar 

  8. Chinnadurai S, Fonnesbeck C, Snyder KM, Sathe NA, Morad A, Likis FE, McPheeters ML (2016) Pharmacologic Interventions for Infantile Hemangioma: A Meta-analysis. Pediatrics 137:e20153896

    Google Scholar 

  9. Del Vecchio A (2014) Evaluation and management of thrombocytopenic neonates in the intensive care unit. Early Hum Dev 90 Suppl 2:S51–5

    Google Scholar 

  10. De Waal KA, Baerts W, Offringa M (2006) Systematic review of the optimal fluid for dilutional exchange transfusion in neonatal polycythaemia. Arch Dis Child Fetal Neonatal Ed 91:F7–10

    Google Scholar 

  11. Drolet BA, Frommelt PC, Chamlin SL, Haggstrom A, Bauman NM, Chiu YE, Chun RH, Garzon MC, Holland KE, Liberman L, MacLellan-Tobert S, Mancini AJ, Metry D, Puttgen KB, Seefeldt M, Sidbury R, Ward KM, Blei F, Baselga E, Cassidy L, Darrow DH, Joachim S, Kwon EK, Martin K, Perkins J, Siegel DH, Boucek RJ, Frieden IJ (2013) Initiation and use of propranolol for infantile hemangioma: report of a consensus conference. Pediatrics 131:128–40

    Google Scholar 

  12. Forestier F, Daffos F, Catherine N, Renard M, Andreux JP (1991) Developmental hematopoiesis in normal human fetal blood. Blood 77:2360–3

    Google Scholar 

  13. Jaffray J, Young G, Ko RH (2016) The bleeding newborn: A review of presentation, diagnosis, and management. Semin Fetal Neonatal Med 21:44–9

    Google Scholar 

  14. John CM, Harkensee C (2005) Thrombolytic agents for arterial and venous thromboses in neonates. Cochrane Database Syst Rev:CD004342

    Google Scholar 

  15. Kaplan C (2001) Immune thrombocytopenia in the foetus and the newborn: diagnosis and therapy. Transfus Clin Biol 8:311–4

    Google Scholar 

  16. Keir AK, Wilkinson D, Andersen C, Stark MJ (2016) Washed versus unwashed red blood cells for transfusion for the prevention of morbidity and mortality in preterm infants. Cochrane Database Syst Rev:CD011484

    Google Scholar 

  17. Kirpalani H, Whyte RK, Andersen C, Asztalos EV, Heddle N, Blajchman MA, Peliowski A, Rios A, LaCorte M, Connelly R, Barrington K, Roberts RS (2006) The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 149:301–7

    Google Scholar 

  18. Kleihauer E, Hildegard B, Betke K (1957) Demonstration von fetalem Hämoglobin in den Erythrozyten eines Blutausstrichs. Klinische Wochenschrift 35:637–8

    Google Scholar 

  19. Maier RF, Obladen M, Muller-Hansen I, Kattner E, Merz U, Arlettaz R, Groneck P, Hammer H, Kossel H, Verellen G, Stock GJ, Lacaze-Masmonteil T, Claris O, Wagner M, Matis J, Gilberg F (2002) Early treatment with erythropoietin beta ameliorates anemia and reduces transfusion requirements in infants with birth weights below 1000 g. J Pediatr 141:8–15

    Google Scholar 

  20. Maier RF, Sonntag J, Walka MM, Liu G, Metze BC, Obladen M (2000) Changing practices of red blood cell transfusions in infants with birth weights less than 1000 g. J Pediatr 136:220–4

    Google Scholar 

  21. Maier RF, Obladen M, Scigalla P, Linderkamp O, Duc G, Hieronimi G, Halliday HL, Versmold HT, Moriette G, Jorch G et al. (1994) The effect of epoetin beta (recombinant human erythropoietin) on the need for transfusion in very-low-birth-weight infants. European Multicentre Erythropoietin Study Group. N Engl J Med 330:1173–8

    Google Scholar 

  22. March MI, Hacker MR, Parson AW, Modest AM, de Veciana M (2013) The effects of umbilical cord milking in extremely preterm infants: a randomized controlled trial. J Perinatol 33:763–7

    Google Scholar 

  23. Mills RJ, Davies MW (2012) Enteral iron supplementation in preterm and low birth weight infants. Cochrane Database Syst Rev:CD005095

    Google Scholar 

  24. Mouzinho A, Rosenfeld CR, Sanchez PJ, Risser R (1994) Revised reference ranges for circulating neutrophils in very-low-birth-weight neonates. Pediatrics 94:76–82

    Google Scholar 

  25. Nathan DG, Orkin SH, Look AT (2003) Nathan and Oski´s Hematology of infancy and childhood. 6th Ed. WB Saunders, Philadelphia

    Google Scholar 

  26. Nowak-Göttl U, Auberger K, Halimeh S, Junker R, Klinge J, Kreuz WD, Ries M, Schlegel N (1999) Thrombolysis in newborns and infants. Thromb Haemost 82 Suppl 1:112–6

    Google Scholar 

  27. Obladen M, Diepold K, Maier RF (2000) Venous and arterial hematologic profiles of very low birth weight infants. European Multicenter rhEPO Study Group. Pediatrics 106:707–11

    Google Scholar 

  28. Obladen M, Sachsenweger M, Stahnke M (1988) Blood sampling in very low birth weight infants receiving different levels of intensive care. Eur J Pediatr 147:399–404

    Google Scholar 

  29. Ohls RK, Christensen RD, Kamath-Rayne BD, Rosenberg A, Wiedmeier SE, Roohi M, Lacy CB, Lambert DK, Burnett JJ, Pruckler B, Schrader R, Lowe JR (2013) A randomized, masked, placebo-controlled study of darbepoetin alfa in preterm infants. Pediatrics 132:e119–27

    Google Scholar 

  30. Ohlsson A, Aher SM (2014) Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev:CD004863

    Google Scholar 

  31. Ovadia SA, Landy DC, Cohen ER, Yang EY, Thaller SR (2015) Local administration of β-blockers for infantile hemangiomas: a systematic review and meta-analysis. Ann Plast Surg 74:256–62

    Google Scholar 

  32. Özek E, Soll R, Schimmel MS (2010) Partial exchange transfusion to prevent neurodevelopmental disability in infants with polycythemia. Cochrane Database Syst Rev:CD005089

    Google Scholar 

  33. Patel RM, Knezevic A, Shenvi N, Hinkes M, Keene S, Roback JD, Easley KA, Josephson CD (2016) Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis in Very Low-Birth-Weight Infants. JAMA 315:889–97

    Google Scholar 

  34. Paul DA, Mackley A, Novitsky A, Zhao Y, Brooks A, Locke RG (2011) Increased odds of necrotizing enterocolitis after transfusion of red blood cells in premature infants. Pediatrics 127:635–41

    Google Scholar 

  35. Pereira SP, Shearer MJ, Williams R, Mieli-Vergani G (2003) Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding. Arch Dis Child Fetal Neonatal Ed 88:F113–8

    Google Scholar 

  36. Puckett RM, Offringa M (2000) Prophylactic vitamin K for vitamin K deficiency bleeding in neonates. Cochrane Database Syst Rev:CD002776

    Google Scholar 

  37. Rabe H, Diaz-Rossello JL, Duley L, Dowswell T (2012) Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes. Cochrane Database Syst Rev:CD003248

    Google Scholar 

  38. Rabe H, Jewison A, Alvarez RF, Crook D, Stilton D, Bradley R, Holden D; Brighton Perinatal Study Group (2011) Milking compared with delayed cord clamping to increase placental transfusion in preterm neonates: a randomized controlled trial. Obstet Gynecol 117:205–11

    Google Scholar 

  39. Rayment R, Brunskill SJ, Soothill PW, Roberts DJ, Bussel JB, Murphy MF (2011). Antenatal interventions for fetomaternal alloimmune thrombocytopenia. Cochrane Database Syst Rev:CD004226

    Google Scholar 

  40. Roberts I, Stanworth S, Murray NA (2008) Thrombocytopenia in the neonate. Blood Rev 22:173–86

    Google Scholar 

  41. Schelonka RL, Yoder BA, desJardins SE, Hall RB, Butler J (1994) Peripheral leukocyte count and leukocyte indexes in healthy newborn term infants. J Pediatr 125:603–6

    Google Scholar 

  42. te Pas AB, Lopriore E, van den Akker ES, Oepkes D, Kanhai HH, Brand A, Walther FJ (2007) Postnatal management of fetal and neonatal alloimmune thrombocytopenia: the role of matched platelet transfusion and IVIG. Eur J Pediatr 166:1057–63

    Google Scholar 

  43. Van Winckel M, De Bruyne R, Van De Velde S, Van Biervliet S (2009) Vitamin K, an update for the paediatrician. Eur J Pediatr 168:127–34

    Google Scholar 

  44. Walka MM, Sonntag J, Kage A, Dudenhausen JW, Obladen M (1998) Complete blood counts from umbilical cords of healthy term newborns by two automated cytometers. Acta Haematol 100:167–73

    Google Scholar 

  45. Whyte R, Kirpalani H (2011) Low versus high haemoglobin concentration threshold for blood transfusion for preventing morbidity and mortality in very low birth weight infants. Cochrane Database Syst Rev:CD000512

    Google Scholar 

  46. Whyte RK, Kirpalani H, Asztalos EV, Andersen C, Blajchman M, Heddle N, LaCorte M, Robertson CM, Clarke MC, Vincer MJ, Doyle LW, Roberts RS (2009) Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion. Pediatrics 123:207–13

    Google Scholar 

  47. Xanthou M, Bracci R, Prindull G (eds) (1993) Neonatal haematology and immunology II. Elsevier, Amsterdam

    Google Scholar 

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Authors and Affiliations

  1. Zentrum für Kinder- und Jugendmedizin, Universitätsklinikum Marburg, Baldingerstraße, 35043, Marburg

    Prof. Dr. Rolf F. Maier

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  1. Prof. Dr. Rolf F. Maier
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Maier, R. (2017). Hämatologische Probleme. In: Neugeborenenintensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53576-9_12

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  • DOI: https://doi.org/10.1007/978-3-662-53576-9_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-53575-2

  • Online ISBN: 978-3-662-53576-9

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