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Akute metabolische Entgleisungen

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Neugeborenenintensivmedizin

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Zusammenfassung

Hypoglykämien zählen zu den häufigsten Stoffwechselentgleisungen in der Neonatalperiode. Frühzeitiges Erkennung, angemessene Überwachung von Risikokindern und adäquate Behandlung tragen dazu bei, spätere Behinderungen zu vermeiden. Angeborene Stoffwechselstörungen sind selten, stellen aber häufig Notfallsituationen dar, die schnelles Handeln erfordern. Typische Leitsymptome und typische Laborkonstellationen helfen differenzialdiagnostisch weiter und erlauben eine adäquate Notfalltherapie.

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Literatur

  1. Adzick NS, Thornton PS, Stanley CA, Kaye RD, Ruchelli E (2004) A multidisciplinary approach to the focal form of congenital hyperinsulinism leads to successful treatment by partial pancreatectomy. J Pediatr Surg 39:270–5

    Google Scholar 

  2. Alkalay AL, Sarnat HB, Flores-Sarnat L, Elashoff JD, Farber SJ, Simmons CF (2006) Population meta-analysis of low plasma glucose thresholds in full-term normal newborns. Am J Perinatol 23:115–9

    Google Scholar 

  3. Arbeiter AK, Kranz B, Wingen AM, Bonzel KE, Dohna-Schwake C, Hanssler L, Neudorf U, Hoyer PF, Buscher R (2010) Continuous venovenous haemodialysis (CVVHD) and continuous peritoneal dialysis (CPD) in the acute management of 21 children with inborn errors of metabolism. Nephrol Dial Transplant 25:1257–65

    Google Scholar 

  4. Arnoux JB, de Lonlay P, Ribeiro MJ, Hussain K, Blankenstein O, Mohnike K, Valayannopoulos V, Robert JJ, Rahier J, Sempoux C, Bellanné C, Verkarre V, Aigrain Y, Jaubert F, Brunelle F, Nihoul-Fékété C (2010) Congenital hyperinsulinism. Early Hum Dev 86:287–94

    Google Scholar 

  5. Bottino M, Cowett RM, Sinclair JC (2011) Interventions for treatment of neonatal hyperglycemia in very low birth weight infants. Cochrane Database Syst Rev: CD007453

    Google Scholar 

  6. Committee on Fetus and Newborn, Adamkin DH (2011) Postnatal glucose homeostasis in late-preterm and term infants. Pediatrics 127:575–9

    Google Scholar 

  7. Christodoulou J, Wilcken B (2004) Perimortem laboratory investigation of genetic metabolic disorders. Semin Neonatol 9:275–80

    Google Scholar 

  8. Crowther CA, Hiller JE, Moss JR, McPhee AJ, Jeffries WS, Robinson JS (2005) Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med 352:2477–86

    Google Scholar 

  9. Gemeinsamer Bundesausschuss (2016) Richtlinie über die Früherkennung von Krankheiten bei Kindern bis zur Vollendung des 6. Lebensjahres (Kinder-Richtlinie) zuletzt geändert am 18. Juni 2015 veröffentlicht im Bundesanzeiger AT 18.08.2016 B1

    Google Scholar 

  10. Häberle J, Boddaert N, Burlina A, Chakrapani A, Dixon M, Huemer M, Karall D, Martinelli D, Crespo PS, Santer R, Servais A, Valayannopoulos V, Lindner M, Rubio V, Dionisi-Vici C (2012) Suggested guidelines for the diagnosis and management of urea cycle disorders. Orphanet J Rare Dis 7:32

    Google Scholar 

  11. Harris DL, Alsweiler JM, Ansell JM, Gamble GD, Thompson B, Wouldes TA, Yu TY, Harding JE; Children with Hypoglycaemia and their Later Development (CHYLD) Study Team (2016) Outcome at 2 Years after Dextrose Gel Treatment for Neonatal Hypoglycemia: Follow-Up of a Randomized Trial. J Pediatr 170:54–9.e1–2

    Google Scholar 

  12. Jensen DM, Korsholm L, Ovesen P, Beck-Nielsen H, Moelsted-Pedersen L, Westergaard JG, Moeller M, Damm P (2009) Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes. Diabetes Care 32:1046–8

    Google Scholar 

  13. McKinlay CJ, Alsweiler JM, Ansell JM, Anstice NS, Chase JG, Gamble GD, Harris DL, Jacobs RJ, Jiang Y, Paudel N, Signal M, Thompson B, Wouldes TA, Yu TY, Harding JE; CHYLD Study Group (2015) Neonatal Glycemia and Neurodevelopmental Outcomes at 2 Years. N Engl J Med 373:1507–18

    Google Scholar 

  14. Prietsch V, Lindner M, Zschocke J, Nyhan WL, Hoffmann GF (2002) Emergency management of inherited metabolic diseases. J Inherit Metab Dis 25:531–46

    Google Scholar 

  15. Rozance PJ, Hay WW Jr (2016) New approaches to management of neonatal hypoglycemia. Matern Health Neonatol Perinatol 2:3

    Google Scholar 

  16. Saudubray JM, Sedel F, Walter JH (2006) Clinical approach to treatable inborn metabolic diseases: an introduction. J Inherit Metab Dis 29:261–74.

    Google Scholar 

  17. Sinclair JC, Bottino M, Cowett RM (2011) Interventions for prevention of neonatal hyperglycemia in very low birth weight infants. Cochrane Database Syst Rev:CD007615

    Google Scholar 

  18. Waisbren SE, Gropman AL; Members of the Urea Cycle Disorders Consortium (UCDC), Batshaw ML (2016) Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium. J Inherit Metab Dis 39:573–84

    Google Scholar 

  19. Weston PJ, Harris DL, Battin M, Brown J, Hegarty JE, Harding JE (2016) Oral dextrose gel for the treatment of hypoglycaemia in newborn infants. Cochrane Database Syst Rev:CD011027

    Google Scholar 

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Authors and Affiliations

  1. Zentrum für Kinder- und Jugendmedizin, Universitätsklinikum Marburg, Baldingerstraße, 35043, Marburg

    Prof. Dr. Rolf F. Maier

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  1. Prof. Dr. Rolf F. Maier
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Maier, R. (2017). Akute metabolische Entgleisungen. In: Neugeborenenintensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53576-9_11

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  • DOI: https://doi.org/10.1007/978-3-662-53576-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-53575-2

  • Online ISBN: 978-3-662-53576-9

  • eBook Packages: Medicine (German Language)

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