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Erkrankungen des Nervensystems

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Neugeborenenintensivmedizin

Zusammenfassung

Schädigungsmechanismen des unreifen Gehirns werden zunehmend besser verstanden, wodurch sich auch Möglichkeiten zu ihrer Verhinderung eröffnen. Die therapeutische Hypothermie hat sich als wirksame Methode zur Neuroprotektion bei hypoxisch-ischämischer Enzephalopathie erwiesen. In diesem Kapitel werden verschiedene diagnostische Möglichkeiten zur Beurteilung der neurologischen Funktion dargestellt. Klinische Erscheinungsformen und therapeutisches Vorgehen bei Fehlbildungen des zentralen Nervensystems, bei zerebralen Krampfanfällen, bei neonatalem Drogenentzug sowie bei intrakraniellen Blutungen werden beschrieben.

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Literatur

  1. Alvaro RE, Khalil M, Qurashi M, Al-Saif S, Al-Matary A, Chiu A, Minski J, Manfreda J, Kwiatkowski K, Cates D, Rigatto H (2012) CO(2) inhalation as a treatment for apnea of prematurity: a randomized double-blind controlled trial. J Pediatr 160:252–257.e1

    Google Scholar 

  2. Azzopardi D (2015) Clinical applications of cerebral function monitoring in neonates. Semin Fetal Neonatal Med 20:154–63

    Google Scholar 

  3. Badhiwala JH, Hong CJ, Nassiri F, Hong BY, Riva-Cambrin J, Kulkarni AV (2015) Treatment of posthemorrhagic ventricular dilation in preterm infants: a systematic review and meta-analysis of outcomes and complications. J Neurosurg Pediatr 28:1–11

    Google Scholar 

  4. Bain E, Middleton P, Crowther CA. Different magnesium sulphate regimens for neuroprotection of the fetus for women at risk of preterm birth. Cochrane Database Syst Rev:CD009302

    Google Scholar 

  5. Bajanowski T, Poets CF (2004) Der plötzliche Säuglingstod: Epidemiologie, Ätiologie, Pathophysiologie und Differentialdiagnostik. Dtsch Arztebl 101: A 3185/B 2695

    Google Scholar 

  6. Bittigau P, Sifringer M, Ikonomidou C (2003) Antiepileptic drugs and apoptosis in the developing brain. Ann N Y Acad Sci 993:103–14

    Google Scholar 

  7. Blair PS, Sidebotham P, Berry PJ, Evans M, Fleming PJ (2006) Major epidemiological changes in sudden infant death syndrome: a 20-year population-based study in the UK. Lancet 367:314–9

    Google Scholar 

  8. Bohnhorst B, Cech K, Peter C, Doerdelmann M (2010) Oral versus nasal route for placing feeding tubes: no effect on hypoxemia and bradycardia in infants with apnea of prematurity. Neonatology 98:143–9

    Google Scholar 

  9. Booth D, Evans DJ (2004) Anticonvulsants for neonates with seizures. Cochrane Database Syst Rev:CD004218

    Google Scholar 

  10. Bredemeyer SL, Foster JP (2012) Body positioning for spontaneously breathing preterm infants with apnoea. Cochrane Database Syst Rev:CD004951

    Google Scholar 

  11. Brouwer MJ, de Vries LS, Groenendaal F, Koopman C, Pistorius LR, Mulder EJ, Benders MJ (2012) New reference values for the neonatal cerebral ventricles. Radiology 262:224–33

    Google Scholar 

  12. Bruschettini M, Romantsik O, Zappettini S, Banzi R, Ramenghi LA, Calevo MG (2016) Heparin for the prevention of intraventricular haemorrhage in preterm infants. Cochrane Database Syst Rev: CD011718

    Google Scholar 

  13. Bruschettini M, Romantsik O, Zappettini S, Banzi R, Ramenghi L, Calevo M (2016) Antithrombin for the prevention of intraventricular hemorrhage in very preterm infants. Cochrane Database Syst Rev: CD011636

    Google Scholar 

  14. Chaudhari T, McGuire W (2012) Allopurinol for preventing mortality and morbidity in newborn infants with hypoxic-ischaemic encephalopathy. Cochrane Database Syst Rev: CD006817

    Google Scholar 

  15. Crowther CA, Crosby DD (2010) Vitamin K prior to preterm birth for preventing neonatal periventricular haemorrhage. Cochrane Database Syst Rev: CD000229

    Google Scholar 

  16. Crowther CA, Crosby DD (2010) Phenobarbital prior to preterm birth for preventing neonatal periventricular haemorrhage. Cochrane Database Syst Rev: CD000164

    Google Scholar 

  17. Czaba-Hnizdo C, Olischar M, Rona Z, Weninger M, Berger A, Klebermass-Schrehof K (2014) Amplitude-integrated electroencephalography shows that doxapram influences the brain activity of preterm infants. Acta Paediatr 103:922–7

    Google Scholar 

  18. Dammann O, Leviton A (1998) Infection remote from the brain, neonatal white matter damage, and cerebral palsy in the preterm infant. Semin Pediatr Neurol 5:190–201

    Google Scholar 

  19. Dani C, Bertini G, Pezzati M, Pratesi S, Filippi L, Tronchin M, Rubaltelli FF (2006) Brain hemodynamic effects of doxapram in preterm infants. Biol Neonate 89:69–74

    Google Scholar 

  20. Darnall RA, Kattwinkel J, Nattie C, Robinson M (1997) Margin of safety for discharge after apnea in preterm infants. Pediatrics 100:795–801

    Google Scholar 

  21. Davis PG, Henderson-Smart DJ (2003) Nasal continuous positive airways pressure immediately after extubation for preventing morbidity in preterm infants. Cochrane Database Syst Rev:CD000143

    Google Scholar 

  22. Deeg KH, Staudt F, von Rohden L (1999) Klassifikation der intrakraniellen Blutungen des Frühgeborenen. Ultraschall Med 20:165–70

    Google Scholar 

  23. Doyle LW, Schmidt B, Anderson PJ, Davis PG, Moddemann D, Grunau RE, O’Brien K, Sankaran K, Herlenius E, Roberts R; Caffeine for Apnea of Prematurity Trial investigators (2014) Reduction in developmental coordination disorder with neonatal caffeine therapy. J Pediatr 165:356–359.e2

    Google Scholar 

  24. Doyle LW, Crowther CA, Middleton P, Marret S, Rouse D (2009) Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus. Cochrane Database Syst Rev:CD004661

    Google Scholar 

  25. Felderhoff-Mueser U, Bittigau P, Sifringer M, Jarosz B, Korobowicz E, Mahler L, Piening T, Moysich A, Grune T, Thor F, Heumann R, Buhrer C, Ikonomidou C (2004) Oxygen causes cell death in the developing brain. Neurobiol Dis 17:273–82

    Google Scholar 

  26. Finnegan LP (1985) Neonatal abstinence. In: Nelson NM (Hrsg) Current therapy in neonatal-perinatal medicine. Mosby, St. Louis

    Google Scholar 

  27. Fowlie PW, Davis PG, McGuire W (2010) Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants. Cochrane Database Syst Rev:CD000174

    Google Scholar 

  28. Gerstner B, DeSilva TM, Genz K, Armstrong A, Brehmer F, Neve RL, Felderhoff-Mueser U, Volpe JJ, Rosenberg PA (2008) Hyperoxia causes maturation-dependent cell death in the developing white matter. J Neurosci 28:1236–45

    Google Scholar 

  29. Grivell RM, Andersen C, Dodd JM (2014) Prenatal versus postnatal repair procedures for spina bifida for improving infant and maternal outcomes. Cochrane Database Syst Rev:CD008825

    Google Scholar 

  30. Hellström-Westas L, Boylan G, Ågren J (2015) Systematic review of neonatal seizure management strategies provides guidance on anti-epileptic treatment. Acta Paediatr 104:123–9

    Google Scholar 

  31. Henderson-Smart DJ, De Paoli AG (2010) Prophylactic methylxanthine for prevention of apnoea in preterm infants. Cochrane Database Syst Rev:CD000432

    Google Scholar 

  32. Henderson-Smart DJ, Steer PA (2010) Caffeine versus theophylline for apnea in preterm infants. Cochrane Database Syst Rev:CD000273

    Google Scholar 

  33. Henderson-Smart DJ, De Paoli AG (2010) Methylxanthine treatment for apnoea in preterm infants. Cochrane Database Syst Rev:CD000140

    Google Scholar 

  34. Henderson-Smart DJ, Steer P (2004) Doxapram treatment for apnea in preterm infants. Cochrane Database Syst Rev:CD000074

    Google Scholar 

  35. Henderson-Smart DJ, Osborn DA (2002) Kinesthetic stimulation for preventing apnea in preterm infants. Cochrane Database Syst Rev:CD000373

    Google Scholar 

  36. Heuchan AM, Evans N, Henderson Smart DJ, Simpson JM (2002) Perinatal risk factors for major intraventricular haemorrhage in the Australian and New Zealand Neonatal Network, 1995–97. Arch Dis Child Fetal Neonatal Ed 86:F86–90

    Google Scholar 

  37. Hummler HD, Poets CF, Vochem M, Hentschel R, Linderkamp O (2006) Mortalität und Morbidität sehr unreifer Frühgeborener in Baden-Württemberg in Abhängigkeit von der Klinikgröße. Ist der derzeitige Grad der Regionalisierung ausreichend? Z Geburtsh Neonatol 210:6–11

    Google Scholar 

  38. Interiano RB, Davidoff AM (2015) Current Management of Neonatal Neuroblastoma. Curr Pediatr Rev 11:179–87

    Google Scholar 

  39. Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG (2013) Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev:CD003311

    Google Scholar 

  40. Kecskes Z, Healy G, Jensen A (2005) Fluid restriction for term infants with hypoxic-ischaemic encephalopathy following perinatal asphyxia. Cochrane Database Syst Rev:CD004337

    Google Scholar 

  41. Klinger G, Beyene J, Shah P, Perlman M (2005) Do hyperoxaemia and hypocapnia add to the risk of brain injury after intrapartum asphyxia? Arch Dis Child Fetal Neonatal Ed 90:F49–52

    Google Scholar 

  42. Kocherlakota P (2014) Neonatal abstinence syndrome. Pediatrics 134:e547–61

    Google Scholar 

  43. Lemyre B, Davis PG, de Paoli AG (2002) Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for apnea of prematurity. Cochrane Database Syst Rev:CD002272

    Google Scholar 

  44. Leuchter RH, Gui L, Poncet A, Hagmann C, Lodygensky GA, Martin E, Koller B, Darqué A, Bucher HU, Hüppi PS (2014) Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age. JAMA 312:817–24

    Google Scholar 

  45. Leviton A, Allred EN, Fichorova RN, Kuban KC, Michael O’Shea T, Dammann O; ELGAN study investigators (2016) Systemic inflammation on postnatal days 21 and 28 and indicators of brain dysfunction 2years later among children born before the 28th week of gestation. Early Hum Dev 93:25–32

    Google Scholar 

  46. Leviton A, Fichorova RN, O’Shea TM, Kuban K, Paneth N, Dammann O, Allred EN; ELGAN Study Investigators (2013) Two-hit model of brain damage in the very preterm newborn: small for gestational age and postnatal systemic inflammation. Pediatr Res 73:362–70

    Google Scholar 

  47. Li AH, Armstrong D, terBrugge KG (2011) Endovascular treatment of vein of Galen aneurysmal malformation: management strategy and 21-year experience in Toronto. J Neurosurg Pediatr 7:3–10

    Google Scholar 

  48. Lobo N, Yang B, Rizvi M, Ma D (2013) Hypothermia and xenon: novel noble guardians in hypoxic-ischemic encephalopathy? J Neurosci Res 91:473–8

    Google Scholar 

  49. Natalucci G, Latal B, Koller B, Rüegger C, Sick B, Held L, Bucher HU, Fauchère JC; Swiss EPO Neuroprotection Trial Group (2016) Effect of Early Prophylactic High-Dose Recombinant Human Erythropoietin in Very Preterm Infants on Neurodevelopmental Outcome at 2 Years: A Randomized Clinical Trial. JAMA 315:2079–85

    Google Scholar 

  50. Nguyen TM, Crowther CA, Wilkinson D, Bain E (2013) Magnesium sulphate for women at term for neuroprotection of the fetus. Cochrane Database Syst Rev:CD009395

    Google Scholar 

  51. Obladen M, Metze B, Henrich W, Aktas A, Czernik C, Schulz-Baldes A (2008) Interdisciplinary surveillance of intraventricular haemorrhage associated conditions in infants <1000 g. Acta Paediatr 97:731–7

    Google Scholar 

  52. Obladen M (2007) Mindestmengen in der Versorgung sehr untergewichtiger Frühgeborener: Eine Literaturübersicht. Z Geburtshilfe Neonatol 211:110–7

    Google Scholar 

  53. Osborn DA, Jeffery HE, Cole MJ (2010) Opiate treatment for opiate withdrawal in newborn infants. Cochrane Database Syst Rev:CD002059

    Google Scholar 

  54. Osborn DA, Jeffery HE, Cole MJ (2010) Sedatives for opiate withdrawal in newborn infants. Cochrane Database Syst Rev:CD002053

    Google Scholar 

  55. Osborn DA, Henderson-Smart DJ (2000) Kinesthetic stimulation versus theophylline for apnea in preterm infants. Cochrane Database Syst Rev:CD000502

    Google Scholar 

  56. Papile L, Burstein J, Burstein R, Koffer H (1978) Incidence and evolution of subependymal and intraventricular hemorrhage. A study of infants with birth weight less than 1500 grams. J Pediatr 92:529 –34

    Google Scholar 

  57. Peranteau WH, Adzick NS (2016) Prenatal surgery for myelomeningocele. Curr Opin Obstet Gynecol 28:111–8

    Google Scholar 

  58. Pin TW, Eldridge B, Galea MP (2009) A review of developmental outcomes of term infants with post-asphyxia neonatal encephalopathy. Eur J Paediatr Neurol 13:224–34

    Google Scholar 

  59. Pisani F, Piccolo B, Cantalupo G, Copioli C, Fusco C, Pelosi A, Tassinari CA, Seri S (2012) Neonatal seizures and postneonatal epilepsy: a 7-y follow-up study. Pediatr Res 72:186–93

    Google Scholar 

  60. Poets CF, Roberts RS, Schmidt B, Whyte RK, Asztalos EV, Bader D, Bairam A, Moddemann D, Peliowski A, Rabi Y, Solimano A, Nelson H; Canadian Oxygen Trial Investigators (2015) Association Between Intermittent Hypoxemia or Bradycardia and Late Death or Disability in Extremely Preterm Infants. JAMA 314:595–603

    Google Scholar 

  61. Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S; NEonatal seizure treatment with Medication Off-patent (NEMO) consortium (2015) Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurol 14:469–77

    Google Scholar 

  62. Rabe H, Diaz-Rossello JL, Duley L, Dowswell T (2012) Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes. Cochrane Database Syst Rev:CD003248

    Google Scholar 

  63. Rakshasbhuvankar A, Paul S, Nagarajan L, Ghosh S, Rao S (2015) Amplitude-integrated EEG for detection of neonatal seizures: a systematic review. Seizure 33:90–8

    Google Scholar 

  64. Ramantani G, Ikonomidou C, Walter B, Rating D, Dinger J (2011) Levetiracetam: safety and efficacy in neonatal seizures. Eur J Paediatr Neurol 15:1–7

    Google Scholar 

  65. Riesgo R, Winckler MI, Ohlweiler L, Ranzan J, Becker M, Salvador S, Magalhaes L, Ribeiro R (2012). Treatment of refractory neonatal seizures with topiramate. Neuropediatrics 43:353–6

    Google Scholar 

  66. Roberts D, Dalziel S (2006) Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev:CD004454

    Google Scholar 

  67. Roll C, Horsch S (2004) Effect of doxapram on cerebral blood flow velocity in preterm infants. Neuropediatrics 35:126–9

    Google Scholar 

  68. Salhab WA, Wyckoff MH, Laptook AR, Perlman JM (2004) Initial hypoglycemia and neonatal brain injury in term infants with severe fetal acidemia. Pediatrics 114:361–6

    Google Scholar 

  69. Sarkar S, Bhagat I, Dechert R, Schumacher RE, Donn SM (2009) Severe intraventricular hemorrhage in preterm infants: comparison of risk factors and short-term neonatal morbidities between grade 3 and grade 4 intraventricular hemorrhage. Am J Perinatol 26:419–24

    Google Scholar 

  70. Sarnat HB, Sarnat MS (1976) Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch Neurol 33:696–705

    Google Scholar 

  71. Schmidt B, Anderson PJ, Doyle LW, Dewey D, Grunau RE, Asztalos EV, Davis PG, Tin W, Moddemann D, Solimano A, Ohlsson A, Barrington KJ, Roberts RS; Caffeine for Apnea of Prematurity (CAP) Trial Investigators (2012) Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity. JAMA 307:275–82

    Google Scholar 

  72. Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, Solimano A, Tin W (2007) Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med 357:1893–902

    Google Scholar 

  73. Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, Solimano A, Tin W (2006) Caffeine therapy for apnea of prematurity. N Engl J Med 354:2112–21

    Google Scholar 

  74. Smit E, Odd D, Whitelaw A (2013) Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants. Cochrane Database Syst Rev:CD001691

    Google Scholar 

  75. Sood BG, McLaughlin K, Cortez J (2015) Near-infrared spectroscopy: applications in neonates. Semin Fetal Neonatal Med 20:164–72

    Google Scholar 

  76. Synnes AR, Macnab YC, Qiu Z, Ohlsson A, Gustafson P, Dean CB, Lee SK; Canadian Neonatal Network (2006) Neonatal intensive care unit characteristics affect the incidence of severe intraventricular hemorrhage. Med Care 44:754–9

    Google Scholar 

  77. Ten Hove CH, Vliegenthart RJ, Te Pas AB, Brouwer E, Rijken M, van Wassenaer-Leemhuis AG, van Kaam AH, Onland W (2016) Long-Term Neurodevelopmental Outcome after Doxapram for Apnea of Prematurity. Neonatology 110:21–6

    Google Scholar 

  78. Thompson CM, Puterman AS, Linley LL, Hann FM, van der Elst CW, Molteno CD, Malan AF (1997) The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome. Acta Paediatr 86:757–61

    Google Scholar 

  79. Toet MC, Hellstrom-Westas L, Groenendaal F, Eken P, de Vries LS (1999) Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 81:F19–23

    Google Scholar 

  80. Tulipan N, Wellons JC 3rd, Thom EA, Gupta N, Sutton LN, Burrows PK, Farmer D, Walsh W, Johnson MP, Rand L, Tolivaisa S, D’alton ME, Adzick NS; MOMS Investigators (2015) Prenatal surgery for myelomeningocele and the need for cerebrospinal fluid shunt placement. J Neurosurg Pediatr 16:613–20

    Google Scholar 

  81. Van Handel M, Swaab H, de Vries LS, Jongmans MJ (2007) Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review. Eur J Pediatr 166:645–54

    Google Scholar 

  82. Whitelaw A, Aquilina K (2012) Management of posthaemorrhagic ventricular dilatation. Arch Dis Child Fetal Neonatal Ed 97:F229–3

    Google Scholar 

  83. Whitelaw A, Odd D (2007) Intraventricular streptokinase after intraventricular hemorrhage in newborn infants. Cochrane Database Syst Rev:CD000498

    Google Scholar 

  84. Whitelaw A, Kennedy CR, Brion LP (2001) Diuretic therapy for newborn infants with posthemorrhagic ventricular dilatation. Cochrane Database Syst Rev:CD002270

    Google Scholar 

  85. Whitelaw A (2001) Repeated lumbar or ventricular punctures in newborns with intraventricular hemorrhage. Cochrane Database Syst Rev:CD000216

    Google Scholar 

  86. Wiese-Posselt M, Tertilt C, Zepp F (2011) Impfempfehlungen für Deutschland. Deutsches Ärzteblatt 108: 771–780

    Google Scholar 

  87. Wilson RD; Genetics Committee, Wilson RD, Audibert F, Brock JA, Carroll J, Cartier L, Gagnon A, Johnson JA, Langlois S, Murphy-Kaulbeck L, Okun N, Pastuck M; Special Contributors, Deb-Rinker P, Dodds L, Leon JA, Lowel HL, Luo W, MacFarlane A, McMillan R, Moore A, Mundle W, O’Connor D, Ray J, Van den Hof M.(2015) Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies. J Obstet Gynaecol Can 37:534–52

    Google Scholar 

  88. Young L, Berg M, Soll R (2016) Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia. Cochrane Database Syst Rev:CD001240

    Google Scholar 

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  1. Zentrum für Kinder- und Jugendmedizin, Universitätsklinikum Marburg, Baldingerstraße, 35043, Marburg

    Prof. Dr. Rolf F. Maier

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Maier, R. (2017). Erkrankungen des Nervensystems. In: Neugeborenenintensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53576-9_10

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