Zusammenfassung
Antidepressiva sind eine heterogene Gruppe von Pharmaka, die bei depressiven Syndromen unterschiedlicher nosologischer Zuordnung und Charakteristik einen stimmungsaufhellenden und/oder antriebsverbessernden Therapieeffekt haben. Zusätzlich sind sie bei einer Reihe weiterer Störungsbilder wirksam, sodass der Begriff »Antidepressiva« nur einen Teilaspekt ihrer therapeutischen Potenz darstellt.
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Literatur
Aan het Rot M, Zarate CA Jr, Charney DS, Mathew SJ (2012) Ketamine for depression: where do we go from here? Biol Psychiatry 72(7): 537–547
Appleton KM, Sallis HM, Perry R et al (2015) Omega-3 fatty acids for depression in adults. Cochrane Database Syst Rev 11: CD004692
Arnow BA, Blasey C, Williams LM et al (2015) Depression subtypes in predicting antidepressant response: a report from the iSPOT-D Trial. Am J Psychiatry 172(8): 743–750
Benkert O (2009) StressDepression. Beck, München
Brunoni AR, Valiengo L, Baccaro A et al (2013) The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial. JAMA Psychiatry 70(4): 383–391
Cipriani A, Purgato M, Furukawa TA et al (2012) Citalopram versus other anti-depressive agentsfor depression. Cochrane Database Syst Rev 7: CD006534
Cooney GM, Dwan K, Greig CA et al (2013) Exercise for depression. Cochrane Database Syst Rev 9: CD004366
Cuijpers P, Sijbrandij M, Koole SL et al (2013) The efficacy of psychotherapy and pharmacotherapy in treating depressive and anxiety disorders: a meta-analysis of direct comparisons. World Psychiatry 12(2): 137–148
Cuijpers P, Sijbrandij M, Koole SL et al (2014) Adding psychotherapy to antidepressant medication in depression and anxiety disorders: a meta-analysis. World Psychiatry 13(1): 56–67
DGPPN, BÄK, KBV, AWMF, AkdÄ, BPtK, BApK, DAGSHG, DEGAM, DGPM, DGPs, DGRW (Hrsg) für die Leitliniengruppe Unipolare Depression (2015) S3-Leitlinie/Nationale VersorgungsLeitlinie Unipolare Depression – Langfassung, 2. Aufl. Version 2. www.depression.versorgungsleitlinien.de (Online-Zugriff: 10.03.2016)
Diener H-C, Weimar C (Hrsg) (2012) Leitlinien für Diagnostik und Therapie in der Neurologie. Herausgegeben von der Kommission »Leitlinien« der Deutschen Gesellschaft für Neurologie, Thieme, Stuttgart
Dold M, Aigner M, Lanzenberger R, Kasper S (2013) Antipsychotic augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a meta-analysis of double-blind, randomized, placebo-controlled trials. Int J Neuropsychopharmacol 16(3): 557–574
Dougherty DD, Rezai AR, Carpenter LL et al (2015) A randomized sham-controlled trial of deep brain stimulation of the ventral capsule/ventral striatum for chronic treatment-resistant depression. Biol Psychiatry 78(4): 240–248
Driessen E, Hollon SD, Bockting CL et al (2015) Does publication bias inflate the apparent efficacy of psychological treatment for major depressive disorder? A systematic review and meta-analysis of US National Institutes of Health-funded trials. PLoS One 10(9): e0137864
Fava M, Memisoglu A, Thase ME et al (2016) Opioid modulation with buprenorphine/samidorphan as adjunctive treatment for inadequate response to antidepressants: a randomized double-blind placebo-controlled trial. Am J Psychiatry 173(5): 499-508
Feder A, Parides MK, Murrough JW et al (2014) Efficacy of intravenous ketamine for treatment of chronic posttraumatic stress disorder: a randomized clinical trial. JAMA Psychiatry 71(6): 681–698
Finnerup NB, Attal N, Haroutounian S et al (2015) Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 14(2): 162–173
Gartlehner G, Hansen RA, Morgan LC et al (2011) Comparative benefits and harms of second-generation antidepressants for treating major depressive disorder: an updated meta-analysis. Ann Intern Med 155(11): 772–875
Guidi J, Tomba E, Fava GA (1026) The sequential integration of pharmacotherapy and psychotherapy in the treatment of major depressive disorder: a meta-analysis of the sequential model and a critical review of the literature. Am J Psych 173(2): 128–137
Gustafsson H, Nordström A, Nordström P (2015) Depression and subsequent risk of Parkinson disease: a nationwide cohort study. Neurology 84(24): 2422–2429
Hackam DG, Mrkobrada M (2012) Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysis. Neurology 79(18): 1862–1865
Hiemke C, Baumann P, Bergemann N et al (2011) AGNP consensus guidelines for therapeutic drug monitoring in psychiatry: update 2011. Pharmacopsychiatry 44(6): 195–235
Hollon SD, DeRubeis RJ, Fawcett J et al (2014) Effect of cognitive therapy with antidepressant medications vs antidepressants alone on the rate of recovery in major depressive disorder: a randomized clinical trial. JAMA Psychiatry 71(10): 1157–1164
Hoskins M, Pearce J, Bethell A et al (2015) Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis. Br J Psychiatry 206(2): 93–100
Jakubovski E, Varigonda AL, Freemantle N et al (2016) Systematic review and meta-analysis: dose-response relationship of selective serotonin reuptake inhibitors in major depressive disorder. Am J Psychiatry 173(2): 174–183
Jarrett RB, Minhajuddin A, Gershenfeld H et al (2013) Preventing depressive relapse and recurrence in higher-risk cognitive therapy responders: a randomized trial of continuation phase cognitive therapy, fluoxetine, or matched pill placebo. JAMA Psychiatry 70(11): 1152–1160
Katon W, Pedersen HS, Ribe AR et al (2015) Effect of depression and diabetes mellitus on the risk for dementia: a national population-based cohort study. JAMA Psychiatry 72(6): 612–619
Kiosses DN, Ravdin LD, Gross JJ et al (2015) Problem adaptation therapy for older adults with major depression and cognitive impairment: a randomized clinical trial. JAMA Psychiatry 72(1): 22–30
Koenen KC, Uddin M, Chang SC et al (2011) SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder. Depress Anxiety 28(8): 639–647
Köhler O, Benros ME, Nordentoft M et al (2014) Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: a systematic review and meta-analysis of randomized clinical trials. JAMA Psychiatry 71(12): 1381–1391
Kok RM, Nolen WA, Heeren TJ (2012) Efficacy of treatment in older depressed patients: a systematic review and meta-analysis of double-blind randomized controlled trials with antidepressants. J Affect Disord 141(2–3): 103–115
Kupfer DJ (1991) Long-term treatment of depression. J Clin Psychiatry 52(Suppl 5): 28–34
Kuyken W, Hayes R, Barrett B et al (2015) Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial. Lancet 386(9988): 63–73
Lam RW, Levitt AJ, Levitan RD et al (2016) Efficacy of bright light treatment, fluoxetine, and the combination in patients with nonseasonal major depressive disorder: a randomized clinical trial. JAMA Psychiatry 73(1): 56–63
Lapidus KA, Levitch CF, Perez AM et al (2014) A randomized controlled trial of intranasal ketamine in major depressive disorder. Biol Psychiatry 76(12): 970–976
Mayo-Wilson E, Dias S, Mavranezouli I et al (2014) Psychological and pharmacological interventions for social anxiety disorder in adults: a systematic review and network meta-analysis. Lancet Psychiatry 1(5): 368–376
McAllister-Williams RH, Anderson IM et al (2016) Antidepressant augmentation with metyrapone for treatment-resistant depression (the ADD study): a double-blind, randomised, placebo-controlled trial. Lancet Psychiatry 3(2): 117–127
Mead GE, Hsieh CF, Lee R et al (2013) Selective serotonin reuptake inhibitors for stroke recovery: a systematic review and meta-analysis. Stroke 44(3): 844–850
Miller M, Swanson SA, Azrael D et al (2014) Antidepressant Dose, Age, and the Risk of Deliberate Self-harm. JAMA Intern Med 174(6): 899–909
Mortensen JK, Larsson H, Johnsen SP, Andersen G (2013) Post stroke use of selective serotonin reuptake inhibitors and clinical outcome among patients with ischemic stroke: a nationwide propensity score-matched follow-up study. Stroke 44(2): 420–442
Nagele P, Duma A, Kopec M et al (2015) Nitrous oxide for treatment-resistant major depression: a proof-of-concept trial. Biol Psychiatry 78(1): 10–18
Nelson JC, Delucchi KL, Schneider LS (2013) Moderators of outcome in late-life depression: a patient-level meta-analysis. Am J Psychiatry 170(6): 651–659
Ostad Haji E, Mann K, Dragicevic A et al (2013) Potential cost-effectiveness of therapeutic drug monitoring for depressed patients treated with citalopram. Ther Drug Monit 35(3) :396–401
Porsteinsson AP, Drye LT, Pollock BG et al; CitAD Research Group (2014) Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA 311(7): 682–691
Sharma T, Guski LS, Freund N, Gøtzsche PC (2016) Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports. BMJ 352: i65
Simpson HB, Foa EB, Liebowitz MR et al (2013) Cognitive-behavioral therapy vs risperidone for augmenting serotonin reuptake inhibitors in obsessive-compulsive disorder: a randomized clinical trial. JAMA Psychiatry 70(11): 1190–1199
Stewart JW, McGrath PJ, Blondeau C et al (2014) Combination antidepressant therapy for major depressive disorder: Speed and probability of remission. J Psychiatr Res 57: 7–14
Stingl JC, Brockmöller J (2013) Personalisierte Pharmakotherapie. Evidenzbasierte Leitlinien und klinische Anwendung pharmakogenetischer Diagnostik. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56(11): 1509–1521
Tadić A, Wachtlin D, Berger M et al (2016) Randomized controlled study of early medication change for non-improvers to antidepressant therapy in major depression – The EMC trial. Eur Neuropsychopharmacol 26(4): 705–716
Voican CS, Corruble E, Naveau S, Perlemuter G (2014) Antidepressant-Induced Liver Injury: A Review for Clinicians. Am J Psychiatry 171(4): 404–415
von Wolff A, Hölzel LP, Westphal A et al (2013) Selective serotonin reuptake inhibitors and tricyclic antidepressants in the acute treatment of chronic depression and dysthymia: a systematic review and meta-analysis. J Affect Disord 144(1–2): 7–15
Wang YP, Chen YT, Tsai CF et al (2014) Short-term use of serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding. Am J Psychiatry 171(1): 54–61
Watts BV, Schnurr PP, Mayo L et al (2013) Meta-analysis of the efficacy of treatments for posttraumatic stress disorder. J Clin Psychiatry 74(6): e541–550
Wenzel-Seifert K, Wittmann M, Haen E (2011) QTc prolongation by psychotropic drugs and the risk of Torsades de Pointes. Dtsch Arztebl Int 108(41): 687–693
WHO (World Health Organization and United Nations High Commissioner for Refugees) (2013) Assessment and Management of Conditions Specifically Related to Stress: mhGAP Intervention Guide Module (version 1.0). Geneva
Zhou X, Ravindran AV, Qin B et al (2015) Comparative efficacy, acceptability, and tolerability of augmentation agents in treatment-resistant depression: systematic review and network meta-analysis. J Clin Psychiatry 76(4): e487–98
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Regen, F., Benkert, O. (2017). Antidepressiva. In: Benkert, O., Hippius, H. (eds) Kompendium der Psychiatrischen Pharmakotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-50333-1_1
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