Skip to main content
SpringerLink
Log in

Granulomatöse Erkrankungen

  • Chapter
  • First Online:
Seltene Lungenerkrankungen

  • 3360 Accesses

Zusammenfassung

Zu den granulomatösen Erkrankungen zählen die Sarkoidose mit ihren besonderen pulmonalen, aber auch extrapulmonalen Manifestationen, die chronische Berylliose, die bronchozentrische und lymphomatoide Granulomatose. Da die chronische Berylliose klinisch, histopathologisch und in der Bildgebung der Sarkoidose genau ähnelt, lässt sie sich nur durch eine genaue Anamnese (Kontakt mit Beryllium) und den Nachweis der Hypersensitivität abgrenzen. Therapeutisch kommen in der Regel Kortikosteroide zum Einsatz, bei der Sarkoidose ggf. zusätzlich spezifische Immunsuppressiva. Die bronchozentrische Granulomatose kommt entweder im Rahmen anderer Entitäten wie Tumorerkrankungen, Vaskulitiden u. a. vor oder stellt eine Komplikation des Asthmas dar. Therapeutisch werden Kortikosteroide genutzt Die lymphomatoide Granulomatose wird heute zu den Lymphomen gezählt. Die Therapie der lymphomatoiden Granulomatose ist nicht standardisiert (Interferon, Chemotherapie u. a.).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Bakkers M, Faber CG, Drent M et al (2010) Pain and autonomic dysfunction in patients with sarcoidosis and small fibre neuropathy. J Neurol 257:2086–2090

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Balmes JR, Abraham JL, Dweik RA et al (2014) An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease. Am J Respir Crit Care Med 190:e34–e59

    Article  PubMed  Google Scholar 

  • Barnett CF, Bonura EJ, Nathan SD et al (2009) Treatment of sarcoidosis-associated pulmonary hypertension. A two-center experience. Chest 135:1455–1461

    Article  PubMed Central  PubMed  Google Scholar 

  • Baughman RP, Culver DA, Judson MA (2011) A concise review of pumonary sarcoidosis. Am J Respir Crit Care Med 183:573–581

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Baughman RP, Drent M, Kavuru M et al (2006) Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement. Am Rev Respir Crit Care Med 174:795–802

    Article  CAS  Google Scholar 

  • Birnie DH, Sauer WH, Bogun F et al (2014) HRS Expert Consensus Statement on the Diagnosis and Management of Arrhythmias Associated With Cardiac Sarcoidosis. Heart Rhythm 11(7):1305–1323

    Article  PubMed  Google Scholar 

  • Bonafede RP, Benatar SR (1987) Bronchocentric granulomatosis and rheumatoid arthritis. BR J Dis Chest 81:197–201

    Article  CAS  PubMed  Google Scholar 

  • Bonella F, Oshimo S, Bauer PC et al (2010) Bronchoalveolar lavage. In: Strausz J, Bollinger CT (Hrsg) Interventional Pulmonology. European Respiratory Society Monograph, Bd. 48., S 59–72

    Chapter  Google Scholar 

  • Bosken CH, Myers JL, Greenberger PA, Katzenstein AA (1988) Pathologic features of allergic bronchopulmonary aspergillosis. Am J Surg Pathol 12:216–222

    Article  CAS  PubMed  Google Scholar 

  • Clayton GM, Wang Y, Crawford F et al (2014) Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell 158:132–142

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Costabel U (2001) Sarcoidosis: clinical update. Eur Respir J 18(32):56–68 (Suppl)

    Google Scholar 

  • Costabel U, Bonella F, Ohshimo S et al (2010) Diagnostic modalities in sarcoidosis: BAL, EBUS and PET. Semin Respir Crit Care Med 31:404–408

    Article  PubMed  Google Scholar 

  • Dee PM, Arora NS, Innes DJ Jr (1982) The pulmonary manifestations of lymphomatoid granulomatosis. Radiology 143:613–618

    Article  CAS  PubMed  Google Scholar 

  • Deutsche Gesellschaft für Pneumologie (1998) Empfehlungen zur Diagnostik und Therapie der Sarkoidose. Pneumologie 52:26–30

    Google Scholar 

  • Fontenot AP, Maier LA (2005) Genetic susceptibility and immune-mediated destruction in beryllium-induced disease. Trends Immunol 26:543–549

    Article  CAS  PubMed  Google Scholar 

  • Friedrichs B, Thiel E (2010) Relapsed pulmonary lymphomatoid granulomatosis grade III: curative treatment with radioimmune therapy and autologous stem cell transplantation. Dtsch Med Wochenschr 135:1857–1860

    Article  CAS  PubMed  Google Scholar 

  • Hernándes-Marqués C, Lassaletta A, Torrelo A et al (2014) Rituximab in lymphomatoid granulomatosis. J Pediatr Hematol Oncol 36:e69–e74

    Article  Google Scholar 

  • Hicken P, Dobie JC, Frew E (1979) The radiology of lymphomatoid granulomatosis in the lung. Clin Radiol 30:661–664

    Article  CAS  PubMed  Google Scholar 

  • Hofmann S, Franke A, Fischer A et al (2008) Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis. Nature Genetics 40:1103–1106

    Article  CAS  PubMed  Google Scholar 

  • Jamier D, Seriès C (1999) Neurosarcoidosis. Review of the literature. Neurochirurgie 45:214–218

    Google Scholar 

  • Jörgensen G (1964) Die Genetik der Sarkoidose. Acta Med Scand 425:209–212

    Google Scholar 

  • Judson MA (2012) The treatment of pulmonary sarcoidosis. Resp Med 106:1351–1361

    Article  Google Scholar 

  • Judson MA, Hirst K, Iyengar SK et al (2006) Comparison of sarcoidosis phenotypes among affected African-American siblings. Chest 130:855–862

    Article  PubMed  Google Scholar 

  • Katzenstein AL, Peiper SC (1990) Detection of Epstein-Barr virus genomes in lymphomatoid granulomatosis: analysis of 29 cases by the polymerase chain reaction technique. Mod Pathol 3:435–441

    CAS  PubMed  Google Scholar 

  • Katzenstein AL, Carrington CB, Liebow AA (1979) Lymphomatoid granulomatosis: a clinicopathologic study of 152 cases. Cancer 43:360–373

    Article  CAS  PubMed  Google Scholar 

  • Katzenstein ALA, Liebow AA, Friedmann PJ (1975) Bronchocentric granulomatosis, mucoid impaction and hypersensitivity reaction to fungi. Am Rev Respir Dis 111:497–537

    CAS  PubMed  Google Scholar 

  • Katzenstein AL, Doxtader E, Narendra S (2010) Lymphomatoid granulomatosis. Insights gained over 4 decades. Am J Surg Pathol 34:e35–e48

    Article  PubMed  Google Scholar 

  • Kirsten D (2013) Sarkoidose. Dtsch Med Wochenschr 138:537–540

    Article  CAS  PubMed  Google Scholar 

  • Kirsten D, Kirsten A (2000) Diagnose und Therapie der Sarkoidose. Med Klin 95:211–212

    Article  CAS  Google Scholar 

  • Kraft P, Hunter DJ (2009) Genetic risk prediction – are we there yet? N Engl J Med 360:1701–1703

    Article  CAS  PubMed  Google Scholar 

  • Li Y, Pabst S, Kubisch C et al (2010) First independent replication study confirms the strong genetic association of ANAX11 with sarcoidosis. Thorax 65:939–940

    Article  PubMed  Google Scholar 

  • Li Y, Wollnik B, Pabst S et al (2006) A BTNL2 gene variant confers to sarcoidosis susceptibility by an increased risk towards the chronic form of the disease. Thorax 61:273–274

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Liebow AA (1973) Pulmonary angiitis and granulomatosis. Am Rev Respir Dis 108:1–18

    CAS  PubMed  Google Scholar 

  • Liebow AA, Carrington CB, Friedman J (1972) Lymphomatoid granulomatosis. Hum Pathol 3:457–558

    Article  CAS  PubMed  Google Scholar 

  • Lynch JP III (2003) Computed tomographic scanning in sarcoidosis. Semin Resp Crit Care Med 24:393–418

    Article  Google Scholar 

  • Maier LA, McGrath DS, Sato H et al (2003) Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. J Immunol 171:6910–6918

    Article  CAS  PubMed  Google Scholar 

  • Mana J, Marcoval J, Graells J et al (1997) Cutaneous involvement in sarcoidosis. Reltionship to systemic disease. Arch Dermatol 133:882–888

    Article  CAS  PubMed  Google Scholar 

  • Mayer AS, Hamzeh N, Maier LA (2014) Sarcoidosis and chronic beryllium disease: similarities and differences. Semin Respir Crit Care Med 35:316–329

    Article  PubMed  Google Scholar 

  • Müller-Quernheim J, Prasse A, Zissel G (2012) Pathogenesis of Sarcoidosis. Presse Med 41:e275–e287

    Article  PubMed  Google Scholar 

  • Müller-Quernheim J, Schürmann M, Hofmann S et al (2008) Genetics of sarcoidosis. Clin Chest Med 29:391–414

    Article  PubMed  Google Scholar 

  • Müller-Quernheim J, Gaede KI, Prasse A, Zissel G (2007) Chronic berylliosis. Pneumologie 61:109–116

    Article  PubMed  Google Scholar 

  • Pabst S, Baumgarten G, Stremmel A et al (2006) Toll-like receptor (TLR) 4 polymorphisms are associated with a chronic course of sarcoidosis. Clin Exp Immunol 143:420–426

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Pabst S, Skowasch D, Grohe C (2012) Sarkoidose Pneumologie 66:96–110

    Article  CAS  Google Scholar 

  • Paramothayan NS, Lasserson TJ, Jones PW (2005) Corticosteroids for pulmonary sarcoidosis. Cochrane Database Syst Rev 2:CD001114

    PubMed  Google Scholar 

  • Pisani RJ, DeRemee RA (1990) Clinical implications of the histopathologic diagnosis of pulmonary lymphomatoid granulomatosis. Mayo Clin Proc 65:151–163

    Article  CAS  PubMed  Google Scholar 

  • Prezant DJ, Dhala A, Goldstein A et al (1999) The incidence, prevalence and severity of sarcoidosis in New York City firefighters. Chest 116:1183–1193

    Article  CAS  PubMed  Google Scholar 

  • Rohatgi PK, Turrisi BC (1984) Bronchocentric granulomatosis and ankylosing spondylitis. Thorax 39:317–318

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Rybicki BA, Harrington D, Major M et al (1996) Heterogeneity of familial risk in sarcoidosis. Genet Epidemiol 13:23–33

    Article  CAS  PubMed  Google Scholar 

  • Scadding JG (1967) Sarcoidosis. Eyr & Spottiswoode, London

    Google Scholar 

  • Scharkoff T (1993) Epidemiologie der Sarkoidose. Pneumologie 47:588–592

    CAS  PubMed  Google Scholar 

  • Shlobin OA, Nathan SD (2012) Management of end-stage sarcoidosis: pulmonary hypertension and lung transplantation. Eur Respir J 39:1520–1533

    Article  PubMed  Google Scholar 

  • Silveira LJ, McCanlies EC, Fingerlin TE et al (2012) Chronic beryllium disease, HLA-DPB1, and the DP peptide binding groove. J Immunol 189:4014–4023

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Stagaki E, Mountford WK, Lackland DT et al (2009) The treatment of lupus pernio: results of 116 treatment courses in 54 patients. Chest 135:468–476

    Article  PubMed  Google Scholar 

  • Statement on Sarcoidosis (1999) Am J Respir Crit Care Med 160:736–755

    Google Scholar 

  • Stern BJ, Krumholz A, Johns C et al (1985) Sarcoidosis and its neurological manifestations. Arch Neurol 42:909–917

    Article  CAS  PubMed  Google Scholar 

  • Sverrild A, Backer V, Kyvik KO et al (2008) Heredity in sarcoidosis: a registry-based twin study. Thorax 63:894–896

    Article  CAS  PubMed  Google Scholar 

  • Tagliavini E, Rossi G, Valli R et al (2013) Lymphomatoid granulomatosis: a practical review for pathologists dealing with this rare pulmonary lymphoproliferative process. Pathologica 105:111–116

    CAS  PubMed  Google Scholar 

  • Tower EE, Malhotra A, Surdulescu V et al (2013) Armodafinil for sarcoidosis-associated fatigue: a double-blind, placebo-controlled, crossover trial. J Pain Symptom Manage 45:159–169

    Article  Google Scholar 

  • Travis WD (1996) Pathology of pulmonary granulomatous vasculitis. Sarcoidosis Vasc Diffuse Lung Dis 13:14–27

    CAS  PubMed  Google Scholar 

  • Twigg HL 3rd, Morris A, Ghedin E et al (2013) Use of bronchoalveolar lavage to assess the respiratory microbiome: signal in the noise. Lancet Respir Med 1:354–356

    Article  PubMed  Google Scholar 

  • Valentonyte R, Hampe J, Huse K et al (2005a) Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Gene 37:357–364

    Article  CAS  Google Scholar 

  • Valentonyte R, Hampe J, Croucher PJ et al (2005b) Study of C-C chemokine receptor 2 alleles in sarcoidosis with emphasis on family.based analysis. Am J Respir Crit Care Med 171:1136–1141

    Article  PubMed  Google Scholar 

  • Ward S, Heyneman LE, Flint JDA et al (2000) Bronchocentric granulomatosis: computed tomographic findings in five patients. Clin Radiol 55:296–300

    Article  CAS  PubMed  Google Scholar 

  • Warren J, Pitchenik AE, Saldana MJ (1985) Bronchocentric granulomatosis with glomerulonephritis. Chest 125:751–756

    Google Scholar 

  • Wurm K (1983) Sarkoidose. Thieme Verlag, Stuttgart

    Google Scholar 

  • Wurm K, Kehler E, Reichelt H (1962) Zur Pathogenese der Sarkoidose (Morbus Boeck): Gehäuftes Sarkoidosevorkommen in tuberkulösen Sippen. Med Klin 57:1760–1764

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. vormals LungenClinic, Großhansdorf, Deutschland

    Prof. Dr. med. Detlef Kirsten

  2. Klinik für Pneumologie, Universitätsklinikum Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland

    Prof. Dr. med. Antje Prasse

  3. Ruhrlandklinik, Universitätsklinikum Essen, Essen, Deutschland

    Prof. Dr. med. Ulrich Costabel

Authors
  1. Prof. Dr. med. Detlef Kirsten
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Prof. Dr. med. Antje Prasse
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Prof. Dr. med. Ulrich Costabel
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Detlef Kirsten .

Editor information

Editors and Affiliations

  1. Pneumologie und Beatmungsmediz, Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg, Germany

    Michael Kreuter

  2. Ruhrlandklinik, Universitätsklinikum Essen, Essen, Nordrhein-Westfalen, Germany

    Ulrich Costabel

  3. Universitätsklinikum Heidelberg, Heidelberg, Baden-Württemberg, Germany

    Felix Herth

  4. Zentrum für Pneumologie & Thoraxchir., LungenClinic Großhansdorf, Großhansdorf, Schleswig-Holstein, Germany

    Detlef Kirsten

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kirsten, D., Prasse, A., Costabel, U. (2016). Granulomatöse Erkrankungen. In: Kreuter, M., Costabel, U., Herth, F., Kirsten, D. (eds) Seltene Lungenerkrankungen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-48419-7_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-48419-7_14

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-48418-0

  • Online ISBN: 978-3-662-48419-7

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation