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Nozizeptives System von Früh- und Neugeborenen

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Schmerztherapie bei Kindern, Jugendlichen und jungen Erwachsenen

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Zusammenfassung

Das nozizeptive System ist in den ersten Lebenswochen extremen Reifungsprozessen unterworfen, die das periphere sensible Nervensystem, die spinale Reizübertragung und die supraspinale Schmerzverarbeitung ebenso betreffen wie die segmentale und absteigende Schmerzhemmung. Dabei spielen Veränderungen der exzitatorischen und inhibitorischen Neurotransmitter eine wichtige Rolle. Schon kleine Frühgeborene sind zur Nozizeption fähig, die Inhibition ist wenig ausgebildet. Es besteht die Gefahr der Entwicklung pathologischer Schmerzzustände (Sensibilisierung). Diese gilt es durch eine adäquate Therapie zu vermeiden.

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Authors and Affiliations

  1. Zentrum für Hirnforschung, Abteilung für Neurophysiologie, Medizinische Universität zu Wien, Spitalgasse 4, 1090, Wien, Austria

    Jürgen Sandkühler

  2. Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Mannheim, Theodor-Kutzer-Ufer 1–3, 68167, Mannheim, Deutschland

    Justus Benrath

Authors
  1. Jürgen Sandkühler
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  2. Justus Benrath
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Editors and Affiliations

  1. Vestische Kinder- und Jugendklinik Datteln, Datteln, Germany

    Boris Zernikow

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Sandkühler, J., Benrath, J. (2015). Nozizeptives System von Früh- und Neugeborenen. In: Zernikow, B. (eds) Schmerztherapie bei Kindern, Jugendlichen und jungen Erwachsenen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45057-4_3

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  • DOI: https://doi.org/10.1007/978-3-662-45057-4_3

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