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Antidementiva

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Arzneiverordnungs- Report 2014

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Zusammenfassung

Größte Gruppe der Antidementiva sind die Cholinesterasehemmer gefolgt von Memantin, das aber nur etwa halb so viel verordnet wird. In beiden Gruppen überwiegen inzwischen die Generika. Traditionelle Antidementiva (Piracetam, Ginkgoextrakt, Nicergolin) ohne gesicherten Nutzen haben ihren rückläufigen Trend fortgesetzt.

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Literatur

  • AD2000 Collaborative Group (2004): Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial. Lancet 363: 2105–2115

    Google Scholar 

  • Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E (2011): Alzheimer's disease. Lancet 377: 1019–1031

    Article  PubMed  Google Scholar 

  • Bickel H (2001): Demenzen im höheren Lebensalter: Schätzungen des Vorkommens und der Versorgungskosten. Z Gerontol Geriat 34: 108–115

    Article  Google Scholar 

  • Birks J (2006): Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD00559–3

    Google Scholar 

  • Birks J, Grimley Evans J (2006): Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev. 2007 Apr 18;(2):CD00312–0

    Google Scholar 

  • Birks J, Harvey RJ (2006): Donepezil for dementia due to Alzheimer's disease. Cochrane Database Syst Rev. 2006 Jan 25; (1): CD00119–0.

    Google Scholar 

  • Birks J, Grimley Evans J, Iakovidou V, Tsolaki M, Holt FE (2009): Rivastigmine for Alzheimer's disease. Cochrane Database Syst Rev 2: CD00119–1

    Google Scholar 

  • Cummings J, Froelich L, Black SE, Bakchine S, Bellelli G, Molinuevo JL, Kressig RW, Downs P, Caputo A, Strohmaier C (2012): Randomized, double-blind, parallel-group, 48-week study for efficacy and safety of a higher-dose rivastigmine patch (15 vs. 10 cm²) in Alzheimer's disease. Dement Geriatr Cogn Disord 33: 341–353

    Article  PubMed  Google Scholar 

  • Davies P, Maloney AJ (1976): Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2: 140–3

    Google Scholar 

  • Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde, Deutsche Gesellschaft für Neurologie (2009): S3-Leitlinie Demenzen. Internet: www.dgn.org/images/stories/dgn/pdf/s3_leitlinie_demenzen.pdf

    Google Scholar 

  • Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen PS, Siemers E, Liu-Seifert H, Mohs R; Alzheimer‘s Disease Cooperative Study Steering Committee; Solanezumab Study Group (2014): Phase 3 trials of solanezumab for mild-to-moderate Alzheimer‘s disease. N Engl J Med 370: 311–321

    Google Scholar 

  • Flicker L, Grimley Evans G (2001): Piracetam for dementia or cognitive impairment. Cochrane Database Syst Rev. 2001;(2):CD001011

    Google Scholar 

  • Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW, Zotova E, Nicoll JA (2008): Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372: 216–223

    Article  PubMed  Google Scholar 

  • Howard R, McShane R, Lindesay J, Ritchie C, Baldwin A, Barber R, Burns A, Dening T, Findlay D, Holmes C, Hughes A, Jacoby R, Jones R, Jones R, McKeith I, Macharouthu A, O‘Brien J, Passmore P, Sheehan B, Juszczak E, Katona C, Hills R, Knapp M, Ballard C, Brown R, Banerjee S, Onions C, Griffin M, Adams J, Gray R, Johnson T, Bentham P, Phillips P (2012): Donepezil and memantine for moderate-to-severe Alzheimer‘s disease. N Engl J Med 366: 893–903

    Article  PubMed  Google Scholar 

  • Institut für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWiG) (2007): Nutzenbewertung von Cholinesterasehemmern bei Patienten mit Alzheimer Demenz, auch im Vergleich mit anderen Therapieoptionen. Im Internet unter: www.iqwig.de/download/A05-19A_Abschlussbericht_Cholinesterasehemmer_bei_Alzheimer_Demenz.pdf

  • Loy C, Schneider L (2006): Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev. 2006 Jan 25; (1): CD00174–7

    Google Scholar 

  • McShane R, Areosa Sastre A, Minakaran N (2006): Memantine for dementia. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD00315–4

    Google Scholar 

  • Muayqil T, Camicioli R (2012): Systematic review and meta-analysis of combination therapy with cholinesterase inhibitors and memantine in Alzheimer‘s disease and other dementias. Dement Geriatr Cogn Dis Extra 2: 546–572

    Article  PubMed Central  PubMed  Google Scholar 

  • National Institute for Health and Clinical Excellence (2011): NICE technology appraisal guidance 217 Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of NICE technology appraisal guidance 111). Internet: www.nice.org.uk/nicemedia/live/13419/ 53619/53619.pdf

    Google Scholar 

  • Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kövari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG (2012): Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 71: 362–381

    Article  PubMed Central  PubMed  Google Scholar 

  • Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck CH, Thal LJ; Alzheimer‘s Disease Cooperative Study Group (2005): Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 352: 2379–2388

    Google Scholar 

  • Raina P, Santaguida P, Ismaila A, Patterson C, Cowan D, Levine M, Booker L, Oremus M (2008): Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med 148: 379–397

    Article  PubMed  Google Scholar 

  • Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators (2014): Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer‘s disease. N Engl J Med 370: 322–333

    Google Scholar 

  • Vellas B, Coley N, Ousset PJ, Berrut G, Dartigues JF, Dubois B, Grandjean H, Pasquier F, Piette F, Robert P, Touchon J, Garnier P, Mathiex-Fortunet H, Andrieu S; GuidAge Study Group (2012): Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial. Lancet Neurol 11: 851–859

    Google Scholar 

  • Winblad B (2005): Piracetam: a review of pharmacological properties and clinical uses. CNS Drug Rev 11: 169–182

    PubMed  Google Scholar 

  • Winblad B, Cummings J, Andreasen N, Grossberg G, Onofrj M, Sadowsky C, Zechner S, Nagel J, Lane R (2007): A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer‘s disease–rivastigmine patch versus capsule. Int J Geriatr Psychiatry 22: 456–467

    PubMed  Google Scholar 

  • Winblad B, Gauthier S, Scinto L, Feldman H, Wilcock GK, Truyen L, Mayorga AJ, Wang D, Brashear HR, Nye JS; The GAL-INT-11/18 Study Group (2008): Safety and efficacy of galantamine in subjects with mild cognitive impairment. Neurology 70: 2024–2035

    Google Scholar 

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Authors and Affiliations

  1. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg

    Prof. Dr. med. Ulrich Schwabe

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  1. Prof. Dr. med. Ulrich Schwabe
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Editors and Affiliations

  1. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg

    Ulrich Schwabe

  2. Bachstraße 29, 50858, Köln

    Dieter Paffrath

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Schwabe, U. (2014). Antidementiva. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs- Report 2014. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43487-1_10

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  • DOI: https://doi.org/10.1007/978-3-662-43487-1_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-43486-4

  • Online ISBN: 978-3-662-43487-1

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