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Demenzielle Erkrankungen bei Menschen mit Down-Syndrom

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Lebensqualität im Alter

Zusammenfassung

Die Lebenserwartung von Menschen mit DS hat in den letzten Jahrzehnten stark zugenommen. Ungefähr 80 % der Menschen mit DS werden beim Älterwerden eine Demenz entwickeln. Somit bildet diese Gruppe die Population mit dem höchsten genetischen Risiko für Demenz. Um diese Diagnose zu stellen, gehört eine korrekte Handhabung der Diagnostik mit einer multidisziplinären Annährung dazu. Andere mögliche Ursachen eines Rückgangs des Funktionsniveaus müssen ausgeschlossen werden. Eine medizinische Behandlung der Demenz ist jedoch nicht möglich. Die Behandlung besteht aus psychosozialen Interventionen, wobei Ko-Morbidität wie beispielsweise Epilepsie auch beachtet werden müssen. Nach der Diagnosestellung Demenz muss man für eine optimale Lebensqualität und eine gute palliative Begleitung sorgen.

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Literatur

  • APA. (2000). American Psychiatric Association: Diagnostic and statistical manual of mental disorders (4. überarb. Aufl.) (DSM-IV-TR) APA. Neu Dehli: Jaypee Brothers Medical Publisher.

    Google Scholar 

  • Aylward, E. H., Burt, D. B., Thorpe, L. U., Lai, F., & Dalton, A. (1997). Diagnosis of dementia in individuals with intellectual disability. Journal of Intellectual Disability Research, 41(2), 152–164.

    Article  Google Scholar 

  • Bittles, A. H., Bower, C., Hussain, R., & Glasson, E. J. (2007). The four ages of Down syndrome. European Journal of Public Health, 17(2), 221–225.

    Article  Google Scholar 

  • Burt, D. B., & Aylward, E. H. (2000). Test battery for the diagnosis of dementia in individuals with intellectual disability. Working Group for the Establishment of Criteria for the Diagnosis of Dementia in Individuals with Intellectual Disability. Journal of Intellectual Disability Research, 44(2), 175–180.

    Article  Google Scholar 

  • Cohen, S. I., Linse, S., Luheshi, L. M., Hellstrand, E., White, D. A., Rajah, L., Otzen, D. E., Vendruscolo, M., Dobson, C. M., & Knowles, T. P. (2013). Proliferation of amyloid-beta42 aggregates occurs through a secondary nucleation mechanism. Proceedings of the National Academy of Sciences of the United States of America, 110(24), 9758–9763.

    Article  Google Scholar 

  • Cooper, S. A., Melville, C. A., & Einfeld, S. L. (2003). Psychiatric diagnosis, intellectual disabilities and Diagnostic Criteria for Psychiatric Disorders for Use with Adults with Learning Disabilities/Mental Retardation (DC-LD). Journal of Intellectual Disability Research, 47(1), 3–15.

    Article  Google Scholar 

  • Coppus, A. M. W. (2015). Dementia and Mortality in Down syndrome, results from a follow-up study.

    Google Scholar 

  • Coppus, A., Evenhuis, H., Verberne, G. J., Visser, F., van Gool, P., Eikelenboom, P., & van Duijin, C. (2006). Dementia and mortality in persons with Down’s syndrome. Journal of Intellectual Disability Research, 50(10), 768–777.

    Article  Google Scholar 

  • Coppus, A. M., Evenhuis, H. M., Verberne, G. J., Visser, F. E., Arias-Vasquez, A., Sayed-Tabatabaei, F. A., Vergeer-Drop, J., Eikelenboom, P., van Gool, W. A., & van Duijn, C. M. (2008a). The impact of apolipoprotein E on dementia in persons with Down’s syndrome. Neurobiology of Aging, 29(6), 828–835.

    Article  Google Scholar 

  • Coppus, A. M., Evenhuis, H. M., Verberne, G. J., Visser, F. E., Oostra, B. A., Eikelenboom, P., van Gool, W. A., Janssens, A. C., & van Duijn, C. M. (2008b). Survival in elderly persons with Down syndrome. Journal of the American Geriatrics Society, 56(12), 2311–2316.

    Article  Google Scholar 

  • Coppus, A. M., Fekkes, D., Verhoeven, W. M., Evenhuis, H. M., & van Duijn, C. M. (2009). Neopterin and the risk of dementia in persons with Down syndrome. Neuroscience Letters, 458(2), 60–64.

    Article  Google Scholar 

  • Coppus, A. M., Schuur, M., Vergeer, J., Janssens, A. C., Oostra, B. A., Verbeek, M. M., & van Duijn, C. M. (2012). Plasma beta amyloid and the risk of Alzheimer’s disease in Down syndrome. Neurobiology of Aging, 33(9), 1988–1994.

    Article  Google Scholar 

  • Dekker, A. D., Coppus, A. M., Vermeiren, Y., Aerts, T., van Duijn, C. M., Kremer, B. P., Naude, P. J., Van Dam, D., & De Deyn, P. P. (2014). Serum MHPG strongly predicts conversion to Alzheimer’s Disease in behaviorally characterized subjects with Down syndrome. Journal of Alzheimer’s Disease, 43, 871–891.

    Google Scholar 

  • Evenhuis, H. M. (1992). Evaluation of a screening instrument for dementia in ageing mentally retarded persons. Journal of Intellectual Disability Research, 36(4), 337–347.

    Article  Google Scholar 

  • Evenhuis, H. M. (1996). Further evaluation of the dementia questionnaire for persons with mental retardation (DMR). Journal of Intellectual Disability Research, 40(4), 369–373.

    Article  Google Scholar 

  • Evenhuis, H. M., Theunissen, M., Denkers, I., Verschuure, H., & Kemme, H. (2001). Prevalence of visual and hearing impairment in a Dutch institutionalized population with intellectual disability. Journal of Intellectual Disability Research, 45(5), 457–464.

    Article  Google Scholar 

  • Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198.

    Article  Google Scholar 

  • Glasson, E. J., Sullivan, S. G., Hussain, R., Petterson, B. A., Montgomery, P. D., & Bittles, A. H. (2002). The changing survival profile of people with Down’s syndrome: Implications for genetic counselling. Clinical Genetics, 62(5), 390–393.

    Article  Google Scholar 

  • Hanney, M., Prasher, V., Williams, N., Jones, E. L., Aarsland, D., Corbett, A., Lawrence, D., Yu, L. M., Tyrer, S., Francis, P. T., Johnson, T., Bullock, R., Ballard, C., & researchers, M. t. (2012). Memantine for dementia in adults older than 40 years with Down’s syndrome (MEADOWS): A randomised, double-blind, placebo-controlled trial. Lancet, 379(9815), 528–536.

    Article  Google Scholar 

  • Hardy, J., & Selkoe, D. J. (2002). The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics. Science, 297(5580), 353–356.

    Article  Google Scholar 

  • Hartley, S. L., Handen, B. L., Devenny, D. A., Hardison, R., Mihaila, I., Price, J. C., Cohen, A. D., Klunk, W. E., Mailick, M. R., Johnson, S. C., & Christian, B. T. (2014). Cognitive functioning in relation to brain amyloid-beta in healthy adults with Down syndrome. Brain, 137(9), 2556–2563.

    Article  Google Scholar 

  • Holland, A. J., Hon, J., Huppert, F. A., Stevens, F., & Watson, P. (1998). Population-based study of the prevalence and presentation of dementia in adults with Down’s syndrome. British Journal of Psychiatry, 172, 493–498.

    Article  Google Scholar 

  • Holland, A. J., Hon, J., Huppert, F. A., & Stevens, F. (2000). Incidence and course of dementia in people with Down’s syndrome: Findings from a population-based study. Journal of Intellectual Disability Research, 44(2), 138–146.

    Article  Google Scholar 

  • Hon, J., Huppert, F. A., Holland, A. J., & Watson, P. (1999). Neuropsychological assessment of older adults with Down’s syndrome: An epidemiological study using the Cambridge Cognitive Examination (CAMCOG). British Journal of Clinical Psychology, 38(2), 155–165.

    Article  Google Scholar 

  • Lott, I. T., Doran, E., Nguyen, V. Q., Tournay, A., Head, E., & Gillen, D. L. (2011). Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation. American Journal of Medical Genetics A, 155A(8), 1939–1948.

    Article  Google Scholar 

  • Mann, D. M. A. (2006). Neuropathology of Alzheimer’s disease in Down syndrome. Abingdon: Radcliffe Publishing Ltd.

    Google Scholar 

  • Margallo-Lana, M. L., Moore, P. B., Kay, D. W., Perry, R. H., Reid, B. E., Berney, T. P., & Tyrer, S. P. (2007). Fifteen-year follow-up of 92 hospitalized adults with Down’s syndrome: Incidence of cognitive decline, its relationship to age and neuropathology. Journal of Intellectual Disability Research, 51(6), 463–477.

    Article  Google Scholar 

  • McCarron, M., Gill, M., McCallion, P., & Begley, C. (2005). Health co-morbidities in ageing persons with Down syndrome and Alzheimer’s dementia. Journal of Intellectual Disability Research, 49(7), 560–566.

    Article  Google Scholar 

  • Mohan, M., Bennett, C., & Carpenter, P. K. (2009a). Galantamine for dementia in people with Down syndrome. Cochrane Database Syst Rev, (1), CD007656.

    Google Scholar 

  • Mohan, M., Bennett, C., & Carpenter, P. K. (2009b). Rivastigmine for dementia in people with Down syndrome. Cochrane Database Syst Rev, (1), CD007658.

    Google Scholar 

  • Mohan, M., Carpenter, P. K., & Bennett, C. (2009c). Donepezil for dementia in people with Down syndrome. Cochrane Database Syst Rev, (1), CD007178.

    Google Scholar 

  • Mullins, D., Daly, E., Simmons, A., Beacher, F., Foy, C. M., Lovestone, S., Hallahan, B., Murphy, K. C., & Murphy, D. G. (2013). Dementia in Down’s syndrome: An MRI comparison with Alzheimer’s disease in the general population. Journal of Neurodevelopmental Disorders, 5(1), 19.

    Article  Google Scholar 

  • Oliver, C., Crayton, L., Holland, A., Hall, S., & Bradbury, J. (1998). A four year prospective study of age-related cognitive change in adults with Down’s syndrome. Psychological Medicine, 28(6), 1365–1377.

    Article  Google Scholar 

  • Prasher, V. P. (1999). Down syndrome and thyroid disorders: A review. Down Syndrome Research and Practice, 6(1), 25–42.

    Article  Google Scholar 

  • Prasher, V., & Haque, M. S. (2005). Misdiagnosis of thyroid disorders in down syndrome: Time to re-examine the myth? American Journal of Mental Retardation, 110(1), 23–27.

    Article  Google Scholar 

  • Prasher, V. P., Farrer, M. J., Kessling, A. M., Fisher, E. M., West, R. J., Barber, P. C., & Butler, A. C. (1998). Molecular mapping of Alzheimer-type dementia in Down’s syndrome. Annals of Neurology, 43(3), 380–383.

    Article  Google Scholar 

  • Prasher, V., Cumella, S., Natarajan, K., Rolfe, E., Shah, S., & Haque, M. S. (2003). Magnetic resonance imaging, Down’s syndrome and Alzheimer’s disease: Research and clinical implications. Journal of Intellectual Disability Research, 47(2), 90–100.

    Article  Google Scholar 

  • Prasher, V. P., Sajith, S. G., Mehta, P., Zigman, W. B., & Schupf, N. (2010). Plasma beta-amyloid and duration of Alzheimer’s disease in adults with Down syndrome. International Journal of Geriatric Psychiatry, 25(2), 202–207.

    Article  Google Scholar 

  • Roizen, N. J., & Patterson, D. (2003). Down’s syndrome. Lancet, 361(9365), 1281–1289.

    Article  Google Scholar 

  • Schupf, N., & Sergievsky, G. H. (2002). Genetic and host factors for dementia in Down’s syndrome. British Journal of Psychiatry, 180, 405–410.

    Article  Google Scholar 

  • Schupf, N., Kapell, D., Lee, J. H., Zigman, W., Canto, B., Tycko, B., & Mayeux, R. (1996). Onset of dementia is associated with apolipoprotein E epsilon4 in Down’s syndrome. Annals of Neurology, 40(5), 799–801.

    Article  Google Scholar 

  • Schupf, N., Patel, B., Pang, D., Zigman, W. B., Silverman, W., Mehta, P. D., & Mayeux, R. (2007). Elevated plasma beta-amyloid peptide Abeta (42) levels, incident dementia, and mortality in Down syndrome. Archives of Neurology, 64(7), 1007–1013.

    Article  Google Scholar 

  • Sekijima, Y., Ikeda, S., Tokuda, T., Satoh, S., Hidaka, H., Hidaka, E., Ishikawa, M., & Yanagisawa, N. (1998). Prevalence of dementia of Alzheimer type and apolipoprotein E phenotypes in aged patients with Down’s syndrome. European Neurology, 39(4), 234–237.

    Article  Google Scholar 

  • Simard, M., & van Reekum, R. (2001). Dementia with Lewy bodies in Down’s syndrome. International Journal of Geriatric Psychiatry, 16(3), 311–320.

    Article  Google Scholar 

  • Smiley, E., Cooper, S. A., Finlayson, J., Jackson, A., Allan, L., Mantry, D., McGrother, C., McConnachie, A., & Morrison, J. (2007). Incidence and predictors of mental ill-health in adults with intellectual disabilities: Prospective study. British Journal of Psychiatry, 191, 313–319.

    Article  Google Scholar 

  • Sparrow, SS, Balla, D., & Cicchetti, D. V. (1984). Vineland adaptive behaviour scales, interview edition, expanded form manual. American Guidance Service. Minnesota: Circle Pines.

    Google Scholar 

  • Strydom, A., & Hassiotis, A. (2003). Diagnostic instruments for dementia in older people with intellectual disability in clinical practice. Aging & Mental Health, 7(6), 431–437.

    Article  Google Scholar 

  • Strydom, A., Livingston, G., King, M., & Hassiotis, A. (2007). Prevalence of dementia in intellectual disability using different diagnostic criteria. British Journal of Psychiatry, 191, 150–157.

    Article  Google Scholar 

  • Thune-Boyle, I. C., Iliffe, S., Cerga-Pashoja, A., Lowery, D., & Warner, J. (2012). The effect of exercise on behavioral and psychological symptoms of dementia: Towards a research agenda. International Psychogeriatrics, 24(7), 1046–1057.

    Article  Google Scholar 

  • Tyrrell, J., Cosgrave, M., McCarron, M., McPherson, J., Calvert, J., Kelly, A., McLaughlin, M., Gill, M., & Lawlor, B. A. (2001). Dementia in people with Down’s syndrome. International Journal of Geriatric Psychiatry, 16(12), 1168–1174.

    Article  Google Scholar 

  • Van Buggenhout, G. J., Trommelen, J. C., Schoenmaker, A., De Bal, C., Verbeek, J. J., Smeets, D. F., Ropers, H. H., Devriendt, K., Hamel, B. C., & Fryns, J. P. (1999). Down syndrome in a population of elderly mentally retarded patients: Genetic-diagnostic survey and implications for medical care. American Journal of Medical Genetics, 85(4), 376–384.

    Article  Google Scholar 

  • van Splunder, J., Stilma, J. S., Bernsen, R. M., Arentz, T. G., & Evenhuis, H. M. (2003). Refractive errors and visual impairment in 900 adults with intellectual disabilities in the Netherlands. Acta Ophthalmologica Scandinavica, 81(2), 123–129.

    Article  Google Scholar 

  • Visser, F. E., Aldenkamp, A. P., van Huffelen, A. C., Kuilman, M., Overweg, J., & van Wijk, J. (1997). Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome. American Journal of Mental Retardation, 101(4), 400–412.

    Google Scholar 

  • Weijerman, M. E., van Furth, A. M., Vonk Noordegraaf, A., van Wouwe, J. P., Broers, C. J., & Gemke, R. J. (2008). Prevalence, neonatal characteristics, and first-year mortality of Down syndrome: A national study. Journal of Pediatrics, 152(1), 15–19.

    Article  Google Scholar 

  • WHO. (1993). World Health Organization, ICD-10: International Statistical Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. WHO.

    Google Scholar 

  • Wisniewski, K. E., Dalton, A. J., McLachlan, C., Wen, G. Y., & Wisniewski, H. M. (1985). Alzheimer’s disease in Down’s syndrome: Clinicopathologic studies. Neurology, 35(7), 957–961.

    Article  Google Scholar 

  • Yang, Q., Rasmussen, S. A., & Friedman, J. M. (2002). Mortality associated with Down’s syndrome in the USA from 1983 to 1997: A population-based study. Lancet, 359(9311), 1019–1025.

    Article  Google Scholar 

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Coppus, A., Telbis-Kankainen, H. (2016). Demenzielle Erkrankungen bei Menschen mit Down-Syndrom. In: Müller, S., Gärtner, C. (eds) Lebensqualität im Alter. Gesundheit. Politik - Gesellschaft - Wirtschaft. Springer VS, Wiesbaden. https://doi.org/10.1007/978-3-658-09976-3_11

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