Abstract
Early infantile autism, originally described by Kanner (1943), is a syndrome defined by a set of clinical features including failure to develop normal social relationships, developmental disturbances of verbal and nonverbal communication, ritualistic and compulsive behaviors, and disturbances of motility and attention.
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Adrien JL, Ornitz E, Barthélémy C, Sauvage D, Lelord G (1987) The presence or absence of certain behaviors associated with infantile autism in severely retarded autistic and nonautistic retarded children and very young normal children. J Autism Dev Disord 17:407–416
American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders (DSM III), 3rd ed. American Psychiatric Association, Washington
Anderson LT, Campbell M, Grega DM, Perry R, Small AM, Green WH (1984) Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms. Am J Psychiatry 141:1195–1202
Barthélémy C, Adrien JL, Tanguay P, Garreau B, Fermanian J, Roux S, Sauvage D, Lelord G (1990) The Behavioral Summarized Evaluation (BSE): validity and reliability of a scale for the assessment of autistic behaviors. J Autism Dev Disord (in press)
Barthélémy C, Bruneau N, Cottet-Eymard JM, Jouve J, Garreau B, Lelord G, Muh JP, Peyrin L (1988) Urinary free and conjugated catecholamines and metabolites in autistic children. J Autism Dev Disord 18:583–590
Barthélémy C, Bruneau N, Jouve J, Martineau J, Muh JP, Lelord G (1989) Urinary dopamine metabolites as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior. J Autism Dev Disord 19:241–254
Bergman P, Escalona SK (1949) Unusual sensitivities in very young children. Psychoanal Study Child 3:333–353
Boullin DJ, Coleman M, O’Brien RA (1970) Abnormalities in platelet 5-hydroxytryptamine efflux in patients with infantile autism. Nature 226:371–372
Boullin DJ, Coleman M, O’Brien RA, Rimland B (1971) Laboratory predictions of infantile autism, based on 5-hydroxytryptamine efflux from platelets, and their correlation with the Rimland E2 scores. J Autism Child Schizophr 1:63–71
Bouyer JJ, Montaron MF, Fabre-Thorpe M, Rougeul A (1986) Compulsive attentive behavior after lesion of the ventral striatum in the cat: a behavioral and electrophysiological study. Exp Neurol 92:698–712
Bruneau N, Roux S, Garreau B, Lelord G (1985) Frontal auditory evoked potentials and augmenting-reducing. Electroencephalogr Clin Neurophysiol 62:364–371
Bruneau N, Barthélémy C, Jouve J, Lelord G (1986) Frontal auditory evoked potential augmenting-reducing and urinary homovanillic acid. Neuropsychobiology 16:78–84
Bruneau N, Garreau B, Roux S, Lelord G (1987) Modulation of auditory evoked potentials with increasing stimulus intensity in autistic children. In: Johnson RJ, Parasuraman R, Rohrbaugh JW (eds) Current trends in event-related potential research (EEG Suppl 40). Elsevier, Amsterdam, pp 584–589
Bruneau N, Arbeille P, Dourneau MC, Garreau B, Pourcelot L, Lelord G (1989a) Evaluation du débit sanguin cérébral par Doppler transcrânien chez des enfants présentant un comportement autistique. C R Acad Sci Paris 308 III:255–260
Bruneau N, Barthélémy C, Roux S, Jouve J, Lelord G (1989b) Auditory evoked potential modifications according to clinical and biochemical responsiveness to fenfluramine treatment in children with autistic behavior. Neuropsychobiology 21:48–52
Bryson CQ (1970) Systematic identification of perceptual disabilities in autistic children. Percept Mot Skills 31:239–246
Buchsbaum MS (1976) Self-regulation of stimulus intensity. In: Schwartz GE, Shapiro D (eds) Consciousness and self-regulation. Plenum, New York, pp 101–135
Campbell M, Friedman E, Green WH, Collins PJ, Small AM, Breuer H (1975) Blood serotonin in schizophrenic children. A preliminary study. Int Pharmacopsychol 10:213–221
Campbell M, Anderson LT, Small AM, Perry R, Green WH, Caplan R (1982a) The effects of haloperidol on learning and behavior in autistic children. J Autism Dev Disord 12:167–175
Campbell M, Rosenbloom S, Perry, R, George AE, Kricheff II, Anderson L, Small AM, Jennings SJ (1982b) Computerized axial tomography in young autistic children. Am J Psychiatry 139:510–512
Cantor DS, Thatcher RW, Hrybyk M, Kaye H (1986) Computerized EEG analysis of autistic children. J Autism Dev Disord 16:169–187
Clark CR, Geffen GM, Geffen LB (1987a) Catecholamines and attention I: Animal and clinical studies. Neurosci Biobehav Rev 11:341–352
Clark CR, Geffen GM, Geffen LB (1987b) Catecholamines and attention II: Pharmacological studies in normal humans. Neurosci Biobehav Rev 11:353–364
Cohen DJ, Shaywitz BA, Johnson NT, Bowers MB (1974) Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid. Arch Gen Psychiatry 31:845–853
Cohen DJ, Caparulo BK, Shaywitz BA, Bowers MB (1977) Dopamine and serotonin metabolism in neuropsychiatrically disturbed children: CSF homovanillic acid and 5-hydroxyindoleacetic acid. Arch Gen Psychiatry 34:545–550
Coleman M (1973) Serotonin and central nervous system syndromes of childhood: a review. J Autism Child Schizophr 3:27–35
Coleman M, Gillberg C (1985) The biology of the autistic syndromes. Praeger, New York
Courchesne E (1986) A neurophysiological view of autism. In: Schopler E, Mesibov GB (eds) Neurobiological issues in autism. Plenum, New York, pp 285–324
Courchesne E, Kilman BA, Galambos R, Lincoln AJ (1984) Autism: processing of novel auditory information assessed by event-related brain potentials. Electroencephalogr Clin Neurophysiol 59:238–248
Courchesne E, Courchesne RY, Hicks G, Lincoln AJ (1985a) Functioning of the brainstem auditory pathway in non-retarded autistic individuals. Electroencephalogr Clin Neurophysiol 61:491–501
Courchesne E, Lincoln AJ, Kilman BA, Galambos R (1985b) Event-related brain potential correlates of the processing of novel visual and auditory information in autism. J Autism Dev Disord 15:55–76
Courchesne E, Hesselink J, Jernigan T, Yeung-Courchesne R (1987) Abnormal neuroanatomy in a non-retarded person with autism: unusual findings with magnetic resonance imaging. Arch Neurol 44:335–341
Courchesne E, Yeung-Courchesne R, Press G, Jernigan TL, Hesselink JR (1988) Hypoplasia of cerebellar vermal lobules VI and VII in infantile autism. N Engl J Med 318:1349–1354
Creak M, Pampiglione G (1969) Clinical and EEG studies on a group of 35 psychotic children. Dev Med Child Neurol 11:218–227
Creasey H, Rumsey JM, Schwartz M, Duara R, Rapoport JL, Rapoport SI (1986) Brain morphometry in autistic men as measured by volumetric computed tomography. Arch Neurol 43:669–672
Damasio AR, Maurer RG (1978) A neurological model for childhood autism. Arch Neurol 35:777–786
Dawson G, Finley C, Phillips S, Lewy A (1989) A comperieson of hemisheric asymmetries in speech-related brain potentials of autistic and dysphasic children. Brain Lang 37:26–41
Deutsch SI (1986) Rationale for the administration of opiate antagonists in treating infantile autism. Am J Ment Defic 90:631–635
Elliott GR, Ciaranello RD (1986) Neurochemical hypotheses of childhood psychoses. In: Schopler E, Mesibov S (eds) Neurobiological issues in autism. Plenum, New York, pp 245–261
Freeman BJ, Ritvo ER, Guthrie D, Schroth P, Ball J (1978) The Behavior Observation Scale for autism: initial methodology, data analysis and preliminary findings on 89 children. J Am Acad Child Psychiatry 17:576–588
Garreau B, Barthélémy C, Domenech J, Sauvage D, Muh JP, Lelord G, Callaway E (1980) Troubles du métabolisme de la dopamine chez des enfants ayant un comportement autistique. Résultats des examens cliniques et des dosages urinaires de l’acide homovanilique. Acta Psychiatr Belg 80:249–265
Garreau B, Tanguay P, Roux S, Lelord G (1984) Etude des potentiels évoqués auditifs du tronc cérébral chez l’enfant normal et chez l’enfant autistique. Rev Electroencephalogr Neurophysiol Clin 14:25–31
Garreau B, Barthélémy C, Martineau J, Bruneau N, Lelord G (1985) Aspects électrophysiologiques dans l’autisme de l’enfant. Encephale 11:145–155
Garreau B, Barthélémy C, Jouve J, Bruneau N, Muh JP, Lelord G (1988) Urinary homovanillic acid levels of autistic children. Dev Med Child Neurol 30:93–98
Gillberg C, Rosenhall H, Johansson E (1983a) Auditory brainstem responses in childhood psychosis. J Autism Dev Disord 13:181–195
Gillberg C, Svennerholm L, Hamilton-Hellberg C (1983b) Childhood psychosis and monoamine metabolites in spinal fluid. J Autism Dev Disord 13:383–396
Gillberg C, Terenius L, Lonnerholm G (1985) Endorphin activity in childhood psychosis. Arch Gen Psychiatry 42:780–783
Glowinski J (1981) Present knowledge on the properties of the mesocortico-frontal dopaminergic neurons. In: Mathysse S (ed) Psychiatry and the biology of the human brain: a symposium dedicated to Seymour HS. Kety. Elsevier, New York, pp 139–164
Gold MS, Gold JR (1975) Autism and attention: theoretical considerations and a pilot study using set reaction time. Child Psychiatry Hum Dev 6:68–80
Goldfarb W (1963) Self-awareness in schizophrenic children. Arch Gen Psychiatry 8:47–60
Hanley HG, Stahl SM, Freedman D (1977) Hyperserotonemia and amine metabolites in autistic and retarded children. Arch Gen Psychiatry 34:521–531
Hetzler BE, Griffin JL (1981) Infantile autism and the temporal lobe of the brain. J Autism Dev Disord 11:317–330
Hoffmann WL, Prior MR (1982) Neuropsychological dimensions of autism in children: a test of the hemispheric dysfunction hypothesis. J Clin Neuropsychol 4:27–41
Hokfelt T, Ljungdahl A, Fuxe K, Johansson O (1974) Dopamine nerve terminals in the rat limbic cortex: aspects of the dopamine hypothesis of schizophrenia. Science 184:177–179
James AL, Barry RJ (1980) Respiratory and vascular responses to simple visual stimuli in autistics, retardates and normals. Psychophysiology 17:541–547
Kanner L (1943) Autistic disturbances of affective contact. Nerv Child 2:217–250
Knight R (1984) Decreased response to novel stimuli after prefrontal lesions in man. Electroencephalogr Clin Neurophysiol 59:9–20
Kootz JP, Cohen DJ (1981) Modulation of sensory intake in autistic children. J Am Acad Child Psychiatry 20:692–701
Kootz JP, Marinelli B, Cohen DJ (1982) Modulation of response to environmental stimulation in autistic children. J Autism Dev Disord 12:185–193
Krug DA, Arick JR, Almond PJ (1980) Behavior checklist for identifying severely handicapped individuals with high levels of autistic behavior. J Child Psychol Psychiatry 21:221–229
Lake CR, Ziegler MG, Murphy DL (1977) Increased norepinephrine levels and decreased ß-hydroxylase activity in primary autism. Arch Gen Psychiatry 34:553–556
Leddet I, Larmande C, Barthélémy C, Chalon F, Sauvage D, Lelord G (1986) Comparison of clinical
Lelord G, Laffont F, Jusseaume P, Stephant JL (1973) Comparative study of conditioning of averaged evoked responses by coupling sound and light in normal and autistic children. Psychophysiology 10:415–427
Lelord G, Callaway E, Muh JP, Arlot JC, Sauvage D, Garreau B, Domenech J (1978) L’acide homovanilique urinaire et ses modifications par ingestion de vitamine B6: Exploration fonctionnelle dans l’autisme de l’enfant? Rev Neurol 134:797–801
Lelord G, Muh JP, Barthélémy C, Martineau J, Garreau B (1981) Effects of pyridoxine and magnesium on autistic symptoms—initial observations. J Autism Dev Disord 11:219–230
Lelord G, Barthélémy C, Sauvage D, Boiron M, Adrien JL, Hameury L (1987) Thérapeutiques d’echange et de dévelopement dans l’autisme de l’enfant, Bases physiologiques. Bull Acad Natl Med (Paris) 171:137–143
Le Moal M, Stinus L, Simon H, Tassin JP, Thierry AM, Blanc G, Glowinski J, Cardo B (1977) Behavioral effects of a lesion in the ventral mesencephalic tegmentum: evidence for involvement of A10 dopaminergic neurons. In: Costa E, Gessa GL (eds) Non-striatal dopaminergic neurons. Adv Biochem Psychopharmacol 16:237–245
Luria AR (1966) Higher cortical functions in man. Basic Books, New York
Maas JW, Hattox SE, Martin DM, Landis DH (1979) A direct method for determining dopamine synthesis and output of dopamine metabolites from brain in awake animals. J Neurochem 32:839–843
Maas JW, Hattok SE, Greene NM, Landis DH (1980) Estimates of dopamine and serotonin synthesis by the awake human brain. J Neurochem 34:1547
Martineau J, Laffont F, Bruneau N, Roux S, Lelord G (1980) Event-related potentials evoked by sensory stimulation in normal, mentally retarded and autistic children. Electroencephalogr Clin Neurophysiol 48:140–153
Martineau J, Barthélémy C, Garreau B, Lelord G (1985) Vitamin B6, magnesium and combined B6-Mg: therapeutic effects in childhood autism. Biol Psychiatry 20:467–478
Martineau J, Garreau B, Roux S, Lelord G (1987) Auditory evoked responses and their modifications during conditioning paradigm in autistic children. J Autism Dev Disord 17:525–539
Morton-Evans A, Hensley R (1978) Paired associate learning in early infantile autism and receptive developmental aphasia. J Autism Child Schizophr 8:61–69
Muh JP, Barthélémy C, Jouve J, Martineau J, Mariotte N, Bruneau N (1987) Les monoamines urinaires dans l’autisme de l’enfant. In: Grémy F, Tomkiewicz S, Ferrari P, Lelord G (eds) Autisme infantile/Infantile autism. INSERM, pp 129–136 (Colloque INSERM, vol. 146)
Muller HF (1985) Prefrontal cortex dysfunction as a common factor in psychosis. Acta Psychiatr Scand 71:431–440
Niéoullon A, Cheramy A, Glowinski J (1978) Release of dopamine in both caudate nuclei and both substantiae nigrae in response to unilateral stimulation of cerebellum in the cat. Brain Res 148:143–152
Niwa S, Ohta M, Yamazaki K (1983) P300 and stimulus evaluation process in autistic subjects. J Autism Dev Disord 13:33–42
Novick B, Kurtzberg D, Vaughan HG (1979) An electrophysiologic indication of defective information storage in childhood autism. Psychiatry Res 1:101–108
Novick B, Vaughan HG, Kurtzberg D, Simson R (1980) An electrophysiologic indication of auditory processing defects in autism. Psychiatry Res 3:107–114
Ornitz EM (1969) Disorders of perception common to early infantile autism and schizophrenia. Compr Psychiatry 10:259–274
Ornitz EM (1974) The modulation of sensory input and motor output in autistic children. J Autism Child Schizophr 4:197–215
Ornitz EM (1983) The functional neuroanatomy of infantile autism. Int J Neurosci 19:85–124
Ornitz EM (1985) Neurophysiology of infantile autism. J Am Acad Child Psychiatry 24:251–262
Ornitz EM, Ritvo ER (1968) Perceptual inconstancy in early infantile autism. Arch Gen Psychiatry 18:76–98
Ornitz EM, Tanguay PE, Lee JCM, Ritvo ER, Sivertsen B, Wilson C (1972) Effects of stimulus interval on the auditory evoked response during sleep in autistic children. J Autism Child Schizophr 2:1450–1456
Ornitz EM, Mo A, Olson ST, Walter DO (1980) Influence of click sound pressure direction on brainstem responses in children. Audiology 19:245–254
Paasonen MK (1968) Platelet 5-hydroxytryptamine as a model in pharmacology. Ann Med Exp Biol Fenn 46:416
Parks SI (1983) The assessment of autistic children: a selective review of available instruments. J Autism Dev Disord 13:255–267
Petrie A (1958) Effects of chlorpromazine and of brain lesions on personality. In: Pennes HD (ed) Psychopharmacology. Harper, New York, pp 99–115
Peyrin L, Cottet-Emard JM, Javoy F, Agid Y, Herbet A, Glowinski J (1978) Long term effects of unilateral 6-hydroxydopamine destruction of the dopaminergic nigrostriatal pathway on the urinary excretion of catecholamines (dopamine, norepinephrine, epinephrine) and their metabolites in the rat. Brain Res 143:567–572
Peyrin L, Simon H, Cottet-Emard JM, Bruneau N, Le Moal M (1982) 6-Hydroxydopamine lesions of dopaminergic A10 neurons. Long-term effects on the urinary excretion of free and conjugated catecholamines and their metabolites in the rat. Brain Res 235:363–369
Pletcher A (1968) Metabolism, transfer and storage of 5HT in blood platelets. Br J Pharmacol 32:1–16
Prior MR, Tress B, Hoffman NL, Boldt D (1984) Computed tomographic study of children with classic autism. Arch Neurol 41:482–484
Rimland B (1971) The differentiation of childhood psychoses: an analysis of checklists for 2218 psychotic children. J Autism Child Schizophr 1:161–174
Ritvo ER, Yuwiler A, Geller E, Ornitz EM, Saeger K, Plotkin S (1970) Increased blood serotonin and platelets in early infantile autism. Arch Gen Psychiatry 23:566–572
Ritvo ER, Freeman BJ, Yuwiler A, Geller A, Schroth P, Yokata A, Mason-Brothers A, August GJ, Klykylo W, Leventhal B, Lewis K, Piggott L, Realmuto G, Stubbs EG, Umansky R (1986) Fenfluramine treatment of autism: UCLA collaborative study of 81 patients at nine medical centers. Psychopharmacology 22:133–140
Rosenbloom S, Campbell M, George AE, Kricheff II, Taleporos E, Anderson L, Reuben RN, Korein J (1984) High resolution CT scanning in infantile autism: a quantitative approach. J Am Acad Child Psychiatry 23:72–77
Rosenblum SM, Arick JR, Krug DA, Stubbs EG, Young NB, Pelson RO (1980) Auditory brainstem evoked responses in autistic children. J Autism Dev Disord 10:215–225
Roux S (1981) Aspects electrophysiologiques du conditionnement des potentials évoqués par des stimulations sensorielles chez l’homme. Doctoral thesis, University of Poitiers
Rumsey JM, Grimes AM, Pikus AM, Duara R, Ismond DR (1984) Auditory brainstem responses in pervasive developmental disorders. Biol Psychiatry 19:1403–1418
Rumsey JM, Duara R, Grady C, Rapoport JL, Margolin RA, Rapoport SI, Cutler NR (1985) Brain metabolism in autism: resting cerebral glucose utilization rates as measured with positron emission tomography. Arch Gen Psychiatry 42:448–455
Ruttenberg BA, Dratman ML, Fraknoi J, Wenar C (1966) An instrument for evaluating autistic children. J Am Acad Child Psychiatry 5:453–478
Ruttenberg BA, Kalish BI, Wenar C, Wolf EG (1977) Behavior rating instrument for autistic and other atypical children. Developmental Center for Autistic Children, Philadelphia
Rutter M (1979) Language, cognition and autism. In: Katzman R (ed) Congenital and acquired cognitive disorders. Raven, New York, pp 247–264
Sahley TL, Panksepp J (1987) Brain opioids and autism: an updated analysis of possible linkages, J Autism Dev Disord 17:201–216
Sandyk R (1986) Further speculations on possible dopamine-opioid link in autism. J Autism Dev Disord 16:89–90
Schain RJ, Freedman DX (1961) Study on 5-hydroxyindole metabolism in autistic and mentally retarded children. J Pediatr 58:315–320
Schopler E, Reichler RJ, De Vellis RF, Daly K (1980) Toward objective classification of childhood autism: childhood autism rating scale (CARS). J Autism Dev Disord 10:91–103
Sedvall G, Farde L, Persson A, Wiesel FA (1986) Imaging of neurotransmitter receptors in the living human brain. Arch Gen Psychiatry 43:995–1005
Sherman M, Ruth N, Shapiro TH (1984) Regional cerebral blood flow in autism. J Autism Dev Disord 14:439–446
Simon H, Le Moal M (1985) Influences des neurones dopaminergiques du mésencéphale sur les processus d’attention et d’intention. Psychologie Médicale 17:939–945
Simon H, Le Moal M, Calas A (1979) Efferents and afferents of the ventral tegmental-A10 region studied after local injection of 3H leucine and horseradish peroxidase. Brain Res 178:17–40
Simon H, Scatton B, Le Moal M (1980) Dopaminergic A10 neurons are involved in cognitive functions. Nature 286:150–151
Skoff BF, Mirsky AF, Turner D (1980) Prolonged brainstem transmission time in autism. Psychiatry Res 2:157–166
Small JG (1971) Sensory evoked responses of autistic children. In: Churchill DW, Alpern GD, De Myer MK (eds) Infantile autism. Thomas, Springfield, pp 224–242
Small JG, De Myer MK, Milstein V (1971) CNV responses of autistic and normal children. J Autism Child Schizophr 1:215–231
Snider SR, Snider RS (1977) Alterations in forebrain catecholamine metabolism produced by cerebellar lesions in the rat. J Neural Transm 40:115–128
Student M, Sohmer H (1978) Evidence from auditory nerve and brainstem evoked responses for an organic brain lesion in children with autistic traits. J Autism Dev Disord 8:13–20 (Erratum 9:309)
Swann AC, Maas JW, Hattox SE, Landis DH (1980) Catecholamine metabolites in human plasma as indices of brain function: effects of debrisoquin. Life Sci 25:1857–1862
Takahashi S, Kanai H, Miyamoto Y (1976) Reassessment of elevated serotonin levels in blood platelets in early infantile autism. J Autism Child Schizophr 6:317–326
Tanguay PE (1976) Clinical and electrophysiological research. In: Ritvo ER (ed) Autism: diagnosis, current research and management. Spectrum, New York, pp 75–84
Tanguay PE, Ornitz EM, Forsythe AB, Ritvo ER (1976) Rapid eye movement (REM) activity in normal and autistic children during REM sleep. J Autism Child Schizophr 6:275–288
Tanguay P, Edwards RM, Buchwald J, Schwafel J, Allen V (1982) Auditory brainstem evoked responses in autistic children. Arch Gen Psychiatry 39:174–180
Taylor MJ, Rosenblatt B, Linschoten L (1982) Electrophysiological study of the auditory system in autistic children. In: Rothenberger A (ed) Event-related potentials in children. Elsevier, Amsterdam, pp 379–386 (Developments in neurology, vol. 6)
Thierry AM, Blanc G, Sobe A, Stinus L, Glowinski J (1973) Dopaminergic terminals in the rat cortex. Science 182:499–501
Tsai L, Stewart MA (1982) Handedness and EEG correlation in autistic children. Biol Psychiatry 17:595–598
Walsh KW (1978) Neuropsychology: a clinical approach. Churchill Livingstone, Edinburgh
Walter WG, Aldridge VJ, Cooper R, O’Gorman G, McCallum C, Winter AL (1971) Neurophysiological correlates of apparent defects of sensorimotor integration in autistic children. In: Alpern GD, De Myer MK (eds) Infantile autism. Thomas, Springfield, pp 265–276
Weizman R, Weizman A, Tyano S, Szekely G, Weissman BA, Sarne Y (1984) Humoral-endorphin blood levels in autistic, schizophrenic, and healthy subjects. Psychopharmacology 82:368–370
Young JG, Cohen DJ, Brown SL, Caparulo BK (1978) Decreased urinary free catecholamines in childhood autism. J Am Acad Child Psychiatry 17:671–678
Young JG, Cohen DJ, Caparulo BK, Brown SL, Maas JW (1979) Decreased 24 hours urinary MHPG in childhood autism. Am J Psychiatry 136:1056–1057
Young JG, Cohen DJ, Kavanagh ME, Landis HD, Shaywitz BA, Maas JW (1981) Cerebrospinal fluid, plasma, and urinary MHPG in children. Life Sci 28:2837–2845
Young JG, Kavanagh ME, Anderson GM, Shaywitz BA, Cohen DJ (1982) Clinical neurochemistry of autism and associated disorders. J Autism Dev Disord 12:147–165
Yuwiler A, Freedman DX (1986) Neurotransmitter research in autism. In: Schopler E, Mesibov GB (eds) Neurobiological issues in autism. Plenum, New York, pp 263–284
Yuwiler A, Ritvo E, Geller E, Glousman R, Schneiderman G, Matsuno D (1975) Uptake and efflux of serotonin from platelets of autistic and nonautistic children. J Autism Dev Disord 5:83–98
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Bruneau, N. et al. (1990). Clinical, Electrophysiological, and Biochemical Markers and Monoaminergic Hypotheses in Autism. In: Rothenberger, A. (eds) Brain and Behavior in Child Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75342-8_14
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