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Anatomie

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Benigne Prostatahyperplasie

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Zusammenfassung

Die Prostata entsteht entwicklungsgeschichtlich an der Mündungsstelle der Wolffund Müller-Gänge im proximalen Sinus urogenitalis und wird durch eine androgengesteuerte epitheliomesenchymale Interaktion in mehereren Entwicklungsschritten realisiert.

Meiner lieben Frau, Dr. med. Margrit Aumüller, in Dankbarkeit gewidmet.

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Literatur

  1. Altenähr E (1982) Pathologie des Prostatakarzinoms. In: Klosterhalfen H, Altenähr E, Franke HD (Hrsg) Das Prostatakarzinom, Pathologie, Diagnostik, Therapie. Thieme, Stuttgart, S 1–71

    Google Scholar 

  2. Andersson S, Russell DW (1990) Structural and biochemical properties of cloned and expressed human and rat Steroid 5α-reductases. Proc Natl Acad Sei 87: 3640–3644

    Article  CAS  Google Scholar 

  3. Aumüller G (1979) Prostate gland and seminal vesicles. In: Oksche A, Vollrath L (Hrsg) Handbuch der mikroskopischen Anatomie Bd 7/5. Springer, Berlin Heidelberg New York, S 1–304

    Google Scholar 

  4. Aumüller G, Seitz J, Bischof W (1983) Immunohistochemical study on the initiation of acid phosphatase secretion in the human prostate. J Androl 4:183–191

    PubMed  Google Scholar 

  5. Aumüller G, Seitz J (1988) Protein secretion and secretory processes in male accessory sex glands. Int RevCytol 121:127–231

    Google Scholar 

  6. Aumüller G, Jungblut T, Malek B, Konrad S, Weihe E (1989) Regional distribution of opioidergic nerves in human and canine prostates. Prostate 14: 279–288

    Article  PubMed  Google Scholar 

  7. Aumüller G, Riva H (1992) Morphology and funetions of the human seminal vesicle. Andrologia 24:183–196

    Article  PubMed  Google Scholar 

  8. Aumüller G, Seitz J, Riva A (1994) Functional morphology of prostate gland. In: Riva A, Testa Riva F, Motta PM (eds) Ultrastructure of male urogenital glands. Kluwer Academic Publishers, Boston Dordrecht London, pp 61–112

    Chapter  Google Scholar 

  9. Aumüller G, Holterhus PM, Eicheler W et al. (1995) Hormonal control of prostatic differentiation and morphogenesis: the impact of apoptosis and Steroid hormone reeeptor expression. In: Habenicht UF, Michna H, Tenniswood M (eds) Apoptosis in hormone-dependent cancers. Springer, Berlin Heidelberg New York, pp 1–33

    Google Scholar 

  10. Bacher M, Rausch U, Goebel H-W, Polzar B, Mannherz HG, Aumüller G(1993) Stromal and epithelial cells from rat ventral prostate during androgen deprivation and estrogen treatment -regulation of transcription. Exp Clin Endocrinol 101: 78–86

    Article  PubMed  CAS  Google Scholar 

  11. Bartsch G, Rohr HP (1977) Ultrastructural stereology. A new approach to the study of prostatic funetion. Invest Urol 14: 301–306

    PubMed  CAS  Google Scholar 

  12. Bazer BT (1980) Basal cell proliferation and differentiation in regeneration of the rat ventral prostate. Invest Urol 17:470–473

    PubMed  CAS  Google Scholar 

  13. Bonkhoff H, Wernert N, Dhom G, Remberger K(1991) Relation of endocrine-paracrine cell to cell proliferation in normal, hyperplastic, and neoplastic human prostate. Prostate 19: 91–98

    Article  PubMed  CAS  Google Scholar 

  14. 14. Bonkhoff H, Remberger K (1996) Differentiation pathways and histogenetic aspects of normal and abnormal prostatic growth: a stem cell model. Prostate 28:98–106

    Article  PubMed  CAS  Google Scholar 

  15. Brody I, Ronquist G, Gottfries A (1983) Ultrastructural localization of the prostasome. An organelle in human seminal plasma. Ups J Med Sei 88:63–80

    Article  CAS  Google Scholar 

  16. Chang SM, Chung LWK (1989) Interaction between prostatic fibroblast and epithelial cells in culture: role of androgen. Endocrinology 125:2719–2726

    Article  PubMed  CAS  Google Scholar 

  17. Chung LWK, Gleave ME, Hsieh, JT, Hong SJ, Zhau HE (1991) Reciprocal mesenchymal-epithelial interaction affecting prostate tumour growth and hormonal responsiveness. Cancer Surv 11: 91–121

    PubMed  CAS  Google Scholar 

  18. Clegg EJ (1957) The musculature of the human prostatic Urethra. J Anat 91: 345–351

    PubMed  CAS  Google Scholar 

  19. Culig Z, Hobisch A, Cronauer MV et al. (1996) Regulation of prostatic growth and funetions by peptide growth factors. Prostate 28: 392–405

    Article  PubMed  CAS  Google Scholar 

  20. Cunha GR (1994) Role of mesenchymal-epithelial interactions in normal and abnormal development of male urogenital glands. In: Riva A, Testa Riva F, Motta PM (eds) Ultrastructure of the male urogenital glands. Kluwer Academic Publishers, Boston Dordrecht London, pp 14–34

    Google Scholar 

  21. de Mesy Jensen K, di Sant’Agnese PA (1994) A review of the ultrastructure of human prostatic and urethral endocrine-paracrine cells and neuroendoerine differentiation in prostatic carcinoma. In: Riva A, Testa Riva F, Motta PM (eds) Ultrastructure of male urogenital glands. Kluwer Academic Publishers, Boston Dordrecht London, pp 139–161

    Chapter  Google Scholar 

  22. Dermer GB (1978) Basal cell proliferation in benign prostatic hyperplasia. Cancer 41:1857–1862

    Article  PubMed  CAS  Google Scholar 

  23. di Sant’Agnese PA (1992) Neuroendoerine differentiation in carcinoma of the prostate. Cancer 70 [Suppl]: 254–268

    Article  PubMed  Google Scholar 

  24. Djakiew D, Tarkington MA, Lynch JH (1990) Paracrine Stimulation of polarized secretion from monolayers of a neoplastic prostatic epithelial cell line by prostatic stromal cell proteins. Cancer Res 50:1966–1974

    PubMed  CAS  Google Scholar 

  25. Djakiew D, Delsite R, Pflug B, Wrathall J, Lynch JH, Onoda M (1991) Regulation of growth by a nerve growth factor-like protein which modulates paracrine interactions between a neoplastic epithelial cell line and stromal cells of the human prostate. Cancer Res 51: 3304–3310

    PubMed  CAS  Google Scholar 

  26. Djakiew D, Pflug B, Delsite R, Lynch JH, Onoda M (1992) Density dependent polarized secretion of a prostatic epithelial cell line. Prostate 20:15–27

    Article  PubMed  CAS  Google Scholar 

  27. Evans BAJ, Harper ME, Daniells CE, Watts CE, Matenhelia S, Green J, Griffiths K (1996) Low incidence of androgen reeeptor gene mutations in human prostatic tumors using single Strand conformation polymorphism analysis. Prostate 28:162–171

    Article  PubMed  CAS  Google Scholar 

  28. Evans GS, Chandler JA (1987) Cell proliferation studies in the rat prostate. Prostate 11: 339–352

    Article  PubMed  CAS  Google Scholar 

  29. Feitz WFJ, Debruyne FMJ, Vooijs GP, Herman CJ, Ramaekers FCS (1986) Intermediate filament proteins as tissue specific markers in normal and malignant urological tissues. J Urol 136: 922–932

    PubMed  CAS  Google Scholar 

  30. Franks LM (1954) Benign nodular hyperplasia of the prostate: a review. Ann R Coli Surg Engl (London) 14:92–106

    Google Scholar 

  31. Glenister TW (1962) The development of the utricle and of the so-called middle or median lobe of the human prostate. J Anat (London) 96:443–445

    CAS  Google Scholar 

  32. Gosling JA, Dixon JS, Critchley HOD, Thompson S-A (1981) A comparative study of the human external sphineter and periurethral levator ani muscles. Brit J Urol 53:35–41

    Article  PubMed  CAS  Google Scholar 

  33. Grignon DJ, Ro JY, Srigley JR, Troncoso R, Raymond K, Ayaly AG (1992) Sclerosing adenosis of the prostate gland. Am J Surg Pathol 16: 383–391

    Article  PubMed  CAS  Google Scholar 

  34. Gundobin NP (1912) Die Besonderheiten des Kindesalters. Grundlegende Tatsachen zur Erkenntnis der Kinderkrankheiten. Allg Med Verlagsanstalt, Berlin

    Google Scholar 

  35. Heiweg G, Strasser H, Knapp R, Wicke K, Frauscher F, zur Nedden D, Bartsch G (1994) Transurethral sonomorphologic evaluation of the male external sphineter of the Urethra. Eur Radiol 4: 525–528

    Google Scholar 

  36. Henle J (1873) Handbuch der systematischen Anatomie des Menschen. II. Handbuch der Eingeweidelehre des Menschen. Viehweg, Braunschweig

    Google Scholar 

  37. Horninger W, Unterlechner H, Strasser H, Bartsch G (1996) Transurethral prostatectomy: mortality and morbidity. Prostate 28:195–200

    Article  PubMed  CAS  Google Scholar 

  38. 38. Huggins C, Webster WO (1948) Duality of human prostate in response to estrogen. J Urol 59: 258–266

    PubMed  CAS  Google Scholar 

  39. Isaacs JT (1987) Control of cell proliferation and cell death in the normal and neoplastic prostate: a stem cell model. In: Rodgers CH, Coffey DS, Cunha G, Grayhack JT, Hinman F, Horton R (eds) Benign prostatic hyperplasia II. Bethesda, NIH Monographs, pp 85–94

    Google Scholar 

  40. Jenkins EP, Andersson S, Imperato-McGinley J, Wilson JD, Russell DW (1992) Genetic and pharmacological evidence for more than one human Steroid 5a-reductase. J Clin Invest 89: 293–300

    Article  PubMed  CAS  Google Scholar 

  41. Jones EG, Harper ME (1992) Studies on the proliferation, secretory activities, and epidermal growth factor receptor expression in benign prostatic hyperplasia explant cultures. Prostate 20: 133–149

    Article  PubMed  CAS  Google Scholar 

  42. Kellokumpu-Lehtinen P, Santti R, Pelliniemi LJ (1980) Correlation of early cytodifferentiation of the human fetal prostate and Leydig cells. Anat Ree 196: 263–273

    Article  CAS  Google Scholar 

  43. Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide ränge implications in tissue kinetics. Br J Cancer 26: 239–257

    Article  PubMed  CAS  Google Scholar 

  44. Kinghorn EM, Bäte AS, Higgins SJ(1987) Growth of rat seminal vesicle epithelial cells in culture: neurotransmitters are required for androgen-regulated synthesis of tissue-specific secretory proteins. Endocrinol 121:1678–1688

    Article  CAS  Google Scholar 

  45. Lierse W (1984) Becken, Bd V: Vorsteherdrüse. In: von Lanz T, Wachsmuth W (Hrsg) Praktische Anatomie, 2. Bd, Teil 8 A. Springer, Berlin Heidelberg New York Tokyo, S 160–168

    Google Scholar 

  46. Lilja H (1990) Cell biology of semenogelin. Andrologia 22[Suppl 1]: 132–141

    Article  PubMed  CAS  Google Scholar 

  47. Lilja H, Oldbring J, Rannevik G, Laurell C-B (1987) Seminal-vesicle secreted proteins and their reactions during gelation and liquefaction of human semen. J Clin Invest 80: 281–285

    Article  PubMed  CAS  Google Scholar 

  48. Lilja H, Abrahamsson P-A (1988) Three predominant proteins secreted by the human prostate gland. Prostate 12: 29–38

    Article  PubMed  CAS  Google Scholar 

  49. Llorca FO, Botär J(1933) Collecteurs lymphatiques de la prostate. Ann Anat Pathol 10: 37–43

    Google Scholar 

  50. Lowsley OS (1912) The development of the human prostate with reference to the development of other struetures at the neck of the urinary bladder. Am J Anat 13: 299–349

    Article  Google Scholar 

  51. Martikainen PM, Mäkelä S, Santti RS, Härkönen PL, Suominen JJO(1987) Interaction of male and female sex hormones in cultured rat prostate. Prostate 11: 291–303

    Article  PubMed  CAS  Google Scholar 

  52. Maygarden SJ, Strom S, Ware JL (1992) Localization of epidermal growth factor receptor by immunohistochemical methods in human prostatic Carcinoma, prostatic intraepithelial neoplasia, and benign hyperplasia. Arch Pathol Lab Med 116: 269–273

    PubMed  CAS  Google Scholar 

  53. McNeal JE (1968) Prostate and verumontanum: regional morphology and pathology of the prostate Am J Clin Pathol 49: 347–357

    PubMed  CAS  Google Scholar 

  54. McNeal JE (1972) The prostate and prostatic Urethra: a morphologic synthesis. J Urol 107: 1008–1016

    PubMed  CAS  Google Scholar 

  55. Merk FB, Ofner P, Kwan PWL, Leav I, Vena RL (1982) Ultrastructural and biochemical expression of divergent differentiation in prostates of castrated dogs treated with estrogen and androgen. Lab Invest 47: 437–450

    PubMed  CAS  Google Scholar 

  56. Merk FB, Warhol MJ, Kwan PWL, Leav I, Alroy J, Ofner P, Pinkus GS (1986) Multiple phenotypes of prostatic glandulär cells in castrated dogs after individual or combined treatment with androgen and estrogen - morphometric, ultrastructural and cytochemical distinetions. Lab Invest 54:442–456

    PubMed  CAS  Google Scholar 

  57. Milanovic SR, Radulovic S, Groot K, Schally AV (1992) Inhibition of growth of PC-82 human prostate cancer line xenografts in nude mice by bombesin antagonist RC-3095 or combination of agonist [D-Trp6]-luteinizing hormone releasing hormone and somatostatin analog RC-160. Prostate 20: 269–280

    Article  Google Scholar 

  58. Nistal M, Santamarfa L, Paniagua R (1992) The ampulla of the duetus deferens in man: morphological and ultrastructural aspects. J Anat 180: 97–104

    PubMed  Google Scholar 

  59. Noordzij MA, van Steenbrugge GJ, van der Kwast TH, Schröder FH (1995) Neuroendocrine cells in the normal, hyperplastic and neoplastic prostate. Urol Res 22: 333–341

    Article  PubMed  CAS  Google Scholar 

  60. Normington K, Russell DW (1992) Tissue distribution and kinetic characteristics of rat Steroid 5a-reductase isoenzymes - evidence for distinet physiological funetions. J Biol Chem 267: 16548–16554

    Google Scholar 

  61. Oelrich TM (1980) The urethral sphineter muscle in the male. Am J Anat 158: 229–246

    Article  PubMed  CAS  Google Scholar 

  62. Pretl K (1944) Zur Frage der Endokrinie der menschlichen Vorsteherdrüse. Virchows Arch (Zellpathol) 312: 393–404

    Google Scholar 

  63. Price DT, Schwin DA, Lomasney JW, Allen LF, Caron MG, Lefkowitz RJ (1993) Identification, quantification, and localization of mRNA for three distinet alpha 1 adrenergic receptor subtypes in human prostate. J Urol 150: 546–551

    PubMed  CAS  Google Scholar 

  64. Riva A, Testa Riva F, Motta PM (eds) (1994) Ultrastructure of the male urogenital glands: prostate, seminal vesicles, urethral, and bulbourethral glands. Kluwer Academic Publishers, Boston Dordrecht London

    Google Scholar 

  65. Ronquist G (1987) Effects of modulators on prostasome membrane-bound ATPase in human seminal plasma. Eur J Clin Invest 17: 231–236

    Article  PubMed  CAS  Google Scholar 

  66. Ronquist G, Brody I (1985) The prostasome: Ist secretion and funetion in man. Biochem Biophys Acta 822: 203–218

    PubMed  CAS  Google Scholar 

  67. Sar M, Lubahn DB, French FS, Wilsin EM (1990) Immunohistochemical localization of the androgen receptor in rat and human tissues. Endocrinol 127: 3180–3186

    Article  CAS  Google Scholar 

  68. Schmitt M, Bausero P, Simoni P, Queuche D, Geoffroy V, Marshai C, Kempf J, Quirin-Stricker C (1995) Positive and negatice effects of nuclear receptors on transcription activation by AP-1 of the human choline acetyltransferase proximal promoter. J Neurosci Res 40:152–164

    Article  PubMed  CAS  Google Scholar 

  69. Schulze H, Barrack ER (1987) Immunohistochemical localization of estrogen receptors in the normal male and female canine urinary tract and prostate. Endocrinol 121:1773–1783

    Article  CAS  Google Scholar 

  70. Srigley JR, Dardick I, Warren R, Hartwick J, Klotz L (1990) Basal epithelial cells of human prostate gland are not myoepithelial cells. Am J Pathol 136:957–966

    PubMed  CAS  Google Scholar 

  71. Stiens R, Helpap B (1981) Histologische und proliferationskinetische Untersuchungen zum Wachstum der Rattenprostata in verschiedenen Lebensaltern. Acta Anat 109: 79–88

    Article  PubMed  CAS  Google Scholar 

  72. Stilling B (1870) Die rationelle Behandlung der Harnröhren-Stricturen, Bd. 1. Kassel

    Google Scholar 

  73. Strasser H, Klima G, Poisel S, Horninger W, Bartsch G (1996) Anatomy and innervation of the rhabdosphincter of the male Urethra. Prostate 28:24–31

    Article  PubMed  CAS  Google Scholar 

  74. Sugimura Y, Cunha GR, Donjacour AA (1986) Morphogenesis of ductal networks in the mouse prostate. Biol Reprod 34:961–971

    Article  PubMed  CAS  Google Scholar 

  75. Tenniswood MP, Guenette RS, Lakins J, Mooibroek M, Wong P, Welsh JE (1992) Active cell death in hormone-dependent tissues. Cancer Metastasis Rev 11:197–220

    Article  PubMed  CAS  Google Scholar 

  76. Tisell L-E, Salander H (1975) The lobes of the human prostate. Scand J Urol Nephrol 9:181–191

    Article  Google Scholar 

  77. Tunn UW, Schüring B, Senge T, Neumann F, Schweikert HU, Rohr HP(1980) Morphometric analysis of prostates in castrated dogs after treatment with androstenediol, estradiol, and cyproterone acetate. Invest Urol 18:289–293

    Google Scholar 

  78. Valaasti A (1980) Autonomie innervation of the prostate. Acta Univ Tamperensis Ser A 113:1–30

    Google Scholar 

  79. Van Poppel H, Vereecken P, de Geeter P, Verduyn H (1983) Hemospermia owing to utricular cyst: embryological summary and surgical review. J Urol 129:608–609

    PubMed  Google Scholar 

  80. Vercaeren I (1996) Androgen regulation of cystatin-related protein and the C3 component of prostatic binding protein in rat ventral prostate and lacrimal gland. PhD Thesis. Katholieke Universität Leuven

    Google Scholar 

  81. Verhagen APM, Aalders TW, Ramaekers FCS, Debruyne FMJ, Schalken JA (1988) Differentiation process in the prostatic epithelium on basis of intermediate filament expression. Prostate 13: 25–47

    Article  PubMed  CAS  Google Scholar 

  82. Vollmer G, Michna H, Ebert K, Knuppen R (1994) Androgen ablation induces tenascin expression in the rat prostate. Prostate 25: 81–90

    Article  PubMed  CAS  Google Scholar 

  83. von Hayek H (1969) Das Bindegewebe und die glatte Muskulatur des Beckenbodens. In: Ferner H, Gisel A, von Hayek H, Krause W, Zaki C (Hrsg) Die Anatomie der Harn- und Geschlechtsorgane. Handbuch der Urologie, Bd I. Springer, Berlin Heidelberg New York, S 289–313

    Google Scholar 

  84. Walsh PC, Lepor H, Eggleston JC (1983) Radical prostatectomy with preservation of sexual function: anatomical and pathological considerations. Prostate 4:473–485

    Article  PubMed  CAS  Google Scholar 

  85. Walsh PC, Quinlan DM, Morton RA, Steiner MS (1990) Radical retropubic prostatectomy Improved anastomosis and urinary continence. Urol Clin North Am 17:679–684

    PubMed  CAS  Google Scholar 

  86. Wang MC, Valenzuela LA, Murphy GP, Chu TM (1979) Purification of a human prostate specific antigen. Unvest Urol 17:159–163

    CAS  Google Scholar 

  87. Wernert N, Seitz G, Achtstätter T(1987) Immunohistochemical investigation of different cytokeratins and vimentin in the prostate from the fetal period up to adulthood and in prostate carcinoma. Pathol Res Pract 182: 617–626

    PubMed  CAS  Google Scholar 

  88. Witorsch RJ (1978) Immunohistochemical studies of prolactin binding in sex accessory organs of the male rat. J Histochem Cytochem 26: 565–580

    Article  PubMed  CAS  Google Scholar 

  89. Yu H, Diamandis EP (1995) Prostate-specific antigen in milk of lactating women. Clin Chem 41: 54–58

    PubMed  CAS  Google Scholar 

  90. Zhao GQ, Bacher M, Friedrichs B et al. (1993) Functional properties of isolated stroma and epithelium from rat ventral prostate during androgen deprivation and estrogen treatment. Exp.Cinendoctrinol 101:6977.

    Google Scholar 

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  1. Urologische Klinik, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland

    Klaus Höfner , Udo Jonas  & Christian G. Stief ,  & 

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Aumüller, G. (2000). Anatomie. In: Höfner, K., Jonas, U., Stief, C.G. (eds) Benigne Prostatahyperplasie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59580-6_2

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