Zusammenfassung
Der Hypothalamus spielt als Relaisstation (Umsetzer) eine wichtige Rolle zur Transformation elektrischer Impulse des ZNS in biochemische Signale (sog. Releasing-Hormone: GnRH, CRF, GHRF, TRH und Somatostatin), die durch Neurosekretion über den Hypophysenstiel zur Hypophyse transportiert werden.
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Literatur
Literatur zu Abschn. 5.7 bis 5.6
Adashi E. (1997) Menstrual cyele: Follicular maturation. In: Rabe T., Runnebaum B. (eds) Manual on assisted reproduction. Springer, Berlin Heidelberg Tokyo New York, p 12–21
Breckwoldt M., Keck C., (1997) Pubertät und Adoleszenz. In: Keck C., Neulen J., Breckwoldt M. (Hrsg) Endokrinologie, Reproduktionsmedizin, Andrologie. Thieme, Stuttgart
Gerhard I., Heinrich U. (1994) Die Pubertät und ihre Störungen. In Runnebaum B., Rabe T. (Hrsg) Gynäkologische Endokrinologie und Fortpflanzungsmedizin. Bd 1, Springer, Berlin Heidelberg New York Tokyo
Gerhard I., Runnebaum B. (1994) Endokrinologie der Frühschwangerschaft. In: Runnebaum B., Rabe T. (Hrsg) Gynäkologische Endokrinologie und Fortpflanzungsmedizin. Bd 2, Springer, Berlin Heidelberg New York Tokyo
Gougeon A. (1986) Dynamics of follicular growth in the human: a model from preliminary results. Human Reprod 1:81–87
Grunewald K., Rabe T., Runnebaum B. (1994) Physiologie des menstruellen Zyklus. In: Runnebaum B., Rabe T. (Hrsg) Gynäkologische Endokrinologie und Fortpflanzungsmedizin. Bd 1, Springer, Berlin Heidelberg New York Tokyo
Grunwald K., Rabe T., Runnebaum B. (1997) Physiology of the menstrual cyele. In: Rabe T., Runnebaum B. (eds) Manual on assisted reproduction. Springer, Berlin Heidelberg New York Tokyo
Kelch R.P., Beitins I.Z. Adolescent sexual development. In: Kappy M.S., Blizzard R.M., Migeon C.J. (eds) Wilkins: The diagnosis and treatment of endocrine disorders in childhood and adolescence. 4th edn, Thomas, Springfield, IL, p 193
Schmitt-Mathiesen H., Hepp H. (1998) Gynäkologie und Geburtshilfe. Schattauer, Stuttgart
Tanner J.M. (1975) Growth and endocrinology of the adolescent, in: Gardner L.: Endocrine and Genetic Diseases of Childhood. Saunders, Philadelphia London
Literatur zu Absch. 5.7
Clayton R.N. (1997) Symptoms, signs and long-term outcomes of adulthood acquired hypopituitarism. In: Lamberts S.W.J. (ed) The diagnosis and Treatment of pituitary deficiency. Bristol, BioScientifica, pp 3–16
European and Australian Multicentre Study (1995) Co-treatment with growth hormone and gonadotropin for induction of ovulation in hypogonadotropic patients: a prospective, randomized, placebo-controlled dose respond study. Fertil Steril 64: 917–923
Gromoll J., Simoni M., Nordhoff V., Behre H.M., de Geyter C., Nieschlag E. (1996) Functional and clinical consequences of mutations in the FSH receptor. Mol-Cell-Endocrinol 125: 177–182
Gromoll J., Simoni M., Nieschlag E. (1996) An activating mutation of the follicle-stimulatung hormone rezeptor autonomously sustains spermatogenesis in a hypophysectomized man. J Clin Endocrinol Metab 81: 1367–70
Hardelin J.E., Petit C. (1995) A molecular approach to the pathophysiology of the X-Iinked Kallmann’s syndrome. Bailliere’ s Clin Endocrinol Metab 9: 489
Jänicke F., Rjosk H.K., Berg, D., Gioning K. (1983) Pulsatile GnRH-Substitution beim Kallmann-Syndrom der Frau. Geburtshilfe Frauenheilkd 43: 351–354
Knoll J.H.M., Cheng S.D., LaLande M.(1994) Allele specificity of DNA replication timing in the Angelman/Prader-Willi syndrome imprinte chromosomal region. Nature Genet 6: 41–46
Lamberts S.W.J., de Herder W.W., van der Lely A.J. (1998) Pituitary insufficiency. Lancet 352
Leyendecker G., Wildt L. (1983) Induction of ovulation with chronic intermittent (pulsatile) administration of GnRH in women with hypothalamic amenorrhoea. J Reprod Fertil 69: 397
Paff D.W. et al. (1982) GnRH neurons and other cellular molecular mechanisms for simple mammalian reproductive secretion. Acta abstet gynecol scand 61: 439–443
Petit, C. (1993)Molecular basis of the X-chromosome-linked Kallmann’s Syndrome. Trends Endocrinol Metab 4: 8
Wood D.F., Franks S. (1998) Hypogonadism in women. In: Grossman A. (ed) Clinical endocrinology. Blackwell Scientific Publications, Oxford, pp 702–717
Literatur zu Abschn. 5.8
Bierich J.R., Burgmann G., Kiessling E. (1989) The spontaneous secretion of GH during nocturnal sleep. Monatsschr Kinderhlk 137: 80
Brown D.C., Stirling H.F., Butler G.E., Kelnar C.J., Wu F.C. (1996) Differentiation of normal male prepuberty and hypogonadotrophic hypogonadism using an ultrasensitive luteinizing hormone assay. Horm Res 46: 83–87
Crowne E.C., Shalet S.M., Wallace W.H.B., Eminson D.M., Price D.A. (1991) Final height in girls with untreated CDGP. Eur J Pediatr 150: 708–712
De la Chapelle A. (1983) Sex chromosome abnormalities. In: Emery A.E.H., Rimoin D.L. (eds) Principles and practice of medical genetics. Vol. I. Churchill Livinstone, Edinburgh, pp 193–215
Haavisto A.M., Dunkel L., Petterson K., Huhtaniemi I.(1990) LH measurements by in vitro bioassay and a highly sensitive immunofluorometric assay improve the distinction beetween boys with constitutional delay of puberty and hypogonadotropic hypogonadism. Pediatr Res 27: 211–214
Hook E.B., Warburton D. (1983) The distribution of chromosomal genotypes associated with Turner’s syndrome: livebirth prevalence rates and evidence for diminished fetal mortality and severity in genotypes associated with structural x abnormalities of mosaicism. Hum Genet 64: 24–27
Nyborg H., Nielson J. (1977) Sex chromosomal abnormalities and cognitive performance: III Field dependence, frame dependence, and failing development of perceptual stability in girls with Turner’s syndrome. J Psychol 96: 205
Rosenfeld R.G., Attie K.M., Frane J. et al. (1998) Growth hormone therapy of Turner’s syndrome: beneficial effect on adult height. J Pediatr 132: 319–324
Stanhope R., Hindmarsh P., Pringle P.J., Holownia P., Honour J., Brook C.G.D. (1987) Oxondralone in duces a sustained rise in physiological growth hormone secretion in boys with constitutional delay of growth and puberty. Pediatrician 14: 183
Waber D.P. (1979) Neuropsychological aspects of Turner’s syndrome. Develop Med Child Neurol 21: 58–70
Waldstreicher J., Seminara S.B., Jameson J.L. et al. (1996) The genetic and clinical heterogeneity of gonadotropin-releasing hormone deficiency in the human. J Clin Endocrinol Metab 81: 4388–4395
Literatur zu Abschn. 5.9
Bettendorf G. (1976) Zum Problem der Gonadotropinbehandlung. Geburtshilfe Frauenheilkd 36: 1017
Cates W., Farley T.M.M., Rowe P.J. (1985) Worldwide pattern of infertility: is Africa different? Lancet, p 596–598
Collet M., Reniers J., Frost E. et al. (1988) Infertility in Central Africa; infection is the cause. Int J Gynaecol Obstet 26/3: 423–428
Daya S. (1989) Efficacy of progesterone support for pregnancy in women with recurrent miscarriage. A meta-analysis of controlled trials. Br J Obstet gynaecol 96: 275–280
Goldstein P., Berrier J., Rosen S., Sacks H.S., Chalmers T.C. (1989) A meta-aanalysis of randomized control trials of progestational agents in pregnancy. Br J Obstet Gynaecol 96: 265–274
Graf M.A., Fischer R. (1996) Diagnostik und Therapie beim ovariellen Hyperstimulationssyndrom. Gynäkologe 29: 300
Insler V., Melmed H., Lunenfeld B. (1972) The cervical score. Int J Gynecol Obstet 10: 223
Kaiser R., Daume E., Lang N. (1968) Ovulationsauslösung mit Clomiphen und Gonadotropin. Med Wochensch 47: 1
Lehmann F., Breckwoldt M. (1991) Gonadotropine: drei Jahrzehnte Entwicklung. HMG-Behandlung in der Praxis. Enke, Stuttgart (Bücherei des Frauenarztes Bd 39)
Leyendecker G., Wildt L. (1983) Induction of ovulation with chronic intermittent (pulsatile) administration of GnRH in women with hypothalamic amenorrhoea. J Reprod Fertil 69: 397
Lunenfeld B., Insler V., Glezerman M. (1992) Diagnosis and treatment of functional infertility, Blackwell, Berlin
Rudolf K., Martens E., Hofmann R., Rüting M. (1993) Ergebnisse der Behandlung der funktionellen Sterilität mit Clomiphen. Zentralbl Gynakol 105: 193
Schenker J.G., Yarkoni S., Granat M. (1981) Multiple pregnancies following induction of ovulation. Fertil Steril 35: 105
Thonneau P., Spira A. (1990) Prevalence of infertility: international data and problems of measurement. Eur J obstet gynecol Reprod Biol 38/1:43–52
Literatur zu Abschn. 5.10
Barret-Connor E., Bush T.L. (1991) östrogen and coronary heart disease in women. J Am Med Assoc 265: 1861–1867
Christiansen C., Christiansen M.S., Transböl I.(1981) Bone mass in postmenopausal women after withdrawal of oestrogenl ge stagen replacement therapy. Lancet 1: 459–461
Collaborative Group on Hormonal Factors in Breast Cancer (1997). Lancet 350: 1047–59
Daly E., Vessey M.P., Hawkins M.M., Carson J.L., Gough P., Marsh S. (1996) Risk of venous thromboembolism in users of hormone replacement therapy. Lancet 348: 977–980
Editorial (1995) START beschreibt Aspekte der AlzheimerKrankheit: Ärztliche Hilfe für Demenzkranke. START 3: 6–18
Grodstein F., Stampfer M.J., Goldhaber S.Z. et al. (1996) Prospective study of exogenous hormones and risk of pulmonary embolism in women. Lancet 348: 983–987
Hemminki E., McPherson K. (1997) Impact ofpostmenopausalhormone therapy on cardiovascularevents and cancer: pooled data from clinical trials. BMJ 315: 149–53
Henderson V.W. (1998a) Östrogens and prevention of Alzheimer’s disease. The Management of the Menopause. Annual Review, Parthenon, London, pp 183–192
Henderson V.W. (1998b) Sexualsteroide und Alzheimer-Krankheit: Therapeutische Überlegungen. In: ESKA (eds) S. 51–60 (IV. Europäischer Menopausen Kongress, Wien)
Hillard T.C., Whitehead M.I. (1991) Hormon Substitutionstherapie-Wege der Verabreichung. In: Medical Communications Services (Hrsg) Kardiovasculäre Wirkungen einer Hormon Substitutionstherapie. Proceedings Internationales Novo Nordisk Symposium Kopenhagen, Dänmark, 1.-2. Februar 1991
Hollihn U.K. (1997) The climacteric-a period of transition. Hormone Replacement Therapy and the Menopause, pp 12–107; Schering
Hulley S. et al. (1998) Randomized Trial of Ostrogen Plus Progestin for Secondary Prevention of Coronary Heart Disease in Postmenopausal Women. JAMA 280: 605–613
Jick H., Derby L.E., Myers M.W., Vasilakis C., Newton K.M. (1996) Risk of hospital admission for idiopathic venous thromboembolism among users of postmenopausal estrogens. Lancet 348: 981–983
Kannel W.B., Hjortland M.C., Mcnamara P.M., Gordon T. (1976) Menopause and risk of cardiovascular disease: the Framingham study. Ann Intern Med 85(4)
Lilly (1998) Produktinformation EVISTA
Potthoff P. et al. (2000) The Menopause Rating Scale (MRS II): methodological standardization in the German population. Zentralbl Gynakol 122(5): 280–6
Rabe T., Grunwald K., Vladescu E., Runnebaum B. (1998) Kardiovaskuläres Risiko und Hormonersatztherapie. Der Gynäkologe 10(31):859–869
Runnebaum B., Rabe T., Holst T. von, Wüster C. (1994) Klimakterium der Frau. In: Runnebaum B., Rabe T. (eds) Gynäkologische Endokrinologie und Reproduktionsmedizin, Bd 1, Springer, Berlin Heidelberg New York Tokyo, S 513–588
Sarrel P. (1989) Effects of ovarian steroids on the cardiovascular system. In: Ginsburg J. (ed) The circulation of the female. Parthenon, Carnforth, New Jersey, pp 117–140
Schiff I., Komarov Sela H., Cramer D., Tulchinsky D., Ryan K.J. (1982) Endometrial hyperplasia in women on cyclic or continuous es trogen regimens. Fertil Steril 37: 79–82
Smith-Bindmann R. et al. (1998) JAMA 280: 1510–1517
Swales J.D. (1996) Cardiovascular complications and the menopause. In: Messerli F.H. (ed) (1996) Hypertension in postmenopausal women, Dekker, pp 139–148
Holst T. von(1982) Hormonelle Diagnostik im Klimakterium der Frau. Habilitationsschrift, Ruprecht-Karls-Universitä ts-Heidelberg
Whitehead M.I. (1986) Prevention of endometrial abnormalities. Acta Obstet Gynecol Scand Suppl 134: 81–91
Literatur zu Abschn. 5.77
Anasti J.N., Flack M.R., Froehlich J., Nelson L.M., Nisula B.C. (1995) A potential novel mechanism for precocious puberty in juvenile hypothyroidism. J Clin Endocrinol Metab 80: 276–279
Balducci R., Boscherini B., Mangianlini A., Morellini M., Toscano V. (1994) Isolated precocious pubarche: an approach. J Clin Endocrinol Metab 79: 582
Blanco-Garcia M., Evain-Brian D., Roger M., Job J.C. (1985) Isolated menses in prepubertal girls. Pediatrics 76: 43
Crowley W.F., Comite F., Vale W., Rivier J., Loriaux D.L., Cutler G.B. (1981) Therapeutic use for pituitary desensitization with a long-acting LHRH agonist: a potential new treatment for idiopathic precocious puberty. J Clin Endocrin Metab 52: 370
Feuillan P.P., Forster C.M., Pescowitz O.H. (1986) Treatment of precocious puberty in the McCune Albright syndrome with the aromatase inhibitor testolactone. New Engl J Med 315: 1115
Freni-Titulaer L.W., Cordero J.F., Haddock L., Lebron G., Martinez R., Mills J.L. (1986) Premature thelarche in Puberto Rico. Am J Dis Child 140: 1263
Garibaldi L.R., Picco P., Magier S., Chevli R., Aceto T. (1991) Serum luteinizing hormone concentrations, as measured by a sensitive immunoradiometric assay in children with normal precocious and delayed pubertal development.J Clin Endocrinol Metab 72: 888
Ibanez L., Potau N., Virdis R. et al. (1993) Postpubertal outcome in girls diagnosed of premature pub arche during childhood: increased frequency of functional ovarian hyperandrogenism. J Clin Endocrinol Metab 76: 1599
Ilicki A., Lewin R.P., Kauli R., Kaufman H., Schachter A., Laron Z. (1984) Premature thelarche-maternal history and sex hormone secretion in 68 girls. Acta Paediatr Scand 73: 756
Kauli R., Galatzer A., Kornreich L., Lazar L., Pertzelan A., Laron Z. (1997) Final height of girls with central precocious pub erty untreated vs. treated with cyproterone acetate or GnRH analogue. A comperative study with reevaluation of predictions by the Bayley-Pinneau method. Horm Res 47(2):54–61
Korth-Schütz S., Levine L.S., New M.I. (1976) Dehydroepiandrosterone sulfate (DS) levels, a rapid test for abnormal adrenal androgen secretion. J Clin Endocrinol Metab 42: 1005
Lee P.A., Dop C. van, Migeon C. (1986) McCune Albright Syndrome: longterm follow up. JAMA 256: 1980
Lee P.A. (1994) Laboratory monitoring of children with precocious puberty. Arch Pediatr Adolesc Med 148: 369
Manasco P.K., Pescowitz O.H., Hill S.C., Jones J.M., Barnes K.M., Hench K.D., Loriaux D.L., Cutler G.B. (1989) Six year results of luteinizing hormone releasing hormone (LHRH) agonist treatment in children with LHRH-dependent precocious puberty. J Pediatr 115: 105
Marshall W.A., Tanner J.M. (1969) Variations in the pattern of pubertal changes in girls. Arch Dis Child 44: 291–296
Nelson K.G. (1983) Premature thelarche in children born prematurely. J Pediatr 103: 756
Oostdijk W., Rikken B., Schreuder S. et al. (1996) Final height in central precocious puberty after long term treatment with slow release GnRH agonist. Arch Dis Child 75: 292–297
Rosenfield R.L. (1994) Selection of children with precocious puberty for treatment with gonadotropin releasing hormone analogs. J Pediatr 124: 989–991
Saggese G., Bertelloni S., Baroncelli G.I., Battini R., Franchi G. (1993) Reduction of bone density: an effect of gonadotropin releasing hormone agonist treatment in central precocious puberty. Eur J Pediatr 152: 7 A
Sippell W.G., Partsch C.J., Hümmelink R., Lorenzen F. (1992) Langzeittherapie mit dem Retard-LHRH-Agonisten Decapeptyl-Depot bei Mädchen mit Pubertas praecox vera. Ergebnisse einer internationalen Multizenterstudie. Gynäkologe 24: 108
Temeck J.W., Pang S., Nelson C., New M.I. (1987) Genetic defects of steroidogenesis in premature pub arche. J Clin Endocrinol Metab 64: 609
Weinstein L.S., Shenker A., Gejman P.V., Merino M.J., Friedman E., Spiegel A.M. (1991) Activating mutations ofthe stimulating G-protein in the McCune Albright Syndrome. New Engl J Med 325: 1688
Literatur zu Abschn. 5.72
Baron J. (1974) Diagnostik und Therapie des Hirsutismus. Zentralb Gynakol 5: 129–142
Bruchowsky N. (1979) Molekulare Wirkung von Androgenen und Antiandrogenen, 7-21. In: Hammerstein J., LachnitFixon U., Neumann F., Plewig G. (Hrsg) Androgenisierungserscheinungen bei der Frau. 1. Aufl, Excerpta Medica, Amsterdam, S 7–21
Ferriman D., Gallwey J.D. (1961) Clinical assessement of body ha ir growth in women. J Clin Endocr 21: 1440–1447
Grunwald (1998) Persönliche Mitteilungen
Leidenberger F. (1997) Klinische Endokrinologie für Frauenärzte. Springer, Berlin Heidelberg New York Tokyo
Rosenfield R.L. (1971) Plasma testosterone binding globulin and indexes of the concentration of unbound plasma androgens in normal and hirsute females. J Clin Endocrinol 32: 717–728
Rabe T., Runnebaum B. (1994) Funktionsteste und Untersuchungsmethoden in der gynäkologischen Endokrinologie und Fortpflanzungsmedizin. In: Runnebaum B., Rabe T. (Hrsg) Gynäkologische Endokrinologie und Fortpflanzungsmedizin, Springer, Berlin Heidelberg new York Tokyo, S 29–98
Rabe T., Grunwald K., Runnebaum, B. (1994) Androgenisierungserscheinungen bei der Frau. In: Runnebaum B., Rabe T. (Hrsg.) Gynäkologische Endokrinologie, Springer, Berlin Heidelberg New York Tokyo, S 589–665
Literatur zu Abschn. 5.73
Blanche H., Vexiau P., Clauin S. et al. (1997) Exhaustive screening of the 21-hydroxylase gene in a population of hyperandrogenic women. Hum Genet 101: 56–60
Dörr H.G., Schulze E. (1998) Das adrenogenitale Syndrom. Gynäkologe 31: 539–548
Dörr H.G., Sippell W.G., Willig R.P. (1992) Pränatale Therapie und Diagnostik des adrenogenitalen Syndroms mit 21-Hyxdroxylasedefekt. Mschr Kinderheilkd 140: 661–663
Geley S., Kapelari K. et al. (1996) CYP11B1 mutations causing congenital adrenal hyperplasia due to 11 ß-hydroxylase deficiency. J Clin Endocr Metab 81: 2896–2901
Hughes I.A., Dyas J., Robinson J., Walker R.F., Fahmy D.R. (1985) Monitoring treatment in congenital adrenal hyperplasia. Use of serial measurements of 17-OH-progesterone in plasma, capillary blood, and saliva. Ann NY Acad Sci 458: 193–202
Jaresch S., Komely E., Kley H.K., Schlaghecke R. (1992) Adrenal incidentaloma and patients with homozygous or heterozygous congenital adrenal hyperplasia. J Clin Endocr Metab 74: 685–689
Laue L., Merke D.P., Jones J.V., Bames K.M., Hili S., Cutler G.B. Jr. (1996) A preliminary study of flutamide, testolactone, and reduced hydrocortisone dose in the treatment of congenital adrenal hyperplasia. J Clin Endocr Metab 81: 3535–3539
Lifton R.P., Dluhy R.G. et al. (1992) A chimaeric 11ß-hydroxylase/aldosterone synthase gene causes Glucocorticoid-remidiable aldosteronism and human hypertension. Nature 355: 262–265
Lin D., Sugawara T. et al. (1995) Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267: 1828–1831
Mauthe I., Laspe H., Knorr D. (1977) Zur Häufigkeit des kongenitalen adrenogenitalen Syndroms (AGS) München 1963-1972. Klin Padiatr 189: 172–176
Miller W.L. (1988) Molecular biology of steroid hormone synthesis. Endocr Rev 9: 295–318
Miller W.L. (1994) Genetics, diagnosis and management of 21-hydroxylase deficiency. J Clin Endocriniol Metab 78: 241–246
Miller W.L., Auchus R.J., Geiler D.H. (1997) The regulation of 17,20 lyase activity. Steroids 62: 133–142
Morel Y., Miller W.L. (1991) Clinical and molecular genetics of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Adv Hum Genet 20: 1–68
New M.I. (1992) Genetic dis orders of adrenal hormone synthesis. Horm Res 37 (Suppl 3):22–33
New M.I. (1994) 21-Hydroxylase deficiency congenital adrenal hyperplasia. J Steroid Biochem Molec Biol 48: 15–22
Pang S. (1997) Congenital adrenal hyperplasia. Bailliere’s Clin Obstet Gynacol 11: 281–306
Pang S. (1997) Congenital adrenal hyperplasia. Endocrinol Metab Clin North Am 26: 853–891
Pang S., Shook M.K. (1997) Current status of neonatal sereening for congenital adrenal hyperplasia. Curr Opin Pediatr 9: 419–423
Prader A. (1958) Vollkommen männliche äußere Genitalentwicklung und Salzverlustsyndrom bei Mädchen mit kongenitalem adrenogenitalem Syndrom. Helv Pediatr Acta 1: 5–15
Sakkal A.H., Zhang L. (1996) Studies of 3ß-hydroxysteroid dehydrogenase genes in infants and children manifesting premature pubarche and increased adrenocorticotropin-stimulated delta 5-steroid levels. J Clin Endocr Metab 81: 3961–3965
Schmidt-Matthiesen H., Hepp H. (1998) Gynäkologie und Geburtshilfe. Schattauer, Stuttgart
Silbernagl A., Despopoulus (1983) Taschenatlas der Physiologie. 2. Aufl. Thieme, Stuttgarl New York
Simard J., Rheaume E. et al. (1993) Molecular basis of congenital adrenal hyperplasia due to 3ß-hydroxysteroid dehydrogenase deficiency. Mol Endocr 7: 716–728
Speiser P.W., Dupont J. et al. (1992) Disease expression and molecular genotype in congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J Clin Inverst 90: 584–595
Speiser P.W., New M.I. (1994) Prenatal diagnosis and treatment of cungenital badrenal hyperplasia. J Pediatr Endocrinol 7: 183–191
Stocco D.M., Clark B.J. (1997) The role of steroidogenic acute regulatory pro tein in adrenal and gonadal steroidogenesis. Steroids 62: 29–36
White P.C., Cumow K.M., Pascoe L. (1994) Disorders of steroid 11ß-hydroxylase isozymes. Endocr Rev 15: 421–438
Wilson R.C., Mercado A.B., Cheng K.C., New M.I. (1995) Steroid 21-hydroxylase deficiency: genotype may not predict phenotype. J Clin Endocrinol Metab 80: 2322–2329
Yanase T., Simpson E.R., Waterinan M.R. (1991) 17a-hydroxylase/ 17,20-lyase deficiency: from clinical investigation to molecular definition. Endocr Rev 12: 91–108
Zachmann M., Tassinari D., Prader A. (1983) Clinical and biochemical variability of congenital adrenal hyperplasia due to 11 ß-hydroxylase deficiency. J Clin Endocr Metab 56: 222–229
Literatur zu Abschn. 5.74
Bergfeld W.F. (1979) Diffuser Haarausfall bei Frauen. In: Orfanos C.E. (Hrsg) Haar und Haarkrankheiten. Fischer, Stuttgart, S 493–503
Bergfeld W.F. (1995) Androgenetic alopecia: an autosomal dominant disorder. Am J Med 98: 95S–98S
Ebling F.J.G. (1986) Hair follicles and associated glands as androgen targets. Clin Endocrinol Metab 15: 319–339
Freinkel R., Freinkel N. (1972) Hair growth in hypothyreoidism. Arch Dermatol 106: 349–352
Gerhard I. (1992) Erst ausschwemmen, dann Dauer-Prophylaxe. In: Medical Tribune 22: 37
Headington J. (1984) Transverse microscopic anatomy of the human scalp. Arch Dermatol 120: 449–456
Klobusch J., Rabe T., Gerhard I., Runnebaum B. (1992) Alopezie und Umweltbelastungen. Klin Lab 38: 469–476
Laue L., Merke D.P., Jones J.V., Bames K.M., Hili S., Cutler G.B. Jr. (1996) A preliminary study of flutamide, testolactone and reduced hydrocortisone dose in the treatment of congenital adrenal hyperplasia. J Clin Endocrinol Metab 81(10):3535–3539
Ludwig E. (1977a) Androgenetische Alopezie. Arch Dermatol 113: 109
Ludwig E. (1977b) Classification of types of androgenetic alopecia (common baldness) occuring in the female sex. Br J Dermatol 97: 247–254
Maguire H.C., Kligman A.M. (1964) Hair plucking as a diagnostic test. J Invest Dermatol 43: 77–80
Orfanos C.E. (1990) Androgenetic alopecia: Clinical aspects and treatment. In: Orfanos C.E., Happle R. (Hrsg) Hair and Hair Diseases. Springer, Berlin Heidelberg New York Tokyo, pp 485–521
Salomon T. (1968) Genetic factors on male alopecia. In: Baccaredda-Boy A., Morretti G., Frey J.R. (Hrsg) Biopathology of pattern alopecia. Karger, Basel, S 39–49
Sawaya M.E., Price V.H. (1997) Different levels of 5 a-reductase type 1 and 11, aromatase, and androgen receptor in hair follicles of women and men with androgenetic alopecia. J Invest Dermatol 109: 296–300
Schurz B., Schmidt J.B., Merka M., Huber J.C. (1986) Zur klinischen Bedeutung des TRH-Tests bei der Sterilitätsabklärung und beim androgenetischen Effluvium. Gynakol Rundsch 26 (Suppl 2):195–198
Tronnier H., Essig F. (1976) Zur internen Therapie des Haarausfalles. Acta Dermatol 2: 147–154
Venning V.A., Dawber R.P.R. (1988) Patterned androgenic alopecia in women. J Am Acad Dermatul 18: 1073–1077
Verbow J.L. (1978) Common baldness occuring in females only in one generation. Brit J Clin Pract 32: 261–262
Zaun H., Perret C. (1990) Intemal diseases affecting hair growth. In: Orfanos C.E., Happle R. (ed) Hair and Hair Diseases. Springer, Berlin Heidelberg New York Tokyo, pp 587–600
Literatur zu Abschn. 5.75
Axelrod L.R., Goldzieher J.W. (1962) The polycystic ovary. III. Steroid biosynthesis in normal and polycystic ovarian tissue. J Clin Endocrinol Metab 22: 359–368
Burghen G.A., Givens J.R., Kitabchi A.E. (1980) Correlation of hyperandrogenism with hyperinsulinemia in polycystic ovarian disease. J Clin Endocrinoi Metab 50: 113
Chang R.J., Geffner M.E. (1985) Associated nonovarian problems of polycystic ovarian disease: insulin resistance. Clin Obstet Gynecol 12: 675–685
Chang R.J., Nakamura R.M., Judd H.L., Kaplan S.A. (1983) Insulin resistance in nonobese patients with polycystic ovarian disease. J Clin Endocrinol Metab 57: 356–359
Erickson G.F., Case E. (1983) Epidermal growth faetor antagonizes ovarian theea-interstitial eytodifferentiation. Mol Cell Endocrinol 31: 71–76
Goldzieher J.W., Green J.A. (1962) The polyzystie ovary. I. Clinical and histologie features. J Clin Endocrinol Metabol 22: 325–335
Kahn C.R., Flier J.S., Bar R.S., Areher J.A., Gorden P., Marhn M.M., Roth J. (1976) The syndromes of insulin resistanee and aeanthosis nigricans. N Engl J Med 294: 739–747
Laatikainen T.J., Apter D.L., Paavonen J.A., Wahlstrom T.R. (1980) Steroids in ovarian and peripheral venous blood in polyeystie ovarian disease. Clin Endocrinol 13: 125–134
Pasquali R., Casimirri F., Venturoli S. et al. (1983) Insulin resistanee in patients with polyeystie ovaries: its relationship to bodyweight and androgen levels. Aeta Endocrinol (Copenh) 104: 110–116
Pasquali R., Fabbri R., Venturoli S., Paradisi R., Antenucci D., Melchionda N. (1986) Effeet of weight loss and antiandrogenie therapy on sex hormone blood levels and insulin resistanee in obese patients with polyeystic ovaries. Am J Obstet Gynecol 154: 139–144
Short R.V. (1962) Further observations on the defective synthesis of ovarian steroids in the Stein-Leventhal syndrome. J Endocrinol 24: 359–368
Short R.V., London D.R. (1961) Defective synthesis of ovarian steroids in the Stein-Leventhal syndrome. BMJ 1: 1724–1731
Shoupe D., Lobo R.A. (1984) The intluence of androgens on insulin resistance. Fertil Steril 41: 385–388
Smith S., Ravniear V.A., Barbieri R.L. (1987) Androgen and insulin response to an oral glucose challenge in hyperandrogenie women. Fertil Steril 48: 72–77
Smith K.D., Steinberger E., Perioff W.H. (1965) Polycystic ovarian disease. Areport of 301 patients. Am J Obstet Gynecol 93: 994–1004
Stuart C.A., Peters E.J., Prince M.J., Richards G., Cavallo A., Meyer W.J. (1986) Insulin resistance with acanthosis nigricans: the roles of obesity and androgen exeess. Metabolism 13: 197–204
Literatur zu Abschn. 5.76
Abs R., Parizel P.M., Beckers A. (1991) Acute effects of Parlodel LAR and response to long-term treatment with bromocriptine in a patient with a follicle stimulating hormone-secreting pituitary adenoma. J Endocrinol Invest 14: 135–138
Katznelson I., Alexander J.M., Bikkal H.A., Jameson J.L., Klibanski A. (1992) Imbalanced follicie-stimulating hormone betasubunit hormone biosynthesis in human pituitary adenomas. J Clin Endocrinol Metab 74: 1343–1351
Kontogeorgos G., Kovacs K., Horvath E., Scheithauer B.W. (1993) Null cell adenomas, oncocytomas, and gonadotroph adenomas of the human pituitary: an immunocytochemical and ultrastructural analysis of 300 cases. Endocr Pathol 4: 20–27
Kovacs K., Horvath E., Rewcastle N.B., Ezrin C. (1980) Gonadotroph cell adenoma of the pituitary in a woman with longstanding hypogonadism. Arch Gynecol 229: 57–65
Kovacs K., Horvath E., Ryan N., Ezrin C. (1980) Null cell adenomas of the human pituitary. Virchows Arch (A) 387: 165–174
Kovacs K., Asa S.L., Horvath E. (1991) Cytogenesis of non-functioning pituitary adenoma (abstract). Endocr Pathol 2: 177–179
Lamberts S.W., Verleun T., Oosterom R., Hotland L., van Ginkel L.A., Loeber J.G., van Vroonhoven C.C., Stefanko S.Z., de Jong F.H. (1987) The effects of bromocriptine, Thyrotropin-releasing hormone, and gonadotropin-releasing hormone on hormone secretion by gonadotropin-secreting pituitary adenomas in vivo and in vitro. J Clin Endocrinol Metab 64: 524–30
Mermillion J.A., Gatchair-Rose A., Svec F. (1995) Pituitary Tumor and low gonadotropins in a patient with Turner’s Syndrome. J State Med Soc 147: 540–543
Nicolis G., Shimshi M., Allen C., Halmi N.S., Kourides I.A. (1988) Gonadotropin-producing pituitary adenoma in a man with long-standing primary hypogonadismn. J Clin Endocrinol Metab 66: 237–241
Polkowska J., Berault A., Hurbain-Kosmath I., Jolly G., Jutisz M. (1991) Bihormonal celle producing gonadotropins and prolactin in a rat pituitary tumor cell line (RC-4B/C). Neuroendocrinology 54: 267–273
Samaan N.A.; Stepanas A.V., Danziger J., Trujillo J. (1979) Reactive pituitary abnormalities in patients with Klinefelter’s and Turner’s Syndromes. Arch Intern Med 139: 198–201
Sano T., Yamada S. (1994) Histologie and immunohistochemical study of clinically nonfunctioning pituitary adenomas: special reference to gonadotropin-positive adenomas. Pathol Int 44: 697–703
Sassolas G., Lejeune H., Trouillas J., Forest M.G., Claustrat B., Lahlou N., Loras B. (1988) Gonadotropin-releasing hormone agonists are unsuccessful in reducing tumoral gonadotropin secretion in two patients with gonadotropin-secreting pituitary adenomas. J Clin Endocrinol Metab 67: 180–185
Spertini F., Deruaz J.P., Perentes E., Pelet B., Gomez F. (1986) Luteinizing hormone (LH) and prolactin-releasing pituitary tumor: possible malignant transformation of the LH cell line. J Clin Endocrinol Metab 62: 849–854
Vance M.L., Ridgway E.C., Thorner M.O. (1985) Follicle-stimulating hormone—and alphasubunit-secreting pituitary tumor treated with bromocriptine. J Clin Endocrinol Metab 61: 580–584
Young W.F. Jr., Scheithauer B.W., Kovaes K.T., Horvath E., Davis D.H., Randall R.V. (1996) Gonadotroph adenoma of the pituitary gland: a clinicopathologic analysis of 100 eases. Mayo Clin Proc 71: 649–656
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v. Hagens, C. et al. (2001). Weibliche Gonaden. In: Nawroth, P.P., Ziegler, R. (eds) Klinische Endokrinologie und Stoffwechsel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56784-1_5
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