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Prolaktin und Brustdrüse

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Klinische Endokrinologie und Stoffwechsel

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Zusammenfassung

Das humane Prolaktin (PRL) ist ein einkettiges Peptidhormon mit 199 Aminosäuren und 3 Disulfidbrücken (Abb.2-1). Die Molekülmasse beträgt 23.000. Prolaktin und Wachstumshormon („growth hormone“ = GH) haben eine ausgeprägte Interspezieshomologie. Es wird angenommen, dass PRL, GH und das plazentare Laktogen (hPL) sich aus einem primordialen Urgen entwickelt haben. Die Transkription des PRL-Gens, welches auf Chromosom 6 lokalisiert ist, wird durch verschiedene Faktoren reguliert. Ein Transkriptionsfaktor ist Pit-1, der nicht nur die PRL-, sondern auch die GH - und TSH -Genexpression stimuliert.

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Authors
  1. F. Peters
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  2. K. v. Werder
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Editors and Affiliations

  1. Medizinische Klinik IV, Universitätsklinikum Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Deutschland

    Peter P. Nawroth

  2. Abteilung Innere Medizin I, Medizinische Universitätsklinik und Poliklinik Heidelberg, Bergheimer Straße 58, 69115, Heidelberg, Deutschland

    Reinhard Ziegler

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© 2001 Springer-Verlag Berlin Heidelberg

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Peters, F., Werder, K.v. (2001). Prolaktin und Brustdrüse. In: Nawroth, P.P., Ziegler, R. (eds) Klinische Endokrinologie und Stoffwechsel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56784-1_2

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  • DOI: https://doi.org/10.1007/978-3-642-56784-1_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62970-9

  • Online ISBN: 978-3-642-56784-1

  • eBook Packages: Springer Book Archive

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