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Zusammenfassung

Noradrenalin, Adrenalin und Dopaminderivate des Katechols (l,2-Dihydroxybenzol) werden im zentralen Nervensystem (ZNS), sympathischen Nerven und Ganglien sowie in den chromaffinen Zellen des Nebennierenmarks (NNM) gebildet. Im ZNS sind Dopamin und Noradrenalin weit verbreitet, während Adrenalin im Gehirn der Säugetiere in relativ niedrigen Konzentrationen gefunden wird. In der Peripherie ist Noradrenalin der Transmitter des postganglionären sympathischen Nervensystems und Dopamin ist als relevanter Regulator an der renalen Durchblutung beteiligt. Adrenalin wird in der Peripherie vor allem in den chromaffinen Zellen des NNM gebildet und freigesetzt.

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Literatur

  • Averbuch S.D., Steakley C., Young R.C., Gelmann E.P., Goldstein D.S., Stull R., Keiser H.R. (1988) Malignant pheochromocytoma: effective treatment with a combination of cyclophosphymide, voncristine and dacarbazine. Ann Int Med 109: 267–273

    Article  PubMed  CAS  Google Scholar 

  • Bannister R., Mathias C.J. (1993) Autonomic failure. Oxford Medical Publications, Oxford

    Google Scholar 

  • Beldjord C., Desclaux-Arramond F., Raffin-Sanson M. et al. (1995) The ret-protooncogene in sporadic pheochromocytomas: Frequent MEN 2-like mutations and new molecular defects. J Clin Endocrinol Metab 80: 2063–2068

    Article  PubMed  CAS  Google Scholar 

  • Bravo E.L. (1996) Plasma or urinary metanephrines for the diagnosis of pheochromocytoma? That is the question. Ann Int Med 125: 331–332

    Article  PubMed  CAS  Google Scholar 

  • Canale M.P., Bravo E.L. (1994) Diagnostic specificity of serum chromogranin A for pheochromocytoma in patients with renal dysfunction. J Clin Endocrinol Metab 78: 1139–44

    Article  PubMed  CAS  Google Scholar 

  • Chen Y., Best J.A., Nagamoto K., Tank A.W. (1996) Regulation of tyrosine hydroxylase gene expression by the ml muscarinic acetylcholine receptor in rat pheochromocytoma cells. Brain Res Mol Brain Res 40: 42–54

    Article  PubMed  CAS  Google Scholar 

  • Duerr E.M., Gimm O., Neuberg D.S., Kum J.B., Clifford S.C., Toledo S.P., Maher E.R., Dahia P.L., Eng C. (1999) Differences in allelic distribution of two polymorphisms in the VHL-associated gene CUL2 in pheochromocytoma patients without somatic CUL2 mutations. J Clin Endocrinol Metab 84: 3207–3211

    Article  PubMed  CAS  Google Scholar 

  • Eisenhofer G., Lenders J.W., Linehan W.M., Walther M.M., Goldstein D.S., Keiser H.R. (1999) Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2. N Engl J Med 340: 1872–1879

    Article  PubMed  CAS  Google Scholar 

  • El-Mestikawy S., Glowinski J., Hamon M. (1983) Tyrosine hydroxylase activation in depolarized dopaminergic terminals-involvement of Ca2 +-dependent phosphorylation. Nature 302: 830–832

    Article  PubMed  CAS  Google Scholar 

  • Kopf D., Bockisch A., Steinert H., Hahn K., Beyer J., Neumann H.P.H., Hensen J., Lehnert H. (1997) Octreotide scintigraphy and catecholamine response to an octreotide challenge in malignant pheochromocytoma. Clin Endocrinol 46: 39–44

    Article  CAS  Google Scholar 

  • Kopf D., Goretzki P.E., Lehnert H. (2000) Clinical management of malignant adrenal tumors. J Cancer Res Clin Oncol 2000, in press

    Google Scholar 

  • Lehnert H. (1995) Diagnostik und Therapie des malignen Phäochromozytoms. In: Leiehnert H, Kopf D, Hensen J. (Hrsg) Endokrine Tumoren-Jahrestagung der Sektion Angewandte Endokrinologie der Deutschen Gesellschaft für Endokrinologie. Bundesdruckerei Neu-Isenburg, S 157–165

    Google Scholar 

  • Ligget, S.B. und Raymond, J.R. (1993) Pharmacology and molecular biology of adrenergic receptors. Bailliere’s Clin Endocrinol Metabol vol 7/2: 279–306

    Article  Google Scholar 

  • Lehnert H. (1998) Regulation of catecholamine synthesizing enzyme gene expression in human pheochromocytoma. Eur J Endocrinol 138: 363–367

    Article  PubMed  CAS  Google Scholar 

  • Manger T., Piatek S., Klose S., Kopf D., Kunz D., Lehnert H., Lippert H. (1997) Bilaterale laparoskopische Adrenalektomie beim Phäochromozytom. Langenbecks Arch Chir Suppl Kongressbd 382: 37–42

    CAS  Google Scholar 

  • Mathias C.J. (1993) Sympathetic nervous system dis orders in man. Bailliere’s Clin Endocrinol Metab 7: 465–490

    Article  CAS  Google Scholar 

  • Minneman K.P. (1988) α-adrenergic receptor subtypes, inositol phosphates, and sources of cell Ca2+. Pharmacol Rev 40: 87–119

    PubMed  CAS  Google Scholar 

  • Mulligan L.M., Eng C., Healey C.S. et al. (1994) Specific mutations of the ret proto-oncogene are related to disease phenotype in MEN 2 A and FMTC. Nature Genet 6: 70–74

    Article  PubMed  CAS  Google Scholar 

  • Mundschenk J., Lehnert H. (1998) Malignant pheochromocytoma. Exp Clin Endocrinol Diabetes 106: 373–376

    Article  PubMed  CAS  Google Scholar 

  • Neumann H.P., Reincke M., Bender B.U., Elsner R., Janetschek G. (1999) Preserved adrenocortical function after laparoscopic bilateral adrenal sparing surgery for hereditary pheochromocytoma. J Clin Endocrinol Metab 84: 2608–2610

    Article  PubMed  CAS  Google Scholar 

  • Perlman, R.L. und Chalfie, M. (1977) Catecholamine release from the adrenal medulla. Clin Endocrinol Metab 6: 551–576

    Article  PubMed  CAS  Google Scholar 

  • Plouin P.F., Catellier G., Fofol I., Corvol P. (1997) Tumor recurrence and hypertension after successful pheochromocytoma operation. Hypertension 29: 1133–1139

    Article  PubMed  CAS  Google Scholar 

  • Preitner F., Muzzin P., Revelli J.P. et al. (1998) Metabolic response to various beta-adrenoceptor agonists in beta3-adrenoceptor knockout mice: evidence for a new betaadrenergic receptor in brown adipose tissue. Br J Pharmacol 124: 1684–1688

    Article  PubMed  CAS  Google Scholar 

  • Ruß H., Staust K., Martel F., Gliese M., Schomig E. (1996) The extraneuronal transporter for monoamine transmitters exists in cells derived from human central nervous system glia. Eur J Neurose 8: 1256–1264

    Article  Google Scholar 

  • Schatz I.J. (1994) Orthostatic hypotension. Clinical diagnosis, testing and treatment. Arch Int Med 144: 1037–1041

    Article  Google Scholar 

  • Schlumberger M., Gicquel C., Lumbroso J. et al. (1992) Malignant pheochromocytoma: Clinical, biological, histologic and therapeutic data in aseries of 20 patients with distant metastases. J Endocrinol Invest 15: 631–642

    PubMed  CAS  Google Scholar 

  • Schubert B., VanDongen A.M,. Kirsch G.E., Brown A.M. (1989) Beta-adrenergic inhibition of cardiac sodium channels by dual G-protein pathways. Science 245: 516–519

    Article  PubMed  CAS  Google Scholar 

  • Shapiro B., Sisson J.C., Lloyd R., Nakajo M., Satterlee W., Beierwalters W.H. (1984) Malignant phaeochromocytoma:clinical, biochemical and scintigraphic characterization. Clin Endocrinol 20: 189–203

    Article  CAS  Google Scholar 

  • Shulkin B.L., Thompson N.W., Shapiro B., Francis I.R., Sisson J.C. (1999) Pheochromocytomas: imaging with 2-(fluorine-18)fluoro-2-deoxy-D-glucose PET. Radiology 212: 35–41

    PubMed  CAS  Google Scholar 

  • Sisson J.C., Shapiro B., Meyers L. et al. (1987) MIBG to map scintigraphically the adrenergic nervous system in man. J Nucl Med 28: 1625–1636

    PubMed  CAS  Google Scholar 

  • Trendelenburg U. (1990) The interaction of transport mechanisms and intracellular enzymes in metabolizing systems. J Neural Transm (Suppl 32):3–18

    Google Scholar 

  • Udenfriend S. (1966) Tyrosine hydroxylase. Pharmacol Rev 18: 43–51

    PubMed  CAS  Google Scholar 

  • Vargas M.P., Zhuang Z., Wang C., Vortmeyer A., Linehan W.M., Merino M.J. (1997) Loss ofheterozygosity on the short arm of chromosomes 1 and 3 in sporadic pheochromocytoma and extra-adrenal paraganglioma. Hum Pathol 28: 411–415

    Article  PubMed  CAS  Google Scholar 

  • Webber J., Macdonald I.A. (1993) Metabolic actions of catecholamines in man. Bailliere’s Clin Endocrin Metabol, vol 7/2: 393–414

    Article  Google Scholar 

  • Winkler H., Sietzen M., Schober M. (1987) The life cyele of catecholamine-storing vesieles. Ann N Y Acad Sci 493: 3–19

    Article  PubMed  CAS  Google Scholar 

  • Wong D.L., Siddall B., Wang W. (1995) Hormonal control of rat adrenal phenylethanolamine N-methyltransferase. Enzyme activity, the final critical pathway. Neuropsychopharmacology 13: 223–234

    Article  PubMed  CAS  Google Scholar 

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© 2001 Springer-Verlag Berlin Heidelberg

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Kopf, D., Schulz, C., Lehnert, H. (2001). Katecholamine. In: Nawroth, P.P., Ziegler, R. (eds) Klinische Endokrinologie und Stoffwechsel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56784-1_13

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  • DOI: https://doi.org/10.1007/978-3-642-56784-1_13

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