Skip to main content
SpringerLink
Log in

Nebenschilddrüse

  • Chapter
Klinische Endokrinologie und Stoffwechsel

  • 221 Accesses

Zusammenfassung

Der Serumkalziumspiegel wird normalerweise in engen Grenzen gehalten, um die ungestörte Gewebefunktion zu gewährleisten. Regelgröße ist hierbei der Spiegel des freien Kalziums (Normalwert: 1,1-1,3 mmol/l), das etwa 50% des Gesamtserumkalziums (Normalwert: 2,2-2,65 mmol/l) ausmacht. Etwa 40 % des Gesamtserumkalziums sind an Albumin gebunden, während etwa 10% als Phosphatoder Zitratsalzkomplexe vorliegen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

Literatur zu Abschn. 10.1

  • Blind E, Nissenson R.A., Strewler G.J. (1995) Parathyroid hormone-related protein. In: Becker K (ed) Principles and practice of endocrinology and metabolism. Lippincott, Philadelphia, pp 467–474

    Google Scholar 

  • Blind E., Schmidt-Gayk H., Scharia S., Flentje D., Fischer S., Göhring U., Hitzler W. (1988) Two-site assay of intact parathyroid hormone in the investigation of primary hyperparat-hyroidism and other disorders of calcium metabolism compared with amidregion assay. J Clin Endocrinol Metab 67: 353–360

    Article  PubMed  CAS  Google Scholar 

  • Brown E.M., Gamba G., Riccardi D. et al. (1993) Cloning and characterization of an extracellular Ca(2 + )-sensing receptor from bovine parathyroid. Nature 366: 575–580

    Article  PubMed  CAS  Google Scholar 

  • Brown E.M., Pollak M., Seidman C.E., Seidman J.G., Chou Y.H., Riccardi D., Hebert S.C. (1995) Calcium-ion-sensing cell-surface receptors. N Engl J Med 333: 234–240

    Article  PubMed  CAS  Google Scholar 

  • Jüppner H., Abou-Samra A.B., Freeman M. et al. (1991) A G-protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254: 1024–1026

    Article  PubMed  Google Scholar 

  • Schipani E., Langmann C., Parfitt A. et al. (1996) Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen’s metaphyseal chondrodysplasia. N Engl J Med 335: 708–714

    Article  PubMed  CAS  Google Scholar 

  • Schmidt-Gayk H, Thomas L (1992) Mineralhaushalt und Nebenschilddrüse. In: Thomas L (ed) Labor und Diagnose. Medizinische Verlagsgesellschaft, Marburg, S 342–386

    Google Scholar 

  • Segre G.V., Goldring S.R. (1993) Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glacagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-protein-linked receptor family. Trends Endocrinol Metab 4: 309–314

    Article  PubMed  CAS  Google Scholar 

Literatur zu Abschn. 10.2

  • Farfel Z., Brothers V.M., Brickman A.S., Conte F., Neer R., Bourne H.R. (1981) Pseudohypoparathyroidism: Inheritance of deficient receptor-cyclase coupling activity. Proc Natl Acad Sci USA 78: 3098–3102

    Article  PubMed  CAS  Google Scholar 

  • Levine M.A., Ahn T.G., Klupt S.F. et al. (1988) Genetic deficiency of the alpha subunit of the guanine nucieotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy. Proc Natl Acad Sci USA 85: 617–621

    Article  PubMed  CAS  Google Scholar 

  • Müller W., Peter H.H., Wilken M. et al. (1988) The DiGeorge syndrome: I. Clinical evaluation and course of partial and complete forms of the syndrome. Eur J Pediatr 147: 496–502

    Article  PubMed  Google Scholar 

  • Patten J.L., Johns D.R., Valle D. et al. (1990) Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright’s hereditary osteodystrophy. N Engl J Med 322: 1412–1419

    Article  PubMed  CAS  Google Scholar 

  • Schilling T., Ziegler R. (1996) Diagnostik und Therapie des Hypoparathyreoidismus. Dtsch Med Wochenschr 121: 841–844

    CAS  Google Scholar 

  • Schilling T., Ziegler R. (1997) Current therapy of hypoparathyroidism-a survey of german endocrinology centers. Exp Clin Endocrinol Diabetes 105: 237–241

    Article  PubMed  CAS  Google Scholar 

  • Ziegler R., Minne H., Raue F., Paar G., Delling G. (1975) Beobachtungen zur Vitamin-D-und Dihydrotachysterin-Vergiftung. Dtsch Med Wochensehr 100: 415–423

    Article  CAS  Google Scholar 

Literatur zu Abschn. 10.3 und 10.4

  • Attie M.F. (1989) Treatment ofhypercalcemia. Endocrinol Metab Clin North Am 18: 807–828

    PubMed  CAS  Google Scholar 

  • Bilezikian J.P. (1992) Managment of acute hypercalcemia. N Engl J Med 326: 1196–1203

    Article  PubMed  CAS  Google Scholar 

  • Bilezikian J.P., Silverberg S.I., Gartenberg F., Kim T.S., Jacobs T.P., Siris E.S., Shane E. (1994) Clinical presentation of primary hyperparathyroidism. In: Bilezikian J.P., Marcus R., Levine M.A. (eds) The parathyroids. Raven, New York, pp 457–470

    Google Scholar 

  • Bilezikian J.P. (1996) Primary hyperparathyroidism. In: Favus J.M. (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism. 3rd edn, Lippincott & Rayen, Philadelphia, pp 181–186

    Google Scholar 

  • Coburn J.W. (1989) Control of serum phosphorus in uremia. N Engl J Med 320: 1140–1142

    Article  PubMed  CAS  Google Scholar 

  • Consensus Development Conferenee Panel (1991) Diagnosis and management of asymptomatic primary hyperparathyroidism. Consensus Development Conference Statement. Ann Intern Med 114: 593–597

    Article  Google Scholar 

  • Doppman J.L. (1996) Preoperative localization of parathyroid tissue in primary hyperparathyroidism. In: Favus J.M. (ed) Primer on the metabolic bone diseases and dis orders of mineral metabolism. 3rd edn, Lippincott & Raven, Philadelphia, pp 553–556

    Google Scholar 

  • Drings P. (1974) Normokalzämischer primärer Hyperparathyreoidismus. Münchner Med Wochenschr 116: 1107

    CAS  Google Scholar 

  • Heath H. 3rd, Hodgson S.F., Kennedy M.A. (1980) Primary hyperparathyroidism: Incidence, morbidity, and potential economic impact in a community. N Engl J Med 302(4):189–193

    Article  PubMed  Google Scholar 

  • Heath H. 3rd (1996) Familial hyperparathyroid syndroms. In: Favus J.M. (ed) Primer on the metabolic bone diseases and dis orders of mineral metabolism. 3rd edn, Lippincott & Raven, Philadelphia, pp 187–189

    Google Scholar 

  • Hruska K.A., Teitelbaum S.L. (1995) Renal osteodystrophy. N Engl J Med 333: 166–174

    Article  PubMed  CAS  Google Scholar 

  • Jockenhövel F., Reinwein D. (1994) Asymptomatischer primärer Hyperparathyreoidismus:Behandeln oder beobachten? Dtseh Med Wochenschr 119: 967–973

    Article  Google Scholar 

  • Kleerekoper M., Bilezikian J.P. (1994) Parathyroidectomy for non-traditional features of primary hyperparathyroidism. Am J Med 96: 99–100

    Article  PubMed  CAS  Google Scholar 

  • Kleerekorer M. (1996) Clinical course of primary hyperparathyroldlsm. In: Favus J.M. (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism. 3rd edn Lippincott & Raven, Philadelphia, pp 171–478

    Google Scholar 

  • Mitchell B.K., Kinder B.K., Cornelius E., Steward A.F. (1995) Primary hyperparathyroidism: Preoperative localization using technetium sestamibi scanning. J Clin Endocrinol Metab 80(1):7–10

    Article  PubMed  CAS  Google Scholar 

  • Nussbaum S.R. (1993) Pathophysiologiy and management of severe hypercalcemia. Endocrinol Metab Clin North Am 22: 343–362

    PubMed  CAS  Google Scholar 

  • Parisien M., Silverberg S.J., Shane E., Dempster D.W., Bilezikian J.P. (1990) Bone disease in primary hyperparathyroidism. Endocrinol Metab Clin North Am 19(1):19–34

    PubMed  CAS  Google Scholar 

  • Payne R.B., Carver M.E., Morgan D.B. (1979) Interpretation of serum total calcium: effects of adjustment for albumin concentration on frequency of abnormal values and on detection of change in the individual. J Clin Pathol 32(1):56–60

    Article  PubMed  CAS  Google Scholar 

  • Pollak M.R. et al. (1993) Mutations in the human Ca++ sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell 75: 1297–1303

    Article  PubMed  CAS  Google Scholar 

  • Roe S.M., Bums R.P., Graham L.D., Brock W.B., Russell W.L. (1994) Cost-effectiveness of preoperative localization studies in primary hyperparathyroid disease. Ann Surg 219(5):582–586

    PubMed  CAS  Google Scholar 

  • Schmidt-Gayk H. (1997) Störungen der Kalzium-und Phosphathomöostase. In: Seibel M.J., Stracke H. (Hrsg) Metabolische Osteopathien. Schattauer, Stuttgart, p 243–275

    Google Scholar 

  • Shane E. (1996) Hypercalcemia:Pathogenesis, Clinical manifestations, differential diagnosis and managment. In: Favus J.M. (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism. 3rd edn, Lippincott & Raven, Philadelphia, pp 177–181

    Google Scholar 

  • Ziegler R., Breckwoldt W., Grußendorf M., Kruse K. (1993) Nebenschilddrüsen und Calciumhomöostase In: Deutsche Gesellschaft für Endokrinologie (Hrsg) Rationelle Diagnostik in der Endokrinologie. Thieme, Stuttgart, S 79–103

    Google Scholar 

  • Ziegler R., Hesch R.D., Kruse K., Raue F., Rothmund M. (1997) Nebenschilddrüsen und Calciumhomöostase (einschließlich Osteopthien) In: Deutsche Gesellschaft für Endokrinologie (Hrsg) Rationelle Diagnostik in der Endokrinologie. Thieme, Stuttgart, S 103–148

    Google Scholar 

Literatur zu Abschn. 10.5

  • Bartl R. (1992) Entstehung und histologische Diagnose von Knochenmetastasen. In: Wüster C.h., Ziegler R. (Hrsg) Knochenmetastasen: Pathophysiologie, Diagnostik und Therapie. Zuckschwerdt, München, pp 1–15

    Google Scholar 

  • Bilezikian J.P. (1992) Management of acute hypercalcemia. N Engl J Med 326: 1196–1203

    Article  PubMed  CAS  Google Scholar 

  • Burtis W.J., Brady T.G., Orloff J.J. et al. (1980) Immunochemical characterization of circulating PTH-related pro tein in patients with humoral hypercalcemia of malignancy. N Engl J Med 322: 1106–1112

    Article  Google Scholar 

  • Diel I.J. (1997) Tumorassoziierte Störungen des Knochen-und Mineralstoffwechsels. In: Seibel M.I., Stracke H. (Hrsg) Metabolische Osteopathien. Schattauer, Stuttgart, pp 276–287

    Google Scholar 

  • Galasko C.S.B. (1981) The anatomy and pathways of skeletal metastases. In: Weiß L., Gilbert A.H. (eds) Bone metastasis. Hall, Boston, pp 49–63

    Google Scholar 

  • Garrett R.I., Durie B.G.M., Nedwin G.E. et al. (1987) Production of the bone resorbing cytokine lymphotoxin by cultured human myeloma cells. N Engl J Med 317: 526–532

    Article  PubMed  CAS  Google Scholar 

  • Harinck H.I.J., Bijvoet O.L.M., Platingh A.S.T. (1987) Role of bone and kidney in tumor-associated hypercalcemia and ist treatment with Bisphosphonate and sodium chloride. Am J Med 82: 1113–1142.

    Article  Google Scholar 

  • Mundy G.R., Martin T.J. (1982) The hypercalcemia of malignancy: pathogenesis and treatment. Metabolism 31: 1247–1277

    Article  PubMed  CAS  Google Scholar 

  • Ralston S.H., Gallacher S.I., Patel U. et al. (1990) Cancer-associated hypercalcemia:morbidity and mortality. Clinical experience in 126 treated patients. Ann Intern Med 112: 499–504

    Article  PubMed  CAS  Google Scholar 

  • Stewart A.F., Horst R., Deftos L.J. et al. (1980) Biochemical evaluation of patients with cancer-associated hypercalcemia: evidence for humoral and non-humoral groups. N Engl J Med 303: 1377–1383

    Article  PubMed  CAS  Google Scholar 

  • Zipf A., Seibel M.J. (1992) Biochemische Labordiagnostik bei Knochenmetastasen. In: Wüster C.h., Ziegler R. (eds) Knochenmetastasen: Pathophysiologie, Diagnostik und Therapie. Zuckschwerdt, München, pp 16–33)

    Google Scholar 

Literatur zu Abschn. 10.6

  • Attie M.F. (1989) Treatment of hypercalcemia. Endocrinol Metab Clin North Am 18: 807–828

    PubMed  CAS  Google Scholar 

  • Bilezikian J.P. (1992) Managment of acute hypercalcemia. N Engl J Med 326: 1196–1203

    Article  PubMed  CAS  Google Scholar 

  • Nussbaum S.R. (1993) Pathophysiologiy and management of severe hypercalcemia. Endocrinol Metab Clin North Am 22: 343–362

    PubMed  CAS  Google Scholar 

  • Schmidt-Gayk H. (1997) Störungen der Kalzium-und Phosphathomöostase. In: Seibel M.I., Stracke H. (Hrsg) Metabolische Osteopathien. Schattauer, Stuttgart, S 243–275

    Google Scholar 

  • Shane E. (1996) Hypercalcemia: Pathogenesis, clinical manifestations, differential diagnosis and managment. In: Favus J.M. (ed) Primeron the metabolic bone diseases and disorders of mineral metabolism. 3rd edn, Lippincott & Raven, Philadelphia, pp 177–181

    Google Scholar 

  • Ziegler R., Breckwoldt W., Grußendorf M., Kruse K. (1993) Nebenschilddrüsen und Calciumhomöostase In: Deutsche Gesellschaft für Endokrinologie (Hrsg) Rationelle Diagnostik in der Endokrinologie. Thieme, Stuttgart, S 79–103

    Google Scholar 

  • Ziegler R., Hesch R.D., Kruse K., Raue F., Rothmund M. (1997) Nebenschilddrüsen und Calciumhomöostase (einschließlich Osteopthien) In: Deutsche Gesellschaft für Endokrinologie (Hrsg) Rationelle Diagnostik in der Endokrinologie. Thieme, Stuttgart, S 103–148

    Google Scholar 

Download references

Authors
  1. M. J. Seibel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Blind
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Schilling
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. W. Woitge
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik IV, Universitätsklinikum Tübingen, Otfried-Müller-Straße 10, 72076, Tübingen, Deutschland

    Peter P. Nawroth

  2. Abteilung Innere Medizin I, Medizinische Universitätsklinik und Poliklinik Heidelberg, Bergheimer Straße 58, 69115, Heidelberg, Deutschland

    Reinhard Ziegler

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Seibel, M.J., Blind, E., Schilling, T., Woitge, H.W. (2001). Nebenschilddrüse. In: Nawroth, P.P., Ziegler, R. (eds) Klinische Endokrinologie und Stoffwechsel. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56784-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-56784-1_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62970-9

  • Online ISBN: 978-3-642-56784-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation