Zusammenfassung
Wachstumsfaktoren gehören zu den wichtigsten Modulatoren von Wachstum, Differenzierung und Regeneration im Intestinaltrakt. Mit dem Begriff Wachstumsfaktor im engeren Sinne wird eine heterogene Gruppe regulatorischer Peptide mit verschiedenartigen strukturellen und funktionellen Eigenschaften zusammengefasst, deren Molekulargewicht in der Regel unter 25.000 liegt. Die Nomenklatur der regulatorischen Peptide ist überlappend und wird in der Literatur z.T. uneinheitlich benutzt [19, 23, 32, 33]. So werden die Begriffe Wachstumsfaktoren, Zytokine, Interleukine, Interferone und Stammzellfaktoren mitunter synonym gebraucht(_ Abb. 18-1).
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Literatur
Babyatsky MW, Podolsky DK (1991) Growth and differentiation in the Gl tract. In: Yamada T, Alpers DH, Owyang C, Powell DW, Silverstein FE (eds) Textbook of gastroenterology. Lippincott, New York London, pp 475–501
Baird A, Böhlen P (1991) Fibroblast growth factors. In: Sporn MB, Roberts AB (eds) Peptide growth factors and their receptors. Springer, Berlin Heidelberg New York Tokio, pp 369–418
Brodsky IG (1998) Hormone, cytokine, and nutrient interactions. In: Shiles ME, Olson JA, Sheik M, Ross AC (eds) Modern nutrition in health and disease. Williams & Wilkins, Baltimore, pp 699–724
Byrne TA, Nompleggi DJ, Wilmore DW (1996) Advances in the management of patients with intestinal failure. Transplant Proc 28: 2683–2690
Carpenter G, Wahl MI (1991) The epidermal growth factor family. In: Sporn MB, Roberts AB (eds) Peptides growth factors and their receptors. Springer, Berlin Heidelberg New York Tokio, pp 69–171
Chen K, Okuma T, Okamura K et al. (1995) Insulin-like growth factor-I prevents gut atrophy and maintains intestinal integrity in septic rats. J Parenter Enteral Nutr 19: 119–124
Dignass A, Lynch-Devaney K, Kindon H et al. (1994) Trefoil peptides promote epithelial migration through a transforming growth factor ß-independent pathway. J Clin Invest 94: 376–383
Dignass AU, Milovic V (1999) Wachstumsfaktoren und Wachstumsregulation im Intestinaltrakt. In: Stein J, Caspary WF (Hrsg) Krankheiten des Dünn- und Dickdarms. Springer, Berlin Heidelberg New York Tokio, S 73–70
Dignass AU, Podolsky DK (1993) Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor beta. Gastroenterology 105: 1323–1332
Dignass AU, Podolsky DK (1996) Growth factors in inflammatory bowel disease. In: Fiocchi C (ed) Cytokines in inflammatory bowel disease. Landes, Austin Georgetown, pp 137–155
Dignass AU, Tsunekawa S, Podolsky DK (1994) Fibroblast growth factors modulate intestinal epithelial cell growth and migration. Gastroenterology 106: 1254–1262
Donnet-Hughes A, Schiffrin EJ, Huggett AC (1995) Expression of MHC antigens by intestinal epithelial cells. Effect of transforming growth factor ß 2 (TGF-ß-2). Clin Exp Immunol 99: 240–244
Dunn JC, Parungo CP, Fonkalsrud EW et al. (1997) Epidermal growth factor selectively enhances functional enterocyte adaptation after massive small bowel resection. J Surg Res 67: 90–93
Felig P (1995) Endocrinology and metabolism, 3rd edn. McGraw-Hill, New York
Fiore NF, Ledniczky G, Liu Q et al. (1998) Comparison of interleukin-11 and epidermal growth factor on residual small intestine after massive small bowel resection. J Pediatr Surg 33: 24–29
Foster HM, Whitehead RH (1990) Intravenous but not intracolonic epidermal growth factor maintains colonocyte proliferation in defunctioned rat colorectum. Gastroenterology 99: 1710–1714
Goodlad RA, Wilson TJ, Lenton W et al. (1987) Intravenous but not intragastric urogastrone-EGF is trophic to the intestine of parenterally fed rats. Gut 28: 573–582
Goodlad RA, Wilson TJ, Lenton W et al. (1985) Urogastrone-epidermal growth factor is trophic to the intestinal epithelium of parenterally fed rats. Experientia 41:1161–1163
Green AR (1989) Peptide regulatory factors: multifunctional mediators of cellular growth and differentiation. Lancet 1: 705–707
Johnson LR (1994) Physiology of the gastrointestinal tract, 3rd edn. Raven Press, New York
Lund PK, Moats-Staats BM, Hynes MA (1986) Somatomedin-C/Insulin-like growth factor I and insulin-like growth factor II MRNAs in rat fetal and adult tissue. J Biol Chem 261: 14539–14544
Murphy MS (1998) Growth factors and the gastrointestinal tract. Nutrition 14:771–774
Nathan C, Sporn M (1991) Cytokines in context. J Cell Biol 113: 981–986
Ohneda K, Ulshen MH, Fuller CR, D’Ercole AJ, Lund PK (1997) Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I. Gastroenterology 112: 444–454
Potten CS, Kellet M, Roberts SA, Rew DA, Wilson GD (1992) Measurement of in vivo proliferation in human colorectal mucosa using bromodeoxyuridine. Gut 33:71–78
Read LC, Thomas FM, Howarth GS (1992) Insulin-like growth factor I and its N-terminal modified analogues induce marked gut growth in dexamethasone-treated rats. J Endocrinol 133: 421–431
Rechler MM, Nissley SP (1991) Insulin-like growth factors. In: Sporn MB, Roberts AB (eds) Peptide growth factors and their receptors. Springer, Berlin Heidelberg New York Tokio, pp 263–367
Reeves JR, Richards RC, Cooke T (1991) The effects of intracolonic EGF on mucosal growth and experimental carcinogenesis. Br J Cancer 63: 223–226
Roberts AB, Sporn MB (1991) The transforming growth factor-ß. In: Sporn MB, Roberts AB (eds) Peptide growth factors and their receptors. Springer, Berlin Heidelberg New York Tokio, pp 417–472
Sands BE, Podolsky DK (1996) The trefoil peptide family. Annu Rev Physiol 58: 253–273
Shull MK, Ormsby I, Kier AB (1992) Targeted disruption of the mouse transforming growth factor ßl gene results in multifocal inflammatory disease. Nature 359:693–699
Sporn MB, Roberts AB (1991) Peptide growth factors and their receptors I and II. Springer, Berlin Heidelberg New York Tokio, pp 98
Sporn MB, Roberts AB (1992) Autocrine secretion —10 years later. Ann Intern Med 117: 408–414
Sullivan PB, Brueton MJ, Tabara ZB et al. (1991) Epidermal growth factor in necrotising enteritis. Lancet 338: 53–54
Swaniker F, Guo W, Fonkalsrud EW et al. (1995) The effect of epidermal growth factor on mucosal function after ileal resection. J Surg Res 58: 565–569
Thompson WA, Lowry SF (1993) Role of growth factors in nutritional support. In: Rombeau JL, Caldwell MD (eds) Clinical nutrition: parenteral nutrition. Saunders, Philadelphia, pp 223–244
Walker-Smith JA, Phillips AD, Walford N et al. (1985) Intravenous epidermal growth factor/urogastrone increases small-intestinal cell proliferation in congenital microvillous atrophy. Lancet II: 1239–1240
Wilmore DW (1999) Growth factors and nutrients in the short bowel syndrome. J Parenter Enteral Nutr 23: S117-S120
Ziegler TR, Estivariz CF, Jonas CR et al. (1999) Interactions between nutrients and peptide growth factors in intestinal growth, repair, and function. J Parenter Enteral Nutr 23: S174–S183
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Dignass, A., Schulz, RJ. (2003). Wachstumsfaktoren in der klinischen Ernährung. In: Stein, J., Jauch, KW. (eds) Praxishandbuch klinische Ernährung und Infusionstherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55896-2_18
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DOI: https://doi.org/10.1007/978-3-642-55896-2_18
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