Zusammenfassung
Die besondere Funktion der Leber im Intermediärstoffwechsel erklärt sich aus ihrer anatomischen Lage. Sie bezieht während der Resorptionsphase die über den Intestinaltrakt aufgenommenen Nahrungsstoffe, Vitamine und Elektrolyte. Eine Ausnahme hiervon machen die Nahrungslipide, die über die Lymphbahnen des Intestinaltrakts gesammelt und über den Ductus thoracicus in den großen Kreislauf verteilt werden und dementsprechend in größerer Verdünnung zur Leber gelangen. Damit ist die Leber als einziges Organ daran angepasst, ein sowohl von der Quantität als auch von der Qualität her sehr variables Stoffangebot zu bewältigen.
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Literatur
Aarsland A, Wolfe RR (1998) Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men. J Lipid Res 39: 1280–1286
Agellon LB, Torchia EC (2000) Intracellular transport of bile acids. Biochim Biophys Acta 1486: 198–209
Aiston S, Trinh KY, Lange AJ et al. (1999) Glucose-6-phosphatase. Overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation. Evidence against feedback inhibition of glucokinase. J Biol Chem 274: 24559–24566
Bollen M, Keppens S, Stalmans W (1998) Specific features of glycogen metabolism in the liver. Biochem J 336: 19–31
Bramlett KS, Yao S, Bums TP (2000) Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7α-hydroxylase gene repression by bile acids. Mol Gen Metab 71: 609–615
Brosnan JT (2000) Glutamate, at the interface between amino acid and carbohydrate metabolism. J Nutr 130: 988S–990S
Brown MS, Goldstein JL (1997) The SREBP-pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89: 331–340
Brown MS, Ye J, Rawson RB, Goldstein JL (2000) Regulated intermembrane proteolysis: A control mechanism conserved from bacteria to humans. Cell 92: 391–398
Browner MF, Fletterick RJ (1992) Phosphorylase: a biological transducer. Trends Biochem Sci 17: 66–71
Cha U, Kim HIf, Kim KS et al. (2000) Identification of transacting factors responsible for the tissue-specific expression of human glucose transporter type 2 isoform gene: cooperative role of hepatocyte nuclear factors Ia and 3b. J Biol Chem 275: 18358–18365
Cohen JC, Vega GL, Grundy SM (1999) Hepatic lipase: new insights from genetic and metabolic studies. Curr Opin Lipidol 10: 259–267
Cohen P (1999) The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction. Phil Trans R Soc Lond 354-B: 485–495
Cohen P, Alessi DR, Cross DA (1997) PDK I, one of the missing links in insulin signal transduction? FEBS Lett 410: 3–10
Connelly PW (1999) The role of hepatic lipase in lipoprotein metabolism. Clin Chim Acta 286: 243–255
Diraison F, Beylot M (1998) Role of human liver lipogenesis and reesterification in triglycerides secretion and in FFA reesterification. Am J Physiol 274: E321–E327
Fafoumoux P, Bruhat A, Jousse C (2000) Amino acid regulation of gene expression. Biochem J 351: 1–12
Fan J, Watanabe T (1998) Hepatic lipase. J Atheroscler Thromb 5: 41–45
Galassetti P, Shiota M, Zinker BA, Wasserman DH, Cherrington AD (1998) A negative arterial-portal vein glucose gradient decreases muscle glucose uptake in the conscious dog. J Physiol 275: E101–E111
Gasa R, Jensen PB, Berman HKt et al. (2000) Distinctive regulatory and metabolic properties of glycogen-targeting subunits of protein phosphatase-1 (PTG, GL, GM /RG1) expressed in hepatocytes. J Biol Chem 275: 26396–26403
Girard J, Ferre P, Foufelle F (1997) Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes. Annu Rev Nutr 17: 325–352
Gordon DA, Jamil H (2000) Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly. Biochim Biophys Acta 1486: 72–83
Gressner AM (1995) In: Greiling H, Gressner AM (Hrsg) Lehrbuch der klinischen Chemie und Pathobiochemie. Schattauer, Stuttgart New York, S. 543–662
Iglesia N, Mukhtar M, Seoane J et al. (2000) The role of the regulatory protein of glucokinase in the glucose sensory mechanism of the hepatocyte. J Biol Chem 275: 10597–10603
Ji ZS, Dichek HL, Miranda DR, Mahley RW (1997) Heparan sulfate proteoglycans participate in hepatic lipase- and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins. J Biol Chem 272: 31285–292
Johnson LN (1992) Glycogen phosphorylase: control by phosphorylation and allosteric effectors. FASEB J 6: 2274–82
Koopmans SJ, Mandarine L, DeFronzo RA (1998) Time course of insulin action on tissue-specific intracellular glucose metabolism in normal rats. Am J Physiol 274: E642–E650
Krieger M (1999) Charting the fate of the «good cholesterol»: identification and characterization of the high-density lipoprotein receptor SR-B I. Annu Rev Biochem 68: 523–558
Livesey G, Wilson PDG, Dainty JR et al. (1998) Simultaneous time-varying systemic appearance of oral and hepatic glucose in adults monitored with stable isotopes. Am J Physiol 275: E717–E728
Magnuson MA (1990) Glucokinase gene structure. Functional implications of molecular genetic studies. Diabetes 39: 523–527
Mahley RW, Ji ZS (l999) Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. J Lipid Res 40: 1–16
Martin G, Nemoto M, Gelman L et al. (2000) The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: Organization, chromosomal localization, and expression. Genomics 66: 296–304
Martin G, Schoonjans K, Lefebvre A-M, Staels B, Auwerx J (1997) Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators. J Biol Chem 272: 28210–28217
Matschinsky FM (1990) Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. Diabetes 39: 647–652
Newgard CB, Brady MJ, O’Doherty RM, Saltiel AR (2000) Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1. Diabetes 49: 1967–1977
O’Doherty RM, Jensen PB, Anderson Pet al. (2000) Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen. J Clin Invest 105: 479–488
Olivier LM, Krisans SK (2000) Peroxisomal protein targeting and identification of peroxisomal targeting signals in cholesterol biosynthetic enzymes. Biochchim Biophys Acta 1529: 89–102
Pagliassotti MJ, Holste LC, Moore MC, Neal DW, Cherrington AD (1996) Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog. J Clin Invest 97: 81–91
Palacin M, Estevez R, Bertran J, Zorzano A (1998) Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev 78: 969–1054
Patel DD, Knight BL, Soutar AK et al. (2000) The effect of peroxisome-proliferator-activated receptor-α on the activity of the Cholesterol 7α-hydroxylase gene. Biochem J 351: 747–753
Po-Shiuan H, Courtney Moore M, Neal DW, Cherrington AD (2000) Importance of the hepatic arterial glucose level in generation of the portal signal in conscious dogs. Am J Physiol 279: E284–E292
Schwarz JM, Chioler RO, Revelly JP et al. (2000) Effects of enteral carbohydrates on de novo lipogenesis in critically ill patients. Am J Clin Nutr 72: 940–945
Srivastava AK, Pandey SK (1998) Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin. Mol Cell Biochem 182: 135–141
Stumpel F, Jungermann K (1997) Sensing by intrahepatic muscarinic nerves of a portal-arterial glucose concentration gradient as a signal for insulin-dependent glucose uptake in the perfused rat liver. FEBS 406: 119–122
Tayior R, Magnusson I, Rothman DL et al. (1996) Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal im normal subjects. J Clin Invest 97: 126–132
Thorens B (1996) Glucose transporters in the regulation of intestinal, renal and liver glucose fluxes. Am J Physiol 270: G541–G553
Tietge UJF, Bakillah A, Maugeais C et al. (1999) Hepatic orerexpression of microsomal triglyceride transfer protein (MTP) results in increased in vivo secretion of VLDL triglycerides and apolipoprotein B. J Lipid Res 40: 2134–2139
Trigatti BL, Rigotti A, Braun A (2000) Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake. Biochim Biophys Acta 1529: 276–286
Van deWerve GA, Lange A, Newgard C et al. (2000) New lessons in the regulation of glucose metabolism taught by the glucose 6-phosphatase system. Eur J Biochem 267, 1533–1549
Van Schaftingen E, Detheux M, Veiga da Cunha M (1994) Short-term control of glucokinase activity: role of a regulatory protein. FASEB J 8: 414–419
Villar-Palasi, C, Guinovart JJ (1997) The role of glucose 6-phosphate in the control of glycogen synthase. FASEB J 11: 544–558
Willnow TE (1999) The low-density lipoprotein receptor gene family: multiple roles in lipid metabolism. J Mol Med 77: 306–315
Yahagi N, Shimano H, Hasty AH et al. (1999) A crucial role of sterol regulatory element binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids. J Biol Chem 274: 35840–35844
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Löffler, G. (2003). Der Stoffwechsel von Nahrungsinhaltstoffen in der Leber. In: Stein, J., Jauch, KW. (eds) Praxishandbuch klinische Ernährung und Infusionstherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55896-2_12
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DOI: https://doi.org/10.1007/978-3-642-55896-2_12
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