Zusammenfassung
Begünstigend für eine Infektion bei Verbrennungswunden wirken hohes Patientenalter, Komorbiditäten, Verbrennungsausmaß, und -tiefe, Stromverbrennungen und ein geschädigtes Areal mit hoher Keimbelastung, wie das Perineum. Gleiches gilt für unsachgemäße Kühlung, Wundabdeckung, Zeitmanagement und Volumensubstitution in der Erstversorgung und insuffizientes Wund- und Hygienemanagement in der stationären Phase. Infiziertes Gewebe sollte débridiert und supportiv mit antibiogrammgerechter Antibiose therapiert werden. Zur Diagnosesicherung ist die Gewebeprobe zuverlässiger als der Abstrich. Erst auf saubere Wunden sollte Spalthaut transplantiert werden. Wundinfektionen treten meist erst 10 Tage nach der Verbrennung auf, wobei Pilze und gramnegative Keime das höchste Risiko für einen Transplantatverlust bedeuten. Die Wundinfektion selbst oder ein Transplantatverlust gehen laut Literatur nicht mit einer erhöhten Sterblichkeit einher.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Ballard J, Edelman L, Saffle J, Sheridan R, Kagan R, Bracco D, Cancio L, Cairns B, Baker R, Fillari P, Wibbenmeyer L, Voight D, Palmieri T, Greenhalgh D, Kemalyan N, Caruso D, Multicenter Trials Group ABA (2008) Positive fungal cultures in burn patients: a multicenter review. Journal of burn care & research : official publication of the American Burn Association 29 (1):213–221. doi:10.1097/BCR.0b013e31815f6ecb
Barajas-Nava LA, Lopez-Alcalde J, Roque i Figuls M, Sola I, Bonfill Cosp X (2013) Antibiotic prophylaxis for preventing burn wound infection. The Cochrane database of systematic reviews 6:CD008738. doi:10.1002/14651858.CD008738.pub2
Branski LK, Al-Mousawi A, Rivero H, Jeschke MG, Sanford AP, Herndon DN (2009) Emerging infections in burns. Surgical infections 10 (5):389–397. doi:10.1089/sur.2009.024
Brusselaers N, Monstrey S, Snoeij T, Vandijck D, Lizy C, Hoste E, Lauwaert S, Colpaert K, Vandekerckhove L, Vogelaers D, Blot S (2010) Morbidity and mortality of bloodstream infections in patients with severe burn injury. American journal of critical care: an official publication, American Association of Critical-Care Nurses 19 (6):e81–87. doi:10.4037/ajcc2010341
Church D, Elsayed S, Reid O, Winston B, Lindsay R (2006) Burn wound infections. Clinical microbiology reviews 19 (2):403–434. doi:10.1128/CMR.19.2.403–434.2006
Cochran A, Morris SE, Edelman LS, Saffle JR (2002) Systemic Candida infection in burn patients: a case-control study of management patterns and outcomes. Surgical infections 3 (4):367–374. doi:10.1089/109629602762539580
Denman SE, McSweeney CS (2006) Development of a real-time PCR assay for monitoring anaerobic fungal and cellulolytic bacterial populations within the rumen. FEMS microbiology ecology 58 (3):572–582. doi:10.1111/j.1574–6941.2006.00190.x
Fleming RY, Zeigler ST, Walton MA, Herndon DN, Heggers JP (1991) Influence of burn size on the incidence of contamination of burn wounds by fecal organisms. The Journal of burn care & rehabilitation 12 (6):510–515
Greenhalgh DG, Saffle JR, Holmes JHt, Gamelli RL, Palmieri TL, Horton JW, Tompkins RG, Traber DL, Mozingo DW, Deitch EA, Goodwin CW, Herndon DN, Gallagher JJ, Sanford AP, Jeng JC, Ahrenholz DH, Neely AN, O’Mara MS, Wolf SE, Purdue GF, Garner WL, Yowler CJ, Latenser BA, American Burn Association Consensus Conference on Burn S, Infection G (2007) American Burn Association consensus conference to define sepsis and infection in burns. Journal of burn care & research : official publication of the American Burn Association 28 (6):776–790. doi:10.1097/BCR.0b013e3181599bc9
Gruteke P, van Belkum A, Schouls LM, Hendriks WD, Reubsaet FA, Dokter J, Boxma H, Verbrugh HA (1996) Outbreak of group A streptococci in a burn center: use of pheno- and genotypic procedures for strain tracking. Journal of clinical microbiology 34 (1):114–118
Gupta A, Matsui K, Lo JF, Silver S (1999) Molecular basis for resistance to silver cations in Salmonella. Nature medicine 5 (2):183–188. doi:10.1038/5545
Heideman M, Bengtsson A (1992) The immunologic response to thermal injury. World journal of surgery 16 (1):53–56
Heimburg D von, Stieghorst W, Khorram-Sefat R, Pallua N (1998) Procalcitonin – a sepsis parameter in severe burn injuries. Burns: journal of the International Society for Burn Injuries 24 (8):745–750
Hodle AE, Richter KP, Thompson RM (2006) Infection control practices in U.S. burn units. Journal of burn care & research: official publication of the American Burn Association 27 (2):142–151. doi:10.1097/01.BCR.0000203493.31642.79
Hogan BK, Wolf SE, Hospenthal DR, D’Avignon LC, Chung KK, Yun HC, Mann EA, Murray CK (2012) Correlation of American Burn Association sepsis criteria with the presence of bacteremia in burned patients admitted to the intensive care unit. Journal of burn care & research : official publication of the American Burn Association 33 (3):371–378. doi:10.1097/BCR.0b013e3182331e87
Horvath EE, Murray CK, Vaughan GM, Chung KK, Hospenthal DR, Wade CE, Holcomb JB, Wolf SE, Mason AD, Jr., Cancio LC (2007) Fungal wound infection (not colonization) is independently associated with mortality in burn patients. Annals of surgery 245 (6):978–985. doi:10.1097/01.sla.0000256914.16754.80
Kollef MH (2003) The importance of appropriate initial antibiotic therapy for hospital-acquired infections. The American journal of medicine 115 (7):582–584
Lee HG, Jang J, Choi JE, Chung DC, Han JW, Woo H, Jeon W, Chun BC (2013) Blood stream infections in patients in the burn intensive care unit. Infection & chemotherapy 45 (2):194–201. doi:10.3947/ic.2013.45.2.194
Mann-Salinas EA, Baun MM, Meininger JC, Murray CK, Aden JK, Wolf SE, Wade CE (2013) Novel predictors of sepsis outperform the American Burn Association sepsis criteria in the burn intensive care unit patient. Journal of burn care & research : official publication of the American Burn Association 34 (1):31–43. doi:10.1097/BCR.0b013e31826450b5
Mayhall CG (2003) The epidemiology of burn wound infections: then and now. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 37 (4):543–550. doi:10.1086/376993
McManus AT, Kim SH, McManus WF, Mason AD, Jr., Pruitt BA, Jr. (1987) Comparison of quantitative microbiology and histopathology in divided burn-wound biopsy specimens. Archives of surgery 122 (1):74–76
Miller PL, Matthey FC (2000) A cost-benefit analysis of initial burn cultures in the management of acute burns. The Journal of burn care & rehabilitation 21 (4):300–303
Munster AM, Smith-Meek M, Dickerson C, Winchurch RA (1993) Translocation. Incidental phenomenon or true pathology? Annals of surgery 218 (3):321–326; discussion 326–327
Murray CK, Loo FL, Hospenthal DR, Cancio LC, Jones JA, Kim SH, Holcomb JB, Wade CE, Wolf SE (2008) Incidence of systemic fungal infection and related mortality following severe burns. Burns : journal of the International Society for Burn Injuries 34 (8):1108–1112. doi:10.1016/j.burns.2008.04.007
Niederman MS (1989) Bacterial adherence as a mechanism of airway colonization. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 8 (1):15–20
Park JH, Heggie KM, Edgar DW, Bulsara MK, Wood FM (2013) Does the type of skin replacement surgery influence the rate of infection in acute burn injured patients? Burns : journal of the International Society for Burn Injuries 39 (7):1386–1390. doi:10.1016/j.burns.2013.03.015
Peck MD, Weber J, McManus A, Sheridan R, Heimbach D (1998) Surveillance of burn wound infections: a proposal for definitions. The Journal of burn care & rehabilitation 19 (5):386–389
Posluszny JA, Jr., Conrad P, Halerz M, Shankar R, Gamelli RL (2011) Surgical burn wound infections and their clinical implications. Journal of burn care & research : official publication of the American Burn Association 32 (2):324–333. doi:10.1097/BCR.0b013e31820aaffe
Pruitt BA Jr, McManus AT (1992) The changing epidemiology of infection in burn patients. World journal of surgery 16 (1):57–67
Pruitt BA Jr, McManus AT, Kim SH, Goodwin CW (1998) Burn wound infections: current status. World journal of surgery 22 (2):135–145
Robson MC, Krizek TJ, Heggers JP (1973) Biology of surgical infection. Current problems in surgery:1–62
Schultz L, Walker SA, Elligsen M, Walker SE, Simor A, Mubareka S, Daneman N (2013) Identification of predictors of early infection in acute burn patients. Burns : journal of the International Society for Burn Injuries 39 (7):1355–1366. doi:10.1016/j.burns.2013.04.009
Sheridan RL, Weber JM, Pasternack MS, Tompkins RG (2001) Antibiotic prophylaxis for group A streptococcal burn wound infection is not necessary. The Journal of trauma 51 (2):352–355
Struck MF (2009) Infection control in burn patients: are fungal infections underestimated? Scandinavian journal of trauma, resuscitation and emergency medicine 17:51; author reply 56. doi:10.1186/1757–7241
Woods DE, Iglewski BH (1983) Toxins of Pseudomonas aeruginosa: new perspectives. Reviews of infectious diseases 5 Suppl 4:S715–722
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Daigeler, A., Lehnhardt, M. (2016). Behandlung der infizierten Verbrennungswunde. In: Lehnhardt, M., Hartmann, B., Reichert, B. (eds) Verbrennungschirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54444-6_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-54444-6_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-54443-9
Online ISBN: 978-3-642-54444-6
eBook Packages: Medicine (German Language)