Zusammenfassung
Die frühzeitige Entfernung des Verbrennungsschorfs ist eine Anforderung an die moderne Verbrennungsbehandlung. Enzymatische Débridementmethoden tiefer Verbrennungswunden wurden bereits vor über 60 Jahren beschrieben. Hierbei kamen insbesondere Enzyme pflanzlichen und bakteriellen Ursprungs zum Einsatz. Diese wurden aber seit den 70er Jahren des vergangenen Jahrhunderts durch die Frühnekrektomie weitestgehend verdrängt, weshalb sich die chirurgische Behandlung angesichts ihrer hohen Effektivität bisweilen als Standardbehandlungstechnik etabliert hat. In diesem Beitrag wird einerseits die Geschichte des enzymatischen Débridements und andererseits aktuell die Anwendung und der Vorteil der selektiven Wirkung eines neuen bromelainbasierten Enzymmixes in der Behandlung tief zweit- und drittgradiger Verbrennungen dargestellt.
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Literatur
Altemeier WA, Coith R, Culbertson W, Tytell A (1951) Enzymatic Débridement of burns. Ann Surg 134:581–587
Bessey PQ (2007) Wound care. In: Herndon DN (Hrsg) Total Burn Care. 3. Aufl Elsevier, S 127–135
Boswick JA (1985) Clinical experience with a new enzymatic debriding agent. In: May SR, Dogo G (Hrsg) Care of the burn wound. Karger, Basel, S 97–100
Burke JF, GoldenTD (1958) A clinical evaluation of enzymatic Débridement with papain-urea-chlorophyllin ointment. AmJ Surg 95:828–842
Connell JF, Rousselot LM (1959) Indications for and application of Debricin ficus protease. Am J Surg 98:685–692
Connell JF, Bowe JJ, Del Guerico L, Rousselot LM (1957) Evaluation of present day concepts in the treatment of the severely burned patient. Am J Surg 93:644–701
Connor GJ, Harvey SC (1946) The pyruvic acid method in deep clinical burns. Ann Surg 124:799–810
Cooper GR, Hodge GB, Beard JW (1943) Enzymatic Débridement in the local treatment of burns. Am J Dis Child 65: 909–911
Cubison TCS, Pape SA, Arkhouse N (2006) Evidence for the link between healing time and the development of hypertrophic scars (HTS) in paediatric burns due to scalds. Burns 32:992–999
Dimick AR (1977) Experience with the use of proteolytic enzyme (Travase) in burn patients. J Trauma 17:948–955
Gant TD (1980) The early enzymatic Débridement and grafting of deep dermal burns to the hand. Plast Reconstr Surg 66:185–190
Garret TA (1969) Bacillus subtilis protease: a new topical agent for Débridement. Clin Med 76(5):11–15
Glasser SR (1940) A new treatment for sloughting wounds: peliminary report. Am J Surg 40:320–322
Gurfinkel R, Rosenberg L, Cohen S, Cohen A, Barezovsky A, Cagnano E, Singer AJ (2010) Histological assessment of tangentially excised burn eschars. Can J Plast Surg 18(3):e33–36
Guzmann E-V, Guzmann MG (1953) The enzymatic Débridement of suppurations, necrotic lesions and burns with papain. J Int Coll Surg 20:695–702
Heinicke RM, Gortner WA (1957) Stem bromelain: a new protease preparation from pineapple plants. Ec Botany 11:225–234
Hummel RP, Kantz DP, MacMillan BG, Altemeier WA (1974) The continuing problem of sepsis following enzymatic Débridement of burns. J Trauma 14:572–579
Janzekowic Z (1970) A new concept in the early excision and immediate grafting of burns. J Trauma 10 (12):1103–1108
Klasen HJ (2000) A review of the nonoperative removal of necrotic tissue from burn wounds. Burns 26 (3):207–222
Klein GKV (1964) Enzymatic Débridement of third degree burns in animals with bromelains—a preliminary report. J Maine Med Assoc 55:169–171
Krieger Y, Bogdanov-Berezovsky A, Gurfinkel R, Silberstein E, Sagi A, Rosenberg L (2012) Efficacy of enzymatic Débridement of deeply burned hands. Burns 38(1):108–112
Krieger Y, Rosenberg L, Lapid O, Glesinger R, Bogdanov-Berezovsky A, Silberstein E, Sagi A, Judkins K (2005) Escharotomy using an enzymatic Débridement agent for treating experimental burn induced compartment syndrome in an animal model. J Trauma 58(6):1259–1264
Krizek TJ, Robson MC, Groshin MG (1974) Experimental burn wound sepsis Ð evaluation of enzymatic Débridement. J Surg Res 17:219–227
Levenson SM (1979) Debriding agents. J Trauma 19:928–930
Levine N, Seifter E, Levenson SM (1971) Enzymatic Débridement of burns. Surg Forum 22:57–58
Levine N, Seifter E, Connerton C, Levenson SM (1973) Débridement of experimental skin burns of pigs with Bromelain, a pineapple-stem enzyme. Plast Reconstr Surg 52:413–424
Makepeace AR (1983) Enzymatic Débridement of burns: a review. Burns Incl Therm Inj 9(3):153–157
Mir Y, Mir L, Benedito R (1964) Débridement by acids in the general treatment of patients with extensive burns. In: Broadbent TR (Hrsg) Transactions of the third international congress of plastic surgery. Exerpta Medica Foundation, Amsterdam, S 177–182
Orgill DP, Piccolo N (2009) Escharotomy and decompressive therapies in burns. J Burn Care Res 30(5):759–768
Pennisi VR, Capozzi A (1975) Travase: observations and controlled study of the effectiveness in burn Débridement. Burns 1:274–278
Rennekampff HO, Schaller HE, Wisser D, Tenenhaus M (2006) Débridement of burn wounds with a water jet surgical tool. Burns 32 (1):64–69
Rosenberg L (2012) Enzymatic Débridement of burn wounds. Herndon DN (ed) Total Burn Care, 4. Aufl. Elsevier, S 131–135
Rosenberg L, Krieger Y, Bogdanov-Berezovski A, Silberstein E, Shoham Y, Singer AJ (2014) A novel rapid and selective enzymatic Débridement agent for burn wound management: A multi-center RCT. Burns 40(3):466–474
Rowan AD, Christopher CW, Kelley SF, Buttle DJ, Ehrlich HP (1990) Débridement of experimental full-thickness skin burns of rats with enzyme fractions derived from pineapple stem. Burns 16:243–246
Schweitzer RJ, Bradsher JT (1951) Acid Débridement of burns with phosphoric-acid gel. New Engl J Med 244: 705–709
Silverstein P, Maxwell P, Duckett C (1987) Enzymatic Débridement. In: Boswick JA (Hrsg) The art and science of burn care. Aspen publishers, Rockville, S 75–81
Teitelmann SL, Movitz D, Zimmermann LM (1952) Enzymatic Débridement of necrotic surfaces. Ann Surg 136:267–271
Wachtel TL, Parks SN, Dimick AR (1983) Early enzymatic Débridement and grafting of burned hand: evaluating the Travase fastgraft method in deep dermal burns. J Burn Care Rehab 4:325–330
Wang XQ, Kempf M, Liu PY, Cuttle L, Chang HE, Kravchuk O, Mill J, Phillips GE, Kimble RM (2008) Conservative surgical Débridement as a burn treatment: supporting evidence from a porcine burn model. Wound Repair Regen 16(6):774–783
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Sander, F., Rosenberg, L. (2016). Enzymatisches Débridement der Verbrennungswunde. In: Lehnhardt, M., Hartmann, B., Reichert, B. (eds) Verbrennungschirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54444-6_12
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