Zusammenfassung
Die diabetischen Spätschäden manifestieren sich in sehr unterschiedlichen Organen. Klinisch relevant sind vor allem die sowohl bei Typ-1- als auch bei Typ-2-Diabetikern auftretenden Spätkomplikationen an Auge, Niere, Nerven sowie Herz und großen Gefäßen.
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Literatur
Literatur zu Abschn. 8.1
DCCT (1993) Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977–986
Deckert T, Feldt-Rasmussen B, Borch-Johnsen K, Jensen T, Kofoed-Enevoldsen A (1989) Albuminuria reflects widespread vascular damage. The Steno hypothesis. Diabetologia 32: 219–226
Gil N, Goldberg R, Neuman T, Garsen M, Zcharia E, Rubinstein AM, van Kuppevelt T, Meirovitz A, Pisano C, Li JP, van der Vlag J, Vlodavsky I, Elkin M (2012) Heparanase is essential for the development of diabetic nephropathy in mice. Diabetes 61: 208–216
Hammes HP, Feng Y, Pfister F, Brownlee M (2011) Diabetic retinopathy: targeting vasoregression. Diabetes 60: 9–16
Hirsch IB, Brownlee M (2010) Beyond HbA1c – Need for additional markers for diabetes microvascular complications. JAMA 303: 2291–2292
Paneni F, Volpe M, Lüscher TF, Cosentino F (2013) SIRT1, p66Shc, and Set7/9 in vascular hyperglycemic memory. Diabetes 62: 1800–1807
Pirart J (1993) Diabetes mellitus and its degenerative complications: a prospective study of 4,400 patients observed between 1947 and 1973. Diabete Metab 3: 97–107
Singh AK, Kari JA (2013) Metabolic syndrome and chronic kidney disease. Curr Opin Nephrol Hypertens 22: 198–203
Thomas MC, Groop PH, Tryggvason K (2012) Towards understanding the inherited susceptibility for nephropathy in diabetes. Curr Opin Nephrol Hypertens 21:195–202
Literatur zu Abschn. 8.2
BARI (1997) Influence of diabetes on 5-year mortality and morbidity in a randomized trial comparing CABG and PTCA in patients with multivessel disease: the Bypass Angioplasty Revascularization Investigation (BARI). Circulation 96(6) : 1761–1769
Camm AJ et al. (2010) Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Europace 12(10): 1360–1420
Charles M et al. (2012) Cardiovascular risk reduction following diagnosis of diabetes by screening: 1-year results from the ADDITION-Cambridge trial cohort. Br J Gen Pract 62(599 ): e396–402
Diehm C et al. (2004) High prevalence of peripheral arterial disease and co-morbidity in 6880 primary care patients: cross-sectional study. Atherosclerosis 172 (1): 95–105
Diehm C et al. (2009) Mortality and vascular morbidity in older adults with asymptomatic versus symptomatic peripheral artery disease. Circulation 120(21): 2053–2061
Doerr R et al. (2011) Oral glucose tolerance test and HbA(1)c for diagnosis of diabetes in patients undergoing coronary angiography: [corrected] the Silent Diabetes Study. Diabetologia 54(11) : 2923–2930
Du X et al. (2009) Risks of cardiovascular events and effects of routine blood pressure lowering among patients with type 2 diabetes and atrial fibrillation: results of the ADVANCE study. Eur Heart J 30(9): 1128–1135
Farkouh ME, Domanski M, Sleeper LA et al. (2012) Strategies for Multivessel Revascularization in Patients with Diabetes. N Engl J Med 367 : 2375–2384
Gerstein HC et al. (2012) Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med 367(4): 319–328
Gibbons RJ et al. (2003) ACC/AHA 2002 guideline update for the management of patients with chronic stable angina-- summary article: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on the Management of Patients With Chronic Stable Angina). J Am Coll Cardiol 41(1): 159–168
Gitt AK, Papp A, Towae F, Deeg E, Senges J, Zahn R Tschoepe D; SWEETHEART Study-Group (2011) Abstract 15682: High 3-year-mortality rates in females with newly diagnosed diabetes after acute STEMI and NSTEMI in clinical practice in Germany: results of the SWEETHEART Registry. Circulation 124: A15682
Haffner SM et al. (1998) Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339(4): 229–234
Hee L et al. (2012) Outcomes of coronary revascularization (percutaneous or bypass) in patients with diabetes mellitus and multivessel coronary disease. Am J Cardiol 110( 5): 643–648
Huxley RR et al. (2011) Meta-analysis of cohort and casecontrol studies of type 2 diabetes mellitus and risk of atrial fibrillation. Am J Cardiol 10 8(1): 56–62
Huxley RR et al. (2012) Type 2 diabetes, glucose homeostasis and incident atrial fibrillation: the Atherosclerosis Risk in Communities study. Heart 98( 2): 133–138
Mellbin LG et al. (2008) The impact of glucose lowering treatment on long-term prognosis in patients with type 2 diabetes and myocardial infarction: a report from the DIGAMI 2 trial. Eur Heart J 29(2): 166–176
Paulus WJ, Tschoepe C (2013) A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol 62( 4): 263–271
Ray KK et al. (2009) Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet 373(9677) : 1765–1772
Renner A et al. (2013) Coronary revascularization in diabetic patients: off-pump versus on-pump surgery. Ann Thorac Surg 96(2): 528–534
Roger VL et al. (2012) Heart disease and stroke statistics – 2012 update: a report from the American Heart Association. Circulation 125(1): e2–e220
Ryden L et al. (2007) Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J 28(1): 88–136
Ryden L et al. (2013) ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: The Task Force on diabetes, prediabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur Heart J 34(39): 3035–3087. doi: 10.1093/eurhe artj/eht108
Scirica BM, Bhatt DL, Braunwald E et al. (2013) Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus. N Engl J Med 369: 1317–1326
Seferovic M et al. (2012) Diabetic cardiomyopathy: ongoing controversies in 2012. Herz 37(8): 880–886
Tschoepe C, Lam CS (2012) Diastolic heart failure: What we still don’t know. Looking for new concepts, diagnostic approaches, and the role of comorbidities. Herz 37(8): 875–879
Wenaweser P et al. (2008) Incidence and correlates of drugeluting stent thrombosis in routine clinical practice. 4-year results from a large 2-institutional cohort study. J Am Coll Cardiol 52(14) : 1134–1140
White WB, Cannon CP, Heller SR et al. (2013) Alogliptin after Acute Coronary Syndrome in Patients with Type 2 Diabetes. N Engl J Med 369(14) : 1327–1335 Wijns W et al. (2010) Guidelines on myocardial revascularization. Eur Heart J 31(20): 2501–2555
Literatur zu Abschn. 8.3
Advance Collaborative Group et al. (2008) Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 358(24): 2560–2572
Aiello LP, Cahill MT, Wong JS (2001) Systemic considerations in the management of diabetic retinopathy. Am J Ophthalmol 132 (5): 760–776
Al-Kateb H, Mirea L, Xie X, Sun L, Liu M, Chen H, Bull SB, Boright AP, Paterson AD (2007) Multiple variants in vascular endothelial growth factor (VEGFA) are risk factors for time to severe retinopathy in type 1 diabetes: the DCCT/EDIC genetics study. Diabetes 56 (8): 2161–2168
Antonetti DA, Klein R, Gardner TW (2012) Diabetic retinopathy. N Engl J Med 366 (13): 1227–1239
Bandello F, Cunha-Vaz J, Chong NV, Lang GE, Massin P, Mitchell P, Porta M, Prunte C, Schlingemann R, Schmidt-Erfurth U (2012) New approaches for the treatment of diabetic macular oedema: recommendations by an expert panel. Eye (Lond) 26 (4): 485–493
Beulens JW et al. (2009) Effects of blood pressure lowering and intensive glucose control on the incidence and progression of retinopathy in patients with type 2 diabetes mellitus: a randomised controlled trial. Diabetologia 52(10): 2027–2036
Boussageon R, Bejan-Angoulvant T, Saadatian-Elahi M, Lafont S, Bergeonneau C, Kassai B, Erpeldinger S, Wright JM, Gueyffier F, Cornu C (2011) Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: meta-analysis of randomised controlled trials. BMJ 343: d4169
Bronson-Castain KW, Bearse MA, Jr., Neuville J, Jonasdottir S, King-Hooper B, Barez S, Schneck ME, Adams AJ (2012) Early neural and vascular changes in the adolescent type 1 and type 2 diabetic retina. Retina 32 (1): 92–102
Chaturvedi N et al. (2008) Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo- controlled trials. Lancet 372(9647): 1394–1402
Chew EY, Ambrosius WT, Davis MD, Danis RP, Gangaputra S, Greven CM, Hubbard L, Esser BA, Lovato JF, Perdue LH, Goff DC, Jr., Cushman WC, Ginsberg HN, Elam MB, Genuth S, Gerstein HC, Schubart U, Fine LJ (2010) Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med 363 (3): 233–244
DCCT (2000) Diabetes Control and Complications Trial Research Group. Effect of pregnancy on microvascular complications in the diabetes control and complications trial. Diabetes Care 23(8): 1084–1091
Duckworth W et al. (2009) Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 360(2): 129–139
Finger RP, Bertram B, Wolfram C, Holz FG (2012) Blindness and visual impairment in Germany: a slight fall in prevalence. Dtsch Arztebl Int 109 (27–28): 484–489
Gaede P et al. (2008) Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med 358(6): 580–591
Hemmingsen B, Lund SS, Gluud C, Vaag A, Almdal T, Hemmingsen C, Wetterslev J (2011) Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials. BMJ 343: d6898
Keech AC, Mitchell P, Summanen PA, O’Day J, Davis TM, Moffitt MS, Taskinen MR, Simes RJ, Tse D, Williamson E, Merrifield A, Laatikainen LT, d’Emden MC, Crimet DC, O’Connell RL, Colman PG (2007) Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet 370 (9600): 1687–1697
Klein R et al. (1999) Association of ocular disease and mortality in a diabetic population. Arch Ophthalmol 117(11): 1487–1495
Kramer CK, Rodrigues TC, Canani LH, Gross JL, Azevedo MJ (2001) Diabetic retinopathy predicts all-cause mortality and cardiovascular events in both type 1 and 2 diabetes: meta-analysis of observational studies. Diabetes Care 34 (5): 1238–1244
Kyto JP, Harjutsalo V, Forsblom C, Hietala K, Summanen PA, Groop PH (2001) Decline in the cumulative incidence of severe diabetic retinopathy in patients with type 1 diabetes. Diabetes Care 34 (9): 2005–2007
Malone JI, Morrison AD, Pavan PR, Cuthbertson DD (2001) Prevalence and significance of retinopathy in subjects with type 1 diabetes of less than 5 years’ duration screened for the diabetes control and complications trial. Diabetes Care 24 (3): 522–526
Nathan DM, Zinman B, Cleary PA, Backlund JY, Genuth S, Miller R, Orchard TJ (2009) Modern-day clinical course of type 1 diabetes mellitus after 30 years’ duration: the diabetes control and complications trial/epidemiology of diabetes interventions and complications and Pittsburgh epidemiology of diabetes complications experience (1983–2005). Arch Intern Med 169 (14): 1307–1316
Rudnisky CJ, Lavergne V, Katz D (2009) Visual acuity after intravitreal triamcinolone for diabetic macular edema refractory to laser treatment: a meta-analysis. Can J Ophthalmol 44 (5): 587–593
Sjolie AK, Klein R, Porta M, Orchard T, Fuller J, Parving HH, Bilous R, Chaturvedi N (2008) Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebocontrolled trial. Lancet 372 (9647): 1385–1393
Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, Zeng J, Luo L, Sun JK, Prakash M, Hamam RN, Tonna S, Constantine R, Ronquillo CC, Sadda S, Avery RL, Brand JM, London N, Anduze AL, King GL, Bernstein PS, Watkins S, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K (2008) Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci USA 105 (19): 6998–7003
UKPDS 33 (1998) United Kingdom Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 352(9131): 837–853
Van Hecke MV, Dekker JM, Nijpels G, Moll AC, Heine RJ, Bouter LM, Polak BC, Stehouwer CD (2005) Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study. Diabetologia. 48(7): 1300–1306
Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, Chen SJ, Dekker JM, Fletcher A, Grauslund J, Haffner S, Hamman RF, Ikram MK, Kayama T, Klein BE, Klein R, Krishnaiah S, Mayurasakorn K, O’Hare JP, Orchard TJ, Porta M, Rema M, Roy MS, Sharma T, Shaw J, Taylor H, Tielsch JM, Varma R, Wang JJ, Wang N, West S, Xu L, Yasuda M, Zhang X, Mitchell P, Wong TY (2012) Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care 35 (3) :556–564
Literatur zu Abschn. 8.4
Bianchi S, Bigazzi R, Campese VM (2006) Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease. Kidney Int 70: 2116–2123
Campbell R, Sangalli F, Perticucci E, Aros C, Viscarra C, Perna A, Remuzzi A, Bertocchi F, Fagiani L, Remuzzi G, Ruggenenti P (2003) Effects of combined ace inhibitor and angiotensin II antagonist treatment in human chronic nephropathies. Kidney Int 63: 1094–1103
Cooper BA, Branley P, Bulfone L, Collins JF, Craig JC, Fraenkel MB, Harris A, Johnson DW, Kesselhut J, Li JJ, Luxton G, Pilmore A, Tiller DJ, Harris DC, Pollock CA (2010) A randomized, controlled trial of early versus late initiation of dialysis. N Engl J Med 363: 609–619
Costacou T, Ellis D, Fried L, Orchard TJ (2007) Sequence of progression of albuminuria and decreased GFR in persons with type 1 diabetes: a cohort study. Am J Kidney Dis 50: 721–732
Fried LF, Emanuele N, Zhang JH, Brophy M, Conner TA, Duckworth W, Leehey DJ, McCullough PA, O’Connor T, Palevsky PM, Reilly RF, Seliger SL, Warren SR, Watnick S, Peduzzi P, Guarino P (2013) Combined angiotensin inhibition for the treatment of diabetic nephropathy. N Engl J Med 369: 1892–1903
Hansen HP, Tauber-Lassen E, Jensen BR, Parving HH (2002) Effect of dietary protein restriction on prognosis in patients with diabetic nephropathy. Kidney Int 62: 220–228
Hansson L, Zanchetti A, Carruthers SG, Dahlöf B, Elmfeldt D, Julius S, Menard J, Rahn KH, Wedel H, Westerling S (1998) Effects of intensive blood-pressure lowering and lowdose aspirin in patients with hypertension: principal results of the hypertension optimal treatment (hot) randomised trial. Lancet 351: 1755–1762
Hasslacher C, Wolf G, Kempe P, Ritz E (2011) Diabetische Nephropathie. Diabetologie 6: S111–S114
Hovind P, Rossing P, Tarnow L, Smidt UM, Parving HH (2001) Remission and regression in the nephropathy of type 1 diabetes when blood pressure is controlled aggressively. Kidney Int 60: 277–283
Hughes DB, Britton ML (2005) Angiotensin-converting enzyme inhibitors or angiotensin ii receptor blockers for prevention and treatment of nephropathy associated with type 2 diabetes mellitus. Pharmacotherapy 25: 1602–1620
Jun M, Perkovic V, Cass A (2011) Intensive glycemic control and renal outcome. Contrib Nephrol 170: 196–208
Klahr S, Levey A, Beck G, Caggiula A, Hunsicker L, Kusek J, Striker G (1994) The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. N Engl J Med 330: 877–884
Kuriyama S (2007) Peritoneal dialysis in patients with diabetes: Are the benefits greater than the disadvantages? Peritoneal dialysis international. J Int Soc Peritoneal Dialysis 27 Suppl 2: S190–195
Mehdi UF, Adams-Huet B, Raskin P, Vega GL, Toto RD (2009) Addition of angiotensin receptor blockade or mineralo corticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy. J Am Soc Nephrol 20: 2641–2650
Molitch ME, Steffes M, Sun W, Rutledge B, Cleary P, de Boer IH, Zinman B, Lachin J (2010) Development and progression of renal insufficiency with and without albuminuria in adults with type 1 diabetes in the diabetes control and complications trial and the epidemiology of diabetes interventions and complications study. Diabetes Care 33: 1536–1543
Navaneethan SD, Nigwekar SU, Sehgal AR, Strippoli GF (2009) Aldosterone antagonists for preventing the progression of chronic kidney disease: A systematic review and metaanalysis. Clin J Am Soc Nephrol 4: 542–551
Palmer ND, Freedman BI (2012) Insights into the genetic architecture of diabetic nephropathy. Curr Diab Rep 12: 423–431
Parving HH, Brenner BM, McMurray JJ, de Zeeuw D, Haffner SM, Solomon SD, Chaturvedi N, Persson F, Desai AS, Nicolaides M, Richard A, Xiang Z, Brunel P, Pfeffer MA (2012) Cardiorenal end points in a trial of aliskiren for type 2 diabetes. N Engl J Med 367: 2204–2213
Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M, Glasziou P, Grobbee DE, Hamet P, Heller S, Liu LS, Mancia G, Mogensen CE, Pan CY, Rodgers A, Williams B (2007) Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the advance trial): A randomised controlled trial. Lancet 370: 829–840
Reutens AT, Atkins RC (2011) Epidemiology of diabetic nephropathy. Contrib Nephrol 170: 1–7
Robertson L, Waugh N, Robertson A (2007) Protein restriction for diabetic renal disease. Cochrane Database Syst Rev: CD002181
Rossing P, Hougaard P, Borch-Johnsen K, Parving HH (1996) Predictors of mortality in insulin dependent diabetes: 10 year observational follow up study. BMJ 313: 779–784
Ruggenenti P, Cravedi P, Remuzzi G (2010) The raas in the pathogenesis and treatment of diabetic nephropathy. Nat Rev Nephrol 6: 319–330
UK Prospective Diabetes Study U (1998) Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. Uk prospective diabetes study group. BMJ 317: 703–713
Van Buren PN, Toto R (2013) Current update in the management of diabetic nephropathy. Curr Diab Rev 9: 62–77
Van den Meiracker AH, Baggen RG, Pauli S, Lindemans A, Vulto AG, Poldermans D, Boomsma F (2006) Spironolactone in type 2 diabetic nephropathy: Effects on proteinuria, blood pressure and renal function. J Hypertens 24: 2285–2292
Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, Held PJ, Port FK (1999) Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 341: 1725–1730
Literatur zu Abschn. 8.5
Abbott CA, Malik RA, van Ross ER, Kulkarni J, Boulton AJ (2011) Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K. Diab Care 34: 2220–2224
Barrett AM, Lucero MA, Le T, Robinson RL, Dworkin RH, Chappell AS (2007) Epidemiology, public health burden, and treatment of diabetic peripheral neuropathic pain: a review. Pain Med 8 (Suppl 2): S50–62
Bundesärztekammer (BÄK), KBV, AWMF (2011) Nationale VersorgungsLeitlinie Neuropathie bei Diabetes im Erwachsenenalter – Langfassung, Version 1.2 (28.11.2011). http://www.deutsche-diabetes-gesellschaft.de/fileadmin/Redakteur/Leitlinien/Evidenzbasierte_Leitlinien/nvl-t2d-neuro-lang.pdf. Zugriff 10 März 2014
Callaghan BC, Cheng HT, Stables CL, Smith AL, Feldman EL (2012a) Diabetic neuropathy: clinical manifestations and current treatments. Lancet Neurol 11: 521–534
Callaghan BC, Hur J, Feldman EL (2012b) Diabetic neuropathy: one disease or two? Curr Opin Neurol 25: 536–541
Chaudhry V, Russell J, Belzberg (2008) Decompressive surgery of lower limbs for symmetrical diabetic peripheral neuropathy. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD006152. doi: 10.1002/14651858. CD006152.pub2.
Daousi C, MacFarlane IA, Woodward A, Nurmikko TJ, Bundred PE, Benbow SJ (2004) Chronic painful peripheral neuropathy in an urban community: a controlled comparison of people with and without diabetes. Diabet Med 21: 976–982
Galer BS, Gianas A, Jensen MP (2000) Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract 47: 123–128
Lauria G, Hsieh ST, Johansson O, Kennedy WR, Leger JM, Mellgren SI, Nolano M, Merkies IS, Polydefkis M, Smith AG, Sommer C, Valls-Sole J (2010) European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. Eur J Neurol 17: 903–912, e44–49
Linn T, Ortac K, Laube H, Federlin K (1996) Intensive therapy in adult insulin-dependent diabetes mellitus is associated with improved insulin sensitivity and reserve: a randomized, controlled, prospective study over 5 years in newly diagnosed patients. Metabolism 45: 1508–1513
Malavige LS, Levy JC (2009) Erectile dysfunction in diabetes mellitus. J Sex Med 6: 1232–1247
Martina ISJ, van Koningsveld R, Schmitz PIM, van der Meché FGA, van Doorn PA (for the European Inflammatory Neuropathy Cause and Treatment (INCAT) group) (1998) Measuring vibration threshold with a graduated tuning fork in normal aging and in patients with polyneuropathy. J Neurol Neurosurg Psychiatry 65: 743–747
Maser RE, Steenkiste AR, Dorman JS, Nielsen VK, Bass EB, Manjoo Q, Drash AL, Becker DJ, Kuller LH, Greene DA et al. (1989) Epidemiological correlates of diabetic neuro pathy. Report from Pittsburgh Epidemiology of Diabetes Complications Study. Diabetes 38: 1456–14161
Wile DJ, Toth C (2010) Association of metformin, elevated homocysteine, and methylmalonic acid levels and clinically worsened diabetic peripheral neuropathy. Diabetes Care 33: 156–161
Literatur zu Abschn. 8.6
Armstrong DG, Lavery LA, Harkless LB (1998) Validation of a diabetic wound classification system.Diabetes Care 21: 856–859
Armstrong DG, Lavery LA, Vazquez JR, Short B, Kimbriel HR, Nixon BP, Boulton AJ (2003) Clinical efficacy of the first metatarsophalangeal joint arthroplasty as a curative procedure for hallux interphalangeal joint wounds in patients with diabetes. Diabetes Care 26: 3284–3287
Baglioni P, Malik M, Okosieme OE (2012) Acute Charcot foot. BMJ 344: e1397
Bundesärztekammer (2010) Nationale Versorgungsleitlinie Typ-2-Diabetes Präventions- und Behandlungsstrategien für Fußkomplikationen Langfassung Version 2.8 Februar 2010 basierend auf der Fassung von November 2006. http://www.deutsche-diabetes-gesellschaft.de/fileadmin/Redakteur/Leitlinien/Evidenzbasierte_Leitlinien/NVLDM2-Fuss-lang-ddg-2.8-100215.pdf. Zugriff 10 März 2014
Eichenholtz SN (1966) Charcot Joints. Thomas, Springfield, IL Emanuele MA, Buchanan BJ, Abraira C (1981) Elevated leg systolic pressures and arterial calcification in diabetic occlusive vascular disease. Diabetes Care 4: 289–292
Faglia E, Favales F, Morabito A (2001) New ulceration, new major amputation, and survival rates in diabetic subjects hospitalized for foot ulceration from 1990 to 1993: a 6.5-year follow-up. Diabetes Care 24: 78–83
Fishco WD (2001) Surgically induced Charcot’s foot. J Am Podiatr Med Assoc 91: 388–393
Frykberg RG, Belczyk R (2008) Epidemiology of the Charcot foot. Clin Podiatr Med Surg 25: 17–28
Game FL, Catlow R, Jones GR, Edmonds ME, Jude EB, Rayman G, Jeffcoate WJ (2012) Audit of acute Charcot’s disease in the UK: the CDUK study. Diabetologia 55: 32–35
Heller G, Günster C, Swart E (2005) Über die Häufigkeit von Amputationen unterer Extremitäten in Deutschland. Dtsch Med Wochenschr 130: 1689–1690
Hochlenert D, Engels G, Altenhofen L (2006) Integrierte Versorgung, Ergebnisse des Netzwerk Diabetischer Fuß Köln und Umgebung. Dt Arztebl 103: A 1680–1683
Hohenberger W, Stirkat F, Bruns J, Schmiegel W, Wesselmann S (2011) Krebsregister und Zentrumsbildung. Onkologe 17: 135–142)
Jeffcoate WJ (2008) Charcot neuro-osteoarthropathy. Diabetes Metab Res Rev 24 (Suppl 1): S62–65
Koller A et al. (2006) Deutsche Diabetes Gesellschaft. AG Diabetischer Fuß. Interdisziplinäre Arbeitsgruppe Schuhversorgung beim diabetischen Fußsyndrom. Schuhversorgung und Risikoklassen beim Diabetischen Fußsyndrom - und analogen Neuro-Angio-Arthropathien. Stand 25.02.2006. http://www.ag-fuss-ddg.de/download/1_Anlage_PG_31_Schuhversorgung%20und%20Risikoklassen%20beim%20DAF_25.05.2006.pdf. Zugriff 10 März 2014
Lawall H, Bramlage P, Amann B (2010) Stem cell and progenitor cell therapy in peripheral artery disease Thromb Haemost 103: 696–709
Lobmann R, Balletshofer B (2011) Diabetisches Fußsyndrom. In: Häring HU et al. (Hrsg) Diabetologie in Klinik und Praxis. Thieme, Stuttgart, S 495, 523
Maciejewski ML, Reiber GE, Smith DG, Wallace C, Hayes S, Boyko EJ (2004) Effectiveness of diabetic therapeutic footwear in preventing reulceration. Diabetes Care 27: 1774–1782
Moura-Neto A, Fernandes TD, Zantut-Wittmann DE, Trevisan RO, Sakaki MH, Santos AL, Nery M, Parisi MC (2012) Charcot foot: skin temperature as a good clinical parameter for predicting disease outcome. Diabetes Res Clin Pract 96: e11–14
Müller E, Bergmann K, Brunk-Loch S, Groene C, Kersken J, Lindloh C, Lobmann R, Mertes B (2006) Arbeitsgruppe Qualitätsmanagement der AG Fuß in der DDG e.V. Fußbehandlungseinrichtung DDG-erste Evaluation. Diabetol Stoffw 1–A195,doi:10.1055/s-2006-943920
Pham H, Armstrong DG, Harvey C, Harkless LB, Giurini JM, Veves A (2000) Screening techniques to identify people at high risk for diabetic foot ulceration: a prospective multicenter trial. Diabetes Care 23: 606–611
Richard JL, Almasri M, Schuldiner S (2012) Treatment of acute Charcot foot with bisphosphonates: a systematic review of the literature. Diabetologia 55: 1258–1264
Risse A (2006) Anthropologische Bedeutung der Polyneuropathien für Patienten und Versorgung – Qualitativer, neophänomenologischer Beitrag. Diabetologe 2: 25–131
Rümenapf G, Geiger S, Schneider B, Amendt K, Wilhelm N, Morbach S, Nagel N (2013) Readmissions of patients with diabetes mellitus and foot ulcers after infra-popliteal bypass surgery – attacking the problem by an integrated case management model ; Vasa 42: 56–67
Sanders LJ, Frykberg RG. Charcot foot. In: Levin M, O’Neal L, Bowker J (eds)The diabetic foot, 5th edn. Mosby-Year Book, Boston, p 149–180
Simon SR, Tejwani SG, Wilson DL, Santner TJ, Denniston NL (2000) Arthrodesis as an early alternative to nonoperative management of charcot arthropathy of the diabetic foot. J Bone Joint Surg Am 82: 939–950
The Saint Vincent Declaration on diabetes care and research in Europe (1989) Acta diabetologia. 10: (Suppl) 143–144 Van Baal J, Hubbard R, Game F, Jeffcoate W (2010) Mortality Associated with Acute Charcot Foot and Neuropathic Foot Ulceration. Diabetes Care. DOI dc09-1428 [pii] 10.2337/dc09-1428
Wagner FW (1981) The dysvascular foot.A system in diagnosis and treatment. Foot Ankle 2: 84–122
Weck M, Rietzsch H., Lawall H, Pichlmeier U, Bramlage P, Schellong S (2008): Intermittent intravenous urokinase for critical limb ischemia in diabetic foot ulceration; Thrombosis and Haemostasis, 100/3: 365–516
Zampa V, Bargellini I, Rizzo L, Turini F, Ortori S, Piaggesi A, Bartolozzi C (2011) Role of dynamic MRI in the follow-up of acute Charcot foot in patients with diabetes mellitus. Skeletal Radiol 40: 991–999
Zander J, Risse A, Kunitz O, Frank J, Emmig U (2012): Anästhesie bei Stoffwechselerkrankungen. In: Rossaint R, Werner C, Zwißler B (Hrsg) Die Anästhesiologie. Springer, Berlin Heidelberg, S 1262–128
Literatur zu Abschn. 8.7
Abber JC, Lue TF, Orvis BR, McClure RD, Williams RD (1986) Diagnostic tests for impotence: a comparison of papaverine injection with the penile-brachial index and nocturnal penile tumescence monitoring. J Urology 135(5): 923–925
Andersson KE, Wagner G (1995) Physiology of penile erection. Physiol Rev 75: 192–236
Baskerville TA, Douglas AJ (2008) Interactions between dopamine and oxytocin in the control of sexual behaviour. Prog Brain Res 170: 277–290
Carson CC (1999) Reconstructive surgery using urological prosthesis. Curr Opin Urol 9: 233–239
Cheitlin MD, Hutter AM, Brindis RG et al. (1999) Use of sildenafil citrate in patients with cardiovascular disease. Circulation 99: 168–177
Enzlin P, Mathieu C, Wanderschueren D, Demyttenaere K (2003) Prevalence and predictors of sexual dysfunction in patients with type 1 diabetes. Diabetes Care 26: 409–414
Fonseca V, Seftel A, Denne J, Fredlund P (2004) Impact of diabetes mellitus on the severity of erectile dysfunction and response to treatment: analysis of data from tadalafil clinical trials. Diabetologia.47(11): 1914–1923
Goldstein I, Lue TF, Padma-Nathan H et al. (1998) Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 338(20): 1397–1404
Goldstein I, Young JM, Fischer J et al. (2003) Vardenafil, a new phosphodiesterase type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind plazebo-controlled fixed-dose study. Diabetes Care 26: 777–783
Jackson G (2004) Treatment of erectile dysfunction in patients with cardiovascular disease : guide to drug selection. Drugs 64: 1533–1545
Klein R, Klein BE Lee KE et al. (1996) Prevalence of self-reported erectile dysfunction in people with long-term IDDM. Diabetes Care 19: 135–141
Klotz T, Sachse R, Heidrich A et al. (2001) Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients: a RigiScan and pharmacokinetic study. World J Urol 19: 32–39
Lue TF (2000) Erectile dysfunction. New Engl J Med 342: 1802–1813
Manning M, Spahn M, Jünemann KP (1998) Gefäßchirurgie, Implantationschirurgie und Vakuumerektionshilfe. Urol A 37: 509–515
Meller SM, Stilp E, Walker CN, Mena-Hurtado C (2013) The link between vasculogenic erectile dysfunction, coronary artery disease, and peripheral artery disease: role of metabolic factors and endovascular therapy. J Invasive Cardiol 25(6): 313–319
Morales A, Gingell C, Collins M et al. (1998) Clinical safety of oral sildenafil citrate (Viagra TM) in the treatment of erectile dysfunction. Int J Impot Res 10: 69–74
Padma-Nathan H, Hellstrom WJ, Kaiser FE et al. (1997) Treatment of men with erectile dysfunction with transurethral alprostadil, Medicated Urethral System for Erection (MUSE) Study Group. N Engl J Med 336: 1–7
Perimenis P, Gyftopoulos K, Athanasopoulos A, Barbalias G (2001) Diabetic impotence treated by intracaver-nosal injections: high treatment compliance and increasing dosage of vaso-active drugs. Eur Urol 40: 398–403
Porst et al. 2001) Porst H, Rosen R, Padma-Nathan H et al. (2001) The efficacy and tolerability of vardenafil, a new oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial. Int J Impot Res 13: 192–199
Rendell MS, Rajfer J, Wicker PA et al. (1999) Sildenafil for treatment of erectile dysfunction in men with diabetes – a randomized controlled trial. Sildenafil Diabetes Study Group. J Am Med Ass 281: 421–426
Safarinejad MR (2004) Oral sildenafil in the treatment of erectile dysfunction in diabetic men: a randomized double blind and plazebo-controlled study. J Diabetes Complications 18: 205–210
Schwartz BG, Jackson G, Stecher VJ, Campoli-Richards DM, Kloner RA (2013) Phosphodiesterase type 5 inhibitors improve endothelial function and may benefit cardiovascular conditions. Am J Med 126(3): 192–199. doi: 10.1016/j.amjmed.2012.08.015
Shabsigh R, Kaufman JM, Steidle C, Padma-Nathan H (2004) Randomized study of testosterone gel as adjunctive therapy to sildenafil in hypogonadal men with erectile dysfunction who do not respond to sildenafil alone. J Urology 172(2): 658–663
Spollett GR (1999) Assessment and management of erectile dysfunctionin men with diabetes. Diabetes Educ 25: 65–73
Stark S, Sachse R, Liedl T et al. (2001) Vardenafil increases penile rigidity and tumenescence in men with erectile dysfunction after a single oral dose Eur Urol 40: 181–190
Stuckey BG, Jadzinsky MN, Murphy LJ et al. (2003) Sildenafil citrate for treatment of erectile dysfunction in men with type 1 diabetes: results of a randomized controlled trial. Diabetes Care 26: 279–284
Literatur zu Abschn. 8.8
Huntley AC (1989) Cutaneou smanifestations of diabetes mellitus. Dermatol Clin 7: 531–546
Meurer M, Stumvoll M, Szeimies RM (2004) Hautveränderungen bei Diabetes mellitus. Hautarzt 55: 428–435
Sullivan KA, Feldman EL (2005) New developments in diabetic neuropathy. CurrOpinNeurol 18: 586–590
Taylor GW, Borgnakke WS (2008) Periodontal disease: associations with diabetes, glycemic control and complications. Oral Diseases 14: 191–203
Wohlrab J, Wohlrab D, Meiss F (2007) Hauterkrankungen bei Diabetes mellitus. J Dtsch Dermatol Ges 5: 37–53
Stratmann B, Tschoepe D (2011) Heart in diabetes: not only a macrovascular disease. Diabetes Care 34 (Suppl 2): S138–144
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Doppler, K. et al. (2014). Diabetische Folgeerkrankungen. In: Schatz, H., Pfeiffer, A. (eds) Diabetologie kompakt. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41358-2_8
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