Zusammenfassung
Zwischen 1958 und 1961 wurden rund 10000 Kinder mit schweren Gliedmaßendefekten geboren, deren Mütter das Schlafmittel Thalidomid eingenommen hatten. Seit dieser Katastrophe herrscht bei pharmazeutischer Industrie, Ärzten und Patientinnen berechtigte Vorsicht — häufig jedoch auch irrationale Panik — im Hinblick auf den Einsatz von Arzneimitteln in der Schwangerschaft. Nach statistischen Erhebungen nehmen 15–50% aller Schwangeren Medikamente im ersten Schwangerschaftsdrittel ein, oft noch in Unkenntnis der Schwangerschaft, was angesichts der sensiblen Phase der Organogenese in den ersten 3 Schwangerschaftsmonaten besonders fatale Auswirkungen haben kann. Seit der Contergan-Affäre ist das Bewusstsein der Öffentlichkeit für derartige Komplikationen besonders geschärft.
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Literatur
Ad Hoc Committee of the Scientific Assembly on Microbiology, Tuberculosis and Pulmonary Infections (1995) Treatment of tuberculosis and tuberculosis infection in adults and children. Clin Infect Dis 21: 9–27
American College of Obstetricians and Gynecologists (1991) Immunization during pregnancy. Technical Bulletin 160
Antiretrovir Pregnancy Registry Steering Committee (2001) Antiretrovir Pregnancy Registry Interim Report for 1 January 1989 through 31 Juli 2001. Wilmington
Briggs GG, Freeman RK, Yaffe SJ (1999) Drugs in Pregnancy and Lactation. 5th edn, Williams & Wilkins, Baltimore
Burtin P, Taddio A, Ariburnu O, Einarson TR, Koren G (1995) Safety of metronidazole in pregnancy: a meta-analysis. Am J Obset Gynecol 172: 525–529
Cohen LS, Friedman JM, Jefferson JW, Johnson EM, Weiner ML (1994) A reevaluation of risk of in utero exposure to lithium. JAMA 271: 146–150
Connor EM, Sperling RS, Gelber R (1994) Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. N Engl J Med 331: 1173–1180
Enders G (1991) Infektionen und Impfungen in der Schwangerschaft. 2. Aufl., Urban & Schwarzenberg, München/Wien/Baltimore
Ericson A, Källen B, Wiholm BE (1999) Delivery outcome after the use of antidepressants in early pregnancy. Eur J Clin Pharmacol 55: 503–508
Gonzalez CH, Marques-Dias MJ, Kim CA (1998) Congenital abnormalities in Brazilian children associated with misoprostol misuse in first trimester of pregnancy. Lancet 351: 1624–1627
Gough AW, Kasali OB, Sigler RE, Baragi V (1992) Quinolone arthropathy — acute toxicity to immatur articular cartilage. Toxicol Pathol 20: 436–449
Hall JG, Pauli RM, Wilson KM (1980) Maternal and fetal sequelae of anticoagulation during pregnancy. Am J Med 68: 122–140
Jacobson SJ, Jones K, Johnson K (1992) Prospective multicenter study of pregnancy outcome after lithium exposure during first trimester. Lancet 339: 530–533
Juchau MR (1989) Bioactivation in chemical teratogenesis. Ann Rev Pharmacol Toxicol 29: 165–187
Keller F, Griesshammer M, Haussler U, Paulus W, Schwarz A (2001) Pregnancy and renal failure: the case for application of dosage guidelines. Drugs 61: 1901–1920
McElhatton PR, Garbis HM, Elefant E, Vial T, Bellemin B, Serafini MA, Arnon J, Rodriguez-Pinilla E, Schaefer C, Pexieder T, Merlob P, dal Verme S (1996) The outcome of pregnancy in 689 women exposed to therapeutic doses of antidepressants. A collaborative study of the European Network of Teratology Information Services (ENTIS). Reprod Toxicol 10: 285–294
Nadel AS, Green JK, Holmes LB, Frigoletto FD, Benacerraf BR (1990) Absence of need for amniocentesis in patients with elevated of maternal serum alpha-fetoprotein and normal ultrasonographic examinations. N Engl J Med 323: 557–561
Nulman I, Rovet J, Stewart DE, Wolpin J, Gardner HA, Theis JGW, Kulin N, Koren G (1997) Neurodevelopment of children exposed in utero to antidepressant drugs. N Engl J Med 336: 258–262
Ornoy A, Ben Ishai PB (1993) Congenital anomalies after oral poliovirus vaccination during pregnancy. Lancet 341: 1162
Pursley TJ, Blomquist IK, Abraham J, Andersen HF, Bartley JA (1996) Fluconazole-induced congenital anomalies in three infants. CID 22: 336–340
Ried S, Beck-Managetta G (1996) Epilepsy, pregnancy and the child. Blackwell Science, Oxford
Robert E (1996) Treating depression in pregnancy. N Engl J Med 335: 1056–1058
Schaefer C, Amoura-Elefant E, VialT, Ornoy A, Garbis H, Robert E, Rodriguez-Pinilla E, Pexieder T, Prapas N, Merlob P (1996) Pregnancy outcome after prenatal quinolone exposure. Europ J Obstet Gynecol Reprod Biol 69: 83–89
Schaefer C, Spielmann H (2001) Arzneiverordnung in Schwangerschaft und Stillzeit. 6. Aufl., Urban & Fischer, München
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Paulus, W. (2004). Medikamente in Schwangerschaft und Stillzeit. In: Schneider, H., Husslein, P., Schneider, KT.M. (eds) Die Geburtshilfe. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18574-8_7
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