Skip to main content

Arterielle Hypertonie

  • Chapter
Klinische Kardiologie
  • 12k Accesses

Zusammenfassung

Die arterielle Hypertonie mit ihren vielfältigen Folgeerscheinungen in Form sekundärer Organbeteiligungen ist von weitreichender gesundheitsökonomischer Bedeutung. Große epidemiologische Studien haben gezeigt, dass das Risiko kardiovaskulärer Erkrankungen wie Herzinfarkt, plötzlicher Herztod, Schlaganfall und Herzinsuffizienz sowie die Entstehung eines chronischen Nierenversagens und peripherer Durchblutungsstörungen mit steigendem diastolischem und systolischem Blutdruck zunimmt. Das Ziel der antihypertensiven Therapie besteht daher in einer zuverlässigen Senkung des kardiovaskulären Gesamtrisikos einschließlich aller reversiblen Risikofaktoren und Begleiterkrankungen (Mancia et al. 2007).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • ACCORD Study Group (2010) Effects of blood pressure control in Type 2 diabetes mellitus. New Engl J Med 362: 1575–1585

    Google Scholar 

  • ALLHAT (2002) The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high risc hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs. diuretic: the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 288: 2981–2997

    Google Scholar 

  • Conroy RM, Pyörälä K, Fitzgerald AP et al. on behalf of the SCORE Project Group (2003) Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J 24: 987–1003

    Google Scholar 

  • Deutsche Hypertonie Gesellschaft (2008) Deutsche Hochdruckliga. Leitlinien zur Diagnostik und Behandlung der arteriellen Hypertonie. www.hochdruckliga.de/guidline.htm und www.leitlinien.net/046-001.pdf. Gesehen 26 Okt 2010

  • ESH-ESC-Guidelines (2003) European Society of Hypertension – European Society of Cardiology.Guidelines for the management of arterial hypertension. J Hypertens 21: 1011–1053

    Google Scholar 

  • He FJ, MacGregor GA (2009) A comprehensive review on salt and health and current experience of world wide salt reduction programmes. J Human Hypertens 23: 363–384

    Article  CAS  Google Scholar 

  • Joint National Committee (2003) The 7th report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. JAMA 289: 2560–2572

    Google Scholar 

  • Kannel WB (1996) Blood pressure as a cardiovascular risk factor. JAMA 275: 1571–1576

    Article  PubMed  CAS  Google Scholar 

  • Krum H, Schlaich M, Whitbourn R et al. (2009) Catheter based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet 373: 1275–1281

    Article  PubMed  Google Scholar 

  • Law MR, Morris JK, Wald NJ (2009) Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomized trials in the context of expectations from prospective epidemiological studies. BMJ 228: 1665

    Article  Google Scholar 

  • MacMahon S, Peto R, Cutler J et al. (1990) Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 335: 765–774

    Article  PubMed  CAS  Google Scholar 

  • Mancia G, Backer G de, Dominiczak A et al. (2007) 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Eur Heart J 28(12): 1462–1536

    PubMed  Google Scholar 

  • Staessen JA, Thijs L, Fagard R et al. (1999) Predicting cardiovascular risk using conventional vs. ambulatory blood pressure in older patients with systolic hypertension. Systolic Hypertension in Europe Trial Investigators. JAMA 282: 539–546

    Article  PubMed  CAS  Google Scholar 

  • Staessen JA, Wang J, Thijs L (2003) Cardiovascular prevention and blood pressure reduction: a qualitative overview updated until 1 March 2003. J Hypertens 21: 1055–1076

    Article  PubMed  CAS  Google Scholar 

  • UKPDS (1998) UK Prospective Diabetes Study Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352: 854– 865

    Google Scholar 

  • Verdecchia P, Staessen JA, Angeli F et al. (2009) Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open label randomized trial. Lancet 374: 525–533

    Article  PubMed  Google Scholar 

  • WHO-ISH-Guidelines-Subcommittee (1999) World Health Organization- International Society of Hypertension Guidelines for the Management of Hypertension. J Hypertens 17: 151–183

    Google Scholar 

Studien

  • ACCORD Study Group (2010) Effects of blood pressure control in Type 2 diabetes mellitus. New Engl J Med 362: 1575–1585

    Google Scholar 

  • ALLHAT (2002) The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high risc hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs. diuretic: the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 288: 2981–2997

    Google Scholar 

  • CAPPP-Studie: Hansson L, Lindholm LH, Niskanen L et al. (1999) For the Captopril Prevention Project (CAPPP) study group. Effect of angiotenzin- converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the captopril prebention project randomized trial. Lancet 353: 611

    Google Scholar 

  • HOPE-Studie: Yusuf S, Sleight P, Pogue J et al. (2000) Effects of an angiotensin- converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 342: 145–153

    Google Scholar 

  • HOT-Studie: Hansson L, Zanchetti A, Carruthers SG et al. (1997). Effects of intensive blood-pressure lowering and low aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT). Lancet 351: 1755–1762

    Google Scholar 

  • LIFE-Studie: Dahlöf B et al. (2002) Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE). A randomized trial against atenolol. Lancet 359: 995– 1003

    Google Scholar 

  • MDRD-Studie: Klahr S, Levey AS, Beck GJ et al. for the Modification of Diet in Renal Disease Study Group (1994) the effects of dietary protein restriction and blood pressure control in the progression of chronic renal disease. N Engl J Med 330: 877–884

    Google Scholar 

  • MERIT-HF Studie: Hjalmarson A, Goldstein S et al for the MERIT-HF Study Group (2000) The Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF) JAMA 283: 1295–1302

    Google Scholar 

  • INVEST-Studie: Mancia G, Messerli F, Bakris G et al. (2007) Blood pressure control and improved cardiovascular outcomes in the INVEST study. Hypertension 50: 299–305

    Google Scholar 

  • PROGRESS Collaborative Group (2001) Randomised trial of a perindoprilbased blood-presure lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack. Lancet. 2 358: 1033– 1041

    Google Scholar 

  • SCORE Deutschland: Conroy RM, Pyörälä K, Fitzgerald AP et al. on behalf of the SCORE Project Group (2003) Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J 24: 987–1003

    Google Scholar 

  • UKPDS 34: UKPDS (1998) UK Prospective Diabetes Study Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352: 854–865

    Google Scholar 

  • UKPDS-38: UK Prospective Diabetes Study Group (1998) Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ 317: 703–713

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Medizin Verlag Heidelberg

About this chapter

Cite this chapter

Baer, F. (2011). Arterielle Hypertonie. In: Erdmann, E. (eds) Klinische Kardiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16481-1_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-16481-1_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-16480-4

  • Online ISBN: 978-3-642-16481-1

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics