Zusammenfassung
Als Antwort auf die andauernde Bedrohung des Organismus durch die verschiedenartigsten Erreger mit vielfältigen Infektionsstrategien haben Wirbeltiere ein kompliziertes Verteidigungssystem entwickelt, das Immunsystem. Es kombiniert Erkennungsvorgänge des angeborenen natürlichen Immunsystems, die die Art des Erregers erkennen und die Art der Immunantwort bestimmen, mit spezifischen, dem individuellen Erreger angepassten Verteidigungsmaßnahmen des adaptiven Immunsystems.
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Literatur
Andoniou CE, Coudert JD, Degli-Esposti MA (2008) Killers and beyond: NK-cell-mediated control of immune responses. Eur J Immunol 38:2938–2942
Apostolopoulos V, Yuriev E, Lazoura E, Yu M, Ramsland PA (2008) MHC and MHC-like molecules: structural perspectives on the design of molecular vaccines. Hum Vaccin 4:400–409
Artis D (2008) Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nat Rev Immunol 8:411–420
Becker C, Stoll S, Bopp T, Schmitt E, Jonuleit H (2006) Regulatory T cells: present facts and future hopes. Med Microbiol Immunol 195:113–124
Beetz S, Wesch D, Marischen L, Welte S, Oberg HH, Kabelitz D (2008) Innate immune functions of human gammadelta T cells. Immunobiology 213:173–182
Fife BT, Bluestone JA (2008) Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol Rev 224:166–182
Grammatikos AP (2008) The genetic and environmental basis of atopic diseases. Ann Med 40:482–495
Kawai T, Akira S (2009) The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol 21:317–337
Keller AM, Schildknecht A, Xiao Y, van den Broek M, Borst J (2008) Expression of costimulatory ligand CD70 on steady-state dendritic cells breaks CD8+ T cell tolerance and permits effective immunity. Immunity 29:934–946
Korn T, Bettelli E, Oukka M, Kuchroo VK (2009) IL-17 and Th17 Cells. Ann Rev Immunol 27:485–517
Merad M, Manz MG (2009) Dendritic cell homeostasis. Blood 113:3418– 3427
Morelli AE, Thomson AW (2007) Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 7:610–621
Nitta T, Murata S, Ueno T, Tanaka K, Takahama Y (2008) Thymic microenvironments for T-cell repertoire formation. Adv Immunol 99:59–94
Peterson P, Org T, Rebane A (2008) Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nat Rev Immunol 8:948–957
Surh CD, Sprent J (2008) Homeostasis of naive and memory T cells. Immunity 29:848–862
Tarlinton DM (2008) Evolution in miniature: selection, survival and distribution of antigen reactive cells in the germinal centre. Immunol Cell Biol 86:133–138
Wrammert J, Ahmed R (2008) Maintainance of serological memory. Biol Chem 389:537–539
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Fleischer, B. (2010). Physiologie und Pathophysiologie des Immunsystems. In: Kiefel, V., Mueller-Eckhardt, C. (eds) Transfusionsmedizin und Immunhämatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12765-6_5
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DOI: https://doi.org/10.1007/978-3-642-12765-6_5
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