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Alloantigene von Thrombozyten

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Transfusionsmedizin und Immunhämatologie

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Zusammenfassung

Menschliche Thrombozyten enthalten ebenso wie alle anderen zellulären Blutelemente genetisch determinierte Alloantigene, die bei vielen Krankheitsbildern wie der neonatalen Alloimmunthrombozytopenie (► Kap. 29), der posttransfusionellen Purpura (► Kap. 37), dem Refraktärzustand bei Thrombozytentransfusionen (► Kap. 24) und bei Transplantationen (► Kap. 32) eine wichtige Rolle spielen. Für die Diagnostik, Prophylaxe und Therapie solcher Krankheitszustände ist es deshalb wichtig, thrombozytäre Antigen-Antikörper-Reaktionen zu kennen. Seit einigen Jahren werden darüber hinaus Zusammenhänge zwischen thrombozytären Alloantigen und arteriellen thrombotischen Ereignissen diskutiert.

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  1. Abteilung für Transfusionsmedizin Universitätsklinikum Rostock AöR, Ernst-Heydemann-Str. 6, 18057, Rostock

    Prof. Dr. V. Kiefel

  2. Institut für Klin, Immunologie u. Transfusionsmedizin Universitätsklinikum Gießen u. Marburg GmbH, Langhansstr. 7, 35385, Gießen

    Dr. rer. nat. S. Santoso

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    Volker Kiefel

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Kiefel, V., Santoso, S. (2010). Alloantigene von Thrombozyten. In: Kiefel, V., Mueller-Eckhardt, C. (eds) Transfusionsmedizin und Immunhämatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12765-6_13

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