Skip to main content
  • 2889 Accesses

Zusammenfassung

Bei Neugeborenen ist die Nierenfunktion im Vergleich zu älteren Kindern und Erwachsenen eingeschränkt (◘ Tab. 8.1, mod. nach [52]). Bedingt durch einen hohen renalen Gefäßwiderstand sind während der Fetalzeit der renale Blutfluss und damit auch die glomeruläre Filtrationsrate (GFR) niedrig. Nach der Geburt sinkt der renale Gefäßwiderstand, renaler Blutfluss und GFR steigen in den ersten Lebensmonaten kontinuierlich an. Erwachsenenwerte werden mit etwa 18 Monaten erreicht.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Adelman RD (1988) The hypertensive neonate. Clin Perinatol 15:567–85

    PubMed  CAS  Google Scholar 

  2. Al-Orifi F, McGillivray D, Tange S, Kramer MS (2000) Urine culture from bag specimens in young children: are the risks too high? J Pediatr 137:221–6

    Article  PubMed  CAS  Google Scholar 

  3. Andreoli SP (2004) Acute renal failure in the newborn. Semin Perinatol 28:112–23

    Article  PubMed  Google Scholar 

  4. Aya K, Tanaka H, Seino Y (2000) Novel mutation in the nephrin gene of a Japanese patient with congenital nephrotic syndrome of the Finnish type. Kidney Int 57:401–4

    Article  PubMed  CAS  Google Scholar 

  5. Bokenkamp A, von Kries R, Nowak-Gottl U, Gobel U, Hoyer PF (2000) Neonatal renal venous thrombosis in Germany between 1992 and 1994: epidemiology, treatment and outcome. Eur J Pediatr 159:44–8

    Article  PubMed  CAS  Google Scholar 

  6. Brion LP, Soll RF (2008) Diuretics for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev:CD001454

    Google Scholar 

  7. Brion LP, Primhak RA, Ambrosio-Perez I (2002) Diuretics acting on the distal renal tubule for preterm infants with (or developing) chronic lung disease. Cochrane Database Syst Rev:CD001817

    Google Scholar 

  8. Buscher AK, Kranz B, Buscher R, Hildebrandt F, Dworniczak B, Pennekamp P, Kuwertz-Broking E, Wingen AM, John U, Kemper M, Monnens L, Hoyer PF, Weber S, Konrad M (2010) Immunosuppression and renal outcome in congenital and pediatric steroid-resistant nephrotic syndrome. Clin J Am Soc Nephrol 11:2075–84

    Article  Google Scholar 

  9. Chadha V, Warady BA, Blowey DL, Simckes AM, Alon US (2000) Tenckhoff catheters prove superior to cook catheters in pediatric acute peritoneal dialysis. Am J Kidney Dis 35:1111–6

    Article  PubMed  CAS  Google Scholar 

  10. Coulthard MG, Sharp J (1995) Haemodialysis and ultrafiltration in babies weighing under 1000 g. Arch Dis Child Fetal Neonatal Ed 73:F162–5

    Article  PubMed  CAS  Google Scholar 

  11. Coulthard MG, Vernon B (1995) Managing acute renal failure in very low birthweight infants. Arch Dis Child Fetal Neonatal Ed 73:F187–92

    Article  PubMed  CAS  Google Scholar 

  12. Cozzolino DJ, Cendron M (1997) Bilateral renal vein thrombosis in a newborn: a case of prenatal renal vein thrombosis. Urology 50:128–31

    Article  PubMed  CAS  Google Scholar 

  13. Crochemore C, Lu J, Wu Y, Liposits Z, Sousa N, Holsboer F, Almeida OF (2005) Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation. Mol Psychiatry 10:790–8

    Article  PubMed  CAS  Google Scholar 

  14. Cuzzolin L, Fanos V, Pinna B, di Marzio M, Perin M, Tramontozzi P, Tonetto P, Cataldi L (2006) Postnatal renal function in preterm newborns: a role of diseases, drugs and therapeutic interventions. Pediatr Nephrol 21:931–8

    Article  PubMed  Google Scholar 

  15. Emery EF, Greenough A (1993) Efficacy of low-dose dopamine infusion. Acta Paediatr 82:430–2

    Article  PubMed  CAS  Google Scholar 

  16. Everdell NL, Coulthard MG, Crosier J, Keir MJ (2005) A machine for haemodialysing very small infants. Pediatr Nephrol 20:636–43

    Article  PubMed  Google Scholar 

  17. Farnoux C, Camard O, Pinquier D, Hurtaud-Roux MF, Sebag G, Schlegel N, Beaufils F (1998) Recombinant tissue-type plasminogen activator therapy of thrombosis in 16 neonates. J Pediatr 133:137–40

    Article  PubMed  CAS  Google Scholar 

  18. Fuchshuber A, Niaudet P, Gribouval O, Jean G, Gubler MC, Broyer M, Antignac C (1996) Congenital nephrotic syndrome of the Finnish type: linkage to the locus in a non-Finnish population. Pediatr Nephrol 10:135–8

    PubMed  CAS  Google Scholar 

  19. Goldman M, Lahat E, Strauss S, Reisler G, Livne A, Gordin L, Aladjem M (2000) Imaging after urinary tract infection in male neonates. Pediatrics 105:1232–5

    Article  PubMed  CAS  Google Scholar 

  20. Gouyon JB, Guignard JP (2000) Management of acute renal failure in newborns. Pediatr Nephrol 14:1037–44

    Article  PubMed  CAS  Google Scholar 

  21. Green TP, Thompson TR, Johnson DE, Lock JE (1983) Furosemide promotes patent ductus arteriosus in premature infants with the respiratory-distress syndrome. N Engl J Med 308:743–8

    Article  PubMed  CAS  Google Scholar 

  22. Group IPDT (1998) International randomised controlled trial of acetazolamide and furosemide in posthaemorrhagic ventricular dilatation in infancy. Lancet 352:433–40

    Article  Google Scholar 

  23. Guignard JP, John EG (1986) Renal function in the tiny, premature infant. Clin Perinatol 13:377–401

    PubMed  CAS  Google Scholar 

  24. Haycock GB (2003) Management of acute and chronic renal failure in the newborn. Semin Neonatol 8:325–34

    Article  PubMed  Google Scholar 

  25. Heaton PA, Smales O, Wong W (1999) Congenital nephrotic syndrome responsive to captopril and indometacin. Arch Dis Child 81:174–5

    Article  PubMed  CAS  Google Scholar 

  26. Heller C, Schobess R, Kurnik K, Junker R, Gunther G, Kreuz W, Nowak-Gottl U (2000) Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors – a multicentre case-control study. For the Childhood Thrombophilia Study Group. Br J Haematol 111:534–9

    Article  PubMed  CAS  Google Scholar 

  27. Hibbert J, Howlett DC, Greenwood KL, MacDonald LM, Saunders AJ (1997) The ultrasound appearances of neonatal renal vein thrombosis. Br J Radiol 70:1191–4

    PubMed  CAS  Google Scholar 

  28. Hinkes BG, Mucha B, Vlangos CN, Gbadegesin R, Liu J, Hasselbacher K, Hangan D, Ozaltin F, Zenker M, Hildebrandt F (2007) Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2). Pediatrics 119:e907–19

    Article  PubMed  Google Scholar 

  29. Holmberg C, Antikainen M, Ronnholm K, Ala Houhala M, Jalanko H (1995) Management of congenital nephrotic syndrome of the Finnish type. Pediatr Nephrol 9:87–93

    Article  PubMed  CAS  Google Scholar 

  30. Kennedy CR, Ayers S, Campbell MJ, Elbourne D, Hope P, Johnson A (2001) Randomized, controlled trial of acetazolamide and furosemide in posthemorrhagic ventricular dilation in infancy: follow-up at 1 year. Pediatrics 108:597–607

    Article  PubMed  CAS  Google Scholar 

  31. Kim MS, Stablein D, Harmon WE (1998) Renal transplantation in children with congenital nephrotic syndrome: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). Pediatr Transplant 2:305–8

    PubMed  CAS  Google Scholar 

  32. Klinge J, Scharf J, Rupprecht T, Boswald M, Hofbeck M (1998) Selective thrombolysis in a newborn with bilateral renal venous and cerebral thrombosis and heterozygous APC resistance. Nephrol Dial Transplant 13:3205–7

    PubMed  CAS  Google Scholar 

  33. Köckerling A, Konrad M, Seyberth HW (1998) Hereditäre Tubulopathien mit Diuretika-ähnlichem Salzverlust. Dtsch Arztebl 95(30):A-1841/B-1582/C-1467

    Google Scholar 

  34. Kosch A, Kuwertz-Broking E, Heller C, Kurnik K, Schobess R, Nowak-Gottl U (2004) Renal venous thrombosis in neonates: prothrombotic risk factors and long-term follow-up. Blood 104:1356–60

    Article  PubMed  CAS  Google Scholar 

  35. Kuhle S, Massicotte P, Chan A, Mitchell L (2004) A case series of 72 neonates with renal vein thrombosis. Data from the 1-800-NO-CLOTS Registry. Thromb Haemost 92:729–33

    PubMed  CAS  Google Scholar 

  36. Lewis V, Whitelaw A (2002) Furosemide for transient tachypnea of the newborn. Cochrane Database Syst Rev:CD003064

    Google Scholar 

  37. Libenson MH, Kaye EM, Rosman NP, Gilmore HE (1999) Acetazolamide and furosemide for posthemorrhagic hydrocephalus of the newborn. Pediatr Neurol 20:185–91

    Article  PubMed  CAS  Google Scholar 

  38. Machuca E, Benoit G, Nevo F, Tete MJ, Gribouval O, Pawtowski A, Brandstrom P, Loirat C, Niaudet P, Gubler MC, Antignac C (2010) Genotype-phenotype correlations in non-Finnish congenital nephrotic syndrome. J Am Soc Nephrol 21:1209–17

    Article  PubMed  CAS  Google Scholar 

  39. Marks SD, Massicotte MP, Steele BT, Matsell DG, Filler G, Shah PS, Perlman M, Rosenblum ND, Shah VS (2005) Neonatal renal venous thrombosis: clinical outcomes and prevalence of prothrombotic disorders. J Pediatr 146:811–6

    Article  PubMed  Google Scholar 

  40. Nuss R, Hays T, Manco-Johnson M (1994) Efficacy and safety of heparin anticoagulation for neonatal renal vein thrombosis. Am J Pediatr Hematol Oncol 16:127–31

    PubMed  CAS  Google Scholar 

  41. Patrakka J, Kestila M, Wartiovaara J, Ruotsalainen V, Tissari P, Lenkkeri U, Mannikko M, Visapaa I, Holmberg C, Rapola J, Tryggvason K, Jalanko H (2000) Congenital nephrotic syndrome (NPHS1): features resulting from different mutations in Finnish patients. Kidney Int 58:972–80

    Article  PubMed  CAS  Google Scholar 

  42. Peters M, Jeck N, Reinalter S, Leonhardt A, Tonshoff B, Klaus GG, Konrad M, Seyberth HW (2002) Clinical presentation of genetically defined patients with hypokalemic salt-losing tubulopathies. Am J Med 112:183–90

    Article  PubMed  Google Scholar 

  43. Pohl M, Zimmerhackl LB, Heinen F, Sutor AH, Schneppenheim R, Brandis M (1998) Bilateral renal vein thrombosis and venous sinus thrombosis in a neonate with factor V mutation (FV Leiden). J Pediatr 132:159–61

    Article  PubMed  CAS  Google Scholar 

  44. Rasoulpour M, Marinelli KA (1992) Systemic hypertension. Clin Perinatol 19:121–37

    PubMed  CAS  Google Scholar 

  45. Reinalter SC, Jeck N, Brochhausen C, Watzer B, Nusing RM, Seyberth HW, Komhoff M (2002) Role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome. Kidney Int 62:253–60

    Article  PubMed  CAS  Google Scholar 

  46. Rodriguez-Soriano J, Vallo A, Oliveros R, Castillo G (1983) Renal handling of sodium in premature and full-term neonates: a study using clearance methods during water diuresis. Pediatr Res 17:1013–6

    Article  PubMed  CAS  Google Scholar 

  47. Savage JM, Jefferson JA, Maxwell AP, Hughes AE, Shanks JH, Gill D (1999) Improved prognosis for congenital nephrotic syndrome of the Finnish type in Irish families. Arch Dis Child 80:466–9

    Article  PubMed  CAS  Google Scholar 

  48. Seri I (1995) Cardiovascular, renal, and endocrine actions of dopamine in neonates and children. J Pediatr 126:333–44

    Article  PubMed  CAS  Google Scholar 

  49. Seri I, Rudas G, Bors Z, Kanyicska B, Tulassay T (1993) Effects of low-dose dopamine infusion on cardiovascular and renal functions, cerebral blood flow, and plasma catecholamine levels in sick preterm neonates. Pediatr Res 34:742–9

    Article  PubMed  CAS  Google Scholar 

  50. Sonntag J, Prankel B, Waltz S (1996) Serum creatinine concentration, urinary creatinine excretion and creatinine clearance during the first 9 weeks in preterm infants with a birth weight below 1500 g. Eur J Pediatr 155:815–9

    Article  PubMed  CAS  Google Scholar 

  51. Toth-Heyn P, Drukker A, Guignard JP (2000) The stressed neonatal kidney: from pathophysiology to clinical management of neonatal vasomotor nephropathy. Pediatr Nephrol 14:227–39

    Article  PubMed  CAS  Google Scholar 

  52. Turner A, Haycock GB (1999) Renal function and renal failure in the newborn. In: Hansen TN, McIntosh N (Hrsg) Current topics in neonatology. W.B. Saunders, London

    Google Scholar 

  53. Warady BA, Belden B, Kohaut E (1999) Neurodevelopmental outcome of children initiating peritoneal dialysis in early infancy. Pediatr Nephrol 13:759–65

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Maier, R.F. (2011). Nierenkrankheiten. In: Maier, R.F., Obladen, M. (eds) Neugeborenenintensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01069-9_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-01069-9_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-01068-2

  • Online ISBN: 978-3-642-01069-9

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics