Skip to main content
SpringerLink
Log in

Hyperbilirubinämie und Morbus haemolyticus neonatorum

  • Chapter
Neugeborenenintensivmedizin

  • 2954 Accesses

Zusammenfassung

Die Hyperbilirubinämie ist wieder aktuell, da in den letzten Jahren auch in Ländern mit entwickeltem Gesundheitswesen der Kernikterus erneut aufgetreten ist [8, 30]. Grund dafür ist eine in den 1990er-Jahren liberalere Einstellung gegenüber erhöhten Bilirubinwerten [3, 44] in Verbindung mit immer früherer Entlassung des Neugeborenen aus der Geburtsklinik [16].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Alcock GS, Liley H (2002) Immunoglobulin infusion for isoimmune haemolytic jaundice in neonates. Cochrane Database Syst Rev:CD003313

    Google Scholar 

  2. Alpay F, Sarici SU, Tosuncuk HD, Serdar MA, Inanc N, Gokcay E (2000) The value of first-day bilirubin measurement in predicting the development of significant hyperbilirubinemia in healthy term newborns. Pediatrics 106:E16

    Article  PubMed  CAS  Google Scholar 

  3. American Academy of Pediatrics (2004) Clinical practice guideline: Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 114:297–316

    Article  Google Scholar 

  4. Arslanoglu S, Moro GE, Tauschel HD, Boehm G (2008) Ursodeoxycholic acid treatment in preterm infants: a pilot study for the prevention of cholestasis associated with total parenteral nutrition. J Pediatr Gastroenterol Nutr 46:228–31

    Article  PubMed  CAS  Google Scholar 

  5. Avent ND, Reid ME (2000) The Rh blood group system: a review. Blood 95:375–87

    PubMed  CAS  Google Scholar 

  6. Benders MJ, van Bel F, van de Bor M (1998) The effect of phototherapy on cerebral blood flow velocity in preterm infants. Acta Paediatr 87:786–91

    Article  PubMed  CAS  Google Scholar 

  7. Benders MJ, van Bel F, van de Bor M (1999) Haemodynamic consequences of phototherapy in term infants. Eur J Pediatr 158:323–8

    Article  PubMed  CAS  Google Scholar 

  8. Bhutani VK, Johnson L (2006) Kernicterus in late preterm infants cared for as term healthy infants. Semin Perinatol 30:89–97

    Article  PubMed  Google Scholar 

  9. Bhutani VK, Gourley GR, Adler S, Kreamer B, Dalin C, Johnson LH (2000) Noninvasive measurement of total serum bilirubin in a multiracial predischarge newborn population to assess the risk of severe hyperbilirubinemia. Pediatrics 106:E17

    Article  PubMed  CAS  Google Scholar 

  10. Bhutani VK, Johnson L, Sivieri EM (1999) Predictive ability of a predischarge hourspecific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics 103:6–14

    Article  PubMed  CAS  Google Scholar 

  11. Bowman J (1997) The management of hemolytic disease in the fetus and newborn. Semin Perinatol 21:39–44

    Article  PubMed  CAS  Google Scholar 

  12. Cameron AD, Swain S, Patrick WJ (1997) Human parvovirus B19 infection associated with hydrops fetalis. Aust N Z J Obstet Gynaecol 37:316–9

    Article  PubMed  CAS  Google Scholar 

  13. Chandar JS, Wolfe SB (1994) Displacement of preexisting thrombus by umbilical vein catheterization. Pediatr Cardiol 15:311–2

    Article  PubMed  CAS  Google Scholar 

  14. Chui DH, Waye JS (1998) Hydrops fetalis caused by alpha-thalassemia: an emerging health care problem. Blood 91:2213–22

    PubMed  CAS  Google Scholar 

  15. Dai J, Parry DM, Krahn J (1997) Transcutaneous bilirubinometry: its role in the assessment of neonatal jaundice. Clin Biochem 30:1–9

    Article  PubMed  CAS  Google Scholar 

  16. Dennery PA , Seidman DS, Stevenson DK (2001) Neonatal hyperbilirubinemia. N Engl J Med 344:581–90

    Article  PubMed  CAS  Google Scholar 

  17. Ebbesen F, Andersson C, Verder H, Grytter C, Pedersen-Bjergaard L, Petersen JR, Schaarup J (2005) Extreme hyperbilirubinaemia in term and near-term infants in Denmark. Acta Paediatr 94:59–64

    Article  PubMed  CAS  Google Scholar 

  18. Entezami M, Halis G, Waldschmidt J, Opri F, Runkel S (1998) Congenital cystic adenomatoid malformation of the lung and fetal hydrops – a case with favourable outcome. Eur J Obstet Gynecol Reprod Biol 79:99–101

    Article  PubMed  CAS  Google Scholar 

  19. Gottstein R, Cooke RW (2003) Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn. Arch Dis Child Fetal Neonatal Ed 88:F6–10

    Article  PubMed  CAS  Google Scholar 

  20. Graziani LJ, Mitchell DG, Kornhauser M, Pidcock FS, Merton DA, Stanley C, McKee L (1992) Neurodevelopment of preterm infants: neonatal neurosonographic and serum bilirubin studies. Pediatrics 89:229–34

    PubMed  CAS  Google Scholar 

  21. Grimmer I, Berger-Jones K, Buhrer C, Brandl U, Obladen M (1999) Late neurological sequelae of non-hemolytic hyperbilirubinemia of healthy term neonates. Acta Paediatr 88:661–3

    Article  PubMed  CAS  Google Scholar 

  22. Gupta AK, Mann SB (1998) Is auditory brainstem response a bilirubin neurotoxicity marker? Am J Otolaryngol 19:232–6

    Article  PubMed  CAS  Google Scholar 

  23. Hansen TW (1997) Acute management of extreme neonatal jaundice – the potential benefits of intensified phototherapy and interruption of enterohepatic bilirubin circulation. Acta Paediatr 86:843–6

    Article  PubMed  CAS  Google Scholar 

  24. Harris MC, Bernbaum JC, Polin JR, Zimmerman R, Polin RA (2001) Developmental follow-up of breastfed term and near-term infants with marked hyperbilirubinemia. Pediatrics 107:1075–80

    Article  PubMed  CAS  Google Scholar 

  25. Inglis GD, Davies MW (2005) Prophylactic antibiotics to reduce morbidity and mortality in neonates with umbilical venous catheters. Cochrane Database Syst Rev:CD005251

    Google Scholar 

  26. Ip S, Chung M, Kulig J, O’Brien R, Sege R, Glicken S, Maisels MJ, Lau J (2004) An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics 114:e130–53

    Article  PubMed  Google Scholar 

  27. Jackson JC (1997) Adverse events associated with exchange transfusion in healthy and ill newborns. Pediatrics 99:E7

    Article  PubMed  CAS  Google Scholar 

  28. Jacquemin E, Lykavieris P, Chaoui N, Hadchouel M, Bernard O (1998) Transient neonatal cholestasis: origin and outcome. J Pediatr 133:563–7

    Article  PubMed  CAS  Google Scholar 

  29. Johnson L, Bhutani VK (1998) Guidelines for management of the jaundiced term and near-term infant. Clin Perinatol 25:555–74, viii

    PubMed  CAS  Google Scholar 

  30. Johnson L, Bhutani VK, Karp K, Sivieri EM, Shapiro SM (2009) Clinical report from the pilot USA Kernicterus Registry (1992 to 2004). J Perinatol 29(Suppl 1):S25–45

    Article  PubMed  Google Scholar 

  31. Kabra NS, Kumar M, Shah SS (2005) Multiple versus single lumen umbilical venous catheters for newborn infants. Cochrane Database Syst Rev:CD004498

    Google Scholar 

  32. Krantz ID, Piccoli DA, Spinner NB (1997) Alagille syndrome. J Med Genet 34:152–7

    Article  PubMed  CAS  Google Scholar 

  33. Lang T, Kappler M, Dietz H, Harms HK, Bertele-Harms R (2000) Biliary atresia: which factors predict the success of a Kasai operation? An analysis of 36 patients. Eur J Med Res 5:110–4

    PubMed  CAS  Google Scholar 

  34. Lee C, Stonestreet BS, Oh W, Outerbridge EW, Cashore WJ (1995) Postnatal maturation of the blood-brain barrier for unbound bilirubin in newborn piglets. Brain Res 689:233–8

    Article  PubMed  CAS  Google Scholar 

  35. Levine Z, Sherer DM, Jacobs A, Rotenberg O (1998) Nonimmune hydrops fetalis due to congenital syphilis associated with negative intrapartum maternal serology screening. Am J Perinatol 15:233–6

    Article  PubMed  CAS  Google Scholar 

  36. Maisels MJ, Kring E (1997) Transcutaneous bilirubinometry decreases the need for serum bilirubin measurements and saves money. Pediatrics 99:599–601

    Article  PubMed  CAS  Google Scholar 

  37. Maisels MJ, Watchko JF (2003) Treatment of jaundice in low birthweight infants. Arch Dis Child Fetal Neonatal Ed 88:F459–63

    Article  PubMed  CAS  Google Scholar 

  38. McDonnell M, Hannam S, Devane SP (1998) Hydrops fetalis due to AB0 incompatibility. Arch Dis Child Fetal Neonatal Ed 78:F220–1

    Article  PubMed  CAS  Google Scholar 

  39. Middlesworth W, Altman RP (1997) Biliary atresia. Curr Opin Pediatr 9:265–9

    Article  PubMed  CAS  Google Scholar 

  40. Mills JF, Tudehope D (2001) Fibreoptic phototherapy for neonatal jaundice. Cochrane Database Syst Rev:CD002060

    Google Scholar 

  41. Moise KJ Jr. (2008) Management of rhesus alloimmunization in pregnancy. Obstet Gynecol 112:164–76

    Article  PubMed  Google Scholar 

  42. Morris BH, Oh W, Tyson JE, Stevenson DK, Phelps DL, O’Shea TM, McDavid GE, Perritt RL, Van Meurs KP, Vohr BR, Grisby C, Yao Q, Pedroza C, Das A, Poole WK, Carlo WA, Duara S, Laptook AR, Salhab WA, Shankaran S, Poindexter BB, Fanaroff AA, Walsh MC, Rasmussen MR, Stoll BJ, Cotten CM, Donovan EF, Ehrenkranz RA, Guillet R, Higgins RD (2008) Aggressive vs. conservative phototherapy for infants with extremely low birth weight. N Engl J Med 359:1885–96

    Article  PubMed  CAS  Google Scholar 

  43. Nakayama H, Kukita J, Hikino S, Nakano H, Hara T (1999) Long-term outcome of 51 liveborn neonates with non-immune hydrops fetalis. Acta Paediatr 88:24–8

    Article  PubMed  CAS  Google Scholar 

  44. Newman TB, Maisels MJ (1992) Evaluation and treatment of jaundice in the term newborn: a kinder, gentler approach. Pediatrics 89:809–18

    PubMed  CAS  Google Scholar 

  45. Newman TB, Maisels MJ (2000) Less aggressive treatment of neonatal jaundice and reports of kernicterus: lessons about practice guidelines. Pediatrics 105:242–5

    Article  PubMed  CAS  Google Scholar 

  46. Newman TB, Liljestrand P, Jeremy RJ, Ferriero DM, Wu YW, Hudes ES, Escobar GJ (2006) Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter or more. N Engl J Med 354:1889–900

    Article  PubMed  CAS  Google Scholar 

  47. O’Dea TJ, Saly G, Holte J (1998) Safety investigation: interaction of infant radiant warmers and bilirubin phototherapy lights in the regulation of temperature of newborn infants. Biomed Instrum Technol 32:355–69

    PubMed  Google Scholar 

  48. Pezzati M, Biagiotti R, Vangi V, Lombardi E, Wiechmann L, Rubaltelli FF (2000) Changes in mesenteric blood flow response to feeding: conventional versus fiber-optic phototherapy. Pediatrics 105:350–3

    Article  PubMed  CAS  Google Scholar 

  49. Robertson A, Karp W, Brodersen R (1991) Bilirubin displacing effect of drugs used in neonatology. Acta Paediatr Scand 80:1119–27

    Article  PubMed  CAS  Google Scholar 

  50. Sabatino G, Verrotti A, Ramenghi LA, Domizio S, Melchionda D, Fulgente T, Paci C, Andreamatteo GD, Thomas A, Onofrj M (1996) Newborns with hyperbilirubinemia: usefulness of brain stem auditory response evaluation. Neurophysiol Clin 26:363–8

    Article  PubMed  CAS  Google Scholar 

  51. Scheidt PC, Graubard BI, Nelson KB, Hirtz DG, Hoffman HJ, Gartner LM, Bryla DA (1991) Intelligence at six years in relation to neonatal bilirubin levels: follow-up of the National Institute of Child Health and Human Development Clinical Trial ofPhototherapy. Pediatrics 87:797–805

    Google Scholar 

  52. Seidman DS, Ergaz Z, Paz I, Laor A, Revel-Vilk S, Stevenson DK, Gale R (1999) Predicting the risk of jaundice in full-term healthy newborns: a prospective population-based study. J Perinatol 19:564–7

    Article  PubMed  CAS  Google Scholar 

  53. Sirota L, Straussberg R, Gurary N, Aloni D, Bessler H (1999) Phototherapy for neonatal hyperbilirubinemia affects cytokine production by peripheral blood mononuclear cells. Eur J Pediatr 158:910–3

    Article  PubMed  CAS  Google Scholar 

  54. Sondheimer JM, Asturias E, Cadnapaphornchai M (1998) Infection and cholestasis in neonates with intestinal resection and long-term parenteral nutrition. J Pediatr Gastroenterol Nutr 27:131–7

    Article  PubMed  CAS  Google Scholar 

  55. Strauss RG (1991) Transfusion therapy in neonates. Am J Dis Child 145:904–11

    PubMed  CAS  Google Scholar 

  56. Suresh GK, Martin CL, Soll RF (2003) Metalloporphyrins for treatment of unconjugated hyperbilirubinemia in neonates. Cochrane Database Syst Rev:CD004207

    Google Scholar 

  57. Swain S, Cameron AD, McNay MB, Howatson AG (1999) Prenatal diagnosis and management of nonimmune hydrops fetalis. Aust N Z J Obstet Gynaecol 39:285–90

    Article  PubMed  CAS  Google Scholar 

  58. Tan KL (1997) Efficacy of bidirectional fiber-optic phototherapy for neonatal hyperbilirubinemia. Pediatrics 99:E13

    Article  PubMed  CAS  Google Scholar 

  59. Teitelbaum DH (1997) Parenteral nutrition-associated cholestasis. Curr Opin Pediatr 9:270–5

    Article  PubMed  CAS  Google Scholar 

  60. Thayyil S, Milligan DW (2006) Single versus double volume exchange transfusion in jaundiced newborn infants. Cochrane Database Syst Rev:CD004592

    Google Scholar 

  61. Ulm B, Ulm MR, Deutinger J, Bernaschek G (1999) Twenty-four cordocenteses in one woman. Fetal Diagn Ther 14:283–5

    Article  PubMed  CAS  Google Scholar 

  62. Urbaniak SJ, Greiss MA (2000) RhD haemolytic disease of the fetus and the newborn. Blood Rev 14:44–61

    Article  PubMed  CAS  Google Scholar 

  63. Van de Bor M, Ens-Dokkum M, Schreuder AM, Veen S, Brand R, Verloove- Vanhorick SP (1992) Hyperbilirubinemia in low birth weight infants and outcome at 5 years of age. Pediatrics 89:359–64

    PubMed  Google Scholar 

  64. Van Kaam AH, van Beek RH, Vergunst-van Keulen JG, Van Der Heijden J, Lutz-Dettinger N, Hop W, Sauer PJ (1998) Fibre optic versus conventional phototherapy for hyperbilirubinaemia in preterm infants. Eur J Pediatr 157:132–7

    Article  PubMed  Google Scholar 

  65. Vohr BR, Karp D, O’Dea C, Darrow D, Coll CG, Lester BM, Brown L, Oh W, Cashore W (1990) Behavioral changes correlated with brain-stem auditory evoked responses in term infants with moderate hyperbilirubinemia. J Pediatr 117:288–91

    Article  PubMed  CAS  Google Scholar 

  66. Wafelman LS, Pollock BH, Kreutzer J, Richards DS, Hutchison AA (1999) Nonimmune hydrops fetalis: fetal and neonatal outcome during 1983–1992. Biol Neonate 75:73–81

    Article  PubMed  CAS  Google Scholar 

  67. Wennberg RP (2000) The blood-brain barrier and bilirubin encephalopathy. Cell Mol Neurobiol 20:97–109

    Article  PubMed  CAS  Google Scholar 

  68. Wong V, Chen WX, Wong KY (2006) Short- and long-term outcome of severe neonatal nonhemolytic hyperbilirubinemia. J Child Neurol 21:309–15

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Gießen und Marburg GmbH Standort Marburg, Baldinger Strasse, 35033, Marburg

    Prof. Dr. med. Rolf F. Maier (Direktor)

Authors
  1. Prof. Dr. med. Rolf F. Maier
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Gießen und Marburg GmbH Standort Marburg, Baldinger Strasse, 35033, Marburg

    Rolf F. Maier (Direktor) (Direktor)

  2. Klinik für Neonatologie, Charité Virchow-Klinikum, Augustenburger Platz 1, 13353, Berlin

    Michael Obladen (em. Direktor) (em. Direktor)

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Maier, R.F. (2011). Hyperbilirubinämie und Morbus haemolyticus neonatorum. In: Maier, R.F., Obladen, M. (eds) Neugeborenenintensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01069-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-01069-9_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-01068-2

  • Online ISBN: 978-3-642-01069-9

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation