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Kardiovaskuläres “tissue engineering”

  • Chapter
Herzchirurgie

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Zusammenfassung

Organerkrankungen im Endstadium sowie der Verlust gesunder, funktionsfähiger Organe und Organ strukturen konfrontieren Medizin und Gesellschaft mit therapeutisch wie sozioökonomisch immensen Problemen. Durch Identifizierung neuer und Verbesserung bestehender Therapieoptionen und hier insbesondere auch der Transplantation von Geweben und Organen konnten im Laufe der letzten Jahre vielfach deutliche therapeutische Fortschritte erzielt und dabei die Prognose einer Reihe von Erkrankungen deutlich verbessert werden. Beide Therapieansätze — rekonstruierend wie substituierend — sind jedoch auch heute noch mit Nachteilen behaftet, die ihre Anwendbarkeit limitieren. Beispiele hierfür sind insbesondere:

  • eine zunehmend große Diskrepanz zwischen Verfügbarkeit und Bedarf an Organen,

  • Entwicklung sekundärer Gesundheitsrisiken wie z. B. Ausbildung von Neoplasien durch notwendige und unabdingbare lebenslange immun suppressive Therapien nach Organtransplantation,

  • Mangel an Spendergeweben wie z. B. arterielle und venöse Blutgefäße allogenen, aber auch autologen Ursprungs,

  • gesteigertes Risiko für Infektionen und thromboembolische Komplikationen nach Implantation mechanischer und alloplastischer Prothesen,

  • gesteigertes Risiko für das Auftreten von Blutungskomplikationen unter antikoagulativer Therapie, die aufgrund einer gesteigerten intrinsischen Thrombogenität alloplastischer Implantate zumeist lebenslang aufrechterhalten werden muss.

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  1. Klinik für Herz-, Thorax-, Transplantations- und Gefäßchirurgie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover

    Prof. Dr. med. Dr. h.c. A. Haverich & Priv.-Doz. Dr. med. M. Wilhelmi

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Haverich, A., Wilhelmi, M. (2010). Kardiovaskuläres “tissue engineering”. In: Herzchirurgie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79713-5_6

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